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Source: Neuroscience
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Total 165 results found since Jan 2013.
Overexpression of microRNA-9a-5p ameliorates NLRP1 inflammasome-mediated ischemic injury in rats following ischemic stroke
Publication date: Available online 16 January 2020Source: NeuroscienceAuthor(s): Cao yuze, Zhang huixue, Lu xiaoyu, Wang Jianjian, Zhang xiaoming, Sun shengnan, Bao zhonglei, Tian wenqi, Ning shangwei, Wang lihua, Cui liyingAbstractThe nucleotide oligomerization domain (NOD)-like receptor (NLR) pyrin domain-containing protein 1 (NLRP1) inflammasome has been shown to contribute to brain injury after ischemic stroke. Our previous study showed that microRNA-9a-5p (miR-9a-5p) ameliorates ischemic injury by regulating neuronal autophagy in rats subjected to middle cerebral artery occlusion (MCAO) surgery. The aims of this study...
Source: Neuroscience - January 17, 2020 Category: Neuroscience Source Type: research
Corrigendum to “Transcriptomic Analysis Reveals Differential Activation of Microglial Genes after Ischemic Stroke in Mice” Neuroscience 348 (2017) 212–227
Publication date: Available online 6 January 2020Source: NeuroscienceAuthor(s): Akbar Khan, Furong Ju, Wenguang Xie, Muhammad Tariq Hafeez, Xiaofeng Cheng, Zhijie Yang, Lirui Zhu, Ting Li, Shengxiang Zhang
Source: Neuroscience - January 7, 2020 Category: Neuroscience Source Type: research
Neuroprotective action of teriflunomide in a mouse model of transient middle cerebral artery occlusion
In this study, we investigated the effects of teriflunomide on brain edema, neurologic deficits, infarct volume, neuroinflammation, blood-brain barrier (BBB) permeability, and neurogenesis in a mouse model of transient middle cerebral artery occlusion (tMCAO). tMCAO mice treated with teriflunomide showed lower brain water content on day 3, milder neurologic deficits and smaller infarct volume on day 7 than those treated with vehicle. Additionally, mice received teriflunomide had fewer activated Iba-1-positive microglia and lower protein levels of interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), and 3-Nitrotyrosine (3-NT...
Source: Neuroscience - December 28, 2019 Category: Neuroscience Source Type: research
Long-term exercise confers equivalent neuroprotection in females despite lower cardiorespiratory fitness
Publication date: Available online 19 December 2019Source: NeuroscienceAuthor(s): Christopher J. Marley, Julien V. Brugniaux, Danielle Davis, Thomas A. Calverley, Thomas S. Owens, Benjamin S. Stacey, Hayato Tsukamoto, Shigehiko Ogoh, Phillip N. Ainslie, Damian M. BaileyAbstractFemales are more prone to cognitive decline, stroke and neurodegenerative disease, possibly due to more marked reductions in cerebral blood flow and cerebrovascular reactivity to CO2 (CVRCO2HYPER) in later life. To what extent regular exercise confers selective neuroprotection in females remains unestablished. To examine this, 73 adults were prospect...
Source: Neuroscience - December 20, 2019 Category: Neuroscience Source Type: research
Neuroprotection by insulin-like growth factor-1 in rats with ischemic stroke is associated with microglial changes and a reduction in neuroinflammation
Publication date: Available online 14 December 2019Source: NeuroscienceAuthor(s): Ahmad Serhan, Joeri L. Aerts, EWGM Boddeke, Ron KooijmanAbstractWe and others have shown that insulin-like growth factor-1 (IGF-1) is neuroprotective when administered systemically shortly following stroke. In the current study, we addressed the hypothesis that microglia mediate neuroprotection by IGF-1 following ischemic stroke. Furthermore, we investigated whether IGF-1 modulates pro- and anti-inflammatory mediators in ischemic brain with a special reference to microglia. Ischemic stroke was induced in normal conscious Wistar rats by infusi...
Source: Neuroscience - December 16, 2019 Category: Neuroscience Source Type: research
Pseudoginsenoside-F11 Accelerates Microglial Phagocytosis of Myelin Debris and Attenuates Cerebral Ischemic Injury Through Complement Receptor 3
Publication date: Available online 29 November 2019Source: NeuroscienceAuthor(s): Yinglu Liu, Chunfu Wu, Zongjuan Hou, Xiaoxiao Fu, Linlin Yuan, Shibo Sun, Haotian Zhang, Depeng Yang, Xuechun Yao, Jingyu YangAbstractAfter ischemic stroke, the degenerated myelin caused by ischemic injury cannot be rapidly cleared away by microglia and interferes with the recovery process. Complement receptor 3 (CR3, CD11b/CD18), belonging to β2 integrin family primarily expressed in phagocytes, is involved in the microglial phagocytosis of myelin debris. We previously found that pseudoginsenoside-F11 (PF11), an ocotillol-type saponin, exer...
Source: Neuroscience - November 30, 2019 Category: Neuroscience Source Type: research
Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway
Publication date: Available online 11 November 2019Source: NeuroscienceAuthor(s): Rui Zhao, Miaofa Ying, Shenglong Gu, Wei Yin, Yanwei Li, Hong Yuan, Sanhua Fang, Mingxing LiAbstractMicroglia activation plays a key role in regulating inflammatory and immune reaction during cerebral ischemia and it exerts pro-inflammatory or anti-inflammatory effect depending on M1/M2 polarization phenotype. Cysteinyl leukotriene 2 receptor (CysLT2R) is a potent inflammatory mediator receptor, and involved in cerebral ischemic injury, but the mechanism of CysLT2R regulating inflammation and neuron damage remains unclear. Here, we found that...
