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Source: Journal of Clinical Neuroscience

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Total 251 results found since Jan 2013.

The role of ASPECTs in patient selection for endovascular therapy – CTA source images versus noncontrast CT
In conclusion, CTA-SI ASPECTs in patient selection for ET seems to be more useful than NCCT ASPECTs. However, both scoring modalities were not found to be independent predictors of good outcome. Outcomes are changeable for the younger population who could continue their lives with mild or no deficits despite having a relatively low initial ASPECTs.
Source: Journal of Clinical Neuroscience - November 5, 2019 Category: Neuroscience Source Type: research

Ischemic stroke caused by giant cell arteritis associated with pulmonary adenocarcinoma
We describe a 77-year-old man with a sudden onset of dizziness, vomiting, and gait disturbances. Following imaging studies, a diagnosis of bulbar ischemic stroke with left vertebral artery stenosis was made. Based on a history of polymyalgia rheumatica, on laboratory tests, and brain digital subtraction angiography, a diagnosis of GCA was advanced and the patient underwent high-dose steroidal therapy. After a total body 18-FGD PET imaging, a pulmonary adenocarcinoma was found.Vertebral artery involvement is a rare but important occurrence in GCA as it carries a high mortality rate, and may require a vigorous therapeutic ap...
Source: Journal of Clinical Neuroscience - November 5, 2019 Category: Neuroscience Source Type: research

Clinical outcomes of moderate to severe acute ischemic stroke in a telemedicine network
The objective of this study was to analyze clinical and imaging based outcomes of moderate to severe stroke following treatment with thrombolysis, thrombectomy or a combination of both in a telemedicine network. Data of this retrospective study was abstracted from the institutional telestroke database. Patients with a National Institute of Health Stroke Scale score (NIH-SS ≥ 10) were included into the study. Primary outcome measure was the difference in NIH-SS at admission compared to discharge from the hospital. Secondary outcome measure was the discharge disposition defined as favorable (discharge to home or rehabi...
Source: Journal of Clinical Neuroscience - November 2, 2019 Category: Neuroscience Source Type: research

Early cardiovascular function and associated hemodynamics in adults with isolated moderate-severe traumatic brain injury: A pilot study
ConclusionSystemic hemodynamic parameters were consistent with an early catecholamine-excess state. While reduced systolic function was associated with lower SVI, there was no relationship with reduced cerebral perfusion, possibly due to normal MAP.
Source: Journal of Clinical Neuroscience - November 2, 2019 Category: Neuroscience Source Type: research

Successful intravenous thrombolysis for ischemic stroke as a complication of coronary intervention in patients with ticagrelor pretreatment
We present two patients established on ticagrelor treated with intravenous thrombolysis for acute ischemic stroke complicating coronary intervention.
Source: Journal of Clinical Neuroscience - October 28, 2019 Category: Neuroscience Source Type: research

Epidemiologic features and risk factors of sepsis in ischemic stroke patients admitted to intensive care: A prospective cohort study
ConclusionsThis study showed that ICU patients with severe ischemic stroke were more susceptible to sepsis during the hospital course.
Source: Journal of Clinical Neuroscience - September 20, 2019 Category: Neuroscience Source Type: research

The diagnostic utility of routine clot analysis after endovascular thrombectomy in a patient with systemic lupus erythematosus and antiphospholipid syndrome
We present a case demonstrating histopathological clot findings after endovascular thrombectomy for acute ischaemic stroke in a 38 year-old male with systemic lupus erythematosus and antiphospholipid syndrome (APS). The differential diagnosis was embolism of a suspected Libman-Sacks vegetation or less likely an in-situ thrombosis. Clot analysis provided guidance with patient management and anticoagulation was commenced. The utility of clot analysis in this case provides support for routine clot analysis, which has been standard practice at our institution, and is likely to evolve as endovascular thrombectomy becomes more widely accessible.
Source: Journal of Clinical Neuroscience - September 18, 2019 Category: Neuroscience Source Type: research

