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P-006 Does clot density predict the success of first-pass clot aspiration in thrombectomy for stroke?
ConclusionClot density may help guide thrombectomy approach for stroke. In our study higher HU values correlated with better recanalization but required more passes. Higher HU values indicating greater clot density correlated with worse post-operative outcomes. Future studies may be required to confirm the findings and gather further evidence to optimize thrombectomy approaches for stroke management based on clot densityDisclosures K. Joshi: None. J. Gernstein: None. Y. Radaideh: None. M. Chen: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Joshi, K., Gernstein, J., Radaideh, Y., Chen, M. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-007 Thrombectomy techniques alter the pathology of harvested clots
ConclusionThe pathological evaluation of the retrieved clot can be affected by the original clot type and the type of mechanical thrombectomy. These differences in changes in clot pathology need to be recognized for stroke research.Abstract P-007 Figure 1Disclosures T. Imahori: 1; C; Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research. M. Ghovvati: None. L. Guo: None. A. M Gajjar: None. S. Tateshima: 2; C; Medtronic, Stryker, Cerenovus, Rapid Medical. N. Kaneko: 2; C; Medtronic, Stryker.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Imahori, T., Ghovvati, M., Guo, L., Gajjar, A., Tateshima, S., Kaneko, N. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-008 Probabilistic ensemble learning for prediction of stroke thrombectomy outcomes from the neurovascular quality initiative-quality outcomes database (NVQI-QOD) registry
ConclusionsThis study demonstrates the utility of probabilistic ensemble learning in clinical decision-making and prognosis. It can provide robust predictions as well as quantify data uncertainty. Our results regarding NIHSS changes reinforce the substantial benefits of MT, that can improve outcomes in nearly half of patients. The degree of disability relevant to the 90-day follow-up mRS can be determined by probabilistic learning available as early as discharge.Disclosures C. Zhou: None. S. Faruqui: None. A. Patel: None. R. Abdalla: None. A. Shaibani: None. M. Potts: None. B. Jahromi: None. S. Ansari: None. D. Cantrell: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Zhou, C., Faruqui, S., Patel, A., Abdalla, R., Shaibani, A., Potts, M., Jahromi, B., Ansari, S., Cantrell, D. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-009 Reperfusion injury after endovascular thrombectomy may be related to pre-treatment infarct topography
ConclusionsGreater basal ganglia infarct volume was associated with a higher risk of HT when accounting for infarct volumes in other regions. Susceptibility vessel sign was associated with basal ganglia infarct volume, which may be related to acute middle cerebral artery perforator occlusion.Disclosures R. Regenhardt: 1; C; National Institutes of Health, Society of Vascular and Interventional Neurology, Heitman Stroke Foundation. 6; C; DSMB for Rapid Medical. A. Bonkhoff: None. M. Schirmer: None. A. Das: None. A. Dmytriw: None. J. Vranic: None. R. Gupta: None. J. Hirsch: None. J. Rabinov: None. C. Stapleton: None. T. Lesli...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Regenhardt, R., Bonkhoff, A., Schirmer, M., Das, A., Dmytriw, A., Vranic, J., Gupta, R., Hirsch, J., Rabinov, J., Stapleton, C., Leslie-Mazwi, T., Patel, A., Rost, N. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-010 Endovascular thrombectomy with or without bridging thrombolysis in acute ischemic stroke: a cost-effectiveness analysis
ConclusionOur cost-effectiveness model suggested that EVT only may be cost-effective for patients with acute ischemic stroke secondary to large vessel occlusion.Disclosures R. Morsi: None. Y. Zhang: None. M. Zhu: None. S. Xie: None. J. Carrión-Penagos: None. H. Desai: None. E. Tannous: None. S. Kothari: None. A. Khamis: None. A. Darzi: None. A. Tarabichi: None. R. Bastin: None. L. Hneiny: None. S. Thind: None. J. Siegler: None. E. Coleman: None. S. Mendelson: None. A. Mansour: None. S. Prabhakaran: None. T. Kass-Hout: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Morsi, R., Zhang, Y., Zhu, M., Xie, S., Carrion-Penagos, J., Desai, H., Tannous, E., Kothari, S., Khamis, A., Darzi, A., Tarabichi, A., Bastin, R., Hneiny, L., Thind, S., Siegler, J., Coleman, E., Mendelson, S., Mansour, A., Prabhakaran, S., Kass-Hout, T. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-011 Risk of intracranial hemorrhage associated with rescue intracranial stenting in patients who receive IV thrombolysis
