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Source: JAHA:Journal of the American Heart Association
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Total 334 results found since Jan 2013.

Compliance With Acute Stroke Care Quality Measures in Hospitals With and Without Primary Stroke Center Certification: The North Carolina Stroke Care Collaborative Stroke
Conclusions PSC certification is associated with an overall improvement in the quality of stroke care in North Carolina; however, room for improvement remains.
Source: JAHA:Journal of the American Heart Association - April 10, 2014 Category: Cardiology Authors: Johnson, A. M., Goldstein, L. B., Bennett, P., O'Brien, E. C., Rosamond, W. D., investigators of the Registry of the North Carolina Stroke Care Collaborative Tags: Stroke Source Type: research

Can a Novel Clinical Risk Score Improve Pneumonia Prediction in Acute Stroke Care? A UK Multicenter Cohort Study Stroke
Conclusions The ISAN score is a simple tool for predicting SAP in clinical practice. External validation is required in ischemic and hemorrhagic stroke cohorts.
Source: JAHA:Journal of the American Heart Association - January 13, 2015 Category: Cardiology Authors: Smith, C. J., Bray, B. D., Hoffman, A., Meisel, A., Heuschmann, P. U., Wolfe, C. D. A., Tyrrell, P. J., Rudd, A. G., the Intercollegiate Stroke Working Party Group Tags: Stroke Source Type: research

Stroke Severity Is a Crucial Predictor of Outcome: An International Prospective Validation Study Stroke
Conclusions In this prospective pilot study, the baseline NIHSS score was essential for prediction of acute ischemic stroke outcomes, followed by age; whereas traditional comorbidity index contributed little to the overall model. Future studies of stroke outcomes between different care systems will benefit from including a baseline NIHSS score.
Source: JAHA:Journal of the American Heart Association - January 21, 2016 Category: Cardiology Authors: Rost, N. S., Bottle, A., Lee, J.-M., Randall, M., Middleton, S., Shaw, L., Thijs, V., Rinkel, G. J. E., Hemmen, T. M., the Global Comparators Stroke GOAL collaborators Tags: Mortality/Survival, Quality and Outcomes, Cerebrovascular Disease/Stroke, Ischemic Stroke Source Type: research

Door-to-Puncture: A Practical Metric for Capturing and Enhancing System Processes Associated With Endovascular Stroke Care, Preliminary Results From the Rapid Reperfusion Registry Stroke
Conclusions The time interval of D2P presents a clinically relevant time frame by which system processes can be targeted to streamline the delivery of IAT care nationally. At present, there is much opportunity to enhance outcomes through reducing D2P.
Source: JAHA:Journal of the American Heart Association - April 25, 2014 Category: Cardiology Authors: Sun, C.-H. J., Ribo, M., Goyal, M., Yoo, A. J., Jovin, T., Cronin, C. A., Zaidat, O., Nogueira, R., Nguyen, T., Hussain, M. S., Menon, B. K., Mehta, B., Jindal, G., Horev, A., Norbash, A., Leslie-Mazwi, T., Wisco, D., Gupta, R. Tags: Stroke Source Type: research

Clinical Prediction Model Suitable for Assessing Hospital Quality for Patients Undergoing Carotid Endarterectomy Stroke
Conclusions The NCDR CEA score, comprising 7 clinical variables, predicts in-hospital stroke or death after CEA. This model can be used to estimate hospital risk-adjusted outcomes for CEA and to assist with the assessment of hospital quality.
Source: JAHA:Journal of the American Heart Association - June 17, 2014 Category: Cardiology Authors: Wimmer, N. J., Spertus, J. A., Kennedy, K. F., Anderson, H. V., Curtis, J. P., Weintraub, W. S., Singh, M., Rumsfeld, J. S., Masoudi, F. A., Yeh, R. W. Tags: Stroke Source Type: research

Atrial Fibrillation, Stroke, and Anticoagulation in Medicare Beneficiaries: Trends by Age, Sex, and Race, 1992-2010 Stroke
Conclusions Ischemic stroke rates among Medicare AF patients decreased significantly in all demographic subpopulations from 1992–2010, coincident with increasing warfarin use. Ischemic stroke rates remained higher and warfarin use rates remained lower for women and blacks with AF, groups whose baseline CHADS scores were higher.
Source: JAHA:Journal of the American Heart Association - June 3, 2014 Category: Cardiology Authors: Shroff, G. R., Solid, C. A., Herzog, C. A. Tags: Stroke Source Type: research

