Query: stroke

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Source: Neurological Research

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Total 184 results found since Jan 2013.

A pharmacoeconomic assessment of recombinant tissue plasminogen activator therapy for acute ischemic stroke in a tertiary hospital in China.
Conclusions: Intravenous rt-PA was associated with lower patients' disabilities, fewer in-hospital days, and comparable total costs compared to conservative therapy for the management of AIS. PMID: 25297471 [PubMed - as supplied by publisher]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research

Preexisting dual antiplatelet treatment increases the risk of post-thrombolysis intracranial hemorrhage in Chinese stroke patients.
DISCUSSION: The risk of developing sICH is low when thrombolysis is given to patients who are on ASA alone. However, there is potential increased risk of sICH if a patient is on dual AP treatment. PMID: 24861494 [PubMed - in process]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research

APOE ϵ 2 allele is an independent risk factor for vulnerable carotid plaque in ischemic stroke patients.
CONCLUSIONS: This study suggests that ϵ 2 allele is an independent risk factor for echolucent and ulcerated carotid plaque. PMID: 24846706 [PubMed - in process]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research

Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR gene) with ischemic stroke: a meta-analysis.
Conclusion: The present study results suggest that MTHFR C677T genetic polymorphism is a probable risk of ischemic stroke. PMID: 25591425 [PubMed - as supplied by publisher]
Source: Neurological Research - January 18, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Influence of internal carotid artery stenosis, blood pressure, glycated hemoglobin, and hemoglobin level on fMRI signals of stroke patients.
Conclusion: It is suggested that both ICA stenosis and arterial BP could influence BOLD signal, while HbA1c and hemoglobin level had no effect on BOLD signal. PMID: 25591421 [PubMed - as supplied by publisher]
Source: Neurological Research - January 18, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Protective effect of telmisartan on neurovascular unit and inflammasome in stroke-resistant spontaneously hypertensive rats.
Discussion: These results suggest that telmisartan comprehensively protected the NVU components by reducing inflammatory reactions relative to AD in hypertensive rats, which could also preclude the risk of AD under hypertension. PMID: 25591419 [PubMed - as supplied by publisher]
Source: Neurological Research - January 18, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Cilostazol may prevent cardioembolic stroke in patients undergoing antiplatelet therapy.
CONCLUSIONS: Cilostazol may prevent cardioembolic stroke in patients undergoing antiplatelet therapy. This could be a novel strategy for cardioembolic stroke prevention potentially by affecting cardiac remodelling, in contrast to secondary anticoagulant therapy. PMID: 25798683 [PubMed - as supplied by publisher]
Source: Neurological Research - March 24, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Primary stroke prevention in China - a new approach.
Authors: Feigin VL, Wang W, Fu H, Liu L, Krishnamurthi R, Bhattacharjee R, Parmar P, Hussein T, Barker-Collo S Abstract The growing burden of stroke in China, along with the increasing cost of health care calls for new, more effective strategies for stroke prevention. These strategies should include increasing awareness of stroke symptoms, awareness of risk factors, and provision of easily available information on means of modifying risk factors. The Stroke Riskometer App is exactly such a tool, available in Mandarin, for adult individuals to calculate their risk of stroke over the next 5 and 10 years, and to ide...
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Enhanced beneficial effects of mild hypothermia by phenothiazine drugs in stroke therapy.
This study combined mild hypothermia with phenothiazine drugs to enhance its neuroprotective effects, thus potentially avoiding side effects. METHODS: Fifty-four male Sprague-Dawley rats were induced with a 2-hour right middle cerebral artery (MCA) occlusion using an intraluminal filament. Five groups were tested: the stroke group without treatment (anal temperature 37.8-38.3°C), the mild hypothermia group (anal temperature 35.0°C), the drugs group (1 mg/kg chlorpromazine and 1 mg/kg promethazine, anal temperature at 37.8-38.3°C), combination therapy with the mild hypothermia and drugs group and the normal contr...
