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Source: Hypertension

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Total 211 results found since Jan 2013.

Effect of Adherence to Antihypertensive Medication on the Long-Term Outcome After Hemorrhagic Stroke in KoreaNovelty and Significance Hemorrhagic Stroke
Hypertension is the single most important risk factor for hemorrhagic stroke, a leading cause of mortality and disability worldwide. Adherence to antihypertensive medication is essential to achieving strict blood pressure control, but poor adherence is common in clinical practice. We evaluated adherence to antihypertensive medication in patients with acute hemorrhagic stroke and its effects on long-term outcome. This was a retrospective cohort study based on a nationwide health insurance claims database in South Korea. We included 1872 hypertensive patients who were admitted with acute hemorrhagic stroke during 2002 to 201...
Source: Hypertension - July 11, 2018 Category: Cardiology Authors: Jinkwon Kim, Cheryl D. Bushnell, Hye Sun Lee, Sang Won Han Tags: Secondary Prevention, Hypertension, Compliance/Adherence, Intracranial Hemorrhage Original Articles Source Type: research

Common Carotid Artery Diameter and Risk of Cardiovascular Events and MortalityNovelty and Significance Epidemiology/Population
Carotid arterial diameter enlargement is a manifestation of arterial remodeling and may be a risk factor for cardiovascular disease (CVD). We evaluated the association between carotid artery diameter and risk of stroke, coronary heart disease, CVD, and all-cause mortality and explored whether the associations could be explained by processes involved in arterial remodeling, that is, blood pressure–related media thickening, arterial stiffness, arterial wall stress, and atherosclerosis. We included 4887 participants (mean age 67±9 years; 54% women) from 4 cohort studies: Rotterdam Study, NEPHROTEST, Hoorn Study, and a stud...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Sanaz Sedaghat, Thomas T. van Sloten, Stephane Laurent, Gerard M. London, Bruno Pannier, Maryam Kavousi, Francesco Mattace–Raso, Oscar H. Franco, Pierre Boutouyrie, M. Arfan Ikram, Coen D.A. Stehouwer Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Ultrasound, Cerebrovascular Disease/Stroke Original Articles Source Type: research

Modeling Superimposed Preeclampsia Using Ang II (Angiotensin II) Infusion in Pregnant Stroke-Prone Spontaneously Hypertensive RatsNovelty and Significance Preeclampsia
Hypertensive disorders of pregnancy are the second leading cause of maternal deaths worldwide. Superimposed preeclampsia is an increasingly common problem and often associated with impaired placental perfusion. Understanding the underlying mechanisms and developing treatment options are crucial. The pregnant stroke-prone spontaneously hypertensive rat has impaired uteroplacental blood flow and abnormal uterine artery remodeling. We used Ang II (angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats to mimic the increased cardiovascular stress associated with superimposed preeclampsia and examine ...
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: Hannah L. Morgan, Elaine Butler, Shona Ritchie, Florian Herse, Ralf Dechend, Elisabeth Beattie, Martin W. McBride, Delyth Graham Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Animal Models of Human Disease, Hypertension, Preeclampsia Original Articles Source Type: research

Abstract P396: The Stroke Belt: Forged in the Heat of the Buckle? A Hypothesis Session Title: Epidemiology
The “stroke belt”(SB) in the SE USA has significantly higher stroke rates in whites (W) and African Americans (AA). HTN is the major driving force. The “Buckle” (B) of the SB, with even higher rates, lies along the costal “low country” plains of the Carolinas. Being born in the B is a powerful exposure that increases risk. Forty percent of all US slaves came thru, slaved and many died in the B of the SB. While reading the scholarly review “Slavery, Disease and Suffering in the Southern Low Country”, by Dr. Peter McCandless, (Cambridge U Press, 2011) I was stuck with the effect of the hot, humid weather with...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Clarence Grim Tags: Poster Abstract Presentations Source Type: research

Abstract P401: The Progress of Carotid Atherosclerosis is Associated With Incident Stroke and Coronary Heart Disease: The Suita Study Session Title: Epidemiology
Conclusions: The novel finding of this study is that CIMT-plaque progression could be a good predictor of new-onset CVD in a general population.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Yoshihiro Kokubo, Makoto Watanabe, Aya Higashiyama, Yoko M Nakao, Fumiaki Nakamura, Yoshihiro Miyamoto Tags: Poster Abstract Presentations Source Type: research

Abstract P444: Surveillance, Control, and Prevention Systems and Community Engagement Process of Hypertension in Singburi, Thailand Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
This study was to convert disease oriented to health promotion approach to primary health care, using “ VICHAI’s 7 Color Balls Model”, which was used for primary screening of hypertension. The target population aged 15-65 which covering more than 90% of Singburi population. The screening result was classified by types and levels of severity of hypertension (blood pressure).The 7 colors are referred to normal
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Vichai Tiienthavorn Tags: Poster Abstract Presentations Source Type: research

