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Source: JAHA:Journal of the American Heart Association
Condition: Heart Failure

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Total 67 results found since Jan 2013.

Gastric Bypass Surgery Produces a Durable Reduction in Cardiovascular Disease Risk Factors and Reduces the Long-Term Risks of Congestive Heart Failure Preventive Cardiology
ConclusionsGastric bypass is associated with a reduced risk of major cardiovascular events and the development of congestive heart failure.
Source: JAHA:Journal of the American Heart Association - May 23, 2017 Category: Cardiology Authors: Benotti, P. N., Wood, G. C., Carey, D. J., Mehra, V. C., Mirshahi, T., Lent, M. R., Petrick, A. T., Still, C., Gerhard, G. S., Hirsch, A. G. Tags: Cardiomyopathy, Heart Failure, Metabolic Syndrome, Remodeling, Cerebrovascular Disease/Stroke Original Research Source Type: research

Local Ancestry and Clinical Cardiovascular Events Among African Americans From the Atherosclerosis Risk in Communities Study Genetics
ConclusionsFuture studies are needed to replicate and/or determine the causal variants driving our associations and explore clinical applications for those consistently associated with CVEs.
Source: JAHA:Journal of the American Heart Association - April 10, 2017 Category: Cardiology Authors: Shendre, A., Irvin, M. R., Wiener, H., Zhi, D., Limdi, N. A., Overton, E. T., Shrestha, S. Tags: Cardiovascular Disease, Epidemiology, Race and Ethnicity, Risk Factors, Heart Failure Original Research Source Type: research

Association of Cardiovascular Health With Subclinical Disease and Incident Events: The Multi-Ethnic Study of Atherosclerosis Epidemiology
ConclusionsThere is a graded inverse association between CVH scores and measures of subclinical and overt cardiovascular disease that is similar across race/ethnic groups.
Source: JAHA:Journal of the American Heart Association - March 20, 2017 Category: Cardiology Authors: Polonsky, T. S., Ning, H., Daviglus, M. L., Liu, K., Burke, G. L., Cushman, M., Eng, J., Folsom, A. R., Lutsey, P. L., Nettleton, J. A., Post, W. S., Sacco, R. L., Szklo, M., Lloyd-Jones, D. M. Tags: Epidemiology, Lifestyle, Primary Prevention, Race and Ethnicity, Vascular Disease Original Research Source Type: research

Cardiovascular Disease and Patterns of Change in Functional Status Over 15 Years: Findings From the Atherosclerosis Risk in Communities (ARIC) Study Epidemiology
ConclusionsThis study documents that a decline in FS precedes incidence of CVD‐related hospitalization by at least 2 years, providing a strong argument for routine preventative assessment of FS among older adults.
Source: JAHA:Journal of the American Heart Association - March 1, 2017 Category: Cardiology Authors: Kucharska-Newton, A., Griswold, M., Yao, Z. H., Foraker, R., Rose, K., Rosamond, W., Wagenknecht, L., Koton, S., Pompeii, L., Windham, B. G. Tags: Cardiovascular Disease, Epidemiology, Primary Prevention, Women Original Research Source Type: research

Long-Term Risk of Cardiovascular Events in Patients With Chronic Kidney Disease Who Have Survived Sepsis: A Nationwide Cohort Study Epidemiology
ConclusionsOur findings highlight the association of sepsis with a significantly increased long‐term risk of cardiovascular events among survivors in the chronic kidney disease population.
Source: JAHA:Journal of the American Heart Association - February 10, 2017 Category: Cardiology Authors: Shih, C.-J., Chao, P.-W., Ou, S.-M., Chen, Y.-T. Tags: Cardiovascular Disease, Epidemiology, Risk Factors Original Research Source Type: research

Myocardial Oxygen Consumption and Efficiency in Aortic Valve Stenosis Patients With and Without Heart Failure Valvular Heart Disease
BackgroundMyocardial oxygen consumption (MVO2) and its coupling to contractile work are fundamentals of cardiac function and may be involved causally in the transition from compensated left ventricular hypertrophy to failure. Nevertheless, these processes have not been studied previously in patients with aortic valve stenosis (AS).Methods and ResultsParticipants underwent 11C‐acetate positron emission tomography, cardiovascular magnetic resonance, and echocardiography to measure MVO2 and myocardial external efficiency (MEE) defined as the ratio of left ventricular stroke work and the energy equivalent of MVO2. We studied...
Source: JAHA:Journal of the American Heart Association - February 6, 2017 Category: Cardiology Authors: Hansson, N. H. S., Sorensen, J., Harms, H. J., Kim, W. Y., Nielsen, R., Tolbod, L. P., Frokiar, J., Bouchelouche, K., Dodt, K. K., Sihm, I., Poulsen, S. H., Wiggers, H. Tags: Metabolism, Heart Failure, Valvular Heart Disease, Imaging, Nuclear Cardiology and PET Original Research Source Type: research