The TeleStroke Mimic (TM)-Score: A Prediction Rule for Identifying Stroke Mimics Evaluated in a Telestroke Network Stroke
Conclusions SMs differ substantially from their iCVD counterparts in their vascular risk profiles and other characteristics. Decision-support tools based on predictive models, such as our TM Score, may help clinicians consider alternate diagnosis and potentially detect SMs during complex, time-critical telestroke evaluations.
Source: JAHA:Journal of the American Heart Association - June 23, 2014 Category: Cardiology Authors: Ali, S. F., Viswanathan, A., Singhal, A. B., Rost, N. S., Forducey, P. G., Davis, L. W., Schindler, J., Likosky, W., Schlegel, S., Solenski, N., Schwamm, L. H., on Behalf of Partners Telestroke Network Tags: Stroke Source Type: research

Cost-Effectiveness of Clopidogrel-Aspirin Versus Aspirin Alone for Acute Transient Ischemic Attack and Minor Stroke Stroke
Conclusions Early 90-day clopidogrel-aspirin regimen for acute TIA or minor stroke is highly cost-effective in China. Although clopidogrel is generic, Plavix is brand in China. If Plavix were generic, treatment with clopidogrel-aspirin would have been cost saving.
Source: JAHA:Journal of the American Heart Association - June 5, 2014 Category: Cardiology Authors: Pan, Y., Wang, A., Liu, G., Zhao, X., Meng, X., Zhao, K., Liu, L., Wang, C., Johnston, S. C., Wang, Y., Wang, Y., the CHANCE Investigators Tags: Stroke Source Type: research

Socioeconomic Position and Incidence of Ischemic Stroke in Denmark 2003-2012. A Nationwide Hospital-Based Study Stroke
Conclusions In Denmark, there is a strong relation between low socioeconomic position and risk for hospitalization for stroke. Lifestyle, as indicated by smoking, obesity, and alcohol consumption, and diabetes appears to increase the risk for stroke in people with lower socioeconomic position.
Source: JAHA:Journal of the American Heart Association - July 16, 2014 Category: Cardiology Authors: Andersen, K. K., Steding-Jessen, M., Dalton, S. O., Olsen, T. S. Tags: Stroke Source Type: research

Short-term Changes in Ambient Particulate Matter and Risk of Stroke: A Systematic Review and Meta-analysis Stroke
Conclusions We found that PM2.5 and PM10 are associated with a 1.4% (95% CI 0.9% to 1.9%) and 0.5% (95% CI 0.3% to 0.7%) higher total cerebrovascular disease mortality, respectively, with evidence of inconsistent, nonsignificant associations for hospital admission for total cerebrovascular disease or ischemic or hemorrhagic stroke. Current limited evidence does not suggest an association between PM2.5-10 and cerebrovascular mortality or morbidity. We discuss the potential sources of variability in results across studies, highlight some observations, and identify gaps in literature and make recommendations for future studies.
Source: JAHA:Journal of the American Heart Association - August 7, 2014 Category: Cardiology Authors: Wang, Y., Eliot, M. N., Wellenius, G. A. Tags: Stroke Source Type: research

Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Classification and Vascular Territory of Ischemic Stroke Lesions Diagnosed by Diffusion-Weighted Imaging Stroke
Conclusions Information on vascular territory of a stroke lesion may be helpful in timely investigation and accurate diagnosis of stroke etiology.
Source: JAHA:Journal of the American Heart Association - August 11, 2014 Category: Cardiology Authors: Chung, J.-W., Park, S. H., Kim, N., Kim, W.-J., Park, J. H., Ko, Y., Yang, M. H., Jang, M. S., Han, M.-K., Jung, C., Kim, J. H., Oh, C. W., Bae, H.-J. Tags: Stroke Source Type: research

Reducing Door-to-Puncture Times for Intra-Arterial Stroke Therapy: A Pilot Quality Improvement Project Stroke
Conclusions In-hospital delays are a major obstacle to timely IAT. A simple approach for achieving substantial time savings is to mobilize the NI and anesthesia teams during patient evaluation and treatment decision making. This parallel workflow resulted in a >30-minute (25%) reduction in median door-to-puncture times.
Source: JAHA:Journal of the American Heart Association - November 11, 2014 Category: Cardiology Authors: Mehta, B. P., Leslie-Mazwi, T. M., Chandra, R. V., Bell, D. L., Sun, C.-H. J., Hirsch, J. A., Rabinov, J. D., Rost, N. S., Schwamm, L. H., Goldstein, J. N., Levine, W. C., Gupta, R., Yoo, A. J. Tags: Stroke Source Type: research

