Query: stroke

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Source: Neurological Research

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Total 184 results found since Jan 2013.

Effects of neuroserpin on clinical outcomes and inflammatory markers in Chinese patients with acute ischemic stroke.
CONCLUSIONS: A larger decrease in NSP levels related to lower levels of inflammatory marker, while higher NSP levels were associated with lower inflammatory markers and better functional outcomes. Decreasing the infarct size may play a role in this process. These results provide more evidence of the neuroprotective effect of NSP in cerebral ischemic patients. Decrease in the Serum NSP level and NSP level at admission may be considered as potential predictive factors for outcome of acute ischemic stroke. PMID: 28738762 [PubMed - as supplied by publisher]
Source: Neurological Research - July 26, 2017 Category: Neurology Tags: Neurol Res Source Type: research

High nonfasting triglyceride concentrations predict good outcome following acute ischaemic stroke.
DISCUSSION: Higher fasting and nonfasting serum TG concentrations predicted good poststroke outcome independently of other prognostic factors. PMID: 28683603 [PubMed - as supplied by publisher]
Source: Neurological Research - July 9, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Relationship of phosphodiesterase 4D (PDE4D) gene polymorphisms with risk of ischemic stroke: a hospital based case-control study.
CONCLUSION: SNP 83 of PDE4D gene may increase the risk for developing IS whereas SNP 87 and SNP45 of PDE4D may not be associated with the risk of IS in the North Indian population. Prospective cohort studies are required to corroborate these findings. PMID: 28562233 [PubMed - as supplied by publisher]
Source: Neurological Research - June 2, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Stroke is a global epidemic: new developments in clinical and translational cerebrovascular diseases research.
Authors: Li WA, Geng X, Ding Y PMID: 28531374 [PubMed - in process]
Source: Neurological Research - May 24, 2017 Category: Neurology Tags: Neurol Res Source Type: research

One-year outcomes and secondary prevention in patients after acute minor stroke: results from the China National Stroke Registry.
CONCLUSIONS: Outcomes in individuals in China who had experienced acute minor stroke were unfavorable, underscoring the importance of early, sustained preventive therapy in this patient population. Combination of secondary prevention medication classes was associated with a lower risk of death. PMID: 28476094 [PubMed - as supplied by publisher]
Source: Neurological Research - May 11, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Risk of hemorrhagic transformation after ischemic stroke in patients with antiphospholipid antibody syndrome.
CONCLUSION: APS is an independent risk factor for hemorrhagic transformation in both thrombolytic and non-thrombolytic treated patients. APS is also associated with longer length and cost of hospital stay. Further research is warranted to identify the unique risk factors in these patients to identify strategies to reduce the risk of hemorrhagic transformation in this subgroup of the population. PMID: 28475479 [PubMed - as supplied by publisher]
Source: Neurological Research - May 8, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Successful aging in community seniors and stroke survivors: current and future strategies.
Authors: Kamat R, Depp CA, Jeste DV Abstract There is growing evidence to suggest that aging is accompanied by enhancement in psychosocial well-being, despite age-related declines in physical and cognitive functioning. A small but growing body of research has reported on positive trajectories of well-being, and its determinants, among community-dwelling seniors as well as in people with specific diseases such as stroke. Current strategies for promoting successful aging include physical, cognitive and social activities, healthy lifestyle, social support, and positive traits such as resilience and optimism. These str...
Source: Neurological Research - May 5, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Identification of IL-17A-derived neural cell type and dynamic changes of IL-17A in serum/CSF of mice with ischemic stroke.
CONCLUSION: We firstly reported astrocytic IL-17A peaks in CSF within 12 h and in serum at 3 d reperfusion after ischemic stroke. IL-17A may exaggerate neuronal injuries through its receptor IL-17R at early stage of ischemic stroke. PMID: 28441917 [PubMed - as supplied by publisher]
Source: Neurological Research - April 28, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Validation of the Essen Stroke Risk Score in different subtypes of ischemic stroke.
CONCLUSIONS: In patients with LAA subtype of non-atrial fibrillation stroke, the ESRS has moderate accuracy in stratifying the risk of both recurrent strokes and major vascular events within the first year. However, the ESRS couldn't accurately stratify the risk of recurrent strokes in patients with small-artery atherosclerosis subtype of non-atrial fibrillation stroke. PMID: 28431475 [PubMed - as supplied by publisher]
Source: Neurological Research - April 24, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Persistence of secondary prevention medication and related factors for acute ischemic stroke and transient ischemic attack in China.
CONCLUSIONS: More than half of patients with AIS and TIA reported discontinuing one or more secondary prevention medications within 3 months of hospital discharge. Several factors associated with medication persistence were identified. Here, we propose strategies that could be implemented to improve the quality of secondary prevention. PMID: 28420316 [PubMed - as supplied by publisher]
Source: Neurological Research - April 21, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Exercise rehabilitation immediately following ischemic stroke exacerbates inflammatory injury.
CONCLUSION: Post-stroke exercise, if too early, may result in elevated levels of cell stress and increased expression of pro-inflammatory cytokines, which may amplify the tissue damage associated with cerebral ischemia/reperfusion injury. The results shed light on the manner in which exercise initiation timing may affect post-stroke rehabilitation. PMID: 28415917 [PubMed - as supplied by publisher]
Source: Neurological Research - April 20, 2017 Category: Neurology Tags: Neurol Res Source Type: research