The effect of HMG-CoA reductase inhibitors on thrombolysis-induced haemorrhagic transformation
Publication date: Available online 11 September 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yousheng Wu, Dan Lu, Anding XuAbstractThrombolysis-induced haemorrhagic transformation is the most challenging preventable complication in thrombolytic therapy. This condition is often associated with poor functional outcome and long-term disease burden. Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are controversially suggested to either increase or decrease the odds of better primary outcomes compared to treatment without statins after thrombolysis in patients or animals; statins are ...
Source: Journal of Clinical Neuroscience - September 12, 2019 Category: Neuroscience Source Type: research

Can initial sarcopenia affect poststroke rehabilitation outcome?
This study investigated the association between the presence of sarcopenia, measured by nonhemiplegic grip strength, and the level of functional recovery, measured by the modified Rankin Scale (mRS) at six months after stroke. We performed a retrospective cohort analysis of a prospectively maintained database of 194 hemiplegic poststroke patients, who had been admitted to the Department of Rehabilitation Medicine of a university-affiliated hospital. At 6 months after stroke, 72.2% of patients had mRS score>3, with more women (81.0% vs. 66.0%, p = 0.024) showing poor recovery. Both men (51.3% vs. 35.9%, p = 0.041)...
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Efficacy of RehaCom cognitive rehabilitation software in activities of daily living, attention and response control in chronic stroke patients
ConclusionsIn conclusion, RehaCom cognitive rehabilitation software has improvement effect on ADL, attention and response control in patients with chronic stroke. Our study reveals a new information about the efficacy of computerized training in the rehabilitation of stroke patients.
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

“Sequential multimodality stimulation” for post-stroke-hemineglect: Feasibility and outcome in a pilot randomized controlled trial
ConclusionMultimodality stimulation, in addition to standard physiotherapy, is feasible and potentially results in better neurocognitive and functional recovery following right hemispheric ischemic strokes. However, larger studies are warranted to prove these preliminary observations beyond doubt.
Source: Journal of Clinical Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

Postoperative 30-day outcomes after craniotomy for supratentorial AVM resection in children
ConclusionIn the NSQIP-P dataset, the incidence of perioperative complications and suboptimal outcomes among patients undergoing AVM resection were low.
Source: Journal of Clinical Neuroscience - September 4, 2019 Category: Neuroscience Source Type: research

Experience with FRED junior flow diverter in treatment of cerebral aneurysms at or distal to the circle of Willis
Publication date: Available online 23 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Rajeev Sivasankar, Manish Shrivastava, Uday S. LimayeAbstractThis retrospective study was aimed at assessing our results of endovascular management using the FRED junior flow diverter in cerebral aneurysms at or distal to the circle of Willis. 12 patients with 15 small cerebral vessel aneurysms at or distal to the circle of Willis underwent endovascular treatment using the FRED junior flow diverter at two tertiary care centres in Mumbai, India. 12 of the 15 aneurysms were unruptured, one was treated in an acutely ruptured se...
Source: Journal of Clinical Neuroscience - August 24, 2019 Category: Neuroscience Source Type: research

Association between homocysteine and multivascular atherosclerosis in stroke-related vascular beds determined by three-dimensional magnetic resonance vessel wall imaging
ConclusionsHomocysteine is independently associated with stroke-related multivascular plaques and combination of age and homocysteine has stronger predictive value.
Source: Journal of Clinical Neuroscience - August 24, 2019 Category: Neuroscience Source Type: research

Cone beam-computed tomography angiography by intravenous contrast injection is reliable to evaluate patients with large vessel occlusion
ConclusionsAlthough prospective study of AIS patients at a radiography department is indispensable, CB-CTA performed in an angiography-suite might be useful to evaluate patients with ELVO.
Source: Journal of Clinical Neuroscience - August 22, 2019 Category: Neuroscience Source Type: research