Comparative Effectiveness of Standard Care With IV Thrombolysis Versus Without IV Thrombolysis for Mild Ischemic Stroke Stroke
Conclusions In this observational registry-based study, standard care with IVT is more effective than not receiving IVT in mild ischemic stroke patients, and there is a statistically nonsignificant risk of symptomatic hemorrhagic transformation.
Source: JAHA:Journal of the American Heart Association - January 9, 2015 Category: Cardiology Authors: Choi, J. C., Jang, M. U., Kang, K., Park, J.-M., Ko, Y., Lee, S.-J., Cha, J.-K., Kim, D.-H., Park, S. S., Park, T. H., Lee, K. B., Lee, J., Kim, J.-T., Cho, K.-H., Yu, K.-H., Oh, M.-S., Lee, B.-C., Cho, Y.-J., Kim, D.-E., Lee, J. S., Lee, J., Gorelick, P. Tags: Stroke Source Type: research

Contemporary Trends and Predictors of Postacute Service Use and Routine Discharge Home After Stroke Stroke
Conclusions Four in 10 stroke patients are discharged home without services. Although little has changed overall in PAC use since 2003, further research is needed to explain the shift in service use by type and its effect on outcomes.
Source: JAHA:Journal of the American Heart Association - February 23, 2015 Category: Cardiology Authors: Prvu Bettger, J., McCoy, L., Smith, E. E., Fonarow, G. C., Schwamm, L. H., Peterson, E. D. Tags: Stroke Source Type: research

Outcomes After Acute Ischemic Stroke in the United States: Does Residential ZIP Code Matter? Stroke
Conclusions Patients from lower-income quartiles had decreased reperfusion on the first admission day, compared with patients from higher-income quartiles. The cost of hospitalization of patients from higher-income quartiles was significantly higher than that of patients from lowest-income quartiles, despite longer hospital stays in the latter group. This might be partially attributable to a lower use of key procedures among patients from lowest-income quartile.
Source: JAHA:Journal of the American Heart Association - March 15, 2015 Category: Cardiology Authors: Agarwal, S., Menon, V., Jaber, W. A. Tags: Stroke Source Type: research

Comprehensive Stroke Centers May Be Associated With Improved Survival in Hemorrhagic Stroke Stroke
Conclusions Hemorrhagic stroke patients admitted to CSCs are more likely to receive neurosurgical and endovascular treatments and be alive at 90 days than patients admitted to other hospitals.
Source: JAHA:Journal of the American Heart Association - May 6, 2015 Category: Cardiology Authors: McKinney, J. S., Cheng, J. Q., Rybinnik, I., Kostis, J. B., the Myocardial Infarction Data Acquisition System (MIDAS 22) Study Group Tags: Stroke Source Type: research

Magnetic Resonance Angiography Detection of Abnormal Carotid Artery Plaque in Patients With Cryptogenic Stroke Stroke
Conclusions Our findings suggest that a proportion of strokes classified as cryptogenic may be mechanistically related to complicated, nonhemodynamically significant cervical carotid artery plaque that can easily be detected by routine magnetic resonance imaging/magnetic resonance angiography acute stroke protocols.
Source: JAHA:Journal of the American Heart Association - June 15, 2015 Category: Cardiology Authors: Gupta, A., Gialdini, G., Lerario, M. P., Baradaran, H., Giambrone, A., Navi, B. B., Marshall, R. S., Iadecola, C., Kamel, H. Tags: Stroke Source Type: research

Perception Versus Actual Performance in Timely Tissue Plasminogen Activation Administration in the Management of Acute Ischemic Stroke Stroke
Conclusions Hospitals often overestimate their ability to deliver timely tPA to treated patients. Our findings indicate the need to routinely provide comparative provider performance rates as a key step to improving the quality of acute stroke care.
Source: JAHA:Journal of the American Heart Association - July 22, 2015 Category: Cardiology Authors: Lin, C. B., Cox, M., Olson, D. M., Britz, G. W., Constable, M., Fonarow, G. C., Schwamm, L., Peterson, E. D., Shah, B. R. Tags: Stroke Source Type: research

Sex Disparities in Stroke: Women Have More Severe Strokes but Better Survival Than Men Stroke
Conclusions Stroke affects women and men differently. Elderly women were affected more severely than elderly men but were more likely to survive.
Source: JAHA:Journal of the American Heart Association - July 6, 2015 Category: Cardiology Authors: Dehlendorff, C., Andersen, K. K., Olsen, T. S. Tags: Stroke Source Type: research