The association between high on-treatment platelet reactivity and early recurrence of ischemic events after minor stroke or TIA.
DISCUSSION: In patients with minor stroke or TIA, the prevalence of HTPR was 22.7%, and HTPR was independently associated with recurrent ischemic events. PMID: 28398139 [PubMed - as supplied by publisher]
Source: Neurological Research - April 13, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Impact of CRP gene and additional gene-smoking interaction on ischemic stroke in a Chinese Han population.
CONCLUSIONS: We found that rs2794521, rs3093059, and rs1205 were associated with decreased IS risk; we also found that gene-gene interaction between rs2794521 and rs3093059, and gene-environment interaction between rs2794521 and smoking were associated with decreased IS risk. PMID: 28287042 [PubMed - as supplied by publisher]
Source: Neurological Research - March 14, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Impact of the PDE4D gene polymorphism and additional SNP-SNP and gene-smoking interaction on ischemic stroke risk in Chinese Han population.
CONCLUSIONS: Our results support an important association of rs966221 and rs12188950 minor allele and its interaction with increased risk of IS risk, and additional interaction between rs966221 and smoking. PMID: 28191858 [PubMed - as supplied by publisher]
Source: Neurological Research - February 15, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study.
DISCUSSION: Dl-3-n-butylphthalide could significantly improve the cognitive function of AIS patients 1 month after stroke. Hcy was involved in the incidence of VD 1 month after AIS. However, further studies are necessary because of differences between groups at baseline. PMID: 28145815 [PubMed - as supplied by publisher]
Source: Neurological Research - February 2, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Atherosclerotic plaque burden of middle cerebral artery and extracranial carotid artery characterized by MRI in patients with acute ischemic stroke in China: association and clinical relevance.
CONCLUSION: Greater atherosclerotic plaque burden and a closer association with stroke severity were found for the MCA as compared to the ipsilateral ECA. Identification of MCA plaque lesions by MRI may be helpful for developing more aggressive strategies for stroke prevention. PMID: 28136710 [PubMed - as supplied by publisher]
Source: Neurological Research - February 2, 2017 Category: Neurology Tags: Neurol Res Source Type: research