Beta-Blocker Use Is Associated With Impaired Left Atrial Function in Hypertension Hypertension
BackgroundImpaired left atrial (LA) mechanical function is present in hypertension and likely contributes to various complications, including atrial arrhythmias, stroke, and heart failure. Various antihypertensive drug classes exert differential effects on central hemodynamics and left ventricular function. However, little is known about their effects on LA function.Methods and ResultsWe studied 212 subjects with hypertension and without heart failure or atrial fibrillation. LA strain was measured from cine steady‐state free‐precession cardiac MRI images using feature‐tracking algorithms. In multivariable models adju...
Source: JAHA:Journal of the American Heart Association - February 3, 2017 Category: Cardiology Authors: Sardana, M., Syed, A. A., Hashmath, Z., Phan, T. S., Koppula, M. R., Kewan, U., Ahmed, Z., Chandamuri, R., Varakantam, S., Shah, E., Gorz, R., Akers, S. R., Chirinos, J. A. Tags: Atrial Fibrillation, Hypertension, Magnetic Resonance Imaging (MRI) Original Research Source Type: research

Relative Contributions of Arterial Stiffness and Hypertension to Cardiovascular Disease: The Framingham Heart Study Epidemiology
ConclusionsA substantial proportion of treated hypertensives have high arterial stiffness, a finding that may explain some of the notable residual CVD risk associated with even well‐controlled hypertension. High PWV is associated with a trend towards increasing CVD risk in both nonhypertensives and hypertensives, a finding that may support the use of arterial stiffness measurements in both populations.
Source: JAHA:Journal of the American Heart Association - October 26, 2016 Category: Cardiology Authors: Niiranen, T. J., Kalesan, B., Hamburg, N. M., Benjamin, E. J., Mitchell, G. F., Vasan, R. S. Tags: Cardiovascular Disease, Epidemiology, High Blood Pressure, Hypertension, Vascular Disease Original Research Source Type: research

Relationship Between QT Interval and Outcome in Low-Flow Low-Gradient Aortic Stenosis With Low Left Ventricular Eȷection Fraction Valvular Heart Disease
ConclusionsIn patients with LF‐LG AS and reduced LVEF, longer QTc interval was associated with worse LV function and increased risk of death. Assessment of QTc may provide a simple and inexpensive tool to enhance risk stratification in LF‐LG AS patients.Clinical Trial RegistrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT 01835028.
Source: JAHA:Journal of the American Heart Association - October 20, 2016 Category: Cardiology Authors: Dahou, A., Toubal, O., Clavel, M.–A., Beaudoin, J., Magne, J., Mathieu, P., Philippon, F., Dumesnil, J. G., Puri, R., Ribeiro, H. B., Larose, E., Rodes-Cabau, J., Pibarot, P. Tags: Heart Failure, Valvular Heart Disease, Echocardiography, Electrocardiology (ECG), Prognosis Original Research Source Type: research

Is an Oral Anticoagulant Necessary for Young Atrial Fibrillation Patients With a CHA2DS2-VASc Score of 1 (Men) or 2 (Women)? Arrhythmia and Electrophysiology
ConclusionsFor atrial fibrillation patients aged 20 to 49 years with 1 risk factor in addition to sex, non–vitamin K antagonist OACs should be considered for stroke prevention to minimize the risk of a potentially fatal or disabling event.
Source: JAHA:Journal of the American Heart Association - October 4, 2016 Category: Cardiology Authors: Hung, Y., Chao, T.-F., Liu, C.-J., Tuan, T.-C., Lin, Y.-J., Chang, S.-L., Lo, L.-W., Hu, Y.-F., Liao, J.-N., Chung, F.-P., Lin, W.-Y., Lin, W.-S., Cheng, S.-M., Chen, T.-J., Lip, G. Y. H., Chen, S.-A. Tags: Atrial Fibrillation Original Research Source Type: research