ConclusionsIn this retrospective study of a 10-year experience at a high-volume comprehensive stroke center, our study shows that rescue stenting after failed mechanical thrombectomy in the setting of prior administration of IV thrombolysis appears to be associated with a higher rate of all types of intracranial hemorrhages, but similar rates of symptomatic intracranial hemorrhage. 90-day functional status was better in the patients who received IV tPA, although the 90-day mortality was higher. Our report suggests that further larger studies are needed to determine the safety and efficacy of RS for failed mechanical thromb...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Nedelcu, S., Kuhn, A., Singh, J., Henninger, N., Puri, A. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-013 The need for speed: reducing endovascular treatment times in ischemic stroke
ConclusionsImproving awareness of process expectations by meeting with stakeholders resulted in a substantial and sustainable decreases in median door to groin puncture and door to first pass times. Implementation of hospital-based PI multidisciplinary team initiatives helped improve our sites work flow and continued to improve our door to 1st pass times.Disclosures H. Shownkeen: None. A. Doerr: None. B. Fill: None. A. Mazumdar: None. D. Pandya: None. K. Buffo: None. A. Stacey: None. T. Iacob: None. L. Stanek: None. J. Carlson: None. L. Spellman: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Shownkeen, H., Doerr, A., Fill, B., Mazumdar, A., Pandya, D., Buffo, K., Stacey, A., Iacob, T., Stanek, L., Carlson, J., Spellman, L. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-020 Anterior circulation site-specific results for stent-assisted coiling - carotid vs. others: one-year outcomes from neuroform atlas stent pivotal trial
ConclusionBased on these findings of the ATLAS IDE trial, the Neuroform Atlas Stent System is a safe and efficacious treatment modality for unruptured anterior circulation intracranial aneurysms in both proximal and distal, bifurcation aneurysms. Additional, studies are needed to assess complication rates in larger populations. This may have important implications for the selection of treatment modalities for intracranial aneurysms.Disclosures R. Hanel*: 1; C; NIH, Interline Endowment, Microvention, Stryker, NX. 2; C; Medtronic, Balt, Stryker, Q’Apel Medical, Inc, Codman Neuro (J&J), Cerenovus, Microvention, Impe...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Hanel, R., Cortez, G., Jankowitz, B., Sauvageau, E., Aghaebrahim, A., Lin, E., Jadhav, A., Gross, B., Khaldi, A., Gupta, R., Frei, D., Loy, D., Lyn Price, L., Hetts, S., Zaidat, O. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-023 Initial experience with transcranial ultrasound through sonolucent cranioplasty after hemicraniectomy for ischemic and hemorrhagic stroke
ConclusionTranscranial ultrasound through large, customized sonolucent cranioplasty is safe and feasible after decompressive hemicraniectomy. This imaging technique may alleviate the cost, transport, and radiation burden of CT in select ICH patients.Abstract P-023 Figure 1Disclosures C. Rossitto: None. H. Tabani: None. A. Reynolds: None. C. Kellner: 1; C; CPK receives research funding from Longeviti Neuro Solutions, Penumbra, Integra, Viz.AI, Minnetronix, Siemens, and Cerebrotech.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Rossitto, C., Tabani, H., Reynolds, A., Kellner, C. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-024 Diffuse correlation spectroscopy in acute ischemic stroke neurointerventional procedures; initial experience and preliminary results
ConclusionsWe showed the feasibility of this non-invasive approach in providing continuous measurement of regional CBF brain tissue properties. In the future, implementations of more robust DCS instruments such as our recently developed pathlength-resolved DCS device could alleviate the limitations of the current DCS technology discovered during this study.Abstract P-024 Figure 1Disclosures M. Mokin: 1; C; NIH NINDS. 2; C; Cerenovus, Medtronic. 4; C; Bendit Technologies, Borvo medical, BrainQ, Endostream, Serenity medical, Synchron, Sim&Cure, QAS.AI, Quantanosis.AI. S. Thanki: None. P. Mohammad: None. S. Sheehy: None. ...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Mokin, M., Thanki, S., Mohammad, P., Sheehy, S., Jones, K., Peto, I., Guerrero, W., Vakharia, K., Burgin, W., Parthasarathy, A. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-026 Extracellular vesicle neurotrophin expression in plasma collected during mechanical thrombectomy from patients with emergent large vessel stroke
