Query: stroke

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Source: Neurological Research

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Total 212 results found since Jan 2013.

Relationship between methylenetetrahydrofolate reductase (MTHFR) gene (A1298C) polymorphism with the risk of stroke: A systematic review and meta-analysis.
Authors: Kumar A, Sharma R, Misra S, Nath M, Kumar P Abstract Studies on relationship between methylenetetrahydrofolate reductase gene (MTHFR) gene A1298C polymorphism with the risk of ischemic as well as hemorrhagic stroke have shown discordant results. Present meta-analysis was aimed to clarify the relationship between MTHFR gene A1298C polymorphism with risk of stroke. A comprehensive literature search for all published articles was performed in electronic database including PubMed, EMbase, Cochrane Library, Trip Databases, Worldwide Science, CINAHL, and Google Scholar up to 31st  December 2019. Pooled odds r...
Source: Neurological Research - August 1, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Relationship between ischemic stroke locations, etiology subtypes, neurological outcomes, and autonomic cardiac function.
CONCLUSIONS: HRV measured after admission is related to the AIS infarction basin, TOAST subtypes, and neurological outcomes at discharge suggesting a possible role for HRV in evaluating AIS and identifying high-risk patients. PMID: 32701421 [PubMed - as supplied by publisher]
Source: Neurological Research - July 25, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Neurological complications of COVID-19: a systematic review.
CONCLUSIONS: Considering the possibility of neurological involvement in patients with SARS-CoV-2 infection can result in earlier diagnosis and treatment; otherwise permanent, irreversible sequelae and even death may follow. More comprehensive studies may indicate that until the end of the present pandemic, young adults with unexplained and unexpected stroke as well as patients with newly diagnosed Guillain-Barré syndrome should be tested for SARS-CoV-2 infection. PMID: 32698732 [PubMed - as supplied by publisher]
Source: Neurological Research - July 25, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Changes in white matter microstructure related to non-linguistic cognitive impairment in post-stroke aphasia.
CONCLUSION: Patients with PSA have non-linguistic cognitive impairment. The integrity of the white matter microstructures can be extensively damaged. Impaired SP and MP in patients with PSA are related to UF damage. PMID: 32697169 [PubMed - as supplied by publisher]
Source: Neurological Research - July 24, 2020 Category: Neurology Tags: Neurol Res Source Type: research

AST to ALT ratio and risk of hemorrhagic transformation in patients with acute ischemic stroke.
CONCLUSIONS: Higher AAR was associated with an increased risk of HT after ischemic stroke. In addition, AAR might be a better biomarker for predicting HT than ALT or AST. PMID: 32697140 [PubMed - as supplied by publisher]
Source: Neurological Research - July 24, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Effect of renal function on association between uric acid and prognosis in acute ischemic stroke patients with elevated systolic blood pressure.
CONCLUSION: The present study suggests that high serum uric acid concentration is associated with better prognosis in ischemic stroke patients with normal renal function, but not in those with abnormal renal function. The establishment of causality between increased uric acid levels and better stroke prognosis needs more suitably designed randomized clinical trials. PMID: 32657261 [PubMed - as supplied by publisher]
Source: Neurological Research - July 15, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF- κB signaling pathway inhibition.
Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-κB signaling pathway inhibition. Neurol Res. 2020 Jul 13;:1-10 Authors: Fan X, Elkin K, Shi Y, Zhang Z, Cheng Y, Gu J, Liang J, Wang C, Ji X Abstract It has been established that poor outcomes in ischemic stroke patients are associated with the post-reperfusion inflammatory response and up-regulation of TLR4. Therefore, suppression of the TLR4 signaling pathway constitutes a potential neuroprotective therapeutic strategy. Schisandrin B, a compound extracted from Schisandra chinensis, has been shown to posse...
Source: Neurological Research - July 15, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The relationship between the platelet to leukocyte ratio and mechanical thrombectomy outcomes in acute ischemic stroke patients.