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotection by peripheral nerve electrical stimulation and remote postconditioning against acute experimental ischaemic stroke.
DISCUSSION: Peripheral nerve ES appears to have a neuroprotective effect in a rat dMCAO model. This effect may indicate a neural protective mechanism underlying beneficial effect of RIPostC. PMID: 25819636 [PubMed - as supplied by publisher]
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Weight loss: indication of brain damage and effect of combined normobaric oxygen and ethanol therapy after stroke.
DISCUSSION: Degree of weight loss after stroke is largely associated with severity of infarction as well as damage reduction after treatment administration. PMID: 25819503 [PubMed - as supplied by publisher]
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Factors impact the adherence rate of prophylaxis for deep venous thrombosis in acute ischaemic stroke patients: an analysis of the China National Stroke Registry.
We examined the factors that impact the adherence rate of DVT prophylaxis in stroke patients from the China National Stroke Registry (CNSR). METHOD: Records of 12 173 acute ischaemic stroke patients with follow-up admitted to 132 hospitals in CNSR from September 1, 2007 to August 30, 2008 were reviewed. Data from 4643 patients eligible for DVT prophylaxis were analysed. Generalised estimating equations were used to identify the patient's and hospital's factors that impact the practice of DVT prophylaxis. RESULTS: Among 4643 acute ischaemic stroke patients eligible for DVT prophylaxis, the overall adherence rate of ...
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Acute recanalization of carotid stenosis is not proper: an experimental ischaemic stroke study.
CONCLUSIONS: Our study suggests that the optimal time to open the CCA stenosis complicating cerebral infarction is at or after 7 days of CCA stenosis. PMID: 25830557 [PubMed - as supplied by publisher]
Source: Neurological Research - April 3, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Quantitative assessment and correlation analysis of cerebral microbleed distribution and leukoaraiosis in stroke outpatients.
DISCUSSION: Cerebral microbleed incidence increased with age. Mixed CMB type displayed the highest incidence. The severity and number of CMBs at any location correlated with LA severity. These results suggested interactions between hypertension and CAA during LA progression. PMID: 25875577 [PubMed - as supplied by publisher]
Source: Neurological Research - April 17, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Recent advances in atrial fibrillation and stroke.
Authors: David Spence J PMID: 25875354 [PubMed - as supplied by publisher]
Source: Neurological Research - April 17, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Association between polyvascular atherosclerosis and estimated glomerular filtration rate in patients with ischaemic stroke: data analysis of the patients in the Chinese National Stroke Registry.
This study evaluated the prevalence of chronic kidney disease (CKD) in ischemic stroke (IS) patients with polyvascular disease (PolyVD) and analysed the relationship between PolyVD and estimated glomerular filtration rate (eGFR) in IS patients. METHODS: Data from 9152 consecutive IS patients from the China National Stroke Registry were analysed. PolyVD was defined as patients with IS and coronary artery disease (CAD) and/or peripheral arterial disease (PAD). Chronic kidney disease was defined as eGFR < 60 mL/minute/1.73 m(2).The prevalence of CKD in IS patients with PolyVD was calculated. Logistic regression w...
Source: Neurological Research - April 22, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Is serum total bilirubin useful to differentiate cardioembolic stroke from other stroke subtypes?
CONCLUSIONS: Serum TB level was independently associated with cardioembolic stroke. The combination of clinical data and serum TB may be a feasible strategy to diagnose cardioembolic stroke in the acute phase. PMID: 25891436 [PubMed - as supplied by publisher]
Source: Neurological Research - April 22, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Music-supported therapy (MST) in improving post-stroke patients' upper-limb motor function: a randomised controlled pilot study.
This study supports that MST, when combined with conventional treatment, is effective for the recovery of motor skills in post-stroke patients. Additionally, it suggests that apart from the repetitive practices of MST, music may play a unique role in improving upper-limb motor function for post-stroke patients. PMID: 25916420 [PubMed - as supplied by publisher]
Source: Neurological Research - April 29, 2015 Category: Neurology Tags: Neurol Res Source Type: research