Racial/Ethnic and Sex Differences in Emergency Medical Services Transport Among Hospitalized US Stroke Patients: Analysis of the National Get With The Guidelines-Stroke Registry Stroke
Conclusions EMS use differed by race/ethnicity and sex. These contemporary data document suboptimal use of EMS transport among US stroke patients, especially by racial/ethnic minorities and those with less recognized stroke symptoms.
Source: JAHA:Journal of the American Heart Association - August 12, 2015 Category: Cardiology Authors: Mochari-Greenberger, H., Xian, Y., Hellkamp, A. S., Schulte, P. J., Bhatt, D. L., Fonarow, G. C., Saver, J. L., Reeves, M. J., Schwamm, L. H., Smith, E. E. Tags: Stroke Source Type: research

Long-Term Antiplatelet Mono- and Dual Therapies After Ischemic Stroke or Transient Ischemic Attack: Network Meta-Analysis Stroke
Conclusions Long-term monotherapy was a better choice than long-term dual therapy, and cilostazol had the best risk–benefit profile for long-term secondary prevention after stroke or transient ischemic attack. More randomized controlled trials in non–East Asian patients are needed to determine whether long-term use of cilostazol is the best option for the prevention of recurrent stroke.
Source: JAHA:Journal of the American Heart Association - August 24, 2015 Category: Cardiology Authors: Xie, W., Zheng, F., Zhong, B., Song, X. Tags: Stroke Source Type: research

Post-Acute Care Data for Predicting Readmission After Ischemic Stroke: A Nationwide Cohort Analysis Using the Minimum Data Set Stroke
Conclusions Individual clinical characteristics from the post–acute care setting resulted in only modest improvement in the c-statistic relative to previous models that used only Medicare Part A data. Individual-level characteristics do not sufficiently account for the risk of acute hospital readmission.
Source: JAHA:Journal of the American Heart Association - September 22, 2015 Category: Cardiology Authors: Fehnel, C. R., Lee, Y., Wendell, L. C., Thompson, B. B., Potter, N. S., Mor, V. Tags: Stroke Source Type: research

Racial Disparities in Intravenous Recombinant Tissue Plasminogen Activator Use Persist at Primary Stroke Centers Stroke
Conclusions Racial disparities in intravenous rt-PA use were not reduced by presentation to PSCs. Black patients were less likely to receive thrombolytic treatment than white patients at both non-PSCs and PSCs. Hispanic patients were less likely to be seen at PSCs relative to white patients and were less likely to receive intravenous rt-PA in the fully adjusted model.
Source: JAHA:Journal of the American Heart Association - October 14, 2015 Category: Cardiology Authors: Aparicio, H. J., Carr, B. G., Kasner, S. E., Kallan, M. J., Albright, K. C., Kleindorfer, D. O., Mullen, M. T. Tags: Stroke Source Type: research

Association of Acute and Chronic Hyperglycemia With Acute Ischemic Stroke Outcomes Post-Thrombolysis: Findings From Get With The Guidelines-Stroke Stroke
Conclusion Acute and chronic hyperglycemia are both associated with increased mortality and worse clinical outcomes in AIS patients treated with tPA. Controlled trials are needed to determine whether acute correction of hyperglycemia can improve outcomes after thrombolysis.
Source: JAHA:Journal of the American Heart Association - September 25, 2015 Category: Cardiology Authors: Masrur, S., Cox, M., Bhatt, D. L., Smith, E. E., Ellrodt, G., Fonarow, G. C., Schwamm, L. Tags: Stroke Source Type: research

"Life's Simple 7" and Long-Term Mortality After Stroke Stroke
Conclusions Achieving a greater number of ideal cardiovascular health metrics is associated with lower long-term risk of dying after stroke. Specifically targeting "Life's Simple 7" goals might have a profound impact, extending survival after stroke.
Source: JAHA:Journal of the American Heart Association - November 20, 2015 Category: Cardiology Authors: Lin, M. P., Ovbiagele, B., Markovic, D., Towfighi, A. Tags: Stroke Source Type: research

Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack Stroke
Conclusions Participants with asymptomatic atherosclerosis did not exhibit an obvious change in gut microbiota and blood TMAO levels; however, stroke and transient ischemic attack patients showed significant dysbiosis of the gut microbiota, and their blood TMAO levels were decreased.
Source: JAHA:Journal of the American Heart Association - November 23, 2015 Category: Cardiology Authors: Yin, J., Liao, S.-X., He, Y., Wang, S., Xia, G.-H., Liu, F.-T., Zhu, J.-J., You, C., Chen, Q., Zhou, L., Pan, S.-Y., Zhou, H.-W. Tags: Stroke Source Type: research

