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Early Adoption of Dabigatran and Its Dosing in US Patients With Atrial Fibrillation: Results From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation Health Services and Outcomes Research
Conclusions Patients receiving dabigatran were younger and at a lower risk of stroke and bleeding. Patients appeared to drive switching from warfarin, whereas clinical characteristics influenced de novo start of dabigatran. These data suggest cautious early uptake of dabigatran, and more careful attention to dosing adjustments is warranted. Clinical Trial Registration URL: Clinicaltrials.gov. Unique identifier: NCT01165710.
Source: JAHA:Journal of the American Heart Association - November 25, 2013 Category: Cardiology Authors: Steinberg, B. A., Holmes, D. N., Piccini, J. P., Ansell, J., Chang, P., Fonarow, G. C., Gersh, B., Mahaffey, K. W., Kowey, P. R., Ezekowitz, M. D., Singer, D. E., Thomas, L., Peterson, E. D., Hylek, E. M., The Outcomes Registry for Better Informed Treatme Tags: Health Services and Outcomes Research Source Type: research

Abnormal Stress-Related Measures of Arterial Stiffness in Middle-Aged and Elderly Men and Women With Impaired Fasting Glucose at Risk for a First Episode of Symptomatic Heart Failure Epidemiology
Conclusion Middle- and older-aged individuals with diabetes or impaired fasting glucose have higher stress measures of arterial stiffness than those with normal fasting glucose. These data emphasize the need for future studies with larger sample sizes to determine whether stress-related elevations in arterial stiffness are related to exercise intolerance and future episodes of heart failure experienced by those with abnormalities of fasting glucose. Clinical Trial Registration URL: http://clinicaltrials.gov/. Unique identifier: NCT00542503.
Source: JAHA:Journal of the American Heart Association - January 14, 2015 Category: Cardiology Authors: Vasu, S., Morgan, T. M., Kitzman, D. W., Bertoni, A., Stacey, R. B., Hamilton, C., Chiles, C., Thohan, V., Hundley, W. G. Tags: Epidemiology Source Type: research

Increased Cardiac Workload in the Upright Posture in Men: Noninvasive Hemodynamics in Men Versus Women Vascular Medicine
Conclusions The foremost difference in cardiovascular regulation between sexes was higher upright hemodynamic workload for the heart in men, a finding not explained by known cardiovascular risk factors or hormonal differences before menopause. Heart rate variability analyses indicated higher sympathovagal balance in men regardless of body position. The deviations in upright hemodynamics could play a role in the differences in cardiovascular risk between men and women. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01742702.
Source: JAHA:Journal of the American Heart Association - June 20, 2016 Category: Cardiology Authors: Kangas, P., Tahvanainen, A., Tikkakoski, A., Koskela, J., Uitto, M., Viik, J., Kähönen, M., Kööbi, T., Mustonen, J., Pörsti, I. Tags: Autonomic Nervous System, Clinical Studies, Hemodynamics Vascular Medicine Source Type: research

Diagnostic Performance of a Smartphone-Based Photoplethysmographic Application for Atrial Fibrillation Screening in a Primary Care Setting Arrhythmia and Electrophysiology
Conclusions The Cardiio Rhythm smartphone PPG application provides an accurate and reliable means to detect AF in patients at risk of developing AF and has the potential to enable population-based screening for AF.
Source: JAHA:Journal of the American Heart Association - July 20, 2016 Category: Cardiology Authors: Chan, P.-H., Wong, C.-K., Poh, Y. C., Pun, L., Leung, W. W.-C., Wong, Y.-F., Wong, M. M.-Y., Poh, M.-Z., Chu, D. W.-S., Siu, C.-W. Tags: Atrial Fibrillation Arrhythmia and Electrophysiology Source Type: research