Angina and Future Cardiovascular Events in Stable Patients With Coronary Artery Disease: Insights From the Reduction of Atherothrombosis for Continued Health (REACH) Registry Coronary Heart Disease
BackgroundThe extent to which angina is associated with future cardiovascular events in patients with coronary artery disease has long been debated.Methods and ResultsIncluded were outpatients with established coronary artery disease who were enrolled in the REACH registry and were followed for 4 years. Angina at baseline was defined as necessitating episodic or permanent antianginal treatment. The primary end point was the composite of cardiovascular death, myocardial infarction, or stroke. Secondary end points included heart failure, cardiovascular hospitalizations, and coronary revascularization. The independent associ...
Source: JAHA:Journal of the American Heart Association - September 28, 2016 Category: Cardiology Authors: Eisen, A., Bhatt, D. L., Steg, P. G., Eagle, K. A., Goto, S., Guo, J., Smith, S. C., Ohman, E. M., Scirica, B. M., the REACH Registry Investigators Tags: Myocardial Infarction, Angina, Coronary Artery Disease Original Research Source Type: research

Ventricular-Arterial Function and Coupling in the Adult Fontan Circulation Congenital Heart Disease
BackgroundIn adult Fontan patients, ventricular or arterial dysfunction may impact homeostasis of the Fontan circulation and predispose to heart failure. We sought to characterize ventricular‐arterial (VA) properties in adult Fontan patients.Methods and ResultsAdult Fontan patients (n=170), including those with right (SRV, n=57) and left (SLV, n=113) dominant ventricular morphology, were compared to age, sex, and body size matched controls (n=170). Arterial function, load‐insensitive measures of contractility, VA coupling, diastolic function, and ventricular efficiency were assessed. Compared to controls, Fontan patien...
Source: JAHA:Journal of the American Heart Association - September 23, 2016 Category: Cardiology Authors: Saiki, H., Eidem, B. W., Ohtani, T., Grogan, M. A., Redfield, M. M. Tags: Congenital Heart Disease, Cardiovascular Surgery Original Research Source Type: research

Quantifying the Association Between Physical Activity and Cardiovascular Disease and Diabetes: A Systematic Review and Meta-Analysis Epidemiology
Conclusions By using a single continuous metric for PA levels, we were able to make a comparison of the effect of PA on CVD incidence and mortality including myocardial infarct (MI), stroke, and heart failure, as well as T2DM. Effect sizes were generally similar for CVD and T2DM, and suggested that the greatest gain in health is associated with moving from inactivity to small amounts of PA.
Source: JAHA:Journal of the American Heart Association - September 14, 2016 Category: Cardiology Authors: Wahid, A., Manek, N., Nichols, M., Kelly, P., Foster, C., Webster, P., Kaur, A., Friedemann Smith, C., Wilkins, E., Rayner, M., Roberts, N., Scarborough, P. Tags: Epidemiology, Exercise, Primary Prevention, Health Services, Meta Analysis Source Type: research

Economic Impact of Moderate-Vigorous Physical Activity Among Those With and Without Established Cardiovascular Disease: 2012 Medical Expenditure Panel Survey Health Services and Outcomes Research
ConclusionsModerate‐vigorous PA ≥30 minutes, ≥5 days/week is associated with significantly lower health care spending and resource utilization among individuals with and without established CVD.
Source: JAHA:Journal of the American Heart Association - September 7, 2016 Category: Cardiology Authors: Valero-Elizondo, J., Salami, J. A., Osondu, C. U., Ogunmoroti, O., Arrieta, A., Spatz, E. S., Younus, A., Rana, J. S., Virani, S. S., Blankstein, R., Blaha, M. J., Veledar, E., Nasir, K. Tags: Cardiovascular Disease, Exercise, Lifestyle, Risk Factors Original Research Source Type: research

Late-Onset Asthma Predicts Cardiovascular Disease Events: The Wisconsin Sleep Cohort Epidemiology
BackgroundAsthma is a heterogeneous syndrome with different clinical subtypes that is associated with an increased risk for cardiovascular disease (CVD). We hypothesized that the late‐onset subtype of asthma is associated with a higher risk of incident CVD.Methods and ResultsParticipants from the Wisconsin Sleep Cohort free of CVD at baseline were followed for a mean (SD) of 13.9 (5.9) years for development of CVD (myocardial infarction, angina, stroke, coronary revascularization, heart failure, or CVD death). Late‐onset asthma was defined as physician‐diagnosed asthma at age ≥18 years. Multivariable Cox regressio...
Source: JAHA:Journal of the American Heart Association - August 24, 2016 Category: Cardiology Authors: Tattersall, M. C., Barnet, J. H., Korcarz, C. E., Hagen, E. W., Peppard, P. E., Stein, J. H. Tags: Cardiovascular Disease, Epidemiology Original Research Source Type: research