Blood Pressure Control and Risk of Stroke or Systemic Embolism in Patients With Atrial Fibrillation: Results From the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) Trial Stroke
Conclusions High BP measurement at any point during the trial was independently associated with a substantially higher risk of stroke or systemic embolism. These results strongly support efforts to treat elevated BP as an important strategy to optimally lower risk of stroke in patients with AF. Clinical Trial Registration URL: https://ClinicalTrials.gov/. Unique identifier: NCT00412984.
Source: JAHA:Journal of the American Heart Association - December 1, 2015 Category: Cardiology Authors: Rao, M. P., Halvorsen, S., Wojdyla, D., Thomas, L., Alexander, J. H., Hylek, E. M., Hanna, M., Bahit, M. C., Lopes, R. D., De Caterina, R., Erol, C., Goto, S., Lanas, F., Lewis, B. S., Husted, S., Gersh, B. J., Wallentin, L., Granger, C. B., the Apixaban Tags: Stroke Source Type: research

Risk Factor Stratification for Intracranial Stenosis in Taiwanese Patients With Cervicocerebral Stenosis Stroke
Conclusions CEIS was associated with higher odds of ischemic stroke compared with isolated ICS and isolated ECS. Smoking and diabetes mellitus, major determinants of CEIS and isolated ICS, should be targeted in therapeutic strategies to reduce the risk of ischemic stroke.
Source: JAHA:Journal of the American Heart Association - December 15, 2015 Category: Cardiology Authors: Sung, Y.-F., Lee, J.-T., Tsai, C.-L., Lin, C.-C., Hsu, Y.-D., Lin, J.-C., Chu, C.-M., Peng, G.-S. Tags: Stroke Source Type: research

Interferon-{beta} Modulates Inflammatory Response in Cerebral Ischemia Stroke
Conclusions Our results demonstrate that IFNβ exerts a protective effect against ischemic stroke through its anti-inflammatory properties and suggest that IFNβ is a potential therapeutic agent, targeting the reperfusion damage subsequent to the treatment with tissue plasminogen activator.
Source: JAHA:Journal of the American Heart Association - January 8, 2016 Category: Cardiology Authors: Kuo, P.-C., Scofield, B. A., Yu, I.-C., Chang, F.-L., Ganea, D., Yen, J.-H. Tags: Inflammation, Translational Studies, Treatment, Ischemic Stroke Source Type: research

Forced Expiratory Volume in the First Second and Aldosterone as Mediators of Smoking Effect on Stroke in African Americans: The Jackson Heart Study Stroke
Conclusions Our findings suggest that the difference in stroke risk between current and never smokers may develop partially through pathways involving lung function and aldosterone and that the mediation effect through aldosterone is independent of blood pressure.
Source: JAHA:Journal of the American Heart Association - January 27, 2016 Category: Cardiology Authors: Wang, W., Shen, G., Shahar, E., Bidulescu, A., Kimberly, W. T., Sheth, K. N., Campbell, B. W., Horbal, S., Correa, A., Griswold, M. E. Tags: Stroke Source Type: research

Rates of Atrial Fibrillation in Black Versus White Patients With Pacemakers Stroke
Conclusions In a population-based sample of patients with pacemakers, black patients had a lower rate of AF compared with white patients. These findings indicate that the persistent racial disparities in rates of ischemic stroke are likely to be related to factors other than undiagnosed AF.
Source: JAHA:Journal of the American Heart Association - February 12, 2016 Category: Cardiology Authors: Kamel, H., Kleindorfer, D. O., Bhave, P. D., Cushman, M., Levitan, E. B., Howard, G., Soliman, E. Z. Tags: Arrhythmias, Atrial Fibrillation, Epidemiology, Race and Ethnicity, Risk Factors Stroke Source Type: research

Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease Stroke
Conclusions A significant reduction of Ndufc2 expression causes complex I dysfunction and contributes to stroke susceptibility in SHRSP. Moreover, our current evidence may suggest that Ndufc2 can contribute to an increased occurrence of early-onset ischemic stroke in humans.
Source: JAHA:Journal of the American Heart Association - February 17, 2016 Category: Cardiology Authors: Rubattu, S., Di Castro, S., Schulz, H., Geurts, A. M., Cotugno, M., Bianchi, F., Maatz, H., Hummel, O., Falak, S., Stanzione, R., Marchitti, S., Scarpino, S., Giusti, B., Kura, A., Gensini, G. F., Peyvandi, F., Mannucci, P. M., Rasura, M., Sciarretta, S., Tags: Basic Science Research, Gene Expression & Regulation, Cerebrovascular Disease/Stroke Source Type: research

