Query: stroke

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Total 145 results found since Jan 2013.

Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway
Publication date: Available online 11 November 2019Source: NeuroscienceAuthor(s): Rui Zhao, Miaofa Ying, Shenglong Gu, Wei Yin, Yanwei Li, Hong Yuan, Sanhua Fang, Mingxing LiAbstractMicroglia activation plays a key role in regulating inflammatory and immune reaction during cerebral ischemia and it exerts pro-inflammatory or anti-inflammatory effect depending on M1/M2 polarization phenotype. Cysteinyl leukotriene 2 receptor (CysLT2R) is a potent inflammatory mediator receptor, and involved in cerebral ischemic injury, but the mechanism of CysLT2R regulating inflammation and neuron damage remains unclear. Here, we found that...
Source: Neuroscience - November 12, 2019 Category: Neuroscience Source Type: research

Cerebrovascular Correlates of Subclinical Attentional Disturbances in Non-stroke Cardiovascular Disease
Publication date: Available online 1 November 2019Source: NeuroscienceAuthor(s): Kayla B. Stefanidis, Ben Isbel, Timo Klein, Jim Lagopoulos, Christopher D. Askew, Mathew J. SummersAbstractEvidence suggests that cerebrovascular hemodynamic disturbances underlie cognitive deterioration secondary to cardiovascular disease (CVD), including manifestations other than stroke, but the mechanisms remain unclear. To date, the majority of studies have used neuropsychological measures validated for the detection of clinically significant cognitive decline but lack the sensitivity to accurately detect subclinical or subtle cognitive ch...
Source: Neuroscience - November 3, 2019 Category: Neuroscience Source Type: research

Caffeine Exacerbates Postictal Hypoxia
Publication date: Available online 31 October 2019Source: NeuroscienceAuthor(s): Thomas J. Phillips, Renaud C. Gom, Marshal D. Wolff, G. Campbell TeskeyAbstractA stroke-like event follows seizures which may be responsible for the postictal state and a contributing factor to the development of seizure-induced brain abnormalities and behavioral dysfunction associated with epilepsy. Caffeine is the world’s most popular drug with ∼85% of people in the USA consuming it daily. Thus, persons with epilepsy are likely to have caffeine in their body and brain during seizures. This preclinical study investigated the effects of ac...
Source: Neuroscience - October 31, 2019 Category: Neuroscience Source Type: research

USP18 Overexpression Protects against Focal Cerebral Ischemia Injury in Mice by Suppressing Microglial Activation
This study aims to determine whether USP18 expression protects against brain damage in ischemic models of stroke. We investigated USP18 expression, overexpression, and knockout under ischemic conditions in vitro and in vivo. Using BV2 microglial cells under oxygen and glucose deprivation (OGD) and 60 min transient middle cerebral artery occlusion (MCAO) in mice as models of ischemia, we assessed the infarct volume, the extent of neurogenesis, the expression of proinflammatory cytokines and Janus Kinases (JAKs)/Signal Transducer and Activator of Transcription (STAT) pathway members. BV2 cells under OGD for 0, 6, 12, or 24 h...
Source: Neuroscience - September 10, 2019 Category: Neuroscience Source Type: research

Sensorimotor Connectivity after Motor Exercise with Neurofeedback in Post-Stroke Patients with Hemiplegia
This study showed neurophysiological evidence that EEG-contingent neurofeedback is a promising strategy to induce intrinsic ipsilesional sensorimotor reorganization, supporting the importance of integrating closed-loop sensorimotor processing at a neurophysiological level.
Source: Neuroscience - July 28, 2019 Category: Neuroscience Source Type: research

Prolonged High Fat Diet Worsens the Cellular Response to a Small, Covert-like Ischemic Stroke
Publication date: Available online 4 February 2019Source: NeuroscienceAuthor(s): Kathleen E. Fifield, Todd M. Rowe, Joanna B. Raman-Nair, Michiru Hirasawa, Jacqueline L. VanderluitAbstractObesity is associated with worse neurological outcomes following overt ischemic strokes. The majority of strokes however, are covert, small strokes that often evade detection. How obesity impacts the cellular response to covert strokes is unclear. Here, we used a diet-induced obesity model by feeding mice a high fat diet (HFD) and examining its impact on the behavioral and cellular responses to either an Endothelin-1-induced focal ischemi...
Source: Neuroscience - February 5, 2019 Category: Neuroscience Source Type: research