Obesity and Subtypes of Incident Cardiovascular Disease Epidemiology
Conclusions The link between obesity and HF was stronger than those for other CVD subtypes and was uniquely unexplained by traditional risk factors. Weight management is likely critical for optimal HF prevention, and nontraditional pathways linking obesity to HF need to be elucidated.
Source: JAHA:Journal of the American Heart Association - July 28, 2016 Category: Cardiology Authors: Ndumele, C. E., Matsushita, K., Lazo, M., Bello, N., Blumenthal, R. S., Gerstenblith, G., Nambi, V., Ballantyne, C. M., Solomon, S. D., Selvin, E., Folsom, A. R., Coresh, J. Tags: Cardiovascular Disease, Epidemiology, Obesity Source Type: research

Nocturnal Hypoxemia Due to Obstructive Sleep Apnea Is an Independent Predictor of Poor Prognosis After Myocardial Infarction Coronary Heart Disease
ConclusionsNocturnal hypoxemia in OSA is an important predictor of poor prognosis for patients after MI. These findings suggest that routine use of low‐cost nocturnal oximetry may be an economical and practical approach to stratify risk in post‐MI patients.
Source: JAHA:Journal of the American Heart Association - July 27, 2016 Category: Cardiology Authors: Xie, J., Sert Kuniyoshi, F. H., Covassin, N., Singh, P., Gami, A. S., Wang, S., Chahal, C. A. A., Wei, Y., Somers, V. K. Tags: Risk Factors, Acute Coronary Syndromes Original Research Source Type: research

Stability of High-Quality Warfarin Anticoagulation in a Community-Based Atrial Fibrillation Cohort: The Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study Epidemiology
Conclusions Nearly 60% of AF patients with high-quality TTR1 on warfarin maintained TTR ≥70% over the next 6 months. A minority deteriorated to very poor TTR. Patient features did not strongly predict TTR in the second 6-month period. Our analyses support watchful waiting for AF patients with initial high-quality warfarin anticoagulation before considering alternative anticoagulants.
Source: JAHA:Journal of the American Heart Association - July 22, 2016 Category: Cardiology Authors: Dallalzadeh, L. O., Go, A. S., Chang, Y., Borowsky, L. H., Fang, M. C., Singer, D. E. Tags: Atrial Fibrillation, Epidemiology, Primary Prevention, Anticoagulants Source Type: research

Ischemic Stroke Risk After Acute Coronary Syndrome Stroke
Conclusions Non-STEMI and STEMI confer an equally increased risk of IS. Studies exploring IS mechanisms in cardiac patients are needed to improve and tailor stroke prevention strategies.
Source: JAHA:Journal of the American Heart Association - July 13, 2016 Category: Cardiology Authors: Yaghi, S., Pilot, M., Song, C., Blum, C. A., Yakhkind, A., Silver, B., Furie, K. L., Elkind, M. S. V., Sherzai, D., Sherzai, A. Z. Tags: Cerebrovascular Disease/Stroke, Acute Coronary Syndromes Source Type: research

Advanced Left Atrial Remodeling and Appendage Contractile Dysfunction in Women Than in Men Among the Patients With Atrial Fibrillation: Potential Mechanism for Stroke Arrhythmia and Electrophysiology
Conclusions More-extensive LA remodeling and deterioration in LAA function were noted in women than in men with high calculated risk of stroke in AF.
Source: JAHA:Journal of the American Heart Association - July 11, 2016 Category: Cardiology Authors: Yu, H. T., Lee, J. S., Kim, T.-H., Uhm, J.-S., Joung, B., Hong, G.-R., Lee, M.-H., Shim, C. Y., Pak, H.-N. Tags: Atrial Fibrillation Arrhythmia and Electrophysiology Source Type: research

Atrial Fibrillation Patients Treated With Long-Term Warfarin Anticoagulation Have Higher Rates of All Dementia Types Compared With Patients Receiving Long-Term Warfarin for Other Indications Cardiovascular Surgery
Conclusions The presence of AF significantly increases risk of dementia, including Alzheimer's disease, compared with matched patients receiving warfarin anticoagulation for other reasons. Quality of anticoagulation management remains an important risk factor for dementia in all patients.
Source: JAHA:Journal of the American Heart Association - July 11, 2016 Category: Cardiology Authors: Bunch, T. J., May, H. T., Bair, T. L., Crandall, B. G., Cutler, M. J., Day, J. D., Jacobs, V., Mallender, C., Osborn, J. S., Stevens, S. M., Weiss, J. P., Woller, S. C. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation Cardiovascular Surgery Source Type: research