Thrombolytic Recanalization of Carotid Arteries Is Highly Dependent on Degree of Stenosis, Despite Sonothrombolysis Stroke
Conclusions In this model, the degree of carotid stenosis had a large effect on thrombolytic recanalization. Sonothrombolysis using standard parameters for intracranial sonothrombolysis did not increase recanalization. Further testing is warranted. The degree of underlying stenosis may be an important predictor of thrombolytic recanalization, and clinical correlation of these findings may provide new approaches to treatment selection for patients with carotid occlusion.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Tomkins, A. J., Hood, R. J., Pepperall, D., Null, C. L., Levi, C. R., Spratt, N. J. Tags: Ultrasound, Cerebrovascular Disease/Stroke, Stenosis, Thrombosis Source Type: research

Ischemic Stroke in Children and Young Adults With Congenital Heart Disease Congenital Heart Disease
Conclusions The risk of developing ischemic stroke was almost 11 times higher in young patients with CHD than in the general population, although absolute risk is low. Cardiovascular comorbidities were strongly associated with the development of ischemic stroke in young CHD patients.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Mandalenakis, Z., Rosengren, A., Lappas, G., Eriksson, P., Hansson, P.-O., Dellborg, M. Tags: Epidemiology, Congenital Heart Disease, Ischemic Stroke Source Type: research

Effect of Adherence to Oral Anticoagulants on Risk of Stroke and Major Bleeding Among Patients With Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusions Adherence to anticoagulation is poor in practice and may be modestly improved with NOACs. Adherence to therapy appears to be most important in patients with CHA2DS2-VASc score ≥2, whereas the benefits of anticoagulation may not outweigh the harms in patients with CHA2DS2-VASc score 0 or 1.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Yao, X., Abraham, N. S., Alexander, G. C., Crown, W., Montori, V. M., Sangaralingham, L. R., Gersh, B. J., Shah, N. D., Noseworthy, P. A. Tags: Arrhythmias, Atrial Fibrillation, Secondary Prevention, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

An Approach to Working Up Cases of Embolic Stroke of Undetermined Source Stroke
Conclusions Our data indicate that patients with cryptogenic embolic stroke show distinct clinical and radiological features depending on the underlying causes.
Source: JAHA:Journal of the American Heart Association - March 22, 2016 Category: Cardiology Authors: Ryoo, S., Chung, J.-W., Lee, M. J., Kim, S. J., Lee, J. S., Kim, G.-M., Chung, C.-S., Lee, K. H., Hong, J. M., Bang, O. Y. Tags: Etiology, Risk Factors, Magnetic Resonance Imaging (MRI), Ischemic Stroke Source Type: research

Identification of PTCSC3 as a Novel Locus for Large-Vessel Ischemic Stroke: A Genome-Wide Association Study Stroke
Conclusions Our data provide strong support for future studies on the role of PTCSC3 in the pathogenesis of LAA stroke and the association between LAA stroke development and thyroid function. In addition, these findings provide insights into the genetic basis of LAA stroke and identify a novel pathway that might be applicable for future therapeutic intervention.
Source: JAHA:Journal of the American Heart Association - March 29, 2016 Category: Cardiology Authors: Lee, T.-H., Ko, T.-M., Chen, C.-H., Lee, M.-T. M., Chang, Y.-J., Chang, C.-H., Huang, K.-L., Chang, T.-Y., Lee, J.-D., Chang, K.-C., Yang, J.-T., Wen, M.-S., Wang, C.-Y., Chen, Y.-T., Hsieh, C.-S., Chou, S.-Y., Liu, Y.-M., Chen, H.-W., Liao, H.-T., Wang, Tags: Genetic, Association Studies, Ischemic Stroke Source Type: research