CONCLUSION: Platelet to leukocyte ratio may be use to assess the risk of functional outcome and sICH in patients with acute anterior circulation occlusion stroke undergoing endovascular treatment in real world China. PMID: 32643590 [PubMed - as supplied by publisher]
Source: Neurological Research - July 11, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Late changes in blood-brain barrier permeability in a rat tMCAO model of stroke detected by gadolinium-enhanced MRI.
DISCUSSION: Our results indicate a significant late opening of the BBB. This is important as the majority of previous studies have only characterised an early acute BBB permeability in ischemia. However, the later period of increased permeability may indicate an optimal time for drug delivery across the BBB, when it is especially suited to drugs targeting delayed processes. PMID: 32600164 [PubMed - as supplied by publisher]
Source: Neurological Research - July 2, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Ligustilide provides neuroprotection by promoting angiogenesis after cerebral ischemia.
CONCLUSION: LGSL promoted focal angiogenesis and attenuated ischemia-induced brain injury, suggesting that LGSL is a potential agent that improves angiogenesis and promotes recovery from ischemic stroke. PMID: 32584207 [PubMed - as supplied by publisher]
Source: Neurological Research - June 27, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Impact of post-stroke disability and disability-perception on health-related quality of life of stroke survivors: the moderating effect of disability-severity.
CONCLUSION: Significant disability exists among stroke survivors and impaired their HRQoL while disability-severity moderating the effect. More stroke survivors have positive attitude towards their disability and impact positively on their physical health. PMID: 32573376 [PubMed - as supplied by publisher]
Source: Neurological Research - June 25, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Intracranial collaterals and arterial wall features in severe symptomatic vertebrobasilar stenosis.
CONCLUSION: Intracranial good collateral of posterior circulation may be associated with lower risk of arterial positive remodeling and culprit plaque diffuse distribution, plaque enhancement in patients with severe sIVBAS. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT02705599. PMID: 32573371 [PubMed - as supplied by publisher]
Source: Neurological Research - June 25, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The effect of cyclosporin a on ischemia-reperfusion damage in a mouse model of ischemic stroke.
DISCUSSION: CsA showed potential as a neuroprotective drug for the treatment of ischemic stroke patients; besides interfering with the typical NF-κB signaling pathway, the Akt pathway may also be involved in the effects of CsA. PMID: 32529968 [PubMed - as supplied by publisher]
Source: Neurological Research - June 14, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Association between mitral regurgitation and clinical outcome after endovascular thrombectomy in stroke patients.
CONCLUSIONS: Significant MR might prevent the clinical recovery of AF patients. PMID: 32497466 [PubMed - as supplied by publisher]
Source: Neurological Research - June 5, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Population-based stroke surveillance using big data: state-wide epidemiological trends in admissions and mortality in New South Wales, Australia.
DISCUSSION: Improved prevention may have underpinned declining intracerebral haemorrhage rates while survival gains suggest that innovations in care are being successfully translated. Mortality in patients surviving the acute period is unchanged and may be increasing for subarachnoid haemorrhage warranting investment in post-discharge care and secondary prevention. PMID: 32449879 [PubMed - as supplied by publisher]
Source: Neurological Research - May 26, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Factors associated with medication persistence among ischemic stroke patients: a systematic review.
Conclusions: Stroke patients' medication persistence decreases over time, and persistence on antiplatelets, anticoagulants, and statin was poor. Several factors were associated with medication persistence, and these factors should be considered in future secondary preventative strategies. PMID: 32321382 [PubMed - as supplied by publisher]
Source: Neurological Research - April 25, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Assessment of the manifestations of atrial fibrillation in patients with acute cerebral stroke - a single-center study based on 998 patients.
Discussion: The above data should prompt neurologists, cardiologists and family doctors to try to detect AF as a risk factor for ischemic stroke which worsens patient prognosis, prolongs hospital stay and contributes to increase in mortality, especially when more effective drug treatment is currently possible. PMID: 32241245 [PubMed - as supplied by publisher]
Source: Neurological Research - April 5, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Human urinary kallidinogenase in treating acute ischemic stroke patients: analyses of pooled data from a randomized double-blind placebo-controlled phase IIb and phase III clinical trial.