A dynamic stroke treatment paradigm.
Authors: Hussain M, Liu L, Ding Y PMID: 25992871 [PubMed - as supplied by publisher]
Source: Neurological Research - May 21, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Thrombolytic treatment decreases glutamate/GABA ratio in serum during acute ischaemic stroke: a pilot study.
Authors: Kurzepa J, Szpetnar M, Hordyjewska A, Wątroba S, Gołąb P, Boguszewska-Czubara A Abstract There is no information about possible effect of recombinant tissue plasminogen activator (rtPA) therapy on excitotoxic/neuroprotective amino acids during acute phase of ischaemic stroke (IS). Our purpose was to evaluate iv thrombolytic treatment on glutamate (Glu) and gamma-aminobutyric acid (GABA) serum levels during acute IS. Eleven thrombolytic (rtPA group) and 12 non-thrombolytic (non-rtPA group) patients with acute IS were enrolled. The serum samples were obtained at three time-points for rtPA group (time-poin...
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research

C-reactive protein gene polymorphisms and gene-environment interactions in ischaemic stroke.
Authors: Chen Z, Yu D, Xu ZW, Li SS, Li XF, Li J, Yang X Abstract Ischaemic stroke is a heterogeneous, multifactorial disease caused by the combination of certain risk factors and genetic factors. Several single nucleotide polymorphisms (SNPs) of C-reactive protein (CRP) have been reported to be associated with serum CRP levels. However, genetic association studies have produced conflicting results regarding the association between these SNPs and ischaemic stroke. In this paper, we conducted a population-based case-control study to determine whether two SNPs of CRP (rs1800947 and rs3093059) are associated with isch...
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Association study between C-reactive protein polymorphisms and ischaemic stroke.
CONCLUSIONS: There is no association between rs1130864 or rs3093059 and ischaemic stroke in Chinese Han population. PMID: 26039816 [PubMed - as supplied by publisher]
Source: Neurological Research - June 4, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Serum CXCL12 levels are associated with stroke severity and lesion volumes in stroke patients.
CONCLUSION: Our study demonstrated that serum CXCL12 levels increased significantly following AIS, and these changes in serum CXCL12 were positively correlated with infarct volume and stroke severity in Chinese sample. PMID: 26100385 [PubMed - as supplied by publisher]
Source: Neurological Research - June 24, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Comparison of carotid atherosclerotic plaque characteristics between patients with first-time and recurrent acute ischaemic stroke using B-mode ultrasound.
CONCLUSION: Stroke recurrence is related to advanced atherosclerosis defined by carotid plaque and its characteristics. PMID: 26100248 [PubMed - as supplied by publisher]
Source: Neurological Research - June 24, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Involuntary, forced and voluntary exercises are equally capable of inducing hippocampal plasticity and the recovery of cognitive function after stroke.
CONCLUSION: Involuntary exercise induced by FES has beneficial effects on cognitive function after vascular dementia comparable to those of forced and voluntary exercise. PMID: 26179091 [PubMed - as supplied by publisher]
Source: Neurological Research - July 17, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Antithrombotic therapy for ischaemic stroke patients with AF/RHD in West China daily practice.
CONCLUSION: Our study suggests that overall real-world use of warfarin in IS patients with AF and/or RHD is low before and after admission in West China. Implementation study on this respect should be conducted in this area to improve the daily practice. PMID: 26178783 [PubMed - as supplied by publisher]
Source: Neurological Research - July 17, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy.
Authors: Subirós N, Pérez-Saad HM, Berlanga JA, Aldana L, García-Illera G, Gibson CL, García-Del-Barco D Abstract BACKGROUND: Stroke continues to be a leading cause of mortality and morbidity worldwide, and novel therapeutic options for ischaemic stroke are urgently needed. In this context, drug combination therapies seem to be a viable approach, which has not been fully explored in preclinical studies. OBJECTIVES: In this work, we assessed the dose-response relationship and therapeutic time window, in global brain ischaemia, of a combined therapeutic approach of recombinant human epidermal growth factor (E...
Source: Neurological Research - August 29, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Wall characteristics and mechanisms of ischaemic stroke in patients with atherosclerotic middle cerebral artery stenosis: a high-resolution MRI study.
CONCLUSIONS: PR or irregular surface plaques were associated with artery-to-artery embolism. Superior location of plaques was associated with PAI. HR-MRI provides insights into intracranial atherosclerosis in vivo, predictive of infarction patterns. PMID: 26315990 [PubMed - as supplied by publisher]
Source: Neurological Research - September 1, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Combined clopidogrel-aspirin treatment for high risk TIA or minor stroke does not increase cerebral microbleeds.
CONCLUSIONS: For the treatment of high-risk TIA or minor stroke patients, the clopidogrel-aspirin treatment did not increase the number of CMB than Aspirin alone. It appears that the extent of CMB was associated with the extent of existing CMB occurred in previous stroke, which was mostly located in cortical, subcortical zone. PMID: 26391570 [PubMed - in process]
Source: Neurological Research - September 25, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Association between interleukin-6 (G174C and C572G) promoter gene polymorphisms and risk of ischemic stroke in North Indian population: a case-control study.
CONCLUSION: Our results suggest that IL-6 (G174C) polymorphism is significantly associated with the risk of IS in North Indian population. However, IL-6 (C572G) polymorphism is found significantly associated with the risk of IS after adjusting the demographic and risk factors variables. Prospective studies with large sample size are required for independent validation. Our findings could be helpful in identifying individuals at increased risk for developing IS. PMID: 26883819 [PubMed - as supplied by publisher]
Source: Neurological Research - February 19, 2016 Category: Neurology Tags: Neurol Res Source Type: research