MiRNA-27b regulates angiogenesis by targeting AMPK in mouse ischemic stroke model
Publication date: Available online 2 December 2018Source: NeuroscienceAuthor(s): Yimei Yuan, Zhaoguang Zhang, ZhenGang Wang, Liu JinlanAbstractStroke is a leading cause of mortality and serious disability worldwide with limited treatment options. Angiogenesis has been reported to involved in post-stroke recovery. Although the molecular mechanisms that regulate angiogenesis remain ambiguous, microRNAs have emerged as effective regulators of angiogenesis, involved in neurological function outcome. The present study aims to investigate the regulatory effects of miRNA-27b on post-stroke angiogenesis. In primary cultured brain ...
Source: Neuroscience - December 2, 2018 Category: Neuroscience Source Type: research

Stroke longitudinal volumetric measures correlate with the behavioral score in non-human primates
Publication date: Available online 24 November 2018Source: NeuroscienceAuthor(s): Gabriel Ramirez-Garcia, Kathleen A. Harrison, Juan Fernandez-Ruiz, Joseph Y. Nashed, Douglas J. CookAbstractStroke is the second leading cause of death worldwide. Brain imaging data from experimental rodent stroke models suggest that size and location of the ischemic lesion relate to behavioral outcome. However, such a relationship between these two variables has not been established in Non-Human Primate (NHP) models. Thus, we aimed to evaluate whether size, location, and severity of stroke following controlled Middle Cerebral Artery Occlusio...
Source: Neuroscience - November 25, 2018 Category: Neuroscience Source Type: research

SNHG12 promotes angiogenesis following ischemic stroke via regulating miR-150/VEGF pathway
In conclusion, SNHG12 promotes the angiogenesis following ischemic stroke via miR-150/VEGF pathway, which further clarified the mechanism of angiogenesis after ischemic stroke and provides a target for the treatment of this disease.
Source: Neuroscience - September 5, 2018 Category: Neuroscience Source Type: research

Apoptosis signal-regulating kinase 1 silencing on astroglial inflammasomes in an experimental model of ischemic stroke
The objective of the present study was to evaluate the role of ASK1 in controlling NLRP2 inflammasomes in astrocytes after cerebral ischemia. In a mouse model of ischemic stroke, the levels of NLRP2 inflammasome components, and interleukin (IL)-1β and IL-18, were quantified in different brain regions. In addition, an astrocyte cell line was subjected to oxygen-glucose deprivation and reperfusion (OGD/R) injury, and the levels of NLRP2 inflammasome factors, IL-1β and IL-18 were evaluated. Ischemic brain injury activated astrocytes. The levels of NLRP2 inflammasome components, IL-1β and IL-18 productions, and cell death i...
Source: Neuroscience - September 1, 2018 Category: Neuroscience Source Type: research

Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke
In conclusion, DTIO has protective effects on acute ischemic stroke and promotes functional recovery during chronic phase, associating with protecting ischemic neurons and astrocytes, inhibiting inflammation, and lessening the glial scar formation via inhibiting of the RIP1K.Graphical abstract
Source: Neuroscience - August 7, 2018 Category: Neuroscience Source Type: research

Emergent uric acid treatment is synergistic with mechanical recanalization in improving stroke outcomes in male and female rats
In conclusion, UA treatment immediately after transient ischemia results in a sex-independent, maintained reduction of brain damage and neurological impairment, better manifested in hyperperfusion conditions. This synergistic effect of UA with mechanical recanalization supports additional clinical testing of UA as an adjunctive treatment to mechanical thrombectomy.Graphical abstract
Source: Neuroscience - August 2, 2018 Category: Neuroscience Source Type: research

Neuroprotective effects of DTIO, a novel analogue of Nec-1, in acute and chronic stages after ischemic stroke
In conclusion, DTIO has protective effects on acute ischemic stroke and promotes functional recovery during chronic phase, associating with protecting ischemic neurons and astrocytes, inhibiting inflammation, and lessening the glial scar formation via inhibiting of the RIP1K.Graphical abstract
Source: Neuroscience - August 2, 2018 Category: Neuroscience Source Type: research