Conclusion: HUK is safe and provides potential clinical benefits as a treatment for acute ischemic stroke. Further large post-marketing observational studies are needed. PMID: 32138624 [PubMed - as supplied by publisher]
Source: Neurological Research - March 7, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Statin effects on post-stroke epilepsy and mortality - Taiwan population-based study.
Conclusion: Statins have a modest but non-significant effect in preventing post-apoplectic epilepsy in Taiwan. Statins decrease post-stroke mortality only in men. Further studies are needed to depict their exact roles in these issues. PMID: 32122287 [PubMed - as supplied by publisher]
Source: Neurological Research - March 4, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The effect of intravenous ginkgolide on clinical improvement of patients with acute ischemic stroke.
Conclusion: Intravenous ginkgolide may improve the outcome of acute ischemic stroke. Differences in effect between pre-marketing and post-marketing studies may be associated with gender, time of onset to enrollment and severity of stroke. PMID: 32048567 [PubMed - as supplied by publisher]
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Flexors activity of affected upper extremity in stroke patients during different standing conditions and their relationships with clinical scales: a cross-sectional study.
Conclusions: The contraction rates of elbowflexor in the affected side increase with the difficulty in different standing postures,and it may be a good index to reflect the changes of muscle tone in postural control. PMID: 32048562 [PubMed - as supplied by publisher]
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Low density lipoprotein cholesterol values and outcome of stroke patients: influence of previous aspirin therapy.
Conclusion: A worse outcome was seen in stroke patients with normal levels of LDLC, but this finding was restricted to patients not under previous aspirin therapy. PMID: 32024449 [PubMed - as supplied by publisher]
Source: Neurological Research - February 8, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Increasing trimethylamine N-oxide levels as a predictor of early neurological deterioration in patients with acute ischemic stroke.
Conclusions: Our study indicated that increasing TMAO levels at admission might be associated with END after acute ischemic stroke. PMID: 31928326 [PubMed - as supplied by publisher]
Source: Neurological Research - January 14, 2020 Category: Neurology Tags: Neurol Res Source Type: research

An analysis of the risk of perioperative ischemic stroke in patients undergoing non-cardiovascular and non-neurological surgeries.
Conclusions: History of stroke and smoking, renal insufficiency, and low HDL-C are independent risk factors for PIS. It is feasible to assess the risk of stroke in preoperative patients using PCE in clinical practice. PMID: 31903867 [PubMed - as supplied by publisher]
Source: Neurological Research - January 7, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Inflammatory biomarkers and risk of ischemic stroke and subtypes: A 2-sample Mendelian randomization study.
Conclusions: Our study did not find convincing evidence to support that inflammatory biomarkers like IL-1Ra, sIL-6R and CRP are causally associated with the risk of ischemic stroke or its subtypes. PMID: 31900081 [PubMed - as supplied by publisher]
Source: Neurological Research - January 6, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Does the nutritional status of acute stroke patients affect the neurological status in the early post-stroke period?
Authors: Wierzbicki K, Horyniecki M, Mamak D, Szopa M, Buchała J, Stawarz G, Florek S, Adamczyk-Sowa M Abstract According to recent reports, malnutrition may be associated with a worse prognosis in stroke patients. The aim of this study was to determine the nutritional status of stroke patients and its impact on neurological and functional status of patients in the early post-stroke period. Our prospective study included a total of 128 patients admitted to the Stroke Unit. The assessment was made in the patients within the first week after the onset of stroke symptoms. Groups of patients with abnormal body mass in...
Source: Neurological Research - November 6, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Association between CPR-related genetic variants and risk of ischemic stroke: a nested case-control study.
Conclusions: Our study showed genetic variants of CRP-related genes were associated with risk of ischemic stroke. Our findings could provide useful data for the etiology of ischemic stroke. PMID: 31584351 [PubMed - as supplied by publisher]
Source: Neurological Research - October 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Thrombolysis with rhPro-UK 3 to 6 hours after embolic stroke in rat.