Air retrieval for clot retrieval; time-metrics and outcomes of stroke patients from rural and remote regions air-transported for mechanical thrombectomy at a state stroke unit
ConclusionWith the availability of an efficient aeromedical retrieval service, LVO stroke patients in rural and remote regions can achieve excellent outcomes following transfer to a high volume thrombectomy unit, even if distances involved are very large.
Source: Journal of Clinical Neuroscience - August 21, 2019 Category: Neuroscience Source Type: research

Thrombolysis’ benefits on early post-stroke language recovery in aphasia patients
ConclusionThe percentage of resolved aphasia was significantly higher in the treated patients compared to the non-treated, with the latter showing a higher percentage of global aphasia. Identifying classic aphasia subtypes after thrombolysis is still possible since reperfused areas do not necessary change the classification or lead to completely different aphasic syndromes. Reperfusion treatment, baseline NIHSS, and lacunar stroke were the main predictors of aphasia recovery.
Source: Journal of Clinical Neuroscience - August 21, 2019 Category: Neuroscience Source Type: research

Neuroprotection for ischemic stroke in the endovascular era: A brief report on the future of intra-arterial therapy
Publication date: Available online 17 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Julius Griauzde, Vijay M. Ravindra, Neeraj Chaudhary, Joseph J. Gemmete, Aditya S. PandeyAbstractMechanical thrombectomy is now at the forefront of the treatment of large vessel acute ischemic stroke (AIS). Selective intra-arterial (IA) access has opened a new avenue for neuroprotection in AIS that has the potential to maximize local benefit while minimizing systemic effects. On a cellular level, neuroprotective strategies are aimed at reducing inflammation and free-radical formation, maintaining blood-brain barrier fidelity...
Source: Journal of Clinical Neuroscience - August 18, 2019 Category: Neuroscience Source Type: research

The effect of uric acid on sleep quality after acute ischemic stroke
In conclusion, high UA levels may reduce the risk of poor sleep quality after acute ischemic stroke. Further randomized controlled trials are necessary in examining whether appropriate UA supplement could provide a potential prevention or therapeutic target for sleep disturbance after stroke.
Source: Journal of Clinical Neuroscience - August 14, 2019 Category: Neuroscience Source Type: research

Brain oscillatory activity and CT perfusion in hyper-acute ischemic stroke
ConclusionThe results of this preliminary study show that the combined use of EEG and CTP, as highly available techniques, in acute ischemic stroke may be helpful in clinical practice and provide information about functional and metabolic aspects of brain involvement. The joint use of these methodologies may give a better clinical insight of the functionality of injured area in the hyperacute phase.
Source: Journal of Clinical Neuroscience - August 12, 2019 Category: Neuroscience Source Type: research

Worsening clinical features in a patient with right middle cerebral artery territory stroke
We describe a case with acute ischemic stroke in the right MCA territory. He developed secondary deterioration for which no obvious cause could be found. He underwent FDG-PET for evaluating carotid plaque inflammation as part of a research study, which revealed considerable hypometabolism in the left cerebellar hemisphere-responsible for the neurological deterioration. This phenomenon is often called ‘crossed cerebellar diaschisis. Various imaging findings are presented.
Source: Journal of Clinical Neuroscience - July 28, 2019 Category: Neuroscience Source Type: research

Fetal origin of posterior cerebral artery related to poor collaterals in patients with acute ischemic stroke
Publication date: Available online 20 July 2019Source: Journal of Clinical NeuroscienceAuthor(s): Pornpatr A. Dharmasaroja, Nattaphol Uransilp, Pritsana PiyabhanAbstractThe anatomic variation of Circle of Willis (CW) has been shown to have a great impact on its compensatory capacity during acute ischemic stroke. The purpose of the study was to evaluate the effect of variations in CW on collateral circulation in patients with acute ischemic stroke who had major artery occlusion. Patients with acute ischemic stroke within 4.5 h of stroke onset who had at least moderate severity of stroke (NIHSS ≥ 6), caused by major ...
Source: Journal of Clinical Neuroscience - July 21, 2019 Category: Neuroscience Source Type: research