Age-dependent Disturbances of Neuronal and Glial Protein Expression Profiles in Areas of Secondary Neurodegeneration Post-stroke
Publication date: Available online 29 July 2018Source: NeuroscienceAuthor(s): Murielle G. Kluge, Kimberley Jones, Lin Kooi Ong, Emma K. Gowing, Michael Nilsson, Andrew N. Clarkson, Frederick R. WalkerAbstractDespite the fact that approximately 80% of strokes occur in those aged over 60 years, many pre-clinical stroke studies have been conducted in younger adult rodents, raising debate about translation and generalizability of these results. We were interested in potential age differences in stroke-induced secondary neurodegeneration (SND). SND involves the death of neurons in areas remote from, but connected to, the site...
Source: Neuroscience - August 2, 2018 Category: Neuroscience Source Type: research

Age dependent disturbances of neuronal and glial protein expression profiles in areas of secondary neurodegeneration post-stroke
Publication date: Available online 29 July 2018Source: NeuroscienceAuthor(s): Murielle G. Kluge, Kimberley Jones, Lin Kooi Ong, Emma K. Gowing, Michael Nilsson, Andrew N. Clarkson, Frederick R. WalkerAbstractDespite the fact that approximately 80% of strokes occur in those aged over 60 years, many pre-clinical stroke studies have been conducted in younger adult rodents, raising debate about translation and generalisability of these results. We were interested in potential age differences in stroke-induced secondary neurodegeneration (SND). SND involves the death of neurons in areas remote from, but connected to, the site o...
Source: Neuroscience - July 29, 2018 Category: Neuroscience Source Type: research

Effect of mirror therapy on recovery of stroke survivors: A systematic review and network meta-analysis
Publication date: Available online 5 July 2018Source: NeuroscienceAuthor(s): Yue Yang, Qingchun Zhao, Yingshi Zhang, Qiong Wu, Xiaowen Jiang, Gang ChengAbstractMirror therapy (MT) as a relatively new rehabilitation technique has been widely applied in stroke patients. A number of randomized controlled trials (RCTs) have investigated the effects of MT for stroke survivors. The main purpose of this network meta-analysis was to investigate the effects of MT on motor function, activities of daily living (ADL), and pain perception in stroke survivors. Several databases were searched to identify RCTs evaluating the effects of MT...
Source: Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research

AMPA receptor antagonist perampanel ameliorates post-stroke functional and cognitive impairments
Publication date: Available online 5 July 2018Source: NeuroscienceAuthor(s): Masataka Nakajima, Satoshi Suda, Kota Sowa, Yuki Sakamoto, Chikako Nito, Yasuhiro Nishiyama, Junya Aoki, Masayuki Ueda, Shoji Yokobori, Marina Yamada, Hiroyuki Yokota, Takashi Okada, Kazumi KimuraAbstractPerampanel (PER), a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor antagonist, clinically used for seizure control, has been reported to exert neuroprotective effects in experimental models of neurodegenerative diseases. However, few studies have investigated the therapeutic effects of PER in brain injury including stro...
Source: Neuroscience - July 10, 2018 Category: Neuroscience Source Type: research

Effect of mirror therapy on recovery of stroke survivors: A systematic review and network meta-analysis
Publication date: Available online 5 July 2018Source: NeuroscienceAuthor(s): Yue Yang, Qingchun Zhao, Yingshi Zhang, Qiong Wu, Xiaowen Jiang, Gang ChengAbstractMirror therapy (MT) as a relatively new rehabilitation technique has been widely applied in stroke patients. A number of randomized controlled trials (RCTs) have investigated the effects of MT for stroke survivors. The main purpose of this network meta-analysis was to investigate the effects of MT on motor function, activities of daily living (ADL), and pain perception in stroke survivors. Several databases were searched to identify RCTs evaluating the effects of MT...
Source: Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

AMPA receptor antagonist perampanel ameliorates post-stroke functional and cognitive impairments
Publication date: Available online 5 July 2018Source: NeuroscienceAuthor(s): Masataka Nakajima, Satoshi Suda, Kota Sowa, Yuki Sakamoto, Chikako Nito, Yasuhiro Nishiyama, Junya Aoki, Masayuki Ueda, Shoji Yokobori, Marina Yamada, Hiroyuki Yokota, Takashi Okada, Kazumi KimuraAbstractPerampanel (PER), a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor antagonist, clinically used for seizure control, has been reported to exert neuroprotective effects in experimental models of neurodegenerative diseases. However, few studies have investigated the therapeutic effects of PER in brain injury including stro...
Source: Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