Source: Neuroscience - November 12, 2019 Category: Neuroscience Source Type: research
Cerebrovascular Correlates of Subclinical Attentional Disturbances in Non-stroke Cardiovascular Disease
Publication date: Available online 1 November 2019Source: NeuroscienceAuthor(s): Kayla B. Stefanidis, Ben Isbel, Timo Klein, Jim Lagopoulos, Christopher D. Askew, Mathew J. SummersAbstractEvidence suggests that cerebrovascular hemodynamic disturbances underlie cognitive deterioration secondary to cardiovascular disease (CVD), including manifestations other than stroke, but the mechanisms remain unclear. To date, the majority of studies have used neuropsychological measures validated for the detection of clinically significant cognitive decline but lack the sensitivity to accurately detect subclinical or subtle cognitive ch...
Source: Neuroscience - November 3, 2019 Category: Neuroscience Source Type: research
Caffeine Exacerbates Postictal Hypoxia
Publication date: Available online 31 October 2019Source: NeuroscienceAuthor(s): Thomas J. Phillips, Renaud C. Gom, Marshal D. Wolff, G. Campbell TeskeyAbstractA stroke-like event follows seizures which may be responsible for the postictal state and a contributing factor to the development of seizure-induced brain abnormalities and behavioral dysfunction associated with epilepsy. Caffeine is the world’s most popular drug with ∼85% of people in the USA consuming it daily. Thus, persons with epilepsy are likely to have caffeine in their body and brain during seizures. This preclinical study investigated the effects of ac...
Source: Neuroscience - October 31, 2019 Category: Neuroscience Source Type: research
USP18 Overexpression Protects against Focal Cerebral Ischemia Injury in Mice by Suppressing Microglial Activation
This study aims to determine whether USP18 expression protects against brain damage in ischemic models of stroke. We investigated USP18 expression, overexpression, and knockout under ischemic conditions in vitro and in vivo. Using BV2 microglial cells under oxygen and glucose deprivation (OGD) and 60 min transient middle cerebral artery occlusion (MCAO) in mice as models of ischemia, we assessed the infarct volume, the extent of neurogenesis, the expression of proinflammatory cytokines and Janus Kinases (JAKs)/Signal Transducer and Activator of Transcription (STAT) pathway members. BV2 cells under OGD for 0, 6, 12, or 24 h...
Source: Neuroscience - September 10, 2019 Category: Neuroscience Source Type: research
Altered Brain Glucose Metabolism Assessed by 18F-FDG PET Imaging Is Associated with the Cognitive Impairment of CADASIL
Publication date: Available online 5 August 2019Source: NeuroscienceAuthor(s): Jingjing Su, Qi Huang, Shuhua Ren, Fang Xie, Yu Zhai, Yihui Guan, Jianren Liu, Fengchun HuaAbstractRecurrent stroke and cognitive impairment are the primary features of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The cognitive deficits in these patients are known to be correlated with structural brain changes, such as white matter lesions and lacunae, and resting-state functional connectivity in brain networks. However, the associations between changes in brain glucose metab...
Source: Neuroscience - August 6, 2019 Category: Neuroscience Source Type: research
Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway
In conclusion, Colivelin induce anti-apoptotic genes up-regulation, and activate JAK/STAT3 signaling after ischemic stroke, which may contribute to its effects of rescuing ischemic neuronal death and axonal remodeling. This study may justify further works to examine Colivelin as a single or adjunct therapy in ischemic stroke.
Source: Neuroscience - July 31, 2019 Category: Neuroscience Source Type: research
Over-Expression of TRPC6 via CRISPR Based Synergistic Activation Mediator in BMSCs Ameliorates Brain Injury in a Rat Model of Cerebral Ischemia/Reperfusion
Publication date: Available online 29 July 2019Source: NeuroscienceAuthor(s): Wenbin Li, Fan Yang, Jinxing Gao, Yushi Tang, Jing Wang, Yujun PanAbstractStroke is a major life-threatening and disabling disease with a restricted therapeutic approach. Bone marrow stromal cells (BMSCs) possess proliferative ability and a multi-directional differentiation potential, and secrete a range of trophic/growth factors that can protect neurons after cerebral ischemia/reperfusion. Transient receptor potential canonical (TRPC) is a family of non-selective channels permeable to Ca2+, with several functions including neuronal survival. Ove...
Source: Neuroscience - July 30, 2019 Category: Neuroscience Source Type: research
Sensorimotor Connectivity after Motor Exercise with Neurofeedback in Post-Stroke Patients with Hemiplegia
This study showed neurophysiological evidence that EEG-contingent neurofeedback is a promising strategy to induce intrinsic ipsilesional sensorimotor reorganization, supporting the importance of integrating closed-loop sensorimotor processing at a neurophysiological level.
Source: Neuroscience - July 28, 2019 Category: Neuroscience Source Type: research
Protective Role of Levetiracetam Against Cognitive Impairment And Brain White Matter Damage in Mouse prolonged Cerebral Hypoperfusion
Publication date: Available online 11 July 2019Source: NeuroscienceAuthor(s): Toshiki Inaba, Nobukazu Miyamoto, Kenichiro Hira, Yuji Ueno, Kazuo Yamashiro, Masao Watanabe, Yoshiaki Shimada, Nobutaka Hattori, Takao UrabeAbstractWhite matter lesions due to cerebral hypoperfusion may be an important pathophysiology in vascular dementia and stroke, although the inherent mechanisms remain to be fully elucidated. The present study, using a mouse model of chronic cerebral hypoperfusion, examined the white matter protective effects of levetiracetam, an anticonvulsant, via the signaling cascade from the activation of cAMP-responsiv...
Source: Neuroscience - July 12, 2019 Category: Neuroscience Source Type: research