Advanced Left Atrial Remodeling and Appendage Contractile Dysfunction in Women Than in Men Among the Patients With Atrial Fibrillation: Potential Mechanism for Stroke Arrhythmia and Electrophysiology
BackgroundThe risk of stroke imposed by atrial fibrillation (AF) is significantly greater in women than men; however, the mechanism remains elusive. We hypothesized that left atrial (LA) remodeling and poor contractile function of LA appendage (LAA) would be more predominant in women than men among AF patients.Methods and ResultsA total of 579 AF patients (216 women vs age‐, AF type–, and incidences of heart failure, hypertension, diabetes mellitus, stroke or transient ischemic attack, and vascular disease–matched 363 men, 61.3±10.2 years old, 70.1% paroxysmal AF) who underwent AF catheter ablation were included. S...
Source: JAHA:Journal of the American Heart Association - July 11, 2016 Category: Cardiology Authors: Yu, H. T., Lee, J. S., Kim, T.-H., Uhm, J.-S., Joung, B., Hong, G.-R., Lee, M.-H., Shim, C. Y., Pak, H.-N. Tags: Atrial Fibrillation Original Research Source Type: research

Atrial Fibrillation Patients Treated With Long-Term Warfarin Anticoagulation Have Higher Rates of All Dementia Types Compared With Patients Receiving Long-Term Warfarin for Other Indications Cardiovascular Surgery
BackgroundThe mechanisms behind the association of atrial fibrillation (AF) and dementia are unknown. We previously found a significantly increased risk of dementia in AF patients taking warfarin with a low percentage of time in therapeutic range. The purpose of this study was to determine the extent to which AF itself increases dementia risk, in addition to long‐term anticoagulation exposure.Methods and ResultsA total of 10 537 patients anticoagulated with warfarin (target INR 2–3), managed by the Clinical Pharmacist Anticoagulation Service with no history of dementia were included. Warfarin indication was for AF (n=...
Source: JAHA:Journal of the American Heart Association - July 11, 2016 Category: Cardiology Authors: Bunch, T. J., May, H. T., Bair, T. L., Crandall, B. G., Cutler, M. J., Day, J. D., Jacobs, V., Mallender, C., Osborn, J. S., Stevens, S. M., Weiss, J. P., Woller, S. C. Tags: Arrhythmias, Electrophysiology, Atrial Fibrillation Original Research Source Type: research

Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease Coronary Heart Disease
Conclusions Although high Lp-PLA2 activity was associated with increased risk of cardiovascular events, pharmacological lowering of Lp-PLA2 activity by 65% did not significantly reduce cardiovascular events in patients with stable coronary heart disease, regardless of the baseline level or the magnitude of change of Lp-PLA2 activity. Clinical Trial Registration URL: https://www.clinicaltrials.gov. Unique identifier: NCT00799903.
Source: JAHA:Journal of the American Heart Association - June 21, 2016 Category: Cardiology Authors: Wallentin, L., Held, C., Armstrong, P. W., Cannon, C. P., Davies, R. Y., Granger, C. B., Hagström, E., Harrington, R. A., Hochman, J. S., Koenig, W., Krug-Gourley, S., Mohler, E. R., Siegbahn, A., Tarka, E., Steg, P. G., Stewart, R. A. H., Weiss, Tags: Biomarkers, Risk Factors, Pharmacology, Treatment, Coronary Artery Disease Coronary Heart Disease Source Type: research

Impact of Sleep-Disordered Breathing on Long-Term Outcomes in Patients With Acute Coronary Syndrome Who Have Undergone Primary Percutaneous Coronary Intervention Coronary Heart Disease
Conclusions The study's results showed that the presence of SDB among patients with acute coronary syndrome following primary percutaneous coronary intervention is associated with a higher incidence of major adverse cardiocerebrovascular events during long-term follow-up.
Source: JAHA:Journal of the American Heart Association - June 15, 2016 Category: Cardiology Authors: Mazaki, T., Kasai, T., Yokoi, H., Kuramitsu, S., Yamaji, K., Morinaga, T., Masuda, H., Shirai, S., Ando, K. Tags: Risk Factors, Quality and Outcomes, Acute Coronary Syndromes Coronary Heart Disease Source Type: research