Conclusions: RhPro-UK had an obvious therapeutic effect on ischemic stroke caused by thrombosis, and could be started within 4.5 h TTW with less side effects of cerebral hemorrhage than that of UK. PMID: 31584350 [PubMed - as supplied by publisher]
Source: Neurological Research - October 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Inpatient statin use and stroke recurrence in patients with or without diabetes mellitus.
Conclusion: Inpatient statin use was associated with lower stroke recurrence in non-diabetic patients after acute ischaemic stroke, but no definite association between inpatient statin use and stroke recurrence in patients with diabetes mellitus was found. PMID: 31328681 [PubMed - as supplied by publisher]
Source: Neurological Research - July 23, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Effect of a novel designed intensive patient care program on cognitive impairment, anxiety, depression as well as relapse free survival in acute ischemic stroke patients: a randomized controlled study.
Conclusions: IPCP presents with a positive influence on improving cognitive impairment and decreasing anxiety as well as depression, while a less effect on improving RFS in AIS patients. Abbreviation: IPCP: intensive patient care program; RFS: relapse free survival; AIS: acute ischemic stroke; MRA: magnetic resonance angiography; ITT: intention-to-treat; LOCF: last observation carried forward. PMID: 31266412 [PubMed - as supplied by publisher]
Source: Neurological Research - July 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Association between socioeconomic status and prognosis after ischemic stroke in South China.
Conclusions: Patients with low income, family caregiver, and no insurance have a poorer prognosis after ischemic stroke that can be partly explained by intermediate variable in the patients' demographic characteristics, cardiovascular disease, behavior lifestyle, and stroke severity. Abbreviations: DALYs: disability-adjusted life years; SES: socioeconomic status; FMC: free medical care; MIUR: medical insurance for urban residents; MIUE: medical insurance for urban employees; NCMS: new rural cooperative medical scheme ; NIHSS: National Institute of Health Stroke Scale ; mRS: modified Rankin scale; OR: odds ratios; CI: confi...
Source: Neurological Research - June 19, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Application of functional near-infrared spectroscopy to explore the neural mechanism of transcranial direct current stimulation for post-stroke depression.
DISCUSSION: tDCS may improve the processing of negative emotions and working memory in patients with PSD by enhancing aerobic metabolism in the PFC, thereby improving depressive symptoms. PMID: 31092142 [PubMed - as supplied by publisher]
Source: Neurological Research - May 17, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Predictive analytics and machine learning in stroke and neurovascular medicine.
Authors: Saber H, Somai M, Rajah GB, Scalzo F, Liebeskind DS Abstract Advances in predictive analytics and machine learning supported by an ever-increasing wealth of data and processing power are transforming almost every industry. Accuracy and precision of predictive analytics have significantly increased over the past few years and are evolving at an exponential pace. There have been significant breakthroughs in using Predictive Analytics in healthcare where it is held as the foundation of precision medicine. Yet, although the research in the field is expanding with the profuse volume of papers applying machine l...
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Microalbuminuria in patients with acute ischemic stroke.
CONCLUSIONS: MAU was found in approximately one-third of patients with acute ischemic stroke. It was correlated with the severity of cerebral infarction at admission and clinical outcomes at 3 months after onset and could be used as a potential indicator of poor prognosis in ischemic stroke patients. PMID: 30931822 [PubMed - as supplied by publisher]
Source: Neurological Research - April 3, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Family history of stroke and death or vascular events within one year after ischemic stroke.
CONCLUSION: This study suggests that maternal stroke history, age<55 years at stroke onset and thrombotic stroke in the patients with a family history are associated with poor outcomes after stroke. Further studies from other samples are needed to replicate our findings due to a reason for excluding some severe stroke patients in this study. PMID: 30829563 [PubMed - as supplied by publisher]
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Exposure to female estrous is beneficial for male mice against transient ischemic stroke.