Brachial-ankle pulse wave velocity for predicting functional outcomes in patients with cryptogenic stroke
Publication date: Available online 18 July 2019Source: Journal of Clinical NeuroscienceAuthor(s): Minho Han, Young Dae Kim, Hyung Jong Park, In Gun Hwang, Junghye Choi, Jimin Ha, Ji Hoe Heo, Hyo Suk NamAbstractEven after extensive standard evaluation, the probable cause of stroke in some patients remains unclear; this condition is defined as cryptogenic stroke (CS). The prognosis of patients with CS is largely undetermined. We investigated whether higher brachial-ankle pulse wave velocities (baPWVs) can predict poor functional outcomes at 3 months after stroke onset in these patients. We investigated patients with CS wit...
Source: Journal of Clinical Neuroscience - July 20, 2019 Category: Neuroscience Source Type: research

Adjunctive statin therapy reduces intracranial hemorrhage and 1-year mortality in patients with atrial fibrillation after acute ischemic stroke: A population-based epidemiological study from Taiwan
ConclusionsStatin therapy reduced the risk of ICH and 1-year mortality in AF patients who experienced acute ischemic stroke.
Source: Journal of Clinical Neuroscience - July 20, 2019 Category: Neuroscience Source Type: research

Perioperative stroke associated in-hospital morbidity and in-hospital mortality in common non-vascular non-neurological surgery
This study identified perioperative stroke as an independent predictor of 30-day in-hospital morbidity and mortality following non-vascular, non-neurological surgery.
Source: Journal of Clinical Neuroscience - July 2, 2019 Category: Neuroscience Source Type: research

Acute isolated aphasia as a challenging symptom in the emergency setting: Predictors of epileptic mimic versus ischemic stroke
ConclusionsOur study underscores the importance of an accurate clinical bed-side assessment as the first step in the diagnostic and therapeutic decision-making process for patients presenting with aphasia. The detection of clinical and anamnestic features associated with an epileptic SM could be useful for the diagnostic process and for time-critical treatments.
Source: Journal of Clinical Neuroscience - June 17, 2019 Category: Neuroscience Source Type: research

Association between gender and stoke recurrence in ischemic stroke patients with high-grade carotid artery stenosis
In conclusion, male gender is associated with increased risk of recurrent ischemic stroke in patients with high-grade ICA stenosis during 5-year follow-up. Further prospective trial to assess whether male gender may benefit from more aggressive vascular risk factors control and treatment strategies for stroke prevention is warranted.
Source: Journal of Clinical Neuroscience - June 17, 2019 Category: Neuroscience Source Type: research

Safety and efficacy of early antiplatelet therapy in acute ischemic stroke patients receiving endovascular treatment: A systematic review and meta-analysis
ConclusionsEarly antiplatelet therapy may be safe in acute ischemic stroke patients, further studies are needed to confirm the efficacy.
Source: Journal of Clinical Neuroscience - May 30, 2019 Category: Neuroscience Source Type: research

Brain abscess complicating ischemic embolic stroke in a patient with cardiac papillary fibroelastoma – Case report and literature review
Publication date: Available online 13 May 2019Source: Journal of Clinical NeuroscienceAuthor(s): Monique Boukobza, Sarah Nahmani, Lydia Deschamps, Jean-Pierre LaissyAbstractA 72-year-old man without obvious risk factors initially presented with acute ischemic stroke and fever, without concomitant infection. Broad spectrum antibiotic therapy was initiated. Transthoracic and Transesophageal echocardiography, and cardiac MRI revealed a 20 mm round mass attached to the anterior mitral valve leaflet, suggesting the diagnosis of a benign cardiac tumor or a vegetation. At the site of infarction an abscess of 11 mm in diameter...
Source: Journal of Clinical Neuroscience - May 15, 2019 Category: Neuroscience Source Type: research