S100β as a biomarker for differential diagnosis of intracerebral hemorrhage and ischemic stroke.
CONCLUSION: S100β could serve as a potential biomarker for differentiating between ICH and IS and predicting short-term functional outcome after ICH. PMID: 27078704 [PubMed - as supplied by publisher]
Source: Neurological Research - April 16, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Notice of duplicate publication: C-reactive protein gene polymorphisms and gene-environment interactions in ischaemic stroke.
Authors: PMID: 27088486 [PubMed - as supplied by publisher]
Source: Neurological Research - April 19, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Combined effects of family history of CVD and heart rate on ischemic stroke incidence among Inner Mongolians in China.
This study aimed to evaluate the combined effects of family history of cardiovascular diseases (FHCVD) and heart rate on ischemic stroke incidence among Inner Mongolians in China. METHODS: A prospective cohort study was conducted among 2589 participants aged 20 years and older from Inner Mongolia, China. The participants were divided into four groups according to status of FHCVD and heart rate and followed up from June 2002 to July 2012. Cox proportional hazards models were used to evaluate the combined effects of FHCVD and heart rate on the incidence of ischemic stroke. RESULTS: A total of 76 ischemic stroke occu...
Source: Neurological Research - April 22, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Low free triiodothyronine levels are related to symptomatic intracranial hemorrhage and poor functional outcomes after intravenous thrombolysis in acute ischemic stroke patients.
CONCLUSION: We found that lower free T3 levels are independently related to post-IVT sICH and poor functional outcomes at discharge in AIS patients with IVT, which should be verified and extended in large cohorts in the future. PMID: 27122235 [PubMed - as supplied by publisher]
Source: Neurological Research - April 30, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Gender disparities and thrombolysis use among patient with first-ever ischemic stroke in Malaysia.
DISCUSSION: First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. There were distinct symptoms at hospital presentation between genders. All our patients discharged home regardless of genders. In summary, Malaysian female first-ever ischemic stroke was older, present with severe stroke, greater number of risk factors and poorer functional outcome and 30-day in-hospital mortality compared to male. PMID: 27142804 [PubMed - as supplied by publisher]
Source: Neurological Research - May 6, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between Endothelial nitric oxide synthase G894T gene polymorphism and risk of ischemic stroke in North Indian population: a case-control study.
CONCLUSION: The findings of the present study suggest that polymorphism in G894T position of eNOS gene might be a risk factor for IS mainly for LVD stroke subtype in North Indian population. Further large prospective studies are required to confirm these findings. PMID: 27168380 [PubMed - as supplied by publisher]
Source: Neurological Research - May 18, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Neurocritical care in the treatment of stroke.
Authors: Dornbos Iii D, Powers CJ, Ding Y, Liu L Abstract In this review, we briefly introduce recent developments and updates in neurocritical care in the treatment of stroke, including both ischemic and hemorrhagic stroke. Time to recanalization remains the major rate limiting step in the treatment of acute ischemic stroke as only a minority of patients arrive within a timeframe appropriate for treatment. Whether caring for a patient following ischemic or hemorrhagic stroke, the principle focus of neurocritical care for acute brain catastrophes is the identification and prevention of secondary brain injury. While...
Source: Neurological Research - May 25, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Crosstalk between microglia and T cells contributes to brain damage and recovery after ischemic stroke.
CONCLUSION: Inflammation mediated by microglia crosstalking to T cells contributes to brain damage and recovery after ischemic stroke. Extensive evidence supports a critical role for the crosstalk of microglia and T cells in the prognosis of brain injury after ischemic stroke. The regulation of the crosstalk may provide a potential therapeutic target for improving the ischemic brain damage. PMID: 27244271 [PubMed - as supplied by publisher]
Source: Neurological Research - June 2, 2016 Category: Neurology Tags: Neurol Res Source Type: research