Circulating Levels of IL-6 Receptor and gp130 and Long-Term Clinical Outcomes in ST-Elevation Myocardial Infarction Coronary Heart Disease
Conclusion High levels of sIL-6R were associated with future cardiovascular events and mortality in STEMI patients, suggesting an important role of the IL-6 signaling system.
Source: JAHA:Journal of the American Heart Association - June 13, 2016 Category: Cardiology Authors: Ritschel, V. N., Seljeflot, I., Arnesen, H., Halvorsen, S., Eritsland, J., Fagerland, M. W., Andersen, G. O. Tags: Biomarkers, Inflammation, Ischemia Coronary Heart Disease Source Type: research

Association of Thoracic Aorta Calcium Score With Exercise Blood Pressure Response and Clinical Outcomes in Elderly Individuals: Differential Impact of Aorta Calcification Compared With Coronary Artery Calcification Preventive Cardiology
Conclusions Aortic calcification was related to SBP response during exercise and was an independent predictor for outcomes, especially stroke, regardless of resting SBP or CACS.
Source: JAHA:Journal of the American Heart Association - April 22, 2016 Category: Cardiology Authors: Cho, I.-J., Chang, H.-J., Cho, I., Heo, R., Lee, S.-E., Shim, C. Y., Hong, G.-R., Chung, N. Tags: Computerized Tomography (CT) Preventive Cardiology Source Type: research

Comparative Effectiveness of Generic Atorvastatin and Lipitor(R) in Patients Hospitalized with an Acute Coronary Syndrome Health Services and Outcomes Research
Conclusions Among older adults discharged alive after ACS hospitalization, we found no significant difference in cardiovascular outcomes or serious, infrequent side effects in patients prescribed generic atorvastatin compared with those prescribed Lipitor® at 1 year. Our findings support the use of generic atorvastatin in ACS, which could lead to substantial cost saving for patients and health care plans without diminishing population clinical effectiveness.
Source: JAHA:Journal of the American Heart Association - April 19, 2016 Category: Cardiology Authors: Jackevicius, C. A., Tu, J. V., Krumholz, H. M., Austin, P. C., Ross, J. S., Stukel, T. A., Koh, M., Chong, A., Ko, D. T. Tags: Atrial Fibrillation, Quality and Outcomes Health Services and Outcomes Research Source Type: research

Validated Risk Score for Predicting 6-Month Mortality in Infective Endocarditis Valvular Heart Disease
Conclusions Six-month mortality after IE is 25% and is predicted by host factors, IE characteristics, and IE complications. Surgery during the index hospitalization is associated with lower mortality but is performed less frequently in the highest risk patients. A simplified risk model may be used to identify specific risk subgroups in IE.
Source: JAHA:Journal of the American Heart Association - April 18, 2016 Category: Cardiology Authors: Park, L. P., Chu, V. H., Peterson, G., Skoutelis, A., Lejko-Zupa, T., Bouza, E., Tattevin, P., Habib, G., Tan, R., Gonzalez, J., Altclas, J., Edathodu, J., Fortes, C. Q., Siciliano, R. F., Pachirat, O., Kanj, S., Wang, A., for the International Collaborat Tags: Clinical Studies, Infectious Endocarditis, Valvular Heart Disease, Mortality/Survival Source Type: research

Off-Hour Admission and Mortality Risk for 28 Specific Diseases: A Systematic Review and Meta-Analysis of 251 Cohorts Epidemiology
Conclusions Off-hour admission is associated with increased mortality risk, and the associations varied substantially for different diseases. Specialists, nurses, as well as hospital administrators and health policymakers can take these findings into consideration to improve the quality and continuity of medical services.
Source: JAHA:Journal of the American Heart Association - March 18, 2016 Category: Cardiology Authors: Zhou, Y., Li, W., Herath, C., Xia, J., Hu, B., Song, F., Cao, S., Lu, Z. Tags: Epidemiology, Risk Factors, Health Services, Meta Analysis, Mortality/Survival Source Type: research