CONCLUSION: Exposure to female estrous reduces mortality and improves functional recovery in MCAO male mice. The study provides the first evidence to support the importance of female interaction to male stroke rehabilitation. ABBREVIATIONS: GAP-43: growth-associated protein-43; SYP: Synaptophysin; MCAO: middle cerebral artery occlusion; OVXs: ovariectomies; CCA: common carotid artery; ECA: external carotid artery; EFE: estrous female exposure; TTC: 2,3,5-triphenyltetrazolium chloride; PAGE: polyacrylamide gel electrophoresis; PVDF: polyvinylidene difluoride; ANOVA: analysis of variance; LSD: least significant differenc...
Source: Neurological Research - March 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model.
CONCLUSIONS: Observed results suggested that paeoniflorin could ameliorate the symptoms and improve the functional capability of PSD rats, similar to the effect of fluoxetine. ABBREVIATIONS: PSD: post-stroke depression; CUMS: chronic unpredictable mild stress stimulation; MCAO: middle cerebral artery occlusion; OFT: open field test; SPT: sucrose preference test, NDS: neurological deficit score, BBT: beam balance test; BDNF: brain-derived neurotrophic factor protein; p-CREB: phosphorylated Cyclic-AMP responsive element binding protein. PMID: 30759063 [PubMed - as supplied by publisher]
Source: Neurological Research - February 15, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Increased risk of post-stroke epilepsy in Chinese patients with a TRPM6 polymorphism.
CONCLUSION: The TRPM6 rs2274924 polymorphism may be associated with susceptibility to epilepsy following stroke, and the C allele may be associated with increased risk of post-stroke epilepsy. The TRPM6 rs2274924 polymorphism may also influence serum levels of Mg2+ in post-stroke epilepsy patients. PMID: 30739590 [PubMed - as supplied by publisher]
Source: Neurological Research - February 12, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Staphylococcus aureus infected embolic stroke upregulates Orm1 and Cxcl2 in a rat model of septic stroke pathology.
CONCLUSIONS: Septic embolic stroke caused brain abscesses, increased mortality and upregulated Orm1 and Cxcl2 gene expressions compared to non-infected embolic stroke. The dramatic Orm1 increase observed in the septic group is unprecedented and suggests a significant biological role of Orm1 during septic neuroinflammation. PMID: 30707086 [PubMed - as supplied by publisher]
Source: Neurological Research - February 4, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Portable fibrobronchoscopic treatment for non-severe ischemic stroke-associated pneumonia patients with dysphagia: a pilot study.
CONCLUSION: Sputum suction and alveolar lavage with portable fibrobronchoscope can significantly improve the hypoxia and pulmonary infections, reduce the inflammatory response, and thus improve the prognosis, rendering suction and alveolar lavage with portable fibrobronchoscope as a safe and effective treatment for non-severe ischemic SAP patients with dysphagia. PMID: 30657017 [PubMed - as supplied by publisher]
Source: Neurological Research - January 19, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Serum levels of insulin-like growth factor-1 and brain-derived neurotrophic factor as potential recovery biomarkers in stroke.
DISCUSSION: Biomarkers have the potential to characterize an individual's potential for recovery from stroke. Neurotrophins such as insulin-like growth factor-1 and brain-derived neurotrophic factor are thought to be important in neurorehabilitation; however, the factors that modulate these biomarkers are not well understood. Resting brain-derived neurotrophic factor and percent change in brain-derived neurotrophic factor were related to physical and cognitive recovery in chronic stroke, albeit weakly. Insulin-like growth factor-1 was not an informative biomarker among chronic stroke patients. The novel finding that fluid ...
Source: Neurological Research - January 9, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke.
CONCLUSION: Stroke induces changes in the RhoA-ROCK pathway in T-cells. CRP and NIHSS score correlated positively in the study. Statins may have an anti-inflammatory effect as statin treatment before stroke reduces post-stroke pro-inflammatory levels. RhoA GTPase and its downstream effectors are possibly the key to improve statin treatment in stroke. PMID: 30574850 [PubMed - as supplied by publisher]
Source: Neurological Research - December 24, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Hyperuricemia and prognosis of acute ischemic stroke in diabetic patients.