When does spasticity in the upper limb develop after a first stroke? A nationwide observational study on 861 stroke patients
This study investigated the time taken for upper extremity spasticity to develop and its regional difference after first-ever stroke onset in a nationwide multicenter study in South Korea. The retrospective observational study included 861 individuals with post-stroke spasticity in the upper limbs. Spasticity in the upper extremity joints was defined as a modified Ashworth Scale score ≥1. The median time to develop upper limb spasticity after stroke onset was 34 days. 12% of post-stroke spasticity cases developed between 2 months and 3 months and 13% developed after 3 months from onset. At the time of diagnosis o...
Source: Journal of Clinical Neuroscience - May 12, 2019 Category: Neuroscience Source Type: research

A troponin study on patients with ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage: Type II myocardial infarction is significantly associated with stroke severity, discharge disposition and mortality
Publication date: Available online 20 April 2019Source: Journal of Clinical NeuroscienceAuthor(s): Ayham M. Alkhachroum, Benjamin Miller, Tarek Chami, Curtis Tatsuoka, Cathy SilaAbstractTroponin elevations due to Type II myocardial infarction (T2MI) are associated with hemorrhagic and ischemic strokes but there is little data on stroke severity, troponin elevation and outcome. We studied 1655 patients from a tertiary medical center between 1/2013-4/2015 using multivariate regression analysis for demographics, vascular risk factors, admission stroke severity, laboratory tests, echocardiogram results and discharge dispositio...
Source: Journal of Clinical Neuroscience - April 21, 2019 Category: Neuroscience Source Type: research

Fabry’s disease and stroke: Effectiveness of enzyme replacement therapy (ERT) in stroke prevention, a review with meta-analysis
ConclusionOur meta-analysis based on the currently available data showed that ERT for Fabry’s disease has beneficial effect on stroke prevention. Female carriers and atypically affected males could be started on ERT as soon as diagnosis is made. Further studies are warranted to support the role of ERT in stroke prevention.
Source: Journal of Clinical Neuroscience - April 5, 2019 Category: Neuroscience Source Type: research

Prognostic value of elevated high-sensitivity cardiac troponin T levels in patients with acute ischemic stroke treated with endovascular thrombectomy
Publication date: Available online 28 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yue-Zhou Cao, Lin-Bo Zhao, Sheng Liu, Qiang-Hui Liu, Lei Jiang, Chun-Gao Zhou, Zhen-Yu Jia, Wei-Zhong Zhou, Jin-Guo Xia, Wen-Tao Wu, Qing-Quan Zu, Shan-Shan Lu, Xiao-Quan Xu, Hai-Bin ShiAbstractOur objective was to assess the impact of hs-cTnT elevation on functional outcome and mortality in AIS patients with large vessel occlusion (LVO) in the anterior circulation 3 months after ET and explore factors affecting hs-cTnT elevation.A total of 143 consecutive AIS patients with large vessel occlusion (LVO) in the anterior circu...
Source: Journal of Clinical Neuroscience - March 29, 2019 Category: Neuroscience Source Type: research

Recurrent ischemic stroke in atrial fibrillation with non-vitamin K antagonist oral anticoagulation
Publication date: Available online 28 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Ho Geol Woo, Inyoung Chung, Dong Seok Gwak, Baik Kyun Kim, Beom Joon Kim, Hee-Joon Bae, Moon-Ku HanAbstractThe etiology or rate of recurrent ischemic stroke according to dosing methods including drug adherence in patients taking non-vitamin K antagonist oral anticoagulants (NOACs) remain uncertain. We investigated the association between dosing methods including drug adherence achieved with NOACs and the presence of major vessel occlusion (MVO) in patients with ischemic stroke with non-valvular atrial fibrillation (NVAF). Fro...
Source: Journal of Clinical Neuroscience - March 29, 2019 Category: Neuroscience Source Type: research