Associations of Plasma Phospholipid and Dietary Alpha Linolenic Acid With Incident Atrial Fibrillation in Older Adults: The Cardiovascular Health Study Arrhythmia and Electrophysiology
Conclusions Results from this prospective cohort study of older adults indicate no association of plasma phospholipid or dietary ALA and incident AF.
Source: JAHA:Journal of the American Heart Association - January 31, 2013 Category: Cardiology Authors: Fretts, A. M., Mozaffarian, D., Siscovick, D. S., Heckbert, S. R., McKnight, B., King, I. B., Rimm, E. B., Psaty, B. M., Sacks, F. M., Song, X., Spiegelman, D., Lemaitre, R. N. Tags: Arrhythmia and Electrophysiology Source Type: research

Cardiovascular and Mortality Risk of Apparent Resistant Hypertension in Women With Suspected Myocardial Ischemia: A Report From the NHLBI-Sponsored WISE Study Hypertension
Conclusions In this cohort of women with evidence of ischemia, aTRH was associated with a profoundly increased long-term risk of major adverse events, including death, that emerged early during follow-up.
Source: JAHA:Journal of the American Heart Association - February 28, 2014 Category: Cardiology Authors: Smith, S. M., Huo, T., Delia Johnson, B., Bittner, V., Kelsey, S. F., Vido Thompson, D., Noel Bairey Merz, C., Pepine, C. J., Cooper-DeHoff, R. M. Tags: Hypertension Source Type: research

Patient Outcomes According to Adherence to Treatment Guidelines for Rhythm Control of Atrial Fibrillation Coronary Heart Disease
Conclusions Adherence to published guidelines in the antiarrhythmic management of AF is associated with improved patient outcomes.
Source: JAHA:Journal of the American Heart Association - April 6, 2015 Category: Cardiology Authors: Qin, D., Leef, G., Alam, M. B., Rattan, R., Munir, M. B., Patel, D., Khattak, F., Vaghasia, N., Adelstein, E., Jain, S. K., Saba, S. Tags: Coronary Heart Disease Source Type: research

Geographic Variations in Cardiovascular Health in the United States: Contributions of State- and Individual-Level Factors Epidemiology
Conclusions There is significant state-level variation in poor CVH that is partly explained by individual- and state-level factors. Additional longitudinal research is warranted to examine the influence of state-level policies and food and physical activity environments on poor CVH.
Source: JAHA:Journal of the American Heart Association - May 27, 2015 Category: Cardiology Authors: Gebreab, S. Y., Davis, S. K., Symanzik, J., Mensah, G. A., Gibbons, G. H., Diez-Roux, A. V. Tags: Epidemiology Source Type: research

Traditional Risk Factors Versus Biomarkers for Prediction of Secondary Events in Patients With Stable Coronary Heart Disease: From the Heart and Soul Study Coronary Heart Disease
Conclusions Novel risk factors are superior to traditional risk factors for predicting 5-year risk of secondary events in patients with stable CHD.
Source: JAHA:Journal of the American Heart Association - July 6, 2015 Category: Cardiology Authors: Beatty, A. L., Ku, I. A., Bibbins-Domingo, K., Christenson, R. H., DeFilippi, C. R., Ganz, P., Ix, J. H., Lloyd-Jones, D., Omland, T., Sabatine, M. S., Schiller, N. B., Shlipak, M. G., Skali, H., Takeuchi, M., Vittinghoff, E., Whooley, M. A. Tags: Coronary Heart Disease Source Type: research

Incremental Value of the CRUSADE, ACUITY, and HAS-BLED Risk Scores for the Prediction of Hemorrhagic Events After Coronary Stent Implantation in Patients Undergoing Long or Short Duration of Dual Antiplatelet Therapy Coronary Heart Disease
Conclusions Our analysis suggests that the CRUSADE score predicts major bleeding similarly to ACUITY and better than HAS BLED in an all-comer population with percutaneous coronary intervention and potentially identifies patients at higher risk of hemorrhagic complications when treated with a long-term dual antiplatelet therapy regimen. Clinical Trial Registration URL: http://clinicaltrials.gov. Unique identifier: NCT00611286.
Source: JAHA:Journal of the American Heart Association - December 7, 2015 Category: Cardiology Authors: Costa, F., Tijssen, J. G., Ariotti, S., Giatti, S., Moscarella, E., Guastaroba, P., De Palma, R., Ando, G., Oreto, G., Zijlstra, F., Valgimigli, M. Tags: Coronary Heart Disease Source Type: research