CONCLUSIONS: HUA independently predicted poor in-hospital outcome of AIS in diabetic patients, especially in patients aged ≤ 75 years. PMID: 30526444 [PubMed - as supplied by publisher]
Source: Neurological Research - December 13, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Reversed ophthalmic artery flow following ischemic stroke: a possible predictor of outcomes following carotid artery stenting.
This study provides evidence that CAS is a valid and effective treatment option regardless of whether patients exhibited ROAF or not. Patients without ROAF were significantly more likely to have improved mid-term functional outcomes compared to those with ROAF. In the group without ROAF admission, CRP may play a role in predicting subsequent functional outcomes, whereas admission Barthel Index was a predictor of outcome in the ROAF group. PMID: 30433861 [PubMed - as supplied by publisher]
Source: Neurological Research - November 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Serum leptin is associated with first-ever ischemic stroke, lesion size and stroke severity in a Chinese cohort.
CONCLUSION: Serum leptin is associated with first-ever AIS, lesion size and stroke severity in a Chinese cohort. PMID: 30433860 [PubMed - as supplied by publisher]
Source: Neurological Research - November 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population.
CONCLUSION: No significant difference was observed between the stroke patients and controls in terms of genotypes and allele distributions. Double combine haplotype CCAA was found to be protective against ischemic stroke when compare to other haplotypes. However, different genotypes of GSTO1 and GSTO2 were observed to have effects on stroke risk in subgroups of diabetics and smokers. In conclusion, the current study is the first to report this finding. PMID: 30417762 [PubMed - as supplied by publisher]
Source: Neurological Research - November 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

D-dimer > 2.785  μg/ml and multiple infarcts ≥3 vascular territories are two characteristics of identifying cancer-associated ischemic stroke patients.
CONCLUSIONS: D-dimer >2.785 μg/ml may be an effective cutoff value and a sensitive index for identifying CAIS patients. AMBIs in ≥3 vascular territories and AMBIs in both the anterior and posterior circulations are two imaging characteristics of CAIS. PMID: 30317943 [PubMed - in process]
Source: Neurological Research - October 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Lp-PLA2 as a risk factor of early neurological deterioration in acute ischemic stroke with TOAST type of large arterial atherosclerosis.
Authors: Wang Y, Hu S, Ren L, Lei Z, Lan T, Cai J, Li C Abstract INTRODUCTION: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a well-known risk factor of atherosclerotic vascular diseases. Nevertheless, its role in the acute phase of ischemic stroke is still unclear. The aim of this study is to identify the relationship between Lp-PLA2 levels and early neurological deterioration (END) in acute ischemic stroke patients with Trial of Org 10 172 in Acute Stroke Treatment (TOAST) subtype of large arterial atherosclerosis (LAA). METHODS: We enrolled Chinese patients with first ever acute ischemic stroke admitt...
Source: Neurological Research - October 10, 2018 Category: Neurology Tags: Neurol Res Source Type: research

The relationship between brain microbleeds and homeostatic markers in the treatment of ischemic stroke.
CONCLUSION: Pathogenesis of AF is involved abnormal changes of hemostasis, endothelial dysfunction, antithrombotic state and inflammation. The homeostatic markers, which play role in these pathways, and the presence of BMBs could use to form a prognostic clinic assessment tool to predict bleeding risk. PMID: 30207930 [PubMed - as supplied by publisher]
Source: Neurological Research - September 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Predictors of mortality and recurrent stroke within five years of intracerebral hemorrhage.
Conclusion Predictors of recurrent stroke were older females, hypertension, diabetes, and brain stem hemorrhage. These findings may help to determine specific treatment strategies and improve quality of health care for such patients. PMID: 30134784 [PubMed - in process]
Source: Neurological Research - August 25, 2018 Category: Neurology Tags: Neurol Res Source Type: research