Ischemic stroke of the “hand knob area”: A case series and literature review
In conclusion, in this series the most prevalent stroke mechanism was SUE, mainly embolic stroke of undetermined source. The outcome was excellent regardless of stroke mechanism.
Source: Journal of Clinical Neuroscience - March 23, 2019 Category: Neuroscience Source Type: research

Beat-to-beat blood pressure variability and heart rate variability in relation to autonomic dysregulation in patients with acute mild-moderate ischemic stroke
Publication date: Available online 12 March 2019Source: Journal of Clinical NeuroscienceAuthor(s): Ge Tian, Li Xiong, Howan Leung, Yannie Soo, Thomas Leung, Lawrence Ka-sing WongAbstractAutonomic dysregulation is common in post-stroke patients. We aimed to correlate beat-to-beat blood pressure variability (BPV) and heart rate variability (HRV) with Ewing’s test classification. We enrolled patients with acute ischemic stroke. Autonomic function was assessed by Ewing battery and dichotomized into minor or significant group. Beat-to-beat blood pressure and heart rate were monitored for calculating the frequency components o...
Source: Journal of Clinical Neuroscience - March 14, 2019 Category: Neuroscience Source Type: research

Platelet-to-neutrophil ratio is a prognostic marker for 90-days outcome in acute ischemic stroke
In this study, a total of 400 AIS patients were included. Demographic, clinical, laboratory data were collected on admission, and PNR was calculated according to platelet and neutrophil counts on admission. The prognosis after 3 months was evaluated by the Barthel index (BI), where BI ≤85 was defined as poor prognosis and BI>85 was defined as good prognosis. Regression analyses were performed, adjusting for confounders. (1) Compared with good prognosis group, PNR level on admission in poor prognosis group was significantly lower, the difference between the two groups was statistically significant (P < 0.05). (2...
Source: Journal of Clinical Neuroscience - February 6, 2019 Category: Neuroscience Source Type: research

Asymptomatic moderate carotid artery stenosis with intraplaque hemorrhage: Progression of degree of stenosis and new ischemic stroke
Publication date: Available online 4 February 2019Source: Journal of Clinical NeuroscienceAuthor(s): Kiyofumi Yamada, Shinichi Yoshimura, Manabu Shirakawa, Kazutaka Uchida, Shigehiro Nakahara, Shuji Nishida, Yasuhiro Iwamoto, Yoshikazu Sato, Masanori KawasakiAbstractCarotid intraplaque hemorrhage (IPH) plays a critical role in the progression of carotid atherosclerotic disease. IPH was associated with high intensity signal (HIS) in the plaque on Maximum intensity projection (MIP) images from routine three dimensional magnetic resonance imaging (3D-TOF MRA). The aim of this study was to evaluate the relationships among HIS,...
Source: Journal of Clinical Neuroscience - February 5, 2019 Category: Neuroscience Source Type: research

The different clinical value of susceptibility vessel sign in acute ischemic stroke patients under different interventional therapy: A systematic review and meta-analysis
Publication date: Available online 1 February 2019Source: Journal of Clinical NeuroscienceAuthor(s): Mingsu Liu, Lin Li, Guangqin LiAbstractAcute ischemic stroke (AIS) subtype, one of the most important factors for selecting therapeutic strategies, is difficult to be accurately diagnosed at admission sometimes. The magnetic susceptibility effect of deoxygenated hemoglobin in red thrombi appeared as hypointense signals in magnetic resonance imaging (MRI) scans. The prognostic value of susceptibility vessel sign (SVS) for stroke subtype, recanalization and outcomes in AIS patients will be comprehensively determined in the pr...
Source: Journal of Clinical Neuroscience - February 1, 2019 Category: Neuroscience Source Type: research