Impact of an Emergency Department Observation Unit Management Algorithm for Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusions Implementation of an emergency department observation unit AF algorithm was associated with significantly decreased hospital admissions without increasing the rates of return emergency department visits, hospitalization, or adverse events within 30 days.
Source: JAHA:Journal of the American Heart Association - February 8, 2016 Category: Cardiology Authors: Bellew, S. D., Bremer, M. L., Kopecky, S. L., Lohse, C. M., Munger, T. M., Robelia, P. M., Smars, P. A. Tags: Arrhythmias, Atrial Fibrillation, Cost-Effectiveness, Quality and Outcomes Arrhythmia and Electrophysiology Source Type: research

Carotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study Epidemiology
Conclusions Cumulative vascular risk factor exposure may increase the risk of CMB, especially in deep regions. The apparent paradoxical association of carotid intima–media thickness progression with lower risk of CMB may reflect benefits of intensive vascular risk factor treatment among persons with higher cardiovascular risk and deserves further investigation. If replicated, the results may have potential implications for assessment of preventive and therapeutic interventions for subclinical cerebral hemorrhage.
Source: JAHA:Journal of the American Heart Association - March 17, 2016 Category: Cardiology Authors: Romero, J. R., Preis, S. R., Beiser, A., DeCarli, C., D'Agostino, R. B., Wolf, P. A., Vasan, R. S., Polak, J. F., Seshadri, S. Tags: Epidemiology, Magnetic Resonance Imaging (MRI), Ultrasound, Cerebrovascular Disease/Stroke, Atherosclerosis Source Type: research

Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors, Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study Kidney in Cardiovascular Disease
Conclusions Even mildly reduced eGFR (under 90 mL/min per 1.73 m2) is associated with elevated 10-year Framingham risk for CHD and 10-year ASCVD risk among Chinese adults.
Source: JAHA:Journal of the American Heart Association - July 21, 2016 Category: Cardiology Authors: Lu, J., Mu, Y., Su, Q., Shi, L., Liu, C., Zhao, J., Chen, L., Li, Q., Yang, T., Yan, L., Wan, Q., Wu, S., Liu, Y., Wang, G., Luo, Z., Tang, X., Chen, G., Huo, Y., Gao, Z., Ye, Z., Wang, Y., Qin, G., Deng, H., Yu, X., Shen, F., Chen, L., Zhao, L., Sun, J., Tags: Cardiovascular Disease, Epidemiology, Lifestyle, Risk Factors Kidney in Cardiovascular Disease Source Type: research

Incidence and Predictors of Complications During Cryoballoon Pulmonary Vein Isolation for Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusions In a large contemporary cohort, cryoballoon PVI is associated with low procedural risk, including lower rates of PNI than previously reported. Older age and 23-mm balloon use were associated with PNI. Our low rate of PNI may reflect more sensitive detection methods, including compound motor action potential monitoring and forced double-deflation.
Source: JAHA:Journal of the American Heart Association - July 20, 2016 Category: Cardiology Authors: Guhl, E. N., Siddoway, D., Adelstein, E., Bazaz, R., Mendenhall, G. S., Nemec, J., Saba, S., Schwartzman, D., Voigt, A., Wang, N. C., Jain, S. K. Tags: Arrhythmias, Catheter Ablation and Implantable Cardioverter-Defibrillator, Electrophysiology, Atrial Fibrillation Arrhythmia and Electrophysiology Source Type: research

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