Constitutive PGC-1 α Overexpression in Skeletal Muscle Does Not Improve Morphological Outcome in Mouse Models of Brain Irradiation or Cortical Stroke
Publication date: 1 August 2018 Source:Neuroscience, Volume 384 Author(s): Lars Karlsson, María Nazareth González-Alvarado, Mar Larrosa-Flor, Ahmed Osman, Mats Börjesson, Klas Blomgren, Hans Georg Kuhn Physical exercise can improve morphological outcomes after ischemic stroke and ameliorate irradiation-induced reduction of hippocampal neurogenesis in rodents, but the mechanisms underlying these effects remain largely unknown. The transcription factor peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is considered to be one of the central factors responsible for exercise-induced benefits in ...
Source: Neuroscience - June 14, 2018 Category: Neuroscience Source Type: research

Genome-wide Integration Study of Circulating miRNAs and Peripheral Whole-Blood mRNAs of Male Acute Ischemic Stroke Patients
This study provides an integrated view of interactions among circulating miRNAs and peripheral whole-blood mRNAs involved in the pathophysiological processes of male AIS.
Source: Neuroscience - April 18, 2018 Category: Neuroscience Source Type: research

Autophagy- and MMP-2/9-mediated Reduction and Redistribution of ZO-1 Contribute to Hyperglycemia-increased Blood –Brain Barrier Permeability During Early Reperfusion in Stroke
Publication date: 1 May 2018 Source:Neuroscience, Volume 377 Author(s): Shuai Zhang, Qier An, Tianfu Wang, Shuping Gao, Guangqian Zhou Post-stroke hyperglycemia during early reperfusion increases blood–brain barrier (BBB) permeability and subsequently aggravates brain injury and clinical prognosis. The decreased level of tight junction proteins (TJPs) has been reported but the underlying mechanism remains largely elusive. Herein we designed to investigate the detailed molecular events in brain microvascular endothelial cells (BMECs) ex and in vivo. After oxygen–glucose deprivation (OGD) for 90 min and reperfusion wi...
Source: Neuroscience - March 21, 2018 Category: Neuroscience Source Type: research

Matrix Metalloproteinase-9 Mediates the Deleterious Effects of α2-Antiplasmin on Blood–Brain Barrier Breakdown and Ischemic Brain Injury in Experimental Stroke
We examined the hypothesis that MMP-9 is an essential downstream mediator of α2-antiplasmin’s deleterious effects during brain ischemia. Middle cerebral artery thromboembolic stroke was induced in a randomized, blinded fashion in mice with increased blood levels of α2-antiplasmin. There was a robust increase in MMP-9 expression (immunofluorescence) in the ischemic vs. the non-ischemic hemisphere of MMP-9+/+ but not MMP-9−/− mice, 24 h after stroke. Brain swelling and hemorrhage were significantly increased in the ischemic vs. the non-ischemic hemisphere of MMP-9+/+ mice. By comparison to MMP-9+/+ mice, the ischem...
Source: Neuroscience - March 3, 2018 Category: Neuroscience Source Type: research

RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway
This study evaluates the contribution of RIP1K to ischemic stroke-induced neuronal and astrocytic cell death, and the activation of autophagic-lysosomal pathway. Using an in vitro oxygen and glucose deprivation (OGD) in primary cultured neurons or astrocytes and a permanent middle cerebral artery occlusion (pMCAO) model in rats or mice, we observed the role of RIP1K in the ischemic neuronal and astrocytic cell death and the underlying mechanisms by pharmacological or genetic inhibition of RIP1K. pMCAO or OGD condition led to an increase in RIP1K, RIP3K and RIP1K–RIP3K complex. RIP1K knockdown or necrostatin-1 (Nec-1, a s...
Source: Neuroscience - December 17, 2017 Category: Neuroscience Source Type: research

Disrupted structural and functional connectivity networks in ischemic stroke patients
Publication date: 19 November 2017 Source:Neuroscience, Volume 364 Author(s): Jingna Zhang, Ye Zhang, Li Wang, Linqiong Sang, Jun Yang, Rubing Yan, Pengyue Li, Jian Wang, Mingguo Qiu Local lesions caused by stroke may result in extensive structural and functional reorganization in the brain. Previous studies of this phenomenon have focused on specific brain networks. Here, we aimed to discover abnormalities in whole-brain networks and to explore the decoupling between structural and functional connectivity in patients with stroke. Fifteen ischemic stroke patients and 23 normal controls (NCs) were recruited in this study. ...
Source: Neuroscience - October 11, 2017 Category: Neuroscience Source Type: research