Treatment Effect of Clopidogrel Plus Aspirin Within 12 Hours of Acute Minor Stroke or Transient Ischemic Attack Stroke
Conclusions Among patients treated within 12 hours, the combination of clopidogrel and aspirin was more effective than aspirin alone in reducing the risk of recurrent ischemic stroke during the 90-day follow-up and did not increase the hemorrhagic risk. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00979589.
Source: JAHA:Journal of the American Heart Association - March 21, 2016 Category: Cardiology Authors: Li, Z., Wang, Y., Zhao, X., Liu, L., Wang, D., Wang, C., Meng, X., Li, H., Pan, Y., Wang, X., Wang, C., Yang, X., Zhang, C., Jing, J., Xian, Y., Johnston, S. C., Wang, Y., on behalf of the CHANCE Investigators Tags: Secondary Prevention, Ischemic Stroke, Transient Ischemic Attack (TIA) Source Type: research

Ischemic Stroke or Systemic Embolism After Transseptal Ablation of Arrhythmias in Patients With Cardiac Implantable Electronic Devices Arrhythmia and Electrophysiology
Conclusion CIEDs are associated with an increased risk of stroke, TIA, or systemic embolism after transseptal ablation, but this risk is attenuated with postablation OAC use. Role of anticoagulation post-transseptal ablation in patients with CIED warrants further investigation.
Source: JAHA:Journal of the American Heart Association - April 13, 2016 Category: Cardiology Authors: Madhavan, M., Yao, X., Sangaralingham, L. R., Asirvatham, S. J., Friedman, P. A., McLeod, C. J., Sugrue, A. M., DeSimone, C. V., Noseworthy, P. A. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Atrial Fibrillation, Ischemic Stroke, Transient Ischemic Attack (TIA) Arrhythmia and Electrophysiology Source Type: research

Prehospital Phase of the Stroke Chain of Survival: A Prospective Observational Study Stroke
Conclusions Fast emergency medical services activation and ambulance transport promoted early hospital arrival and treatment. Although patient-dependent delays still dominate the prehospital process, it should be ensured that the minutes on the scene are well spent.
Source: JAHA:Journal of the American Heart Association - May 2, 2016 Category: Cardiology Authors: Puolakka, T., Strbian, D., Harve, H., Kuisma, M., Lindsberg, P. J. Tags: Stroke Source Type: research

Derivation and Validation of a Modified Short Form of the Stroke Impact Scale Stroke
Conclusions Using multiple, complementary methods, we have derived an SF-SIS and demonstrated content, convergent, and discriminant validity. This shortened SIS should allow collection of robust quality of life data with less associated test burden.
Source: JAHA:Journal of the American Heart Association - May 20, 2016 Category: Cardiology Authors: MacIsaac, R., Ali, M., Peters, M., English, C., Rodgers, H., Jenkinson, C., Lees, K. R., Quinn, T. J., the VISTA Collaboration Tags: Stroke Source Type: research

Increasing Incidence of Hospitalization for Stroke and Transient Ischemic Attack in Young Adults: A Registry-Based Study Stroke
Conclusions The incidence rates of first-time hospitalizations for ischemic stroke and TIA in young Danish adults have increased substantially since the mid 1990s. The increase was particularly prominent in the most recent years.
Source: JAHA:Journal of the American Heart Association - May 11, 2016 Category: Cardiology Authors: Tibaek, M., Dehlendorff, C., Jorgensen, H. S., Forchhammer, H. B., Johnsen, S. P., Kammersgaard, L. P. Tags: Epidemiology, Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Source Type: research

Comparative Effectiveness of Interventions for Stroke Prevention in Atrial Fibrillation: A Network Meta-Analysis Arrhythmia and Electrophysiology
Conclusions The entire spectrum of therapy to prevent thromboembolism in nonvalvular AF significantly reduced stroke/systemic embolism events and mortality.
Source: JAHA:Journal of the American Heart Association - May 20, 2016 Category: Cardiology Authors: Tereshchenko, L. G., Henrikson, C. A., Cigarroa, J., Steinberg, J. S. Tags: Atrial Fibrillation, Anticoagulants, Treatment, Meta Analysis, Cerebrovascular Disease/Stroke Arrhythmia and Electrophysiology Source Type: research

Trends in Acute Ischemic Stroke Hospitalizations in the United States Stroke
Conclusions Although overall stroke hospitalizations declined in the United States, the reduction was more pronounced among older individuals, women, Hispanics, and whites. Renewed efforts at targeting risk factor control among vulnerable individuals may be warranted.
Source: JAHA:Journal of the American Heart Association - May 11, 2016 Category: Cardiology Authors: Ramirez, L., Kim-Tenser, M. A., Sanossian, N., Cen, S., Wen, G., He, S., Mack, W. J., Towfighi, A. Tags: Cardiovascular Disease, Cerebrovascular Disease/Stroke, Ischemic Stroke Source Type: research