ARHGEF10 gene polymorphism is closely associated with the risk of ischemic stroke in Northern Han Chinese population.
This study aims to evaluate the potential association of the single nucleotide polymorphisms (SNPs) of ARHGEF10 with ischemic stroke (IS) in northern Han Chinese population. Three SNPs of ARHGEF10 gene were analyzed in 385 IS patients and 362 hypertension control patients using the ligase detection reaction (LDR) method. Logistic regression analysis demonstrated that GG genotypes of SNP rs2280887 were associated with an increased risk of IS in dominant, recessive, and additive models. Moreover, SNP rs9657362 and SNP rs4480162 were significantly associated with IS in dominant and additive models. These results indicate that...
Source: Neurological Research - December 11, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Rosuvastatin prevents aortic arch plaque progression and improves prognosis in ischemic stroke patients.
DISCUSSION: Rosuvastatin therapy prevented aortic arch plaque progression in IS patients with CAP, and may also have long-term clinical benefits. PMID: 27915586 [PubMed - as supplied by publisher]
Source: Neurological Research - December 7, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Reduction in spasticity in stroke patient with paraffin therapy.
CONCLUSION: Paraffin therapy may be a kind of noninvasive, promising method to reduce spasticity of stroke patients. PMID: 27876449 [PubMed - as supplied by publisher]
Source: Neurological Research - November 24, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Gonadal steroids block the calpain-1-dependent intrinsic pathway of apoptosis in an experimental rat stroke model.
CONCLUSION: We conclude that a combined steroid treatment inhibits ischemia-induced neuronal apoptosis through the regulation of intrinsic pathways. PMID: 27832728 [PubMed - as supplied by publisher]
Source: Neurological Research - November 13, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Cerebral density and perfusion measured among heart disease patients with and without stroke.
Authors: Obara K, Meyer JS, Muramatsu K, Mortel KF Abstract This' investigation was designed to clarify the chronic effects of cardiogenic emboli on cerebral perfusion and tissue densities within remaining noninfarcted brain. Local cerebral perfusion and tissue densities were measured by xenon-contrasted CT scanning and compared by cross-sectional designs among normal volunteers without heart disease (Group C, n - 44), normal volunteers with heart disease (Group N, n =20), patients with heart disease and lacunar infarctions (Group L, n = 31) and patients with heart disease associated with cardiogenic cerebral embol...
Source: Neurological Research - November 10, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Stroke recurrence among 30 days survivors of ischemic stroke in a prospective community-based study.
Authors: Ryglewicz D, Baranska-Gieruszczak M, Czlonkowska A, Lechowicz W, Hier D Abstract A cohort of 209 patients (105 men and 104 women), who survived 30 days after "first ever-in-lifetime ischemic stroke' were followed for one year. Predictors ofsurvival were examined by log-rank test and Cox proportional hazards method. Twenty-four patients had a stroke recurr~nce (11.4%). Thirteen of the patients with recurrent stroke (54%) died because of the sequelae of the second stroke. Stroke recurred in 16% of patients with stoke due to atherosclerosis, in 12.5% of patients with cardioembolic stroke, and in 4.4% of patie...
Source: Neurological Research - November 10, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Risk factors between intracranial-extracranial atherosclerosis and anterior-posterior circulation stroke in ischaemic stroke.
CONCLUSION: Risk factors are different between ICAS and ECAS, ACS and PCS, and ICAS/ECAS with ACS/PCS. Thus, targeted strategies are needed to consider these differences to prevent, treat and manage these diseases. PMID: 27796172 [PubMed - as supplied by publisher]
Source: Neurological Research - November 1, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Clustering of cardiovascular risk factors and stroke: a prospective cohort study in Inner Mongolia.
CONCLUSION: The clustering of CVRFs increased the risk of stroke. On the basis of FHCVD, the clustering of hypertension with other CVRFs and the clustering of diabetes with tachycardia had higher predictive value for stroke than other cluster. PMID: 27730847 [PubMed - as supplied by publisher]
Source: Neurological Research - October 14, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotective effect of epidermal growth factor plus growth hormone-releasing peptide-6 resembles hypothermia in experimental stroke.
DISCUSSION: With hypothermia being a good standard neuroprotectant reference, these results provide additional proof of principle for EGF and GHRP-6 co-administration as a potentially neuroprotective stroke therapy. PMID: 27665924 [PubMed - as supplied by publisher]
Source: Neurological Research - September 27, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotection by intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats in a model of ischemic stroke.
This study was undertaken to further explore the potential mechanisms underlying the neuroprotective effects of BMRMNCs in the same model. Rats were intravenously pre-treated with 5-FU, and BMRMNCs were collected 7 days later and subjected to flow cytometry for detection of CD34, CD45 and CD90. Middle cerebral artery occlusion (MCAO) was induced in rats, and BMMNCs and BMRMNCs were independently transplanted via the tail vein at 24 h after MCAO. NISSL staining was performed 14 days after cell transplantation and the viable cells in the hippocampus were counted. Stromal cell-derived factor 1 (SDF-1) mRNA expression was d...
Source: Neurological Research - August 4, 2016 Category: Neurology Tags: Neurol Res Source Type: research