Administration of sonic hedgehog protein induces angiogenesis and has therapeutic effects after stroke in rats
Publication date: 3 June 2017 Source:Neuroscience, Volume 352 Author(s): Sheng-cai Chen, Ming Huang, Quan-wei He, Yan Zhang, Elvis Nana Opoku, Hang Yang, Hui-juan Jin, Yuan-peng Xia, Bo Hu The Sonic hedgehog (Shh) signaling pathway is recapitulated in response to ischemic injury. Here, we investigated the clinical implications of Shh protein in the ischemic stroke and explored the underlying mechanism. Intracerebroventricular injection of Shh, Cyclopamine, or anti-vascular endothelial growth factor (VEGF) was performed immediately after permanent middle cerebral artery occlusion (pMCAO) surgery and lasted for 7days (d). P...
Source: Neuroscience - April 26, 2017 Category: Neuroscience Source Type: research

Oral administration of corticosterone at stress-like levels drives microglial but not vascular disturbances post-stroke
Publication date: 3 June 2017 Source:Neuroscience, Volume 352 Author(s): Katarzyna Zalewska, Lin Kooi Ong, Sarah J. Johnson, Michael Nilsson, Frederick R. Walker Exposure to chronic stress following stroke has been shown, both clinically and pre-clinically, to impact negatively on the recovery process. While this phenomenon is well established, the specific mechanisms involved have remained largely unexplored. One obvious signaling pathway through which chronic stress may impact on the recovery process is via corticosterone, and its effects on microglial activity and vascular remodeling. In the current study, we were inte...
Source: Neuroscience - April 18, 2017 Category: Neuroscience Source Type: research

Post-stroke treatment with 17 β-estradiol exerts neuroprotective effects in both normotensive and hypertensive rats
Publication date: 21 April 2017 Source:Neuroscience, Volume 348 Author(s): Wendy Stoop, Deborah De Geyter, Sofie Verachtert, Sofie Brouwers, Peggy Verdood, Jacques De Keyser, Ron Kooijman Although ischemic stroke is a major cause of death worldwide and the predominant cause of acquired disability, the only effective drug therapy that has been developed thus far is reperfusion by tissue plasminogen activator. Since most patients do not qualify for this treatment, new methods have to be developed. It is well known that estradiol (E2) exerts neuroprotective effects in different models of cerebral ischemia, but post-stroke tr...
Source: Neuroscience - March 16, 2017 Category: Neuroscience Source Type: research

Transcriptomic analysis reveals differential activation of microglial genes after ischemic stroke in mice
Publication date: 21 April 2017 Source:Neuroscience, Volume 348 Author(s): Akbar Khan, Furong Ju, Wenguang Xie, Muhammad Tariq Hafeez, Xiaofeng Cheng, Zhijie Yang, Lirui Zhu, Ting Li, Shengxiang Zhang Microglia are immune cells in the brain and play a pivotal role in the progression of ischemic injury, but the gene expression and signaling pathways related to the activation of microglia following ischemia remain unclear. In our experiment, we used digital gene expression (DGE) analysis to profile the transcriptome of ischemic tissue in a photothrombosis model. DGE analysis identified that a total of 749 genes were differe...
Source: Neuroscience - March 8, 2017 Category: Neuroscience Source Type: research

Group comparison of cortical fiber connectivity map: An application between post-stroke patients and healthy subjects
This study demonstrated the feasibility of vertex-wise group comparison for evaluating cortical fiber connectivity density. The FiCD method has good intra- and inter-individual reproducibility, and accurately reflects the affected cortical regions in post-stroke patients. This method may be helpful for neuroscience research.
Source: Neuroscience - January 12, 2017 Category: Neuroscience Source Type: research

Direct comparison of microglial dynamics and inflammatory profile in photothrombotic and arterial occlusion evoked stroke
In this study, we have evaluated the impact of these two types of stroke in the cell survival and evolution of stroke, focusing on microglial cells, the first responders to cell injury. Two groups of heterozygote Cx3CR1-GFP reporter mice (to follow microglia) were subject to stroke injury either with coagulator-mediated occlusion or photothrombotic MCA damage. Microglial cells’ dynamics of activation and phagocytosis together with astrocytic response and leukocyte infiltration were characterized at 1, 3 and 7days after damage. Photothrombotic stroke delayed microglial and astrocytic invasion of the ischemic core and accu...
Source: Neuroscience - January 12, 2017 Category: Neuroscience Source Type: research

TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats
Conclusions: TFP5 is comparable to MH in improving neurological outcomes in early-stage adult ischemic stroke. When TFP5 is given along with MH, less neurological deficit tends to be achieved.
Source: Neuroscience - January 2, 2017 Category: Neuroscience Source Type: research

Increased functional connectivity one week after motor learning and tDCS in stroke patients
Publication date: 6 January 2017 Source:Neuroscience, Volume 340 Author(s): Stéphanie Lefebvre, Laurence Dricot, Patrice Laloux, Philippe Desfontaines, Frédéric Evrard, André Peeters, Jacques Jamart, Yves Vandermeeren Recent studies using resting-state functional magnetic resonance imaging (rs-fMRI) demonstrated that changes in functional connectivity (FC) after stroke correlate with recovery. The aim of this study was to explore whether combining motor learning to dual transcranial direct current stimulation (dual-tDCS, applied over both primary motor cortices (M1)) modulated FC in stroke patients. Twenty-two chronic...
Source: Neuroscience - November 26, 2016 Category: Neuroscience Source Type: research

Neural network remodeling underlying motor map reorganization induced by rehabilitative training after ischemic stroke
Publication date: 17 December 2016 Source:Neuroscience, Volume 339 Author(s): Naohiko Okabe, Takashi Shiromoto, Naoyuki Himi, Feng Lu, Emi Maruyama-Nakamura, Kazuhiko Narita, Nobuhisa Iwachidou, Yoshiki Yagita, Osamu Miyamoto Motor map reorganization is believed to be one mechanism underlying rehabilitation-induced functional recovery. Although the ipsilesional secondary motor area has been known to reorganize motor maps and contribute to rehabilitation-induced functional recovery, it is unknown how the secondary motor area is reorganized by rehabilitative training. In the present study, using skilled forelimb reaching ta...
Source: Neuroscience - October 28, 2016 Category: Neuroscience Source Type: research

Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke
Publication date: 19 November 2016 Source:Neuroscience, Volume 337 Author(s): Honglin Yan, Jingping Yuan, Likun Gao, Jie Rao, Jichang Hu Maternally expressed gene 3 (MEG3) is suggested to function as a long non-coding RNA (lncRNA) and to play roles in various human cancers. However, the functional properties of MEG3 in ischemic stroke remain unknown. Here, we report that expression of MEG3 is upregulated following ischemia in adult mice. Moreover, cerebral ischemia recruits p53 into the MEG3 complex in ischemic tissues. MEG3 directly binds with the p53 DNA binding domain (DBD) consisting of amino acids 271–282 (p53-DBD2...
Source: Neuroscience - October 2, 2016 Category: Neuroscience Source Type: research

Abolished perineuronal nets and altered parvalbumin-immunoreactivity in the nucleus reticularis thalami of wildtype and 3xTg mice after experimental stroke
In conclusion, these data confirm PNs as highly sensitive constituents of the ECM along with impaired neuronal integrity of GABAergic neurons. Therefore, specific targeting of ECM components might appear as a promising strategy for future treatment strategies in stroke.
Source: Neuroscience - September 24, 2016 Category: Neuroscience Source Type: research

Methylene Blue promotes cortical neurogenesis and ameliorates behavioral deficit after photothrombotic stroke in rats
We report that MB significantly enhanced cell proliferation and neurogenesis, as evidenced by the increased co-localizations of BrdU/NeuN, BrdU/DCX, BrdU/MAP2 and BrdU/Ki67 in the peri-infarct zone compared with vehicle controls. MB thus effectively limited infarct volume and improved neurological deficits compared to PT control animals. The effects of MB were accompanied with an attenuated level of reactive gliosis and release of pro-inflammatory cytokines, as well as elevated levels of cytochrome c oxidase activity and ATP production in peri-infarct regions. Our study provides important information that MB has the abilit...
Source: Neuroscience - September 12, 2016 Category: Neuroscience Source Type: research