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF Arrhythmia and Electrophysiology
Conclusions In a large population of patients anticoagulated for nonvalvular atrial fibrillation, 7 in 10 deaths were cardiovascular, whereas <1 in 10 deaths were caused by nonhemorrhagic stroke or systemic embolism. Optimal prevention and treatment of heart failure, renal impairment, chronic obstructive pulmonary disease, and diabetes may improve survival. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00403767.
Source: JAHA:Journal of the American Heart Association - March 8, 2016 Category: Cardiology Authors: Pokorney, S. D., Piccini, J. P., Stevens, S. R., Patel, M. R., Pieper, K. S., Halperin, J. L., Breithardt, G., Singer, D. E., Hankey, G. J., Hacke, W., Becker, R. C., Berkowitz, S. D., Nessel, C. C., Mahaffey, K. W., Fox, K. A. A., Califf, R. M., for the Tags: Atrial Fibrillation, Sudden Cardiac Death, Heart Failure, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

Ischemic Stroke in Children and Young Adults With Congenital Heart Disease Congenital Heart Disease
Conclusions The risk of developing ischemic stroke was almost 11 times higher in young patients with CHD than in the general population, although absolute risk is low. Cardiovascular comorbidities were strongly associated with the development of ischemic stroke in young CHD patients.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Mandalenakis, Z., Rosengren, A., Lappas, G., Eriksson, P., Hansson, P.-O., Dellborg, M. Tags: Epidemiology, Congenital Heart Disease, Ischemic Stroke Source Type: research

Effect of Adherence to Oral Anticoagulants on Risk of Stroke and Major Bleeding Among Patients With Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusions Adherence to anticoagulation is poor in practice and may be modestly improved with NOACs. Adherence to therapy appears to be most important in patients with CHA2DS2-VASc score ≥2, whereas the benefits of anticoagulation may not outweigh the harms in patients with CHA2DS2-VASc score 0 or 1.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Yao, X., Abraham, N. S., Alexander, G. C., Crown, W., Montori, V. M., Sangaralingham, L. R., Gersh, B. J., Shah, N. D., Noseworthy, P. A. Tags: Arrhythmias, Atrial Fibrillation, Secondary Prevention, Intracranial Hemorrhage, Ischemic Stroke Arrhythmia and Electrophysiology Source Type: research

Impact of an Emergency Department Observation Unit Management Algorithm for Atrial Fibrillation Arrhythmia and Electrophysiology
Conclusions Implementation of an emergency department observation unit AF algorithm was associated with significantly decreased hospital admissions without increasing the rates of return emergency department visits, hospitalization, or adverse events within 30 days.
Source: JAHA:Journal of the American Heart Association - February 8, 2016 Category: Cardiology Authors: Bellew, S. D., Bremer, M. L., Kopecky, S. L., Lohse, C. M., Munger, T. M., Robelia, P. M., Smars, P. A. Tags: Arrhythmias, Atrial Fibrillation, Cost-Effectiveness, Quality and Outcomes Arrhythmia and Electrophysiology Source Type: research

Reducing the Blood Pressure-Related Burden of Cardiovascular Disease: Impact of Achievable Improvements in Blood Pressure Prevention and Control Epidemiology
Conclusions Modest population-wide shifts in systolic blood pressure could have a substantial impact on cardiovascular disease incidence and should be developed in parallel with interventions targeting populations with blood pressure above goal.
Source: JAHA:Journal of the American Heart Association - October 27, 2015 Category: Cardiology Authors: Hardy, S. T., Loehr, L. R., Butler, K. R., Chakladar, S., Chang, P. P., Folsom, A. R., Heiss, G., MacLehose, R. F., Matsushita, K., Avery, C. L. Tags: Epidemiology Source Type: research

Long-Term Prognostic Risk in Lower Extremity Peripheral Arterial Disease as a Function of the Number of Peripheral Arterial Lesions Health Services and Outcomes Research
Conclusions Among PAD patients, a greater number of lesions is associated with an increased risk of an adverse prognosis over 3 years of follow-up. Assessing the number of lower extremity lesions might serve as a simple risk-stratification tool at initial PAD diagnosis.
Source: JAHA:Journal of the American Heart Association - October 26, 2015 Category: Cardiology Authors: Smolderen, K. G., van Zitteren, M., Jones, P. G., Spertus, J. A., Heyligers, J. M., Nooren, M. J., Vriens, P. W., Denollet, J. Tags: Health Services and Outcomes Research Source Type: research