The relationship of platelet-to-lymphocyte ratio with clinical outcome and final infarct core in acute ischemic stroke patients who have undergone endovascular therapy.
In this study we aimed to evaluate whether the PLR had a prognostic role in stroke patients undergoing thrombectomy and attempted to determine the effect that this ratio had on their survival. METHODS: Over a three-year period, demographic, clinical, and angiographic findings of 57 consecutive patients with acute ischemic stroke who underwent mechanical thrombectomy were evaluated. RESULTS: The patients were divided into two groups on the basis of a PLR level cut-off value of 145 based on receiver operating characteristic (ROC) curve. Successful revascularization (mTICI 2b and 3) was achieved in 42 of 57 (73.7%) pa...
Source: Neurological Research - August 3, 2016 Category: Neurology Tags: Neurol Res Source Type: research

A comparison of risk factors and prognosis between intra and extracranial acute atherosclerotic stroke in the Turkish population: a prospective study.
CONCLUSIONS: The prevalence of risk factors differs between ICAS and ECAS, and their influence differs for stroke severity and prognosis. PMID: 27477568 [PubMed - as supplied by publisher]
Source: Neurological Research - August 3, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Role of Interleukin-10 (-1082A/G) gene polymorphism with the risk of ischemic stroke: a meta-analysis.
Authors: Kumar P, Yadav AK, Misra S, Kumar A, Chakravarty K, Prasad K Abstract The role of anti-inflammatory Interleukin-10 (IL-10) cytokine gene polymorphism with the risk of ischemic stroke (IS) remains controversial. The aim of present meta-analysis was to investigate the association of IL-10 (-1082 A/G) gene polymorphism with the risk of IS. A literature search for candidate gene association studies published before 29 February 2016 was conducted in the PubMed, EMBASE, Google Scholar, and TRIP database. The following search terms were used: 'Interleukin-10' or 'IL-10' and 'Ischemic stroke' or 'IS' and 'Cerebral...
Source: Neurological Research - July 3, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Curcumin protects against stroke and increases levels of Notch intracellular domain.
CONCLUSION: Curcumin may protect from focal cerebral ischemia reperfusion injury as well as stimulate neurogenesis by activating the Notch signaling pathway. PMID: 27320251 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Frequency and risk factors of spontaneous hemorrhagic transformation following ischemic stroke on the initial brain CT or MRI: data from the China National Stroke Registry (CNSR).
DISCUSSION: Spontaneous HT occurred in 0.92% of the patients with IS in the acute stage. Being female, excess alcohol consumption, atrial fibrillation, and a prolonged period between IS onset and initial imaging were associated with an increased risk of spontaneous HT. PMID: 27320249 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between serum cystatin C levels and the severity or potential risk factors of acute ischemic stroke.
CONCLUSION: Our study suggests that there is a close relationship between cystatin C and acute ischemic stroke, independently of conventional risk factors. But the levels of cystatin C are not correlated with the stroke severity. PMID: 27320246 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Pharmacological hypothermia: a potential for future stroke therapy?
Authors: Liu K, Khan H, Geng X, Zhang J, Ding Y Abstract Mild physical hypothermia after stroke has been associated with positive outcomes. Despite the well-studied beneficial effects of hypothermia in the treatment of stroke, lack of precise temperature control, intolerance for the patient, and immunosuppression are some of the reasons which limit its clinical translation. Pharmacologically induced hypothermia has been explored as a possible treatment option following stroke in animal models. Currently, there are eight classes of pharmacological agents/agonists with hypothermic effects affecting a multitude of sys...
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Ongoing progress and new developments in the clinical approach to stroke and cerebrovascular disease: new paradigms: a novel outlook into stroke.
Authors: Hafeez A, Liu L, Ding Y PMID: 27320242 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