Does aging with a cortical lesion increase fall-risk: Examining effect of age versus stroke on intensity modulation of reactive balance responses from slip-like perturbations
We examined whether aging with and without a cerebral lesion such as stroke affects modulation of reactive balance response for recovery from increasing intensity of sudden slip-like stance perturbations. Ten young adults, older age-match adults and older chronic stroke survivors were exposed to three different levels of slip-like perturbations, level 1 (7.75m/s2), Level II (12.00m/s2) and level III (16.75m/s2) in stance. The center of mass (COM) state stability was computed as the shortest distance of the instantaneous COM position and velocity relative to base of support (BOS) from a theoretical threshold for backward lo...
Source: Neuroscience - August 4, 2016 Category: Neuroscience Source Type: research

Decline of microtubule-associated protein tau after experimental stroke in differently aged wild-type and 3xTg mice with Alzheimer-like alterations
In conclusion, microtubule-associated protein tau was robustly identified as a highly sensitive cytoskeletal constitute under ischemic conditions, suggesting a pivotal role during the transition process toward long-lasting tissue damage. Consequently, cytoskeletal elements appear as promising targets for novel therapeutic approaches with the objective to impede ischemia-induced irreversible cellular degradation.
Source: Neuroscience - June 4, 2016 Category: Neuroscience Source Type: research

Therapeutic benefits of combined treatment with tissue plasminogen activator and 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-d-pyranoside in an animal model of ischemic stroke
In this study, a rat model of embolic middle cerebral artery occlusion (MCAO) was used to mimic ischemic stroke. The embolic MCAO rats were intravenously (iv) injected with tPA alone, SalA-4g alone, or a combination of tPA and SalA-4g. Compared to treatment with tPA alone at 4h post MCAO, combined treatment with tPA at 4h post MCAO and SalA-4g starting at 4h post MCAO and continuing for 3days at an interval of 24h significantly reduced neurological deficits and infarct volume, and significantly inhibited the intracerebral bleeding, edema formation, neuronal loss, and cellular apoptosis in the ischemic brain. Our results su...
Source: Neuroscience - April 26, 2016 Category: Neuroscience Source Type: research

Peri-infarct depolarizations during focal ischemia in the awake Spontaneously Hypertensive Rat. Minimizing anesthesia confounds in experimental stroke
Publication date: 14 June 2016 Source:Neuroscience, Volume 325 Author(s): K. Kudo, L. Zhao, T.S. Nowak Anesthesia profoundly impacts peri-infarct depolarizations (PIDs), but only one prior report has described their monitoring during experimental stroke in awake animals. Since temporal patterns of PID occurrence are model specific, the current study examined PID incidence during focal ischemia in the awake Spontaneously Hypertensive Rat (SHR), and documented the impact of both prior and concurrent isoflurane anesthesia. For awake recordings, electrodes were implanted under isoflurane anesthesia 1day to 5weeks prior to...
Source: Neuroscience - April 11, 2016 Category: Neuroscience Source Type: research

Bone marrow stromal cells inhibits HMGB1-mediated inflammation after stroke in type 2 diabetic rats
Publication date: 2 June 2016 Source:Neuroscience, Volume 324 Author(s): J. Hu, B. Liu, Q. Zhao, P. Jin, F. Hua, Z. Zhang, Y. Liu, K. Zan, G. Cui, X. Ye High-mobility group box 1 (HMGB1), a ligand of receptor for advanced glycation endproducts (RAGE), functions as a proinflammatory factor. It is mainly involved in inflammatory activation and contributes to the initiation and progression of stroke. By using a model of transient middle cerebral artery occlusion (MCAo) in type 2 diabetic rats, we investigated the changes of pro-inflammation mediators, blood–brain barrier (BBB) leakage and functional outcome afte...
Source: Neuroscience - March 13, 2016 Category: Neuroscience Source Type: research

Effects of unilateral stroke on multi-finger synergies and their feed-forward adjustments
Publication date: 5 April 2016 Source:Neuroscience, Volume 319 Author(s): H.J. Jo, C. Maenza, D.C. Good, X. Huang, J. Park, R.L. Sainburg, M.L. Latash We explored the changes in multi-finger synergies in patients after a single cortical stroke with mild motor impairments. We hypothesized that both synergy indices and anticipatory synergy adjustments prior to the initiation of a self-paced quick action would be diminished in the patients compared to age-matched controls. The patients with history of cortical stroke, and age-matched controls (n =12 in each group) performed one-finger and multi-finger accurate force ...
Source: Neuroscience - February 10, 2016 Category: Neuroscience Source Type: research