DiscussionThese data suggest that EV proBDNF/BDNF levels can reflect vascular changes that lead to decreased cognition and should be explored further for translational applications.Disclosures A. Trout: None. D. Britsch: None. W. Naberhaus: None. J. Turchan-Cholewo: None. C. McLouth: None. L. Whitnel-Smith: None. J. Frank: None. J. Roberts: None. P. Shivani: None. D. Dornboss III: None. J. Harp: None. K. Pennypacker: None. A. Stowe: None. J. Fraser: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Trout, A., Britsch, D., Naberhaus, W., Turchan-Cholewo, J., McLouth, C., Whitnel-Smith, L., Frank, J., Roberts, J., Shivani, P., Dornboss, D., Harp, J., Pennypacker, K., Stowe, A., Fraser, J. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

P-028 Impact of the covid-19 pandemic on the intracranial aneurysm treatment and associated outcomes: a propensity score matching study
Conclusions and RelevanceThe COVID-19 pandemic has significantly impacted the healthcare system and has led to changes in the treatment of various neurological conditions, including ICAs. The pandemic resulted in a shift in the treatment of SAH and an increase in endovascular procedures over open surgical clipping. COVID-19 infection has been associated with an increased risk of ischemic stroke and worsened outcomes for stroke patients. Further research is necessary to understand the long-term effects of the pandemic on the healthcare system and patient outcomes.Disclosures A. Ghaith: None. M. Ghanem: None. E. Greco: None....
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Ghaith, A., Ghanem, M., Greco, E., Rios-Zermeno, J., Bon Nieves, A., Kashyap, S., Tawk, R., Bydon, M. Tags: SNIS 20th annual meeting oral poster abstracts Source Type: research

E-002 Procedural, clinical and safety outcomes in acute ischemic stroke stratified by operator techniques and clot location - insights from the ASSIST registry
ConclusionsASSIST provides insights into the effectiveness and safety of different MT techniques as stratified by clot location to improve reperfusion rates, functional outcomes, and quality of life for AIS patients worldwide. ClinicalTrials.gov ID: NCT03845491Disclosures R. Gupta: 2; C; Rapid Medical, Vesalio. 6; C; PI, ASSIST Registry Stryker Neurovascular PI, DISTALS Study, Rapid Medical PI, RECCLAIM II study, Zoll PI, CLEAR Study, Vesalio, CEC MIND Trial Penumbra, Steering committee ELEVATE Trial, Medtronic Steering committee MEMBRANE Trial, Cerenovous. D. Vollherbst: 1; C; MicroVention (unrelated to this work). 2; C; ...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Gupta, R., Vollherbst, D., Miralbes, S., Naravetla, B., Spiotta, A., Loehr, C., Martinez-Galdamez, M., McTaggart, R., Defreyne, L., Vega, P., Zaidat, O., Price, L., Liebeskind, D., Möhlenbruch, M. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-005 Robotic neuroendovascular interventions: a systematic review of the USA experience
ConclusionThis review demonstrates the feasibility and safety of robotic use for neurovascular interventions, including aneurysmal and CAS procedures. Future clinical investigations can potentially assess its usefulness for acute stroke interventions with inherent geographic locations.Abstract E-005 Figure 1Abstract E-005 Figure 2Disclosures A. Ghaith: None. M. Ghanem: None. R. Jarrah: None. O. Akinnusotu: None. M. Bydon: None. B. Bendok: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Ghaith, A., Ghanem, M., Jarrah, R., Akinnusotu, O., Bydon, M., Bendok, B. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-006 U.S. health care system-wide transition from alteplase to tenecteplase before mechanical thrombectomy: functional outcomes, early reperfusion rates, intracranial bleeding and femoral access site complications
ConclusionsThe first-year experience demonstrates the effectiveness and safety of the transitioning from TPA to TNK. The higher early recanalization rates with TNK are striking. Additional studies are required to investigate whether TNK is superior to TPA in the setting of LVO stroke.Disclosures M. Collins: None. C. Schirmer: None. G. Weiner: None. O. Goren: None. I. Melamed: None. S. Dalal: None. M. Kole: None. A. Noto: None. P. Hendrix: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Collins, M., Schirmer, C., Weiner, G., Goren, O., Melamed, I., Dalal, S., Kole, M., Noto, A., Hendrix, P. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

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