Fluid and energy intake in stroke patients during acute hospitalization in a stroke unit
Publication date: Available online 14 January 2019Source: Journal of Clinical NeuroscienceAuthor(s): Alex Buoite Stella, Marina Gaio, Giovanni Furlanis, Pauline Douglas, Marcello Naccarato, Paolo ManganottiAbstractProper hydration and nutrition have been found to be contributing factors to a better recovery in patients after stroke. A better knowledge of factors influencing fluid and energy intake may contribute to a better care of the acute stroke patient. Aim of this study was to describe hydration status, fluid intake, and energy intake of stroke patients during acute hospitalization in a stroke unit. A retrospective de...
Source: Journal of Clinical Neuroscience - January 15, 2019 Category: Neuroscience Source Type: research

Implementation of multiphase computed tomography angiography in management of patients with acute ischemic stroke in clinical practice
Publication date: Available online 19 December 2018Source: Journal of Clinical NeuroscienceAuthor(s): Nattaphol Uransilp, Pornpatr A. Dharmasaroja, Arvemas Watcharakorn, Sombat MuengtaweepongsaAbstractMultiphase computed tomography angiography (CTA) provides information on the status of major cranial arteries and extent of brain collateralization. The purpose of the study was to determine whether implementation of multiphase CTA in routine clinical practice was feasible, safe and useful. Patients with acute ischemic stroke (NIHSS ≥ 6) were included. Multiphase CTA was performed. Duration of performing multiphase CTA,...
Source: Journal of Clinical Neuroscience - December 21, 2018 Category: Neuroscience Source Type: research

Abnormal red blood cell indices increase the risk of arterial ischemic stroke in children
Publication date: Available online 19 December 2018Source: Journal of Clinical NeuroscienceAuthor(s): Chaiyos Khongkhatithum, Praguywan Kadegasem, Werasak Sasanakul, Lunliya Thampratankul, Ampaiwan Chuansumrit, Nongnuch SirachainanAbstractA high red cell distribution width (RDW) and low hemoglobin level increase the risk of arterial ischemic stroke (AIS), mostly in adults. The mechanisms related to AIS remain unknown. A total of 233 subjects (90 patients and 143 healthy controls [HC]) were enrolled. The mean(SD) age in patients and HC was 9.5(3.8) and 11.4(1.8) years, respectively. We found increased odds ratios (ORs) for ...
Source: Journal of Clinical Neuroscience - December 21, 2018 Category: Neuroscience Source Type: research

Blood microRNA-93 as an indicator for diagnosis and prediction of functional recovery of acute stroke patients
Publication date: Available online 19 December 2018Source: Journal of Clinical NeuroscienceAuthor(s): Qingfeng Ma, Guangwen Li, Zhen Tao, Jue Wang, Rongliang Wang, Ping Liu, Yumin Luo, Haiping ZhaoAbstractThe present study evaluated the diagnostic and predictive potential of microRNA-93 in acute ischemic stroke (AIS) patients within 6 h of stroke onset and its regulation on microglial inflammation in vitro. Our results showed that the miR-93 levels in plasma and neutrophil detected by real-time PCR were evidently reduced in AIS patients, and Pearson's correlation analysis showed that miR-93 levels in plasma and neutrophi...
Source: Journal of Clinical Neuroscience - December 21, 2018 Category: Neuroscience Source Type: research

Risk factors for ischemic stroke post bone fracture
Publication date: Available online 7 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Qi An, Zhe Chen, Kang Huo, Hua Su, Qiu-Min QuAbstractStroke is one of the most devastating complications after bone fracture. However, due to the rarity of the complication, the risk factor for post fracture stroke remains unknown. We retrospectively reviewed 2914 fractured adults referred to the first affiliated hospital of Xi’an Jiaotong University, a regional referral center of China, from January 2008 to May 2013. As a result, among the 2914 patients, 13 of them had newly onset stroke within a median of 4 days after...
Source: Journal of Clinical Neuroscience - November 8, 2018 Category: Neuroscience Source Type: research