Impaired implicit learning and feedback processing after stroke
Publication date: 9 February 2016 Source:Neuroscience, Volume 314 Author(s): J.M. Lam, C. Globas, J.A. Hosp, H.-O. Karnath, T. Wächter, A.R. Luft The ability to learn is assumed to support successful recovery and rehabilitation therapy after stroke. Hence, learning impairments may reduce the recovery potential. Here, the hypothesis is tested that stroke survivors have deficits in feedback-driven implicit learning. Stroke survivors (n =30) and healthy age-matched control subjects (n =21) learned a probabilistic classification task with brain activation measured using functional magnetic resonance imaging in a subse...
Source: Neuroscience - December 18, 2015 Category: Neuroscience Source Type: research

Rehabilitation and plasticity following stroke: Insights from rodent models
Publication date: 17 December 2015 Source:Neuroscience, Volume 311 Author(s): M. Caleo Ischemic injuries within the motor cortex result in functional deficits that may profoundly impact activities of daily living in patients. Current rehabilitation protocols achieve only limited recovery of motor abilities. The brain reorganizes spontaneously after injury, and it is believed that appropriately boosting these neuroplastic processes may restore function via recruitment of spared areas and pathways. Here I review studies on circuit reorganization, neuronal and glial plasticity and axonal sprouting following ischemic damage...
Source: Neuroscience - November 12, 2015 Category: Neuroscience Source Type: research

Inhibition of interleukin-6 abolishes the promoting effects of pair housing on post-stroke neurogenesis
In conclusion, our results suggest that IL-6 is an important mediator of social interaction on neurogenesis and long-term functional recovery after ischemic stroke. Graphical abstract
Source: Neuroscience - September 11, 2015 Category: Neuroscience Source Type: research

MiR-207/352 regulate lysosomal-associated membrane proteins and enzymes following ischemic stroke
Publication date: 1 October 2015 Source:Neuroscience, Volume 305 Author(s): J. Tao, W. Liu, G. Shang, Y. Zheng, J. Huang, R. Lin, L. Chen The role of microRNAs (miRNAs) in lysosome-mediated neuronal death and survival following ischemic stroke remains unknown. Herein, using miRNA and mRNA gene expression profiling microarrays, we identified the differentially expressed 24 miRNAs and 494 genes in the cortical peri-infarct area, respectively. Integrating the miRNA targets and mRNA expression profiles, we found 47 genes of miRNA targets, including lysosomal-associated membrane protein 2 (LAMP2), Hexb, Bcl2, etc. MiR-...
Source: Neuroscience - August 8, 2015 Category: Neuroscience Source Type: research

Reduced severity of ischemic stroke and improvement of mitochondrial function after dietary treatment with the anaplerotic substance triheptanoin
Publication date: 6 August 2015 Source:Neuroscience, Volume 300 Author(s): T.M. Schwarzkopf , K. Koch , J. Klein Triheptanoin, an oily substance, consists of glycerol bound to three molecules of heptanoic acid, a C7 odd-chain fatty acid. A triheptanoin-rich diet has anaplerotic effects because heptanoate metabolism yields succinate which delivers substrates to the Krebs cycle. While previous studies on the effects of triheptanoin focused on metabolic disorders and epilepsy, we investigated triheptanoin’s effect on ischemic stroke. Mice were fed a triheptanoin-enriched diet for 14days; controls received soybean oil. Onl...
Source: Neuroscience - June 3, 2015 Category: Neuroscience Source Type: research

Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model
In this study, in contrast to the global inhibition of p53 function by pharmacological inhibitors and in traditional p53 ko mice, we utilized a neuronal specific conditional ko mouse line (CamcreTRP53 loxP/loxP) to achieve forebrain neuronal specific deletion of p53 and examined the role of the p53 gene in ischemia-induced cell death in neurons. Expression of p53 after stroke is examined using the immunohistochemical method and the outcome of stroke is examined by analysis of infarction size and behavioral deficits caused by stroke. Our data showed that p53 expression is upregulated in the ischemic region in neuronal cells...
Source: Neuroscience - April 6, 2015 Category: Neuroscience Source Type: research

In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke
Conclusions: We conclude that the combined approach of USPIO-MRI and [11C]PK11195-PET allows to observe post-stroke inflammatory processes in the living animal in an intraindividual and longitudinal fashion, predicting long-term tissue fate. The non-invasive imaging methods do not affect the immune system and have been applied to human subjects before. Translation into clinical applications is therefore feasible. Graphical abstract
Source: Neuroscience - March 11, 2015 Category: Neuroscience Source Type: research