PPARG gene C161T CT/TT associated with lower blood lipid levels and ischemic stroke from large-artery atherosclerosis in a Han population in Guangdong.
CONCLUSION: In this Han population, PPARG C161T CT/TT was associated with LAA ischemic stroke and lower levels of blood TC and LDL-C, but was not an independent risk factor for LAA ischemic stroke. PMID: 27264718 [PubMed - as supplied by publisher]
Source: Neurological Research - June 9, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Curcumin protects against stroke and increases levels of Notch intracellular domain.
CONCLUSION: Curcumin may protect from focal cerebral ischemia reperfusion injury as well as stimulate neurogenesis by activating the Notch signaling pathway. PMID: 27320251 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Frequency and risk factors of spontaneous hemorrhagic transformation following ischemic stroke on the initial brain CT or MRI: data from the China National Stroke Registry (CNSR).
DISCUSSION: Spontaneous HT occurred in 0.92% of the patients with IS in the acute stage. Being female, excess alcohol consumption, atrial fibrillation, and a prolonged period between IS onset and initial imaging were associated with an increased risk of spontaneous HT. PMID: 27320249 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between serum cystatin C levels and the severity or potential risk factors of acute ischemic stroke.
CONCLUSION: Our study suggests that there is a close relationship between cystatin C and acute ischemic stroke, independently of conventional risk factors. But the levels of cystatin C are not correlated with the stroke severity. PMID: 27320246 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Pharmacological hypothermia: a potential for future stroke therapy?
Authors: Liu K, Khan H, Geng X, Zhang J, Ding Y Abstract Mild physical hypothermia after stroke has been associated with positive outcomes. Despite the well-studied beneficial effects of hypothermia in the treatment of stroke, lack of precise temperature control, intolerance for the patient, and immunosuppression are some of the reasons which limit its clinical translation. Pharmacologically induced hypothermia has been explored as a possible treatment option following stroke in animal models. Currently, there are eight classes of pharmacological agents/agonists with hypothermic effects affecting a multitude of sys...
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Ongoing progress and new developments in the clinical approach to stroke and cerebrovascular disease: new paradigms: a novel outlook into stroke.
Authors: Hafeez A, Liu L, Ding Y PMID: 27320242 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Role of Interleukin-10 (-1082A/G) gene polymorphism with the risk of ischemic stroke: a meta-analysis.
Authors: Kumar P, Yadav AK, Misra S, Kumar A, Chakravarty K, Prasad K Abstract The role of anti-inflammatory Interleukin-10 (IL-10) cytokine gene polymorphism with the risk of ischemic stroke (IS) remains controversial. The aim of present meta-analysis was to investigate the association of IL-10 (-1082 A/G) gene polymorphism with the risk of IS. A literature search for candidate gene association studies published before 29 February 2016 was conducted in the PubMed, EMBASE, Google Scholar, and TRIP database. The following search terms were used: 'Interleukin-10' or 'IL-10' and 'Ischemic stroke' or 'IS' and 'Cerebral...
Source: Neurological Research - July 3, 2016 Category: Neurology Tags: Neurol Res Source Type: research