PPARG gene C161T CT/TT associated with lower blood lipid levels and ischemic stroke from large-artery atherosclerosis in a Han population in Guangdong.
CONCLUSION: In this Han population, PPARG C161T CT/TT was associated with LAA ischemic stroke and lower levels of blood TC and LDL-C, but was not an independent risk factor for LAA ischemic stroke. PMID: 27264718 [PubMed - as supplied by publisher]
Source: Neurological Research - June 9, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Crosstalk between microglia and T cells contributes to brain damage and recovery after ischemic stroke.
CONCLUSION: Inflammation mediated by microglia crosstalking to T cells contributes to brain damage and recovery after ischemic stroke. Extensive evidence supports a critical role for the crosstalk of microglia and T cells in the prognosis of brain injury after ischemic stroke. The regulation of the crosstalk may provide a potential therapeutic target for improving the ischemic brain damage. PMID: 27244271 [PubMed - as supplied by publisher]
Source: Neurological Research - June 2, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Neurocritical care in the treatment of stroke.
Authors: Dornbos Iii D, Powers CJ, Ding Y, Liu L Abstract In this review, we briefly introduce recent developments and updates in neurocritical care in the treatment of stroke, including both ischemic and hemorrhagic stroke. Time to recanalization remains the major rate limiting step in the treatment of acute ischemic stroke as only a minority of patients arrive within a timeframe appropriate for treatment. Whether caring for a patient following ischemic or hemorrhagic stroke, the principle focus of neurocritical care for acute brain catastrophes is the identification and prevention of secondary brain injury. While...
Source: Neurological Research - May 25, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between Endothelial nitric oxide synthase G894T gene polymorphism and risk of ischemic stroke in North Indian population: a case-control study.
CONCLUSION: The findings of the present study suggest that polymorphism in G894T position of eNOS gene might be a risk factor for IS mainly for LVD stroke subtype in North Indian population. Further large prospective studies are required to confirm these findings. PMID: 27168380 [PubMed - as supplied by publisher]
Source: Neurological Research - May 18, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia.
DISCUSSION: First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. There were distinct symptoms at hospital presentation between genders. All our patients discharged home regardless of genders. In summary, Malaysian female first-ever ischemic stroke was older, present with severe stroke, greater number of risk factors and poorer functional outcome and 30-day in-hospital mortality compared to male. PMID: 27142804 [PubMed - as supplied by publisher]
Source: Neurological Research - May 6, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Low free triiodothyronine levels are related to symptomatic intracranial hemorrhage and poor functional outcomes after intravenous thrombolysis in acute ischemic stroke patients.
CONCLUSION: We found that lower free T3 levels are independently related to post-IVT sICH and poor functional outcomes at discharge in AIS patients with IVT, which should be verified and extended in large cohorts in the future. PMID: 27122235 [PubMed - as supplied by publisher]
Source: Neurological Research - April 30, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Combined effects of family history of CVD and heart rate on ischemic stroke incidence among Inner Mongolians in China.
This study aimed to evaluate the combined effects of family history of cardiovascular diseases (FHCVD) and heart rate on ischemic stroke incidence among Inner Mongolians in China. METHODS: A prospective cohort study was conducted among 2589 participants aged 20 years and older from Inner Mongolia, China. The participants were divided into four groups according to status of FHCVD and heart rate and followed up from June 2002 to July 2012. Cox proportional hazards models were used to evaluate the combined effects of FHCVD and heart rate on the incidence of ischemic stroke. RESULTS: A total of 76 ischemic stroke occu...
Source: Neurological Research - April 22, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Notice of duplicate publication: C-reactive protein gene polymorphisms and gene-environment interactions in ischaemic stroke.
Authors: PMID: 27088486 [PubMed - as supplied by publisher]
Source: Neurological Research - April 19, 2016 Category: Neurology Tags: Neurol Res Source Type: research