Thrombectomy in stroke of unknown onset, wake up stroke and late presentations: Australian experience from 2 comprehensive stroke centres
This study shows good ‘real world’ outcomes, comparable to published RCTs, in patients with unknown-onset, or late presentation, stroke treated with EVT more than 6 h from stroke onset.
Source: Journal of Clinical Neuroscience - November 8, 2018 Category: Neuroscience Source Type: research

“In Safe Hands” – A costly integrated care program with limited benefits in stroke unit care
Publication date: Available online 6 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Sheila Jala, Sarah Giaccari, Melissa Passer, Carin Bertmar, Susan Day, Dayna Griffith, Martin KrauseAbstractGiven reported favourable outcomes of accountable care unit models of health care delivery (Taylor et al., 2017; Stein et al., 2015; Kara et al., 2015), the Clinical Excellence Commission of NSW has embraced “In Safe Hands” (ISH) to enhance coordination of care. ISH embraces the structured interdisciplinary bedside round (SIBR) component, for which reported outcomes include reduced length of stay (Taylor et al., 2...
Source: Journal of Clinical Neuroscience - November 6, 2018 Category: Neuroscience Source Type: research

Iron nanoparticle contrast enhanced microwave imaging for emergent stroke: A pilot study
Publication date: Available online 1 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Joseph S. Hudson, Timothy K. Chung, Benjamin S. Prout, Yasunori Nagahama, Madhavan L. Raghavan, David M. HasanAbstractEmergent stroke is mostly evaluated using hospital based imaging. Quick imaging allows for rapid administration of IV thrombolysis and outcome improvement. Microwave imaging (MI) is an emerging portable imaging modality. Iron oxide nanoparticles are known to interact with microwave frequency electromagnetic radiation. In this manuscript, we provide proof of concept for a novel iron oxide nanoparticle enhance...
Source: Journal of Clinical Neuroscience - November 2, 2018 Category: Neuroscience Source Type: research

Emergency medical services for acute ischemic stroke: Hub-and-spoke model versus exclusive care in comprehensive centers
ConclusionsUsing a comprehensive all-payer cohort of acute ischemic stroke patients in New York State we demonstrated that patients treated in a hub-and-spoke model were not associated with worse outcomes than patients receiving care exclusively in comprehensive institutions. This needs to be taken into consideration when considering acute emergency services in this setting.
Source: Journal of Clinical Neuroscience - October 20, 2018 Category: Neuroscience Source Type: research

Impact of risk factors for recurrence after the first ischemic stroke in adults: A systematic review and meta-analysis
Publication date: Available online 16 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Shengbang Zheng, Baodong YaoAbstractRisk factors for first-ever stroke have been studied extensively, while those for recurrent stroke are not accurately understood. To provide the adequate secondary prevention for the patients, it is necessary to reveal the risk factors that dominate recurrent stroke. Multiple databases were adopted to search for the relevant studies and full-text articles involving in the risk factors for stroke recurrence were reviewed. Meta-analyses were performed with Review Manager 5.0 to estimate the...
Source: Journal of Clinical Neuroscience - October 17, 2018 Category: Neuroscience Source Type: research

Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons
In this study, we sequentially enrolled five sub-acute stroke patients who had undergone gait training and nine healthy persons. We used fMRI to detect neuronal activation during gait observation. During the observation period in the stroke group, neural activity in the left inferior parietal lobule, right and left inferior frontal gyrus was significantly higher than during the rest period. In the healthy group, neural activity in the left inferior parietal lobule, left inferior frontal gyrus, left middle frontal gyrus, left superior temporal lobule and right and left middle temporal gyrus was significantly higher than dur...
Source: Journal of Clinical Neuroscience - October 12, 2018 Category: Neuroscience Source Type: research