Left Ventricular Structure and Risk of Cardiovascular Events: A Framingham Heart Study Cardiac Magnetic Resonance Study Epidemiology
Conclusions Among adults free of prevalent CVD in the community, greater LVMI and LV concentric hypertrophy are associated with a marked increase in adverse incident CVD events. The potential benefit of aggressive primary prevention to modify LV mass and geometry in these adults requires further investigation.
Source: JAHA:Journal of the American Heart Association - September 15, 2015 Category: Cardiology Authors: Tsao, C. W., Gona, P. N., Salton, C. J., Chuang, M. L., Levy, D., Manning, W. J., O'Donnell, C. J. Tags: Epidemiology Source Type: research

Effects of Cardiac Resynchronization Therapy on Cardiac Remodeling and Contractile Function: Results From Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) Heart Failure
Conclusion In patients with NYHA Class I/II heart failure, cardiac resynchronization therapy exerts favorable changes in left ventricular end-systolic and end-diastolic volumes and the volume intercept. The volume intercept may be useful to gain insight into prognosis in heart failure. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT00271154.
Source: JAHA:Journal of the American Heart Association - September 11, 2015 Category: Cardiology Authors: St. John Sutton, M., Cerkvenik, J., Borlaug, B. A., Daubert, C., Gold, M. R., Ghio, S., Chirinos, J. A., Linde, C., Ky, B. Tags: Heart Failure Source Type: research

Individual and Combined Risk Factors for Incident Atrial Fibrillation and Incident Stroke: An Analysis of 3 Million At-Risk US Patients Arrhythmia and Electrophysiology
Conclusions Adults with combinations of known risk factors are at increased risk of incident AF and stroke, but combinations of risk factors are not always additive.
Source: JAHA:Journal of the American Heart Association - July 23, 2015 Category: Cardiology Authors: Chyou, J. Y., Hunter, T. D., Mollenkopf, S. A., Turakhia, M. P., Reynolds, M. R. Tags: Arrhythmia and Electrophysiology Source Type: research

Increased Stiffness Is the Major Early Abnormality in a Pig Model of Severe Aortic Stenosis and Predisposes to Congestive Heart Failure in the Absence of Systolic Dysfunction Heart Failure
Conclusion Increased stiffness is the major early pathological process that predisposes to congestive heart failure without abnormalities in systolic function and relaxation in a clinically relevant animal model of aortic stenosis.
Source: JAHA:Journal of the American Heart Association - May 20, 2015 Category: Cardiology Authors: Ishikawa, K., Aguero, J., Oh, J. G., Hammoudi, N., A. Fish, L., Leonardson, L., Picatoste, B., Santos-Gallego, C. G., M. Fish, K., Hajjar, R. J. Tags: Heart Failure Source Type: research

Patient Outcomes According to Adherence to Treatment Guidelines for Rhythm Control of Atrial Fibrillation Coronary Heart Disease
Conclusions Adherence to published guidelines in the antiarrhythmic management of AF is associated with improved patient outcomes.
Source: JAHA:Journal of the American Heart Association - April 6, 2015 Category: Cardiology Authors: Qin, D., Leef, G., Alam, M. B., Rattan, R., Munir, M. B., Patel, D., Khattak, F., Vaghasia, N., Adelstein, E., Jain, S. K., Saba, S. Tags: Coronary Heart Disease Source Type: research

Clinical Prediction Model Suitable for Assessing Hospital Quality for Patients Undergoing Carotid Endarterectomy Stroke
Conclusions The NCDR CEA score, comprising 7 clinical variables, predicts in-hospital stroke or death after CEA. This model can be used to estimate hospital risk-adjusted outcomes for CEA and to assist with the assessment of hospital quality.
Source: JAHA:Journal of the American Heart Association - June 17, 2014 Category: Cardiology Authors: Wimmer, N. J., Spertus, J. A., Kennedy, K. F., Anderson, H. V., Curtis, J. P., Weintraub, W. S., Singh, M., Rumsfeld, J. S., Masoudi, F. A., Yeh, R. W. Tags: Stroke Source Type: research

Atrial Fibrillation, Stroke, and Anticoagulation in Medicare Beneficiaries: Trends by Age, Sex, and Race, 1992-2010 Stroke
Conclusions Ischemic stroke rates among Medicare AF patients decreased significantly in all demographic subpopulations from 1992–2010, coincident with increasing warfarin use. Ischemic stroke rates remained higher and warfarin use rates remained lower for women and blacks with AF, groups whose baseline CHADS scores were higher.
Source: JAHA:Journal of the American Heart Association - June 3, 2014 Category: Cardiology Authors: Shroff, G. R., Solid, C. A., Herzog, C. A. Tags: Stroke Source Type: research