S100β as a biomarker for differential diagnosis of intracerebral hemorrhage and ischemic stroke.
CONCLUSION: S100β could serve as a potential biomarker for differentiating between ICH and IS and predicting short-term functional outcome after ICH. PMID: 27078704 [PubMed - as supplied by publisher]
Source: Neurological Research - April 16, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between interleukin-6 (G174C and C572G) promoter gene polymorphisms and risk of ischemic stroke in North Indian population: a case-control study.
CONCLUSION: Our results suggest that IL-6 (G174C) polymorphism is significantly associated with the risk of IS in North Indian population. However, IL-6 (C572G) polymorphism is found significantly associated with the risk of IS after adjusting the demographic and risk factors variables. Prospective studies with large sample size are required for independent validation. Our findings could be helpful in identifying individuals at increased risk for developing IS. PMID: 26883819 [PubMed - as supplied by publisher]
Source: Neurological Research - February 19, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Combined clopidogrel-aspirin treatment for high risk TIA or minor stroke does not increase cerebral microbleeds.
CONCLUSIONS: For the treatment of high-risk TIA or minor stroke patients, the clopidogrel-aspirin treatment did not increase the number of CMB than Aspirin alone. It appears that the extent of CMB was associated with the extent of existing CMB occurred in previous stroke, which was mostly located in cortical, subcortical zone. PMID: 26391570 [PubMed - in process]
Source: Neurological Research - September 25, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Wall characteristics and mechanisms of ischaemic stroke in patients with atherosclerotic middle cerebral artery stenosis: a high-resolution MRI study.
CONCLUSIONS: PR or irregular surface plaques were associated with artery-to-artery embolism. Superior location of plaques was associated with PAI. HR-MRI provides insights into intracranial atherosclerosis in vivo, predictive of infarction patterns. PMID: 26315990 [PubMed - as supplied by publisher]
Source: Neurological Research - September 1, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy.
Authors: Subirós N, Pérez-Saad HM, Berlanga JA, Aldana L, García-Illera G, Gibson CL, García-Del-Barco D Abstract BACKGROUND: Stroke continues to be a leading cause of mortality and morbidity worldwide, and novel therapeutic options for ischaemic stroke are urgently needed. In this context, drug combination therapies seem to be a viable approach, which has not been fully explored in preclinical studies. OBJECTIVES: In this work, we assessed the dose-response relationship and therapeutic time window, in global brain ischaemia, of a combined therapeutic approach of recombinant human epidermal growth factor (E...
Source: Neurological Research - August 29, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Involuntary, forced and voluntary exercises are equally capable of inducing hippocampal plasticity and the recovery of cognitive function after stroke.
CONCLUSION: Involuntary exercise induced by FES has beneficial effects on cognitive function after vascular dementia comparable to those of forced and voluntary exercise. PMID: 26179091 [PubMed - as supplied by publisher]
Source: Neurological Research - July 17, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Antithrombotic therapy for ischaemic stroke patients with AF/RHD in West China daily practice.
CONCLUSION: Our study suggests that overall real-world use of warfarin in IS patients with AF and/or RHD is low before and after admission in West China. Implementation study on this respect should be conducted in this area to improve the daily practice. PMID: 26178783 [PubMed - as supplied by publisher]
Source: Neurological Research - July 17, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Serum CXCL12 levels are associated with stroke severity and lesion volumes in stroke patients.
CONCLUSION: Our study demonstrated that serum CXCL12 levels increased significantly following AIS, and these changes in serum CXCL12 were positively correlated with infarct volume and stroke severity in Chinese sample. PMID: 26100385 [PubMed - as supplied by publisher]
Source: Neurological Research - June 24, 2015 Category: Neurology Tags: Neurol Res Source Type: research