Intravenous Thrombolysis for Acute Ischemic Stroke in Patients Receiving Antiplatelet Therapy: A Systematic Review and Meta-analysis of 19 Studies Stroke
Conclusions Patients with acute ischemic stroke receiving long-term antiplatelet medications were associated with greater risks of developing symptomatic intracranial hemorrhage after systemic thrombolysis. However, the overall independent association between prestroke antiplatelet therapy and unfavorable outcomes or mortality was insignificant.
Source: JAHA:Journal of the American Heart Association - May 20, 2016 Category: Cardiology Authors: Luo, S., Zhuang, M., Zeng, W., Tao, J. Tags: Meta Analysis, Quality and Outcomes, Ischemic Stroke Source Type: research

Stroke Ready Intervention: Community Engagement to Decrease Prehospital Delay Stroke
Conclusions Stroke Ready increased stroke preparedness, a necessary step toward increasing acute stroke treatment rates. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT01499173.
Source: JAHA:Journal of the American Heart Association - May 20, 2016 Category: Cardiology Authors: Skolarus, L. E., Zimmerman, M. A., Bailey, S., Dome, M., Murphy, J. B., Kobrossi, C., Dombrowski, S. U., Burke, J. F., Morgenstern, L. B. Tags: Race and Ethnicity, Cerebrovascular Disease/Stroke Source Type: research

Efficacy and Safety of Edoxaban in Elderly Patients With Atrial Fibrillation in the ENGAGE AF-TIMI 48 Trial Stroke
Conclusions Age has a greater influence on major bleeding than thromboembolic risk in patients with atrial fibrillation. Given the higher rates of bleeding and death with increasing age, treatment of elderly patients with edoxaban provides an even greater absolute reduction in safety events over warfarin, compared to treatment with edoxaban versus warfarin in younger patients. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00781391.
Source: JAHA:Journal of the American Heart Association - May 20, 2016 Category: Cardiology Authors: Kato, E. T., Giugliano, R. P., Ruff, C. T., Koretsune, Y., Yamashita, T., Kiss, R. G., Nordio, F., Murphy, S. A., Kimura, T., Jin, J., Lanz, H., Mercuri, M., Braunwald, E., Antman, E. M. Tags: Atrial Fibrillation, Complications, Mortality/Survival, Intracranial Hemorrhage, Ischemic Stroke Source Type: research

No Decline in the Risk of Stroke Following Incident Atrial Fibrillation Since 2000 in the Community: A Concerning Trend Epidemiology
Conclusions Strokes/TIAs are frequent after AF, occurring in 10% of patients after 5 years of follow-up. The occurrence of stroke/TIA did not decline over the last decade, which may be influenced by a leveling off of anticoagulation use. This concerning trend has major public health implications.
Source: JAHA:Journal of the American Heart Association - June 13, 2016 Category: Cardiology Authors: Chamberlain, A. M., Brown, R. D., Alonso, A., Gersh, B. J., Killian, J. M., Weston, S. A., Roger, V. L. Tags: Atrial Fibrillation, Epidemiology, Ischemic Stroke, Transient Ischemic Attack (TIA) Source Type: research

Ischemic Stroke Risk After Acute Coronary Syndrome Stroke
Conclusions Non-STEMI and STEMI confer an equally increased risk of IS. Studies exploring IS mechanisms in cardiac patients are needed to improve and tailor stroke prevention strategies.
Source: JAHA:Journal of the American Heart Association - July 13, 2016 Category: Cardiology Authors: Yaghi, S., Pilot, M., Song, C., Blum, C. A., Yakhkind, A., Silver, B., Furie, K. L., Elkind, M. S. V., Sherzai, D., Sherzai, A. Z. Tags: Cerebrovascular Disease/Stroke, Acute Coronary Syndromes Source Type: research

Particulate Matter and Hospital Admissions for Stroke in Beijing, China: Modification Effects by Ambient Temperature Stroke
Conclusions This study suggests that the associations of PM2.5, PM2.5–10, and PM10 with stroke admissions differed across levels of temperature. Short-term exposure to PM2.5, PM2.5–10, and PM10 was positively associated with hospital admissions for ischemic and hemorrhagic stroke on warm days (>13.5°C).
Source: JAHA:Journal of the American Heart Association - July 13, 2016 Category: Cardiology Authors: Huang, F., Luo, Y., Guo, Y., Tao, L., Xu, Q., Wang, C., Wang, A., Li, X., Guo, J., Yan, A., Guo, X. Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Source Type: research