The relationship of platelet-to-lymphocyte ratio with clinical outcome and final infarct core in acute ischemic stroke patients who have undergone endovascular therapy.
In this study we aimed to evaluate whether the PLR had a prognostic role in stroke patients undergoing thrombectomy and attempted to determine the effect that this ratio had on their survival. METHODS: Over a three-year period, demographic, clinical, and angiographic findings of 57 consecutive patients with acute ischemic stroke who underwent mechanical thrombectomy were evaluated. RESULTS: The patients were divided into two groups on the basis of a PLR level cut-off value of 145 based on receiver operating characteristic (ROC) curve. Successful revascularization (mTICI 2b and 3) was achieved in 42 of 57 (73.7%) pa...
Source: Neurological Research - August 3, 2016 Category: Neurology Tags: Neurol Res Source Type: research

A comparison of risk factors and prognosis between intra and extracranial acute atherosclerotic stroke in the Turkish population: a prospective study.
CONCLUSIONS: The prevalence of risk factors differs between ICAS and ECAS, and their influence differs for stroke severity and prognosis. PMID: 27477568 [PubMed - as supplied by publisher]
Source: Neurological Research - August 3, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotection by intravenous transplantation of bone marrow mononuclear cells from 5-fluorouracil pre-treated rats in a model of ischemic stroke.
This study was undertaken to further explore the potential mechanisms underlying the neuroprotective effects of BMRMNCs in the same model. Rats were intravenously pre-treated with 5-FU, and BMRMNCs were collected 7 days later and subjected to flow cytometry for detection of CD34, CD45 and CD90. Middle cerebral artery occlusion (MCAO) was induced in rats, and BMMNCs and BMRMNCs were independently transplanted via the tail vein at 24 h after MCAO. NISSL staining was performed 14 days after cell transplantation and the viable cells in the hippocampus were counted. Stromal cell-derived factor 1 (SDF-1) mRNA expression was d...
Source: Neurological Research - August 4, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotective effect of epidermal growth factor plus growth hormone-releasing peptide-6 resembles hypothermia in experimental stroke.
DISCUSSION: With hypothermia being a good standard neuroprotectant reference, these results provide additional proof of principle for EGF and GHRP-6 co-administration as a potentially neuroprotective stroke therapy. PMID: 27665924 [PubMed - as supplied by publisher]
Source: Neurological Research - September 27, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Clustering of cardiovascular risk factors and stroke: a prospective cohort study in Inner Mongolia.
CONCLUSION: The clustering of CVRFs increased the risk of stroke. On the basis of FHCVD, the clustering of hypertension with other CVRFs and the clustering of diabetes with tachycardia had higher predictive value for stroke than other cluster. PMID: 27730847 [PubMed - as supplied by publisher]
Source: Neurological Research - October 14, 2016 Category: Neurology Tags: Neurol Res Source Type: research