Abstract P451: Cerebrovasuclular Events in Patients With Primary Aldosteronism: Results of the PA Sendai Study Registry Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Background: Hyperaldosteronism is associated with the risk of cardio-and cerebrovascular events (CVE) that is independent of blood pressure levels and Primary aldosteronism (PA) display a higher risk of CVE compared with essential hypertension (EH).Objective: Our objective was to elucidate the prevalence of symptomatic stroke in PA patients and to characterize their clinical features.Design and Setting: This was a retrospective cross-sectional single center study (PA Sendai Study registry) between 2007 and 2016 in Japan.Patient: 807 patients with PA were registered and analyzed. The all patients were performed adrenal veno...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Masataka Kudo, Ryo Morimoto, Syuji Mugikura, Yuta Tezuka, Kei Omata, Mashiro Nezu, Yasuhiro Igarashi, Kazumasa Seiji, Kei Takase, Sadayoshi Ito, Fumitoshi Satoh Tags: Poster Abstract Presentations Source Type: research

Abstract P452: Evaluation of Pathological Basis of a Shrsp-based Congenic Strain Characterized by Early Stroke Occurrence Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Objectives: The stroke-prone spontaneously hypertensive rat (SHRSP) is a well-known model for essential hypertension and cerebral stroke. In the previous studies, we have identified a major blood pressure (BP) QTL on chromosome (chr) 1 of SHRSP and have explored gene(s) on the BP QTL responsible for hypertensive phenotypes of this strain through physiological analyses using reciprocal congenic strains between SHRSP and a normotensive control (Wistar-Kyoto rat, WKY). In a recent observation, we unexpectedly found that a SHRSP-based congenic strain, harboring a 0.3-Mbp fragment of the chr1 QTL, has developed stroke earlier t...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Hiroki Ohara, Davis L Ngarashi, Toru Nabika Tags: Poster Abstract Presentations Source Type: research

Abstract P454: Does Intensive Pulse Pressure control results in lower rates of cardiovascular events? An Analysis of Systolic BP Intervention Trial (SPRINT) database Session Title: Hypertension and Aging and Cerebrovascular Disease and Stroke
Conclusion: In the SPRINT database of 9347 participants, we found that higher PP conferred an increased risk for multiple adverse cardiovascular event. Our study is among the largest US studies of PP and adds further support to the prognostic utility of PP. In addition, the SPRINT database offers a contemporary analysis of the relationship between PP and DBP, which is important given that nature pathophysiology of blood pressure. Current study also strengthen the possibility that DBP
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Quan Tran Tags: Poster Abstract Presentations Source Type: research

Abstract P521: Relationship Between Carotid Arterial Elastic Properties and Central Aortic Hemodynamics in Patients with Stroke Session Title: Vascular
This study aims to investigate the association between carotid artery parameters and central aortic hemodynamics in patients with ischemic stroke.Methods: A total of 101 consecutive patients with ischemic stroke who underwent clinically indicated transesophageal echocardiography (TEE) were performed carotid ultrasonography to assess vascular elastic properties. Using velocity-vector imaging (VVI), instantaneous vessel area (cm2) and deformation as fractional area change (FAC, %) and circumferential strain (%) were obtained in both cross-sectional image of common carotid artery (CA) and descending thoracic aorta (DTA) durin...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Sung-ai Kim, Sang-Ho Jo, Kyung-Ha Park, Hyun-Sook Kim Tags: Poster Abstract Presentations Source Type: research

Abstract P257: Investigating Angiotensin II Infusion as a Model of Superimposed Preeclampsia in Pregnant Stroke Prone Spontaneously Hypertensive Rats Session Title: Onsite Poster Competition II
Background: Hypertensive disorders of pregnancy are a leading cause of maternal mortality worldwide. Chronic hypertension with superimposed preeclampsia is becoming more prevalent in modern society. Animal models are vital for understanding this condition. Our aim was to induce a preeclamptic phenotype in pregnant stroke prone spontaneously hypertensive (SHRSP) rats by angiotensin II (AngII) infusion.Methods: AngII, at a dose of 500ng/kg/min or 1000ng/kg/min, was administered by minipump in pregnant SHRSP rats from gestational day (GD)10. Cardiovascular and renal changes were monitored using radiotelemetry, echocardiograph...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Hannah L Morgan, Elaine Butler, Elisabeth Beattie, Martin W McBride, Delyth Graham Tags: Poster Abstract Presentations Source Type: research

Abstract P532: Hypertension and Gender Differences in Acute Ischemic Stroke Patients Treated With Rtpa Session Title: Genetics and Epigenetics
Conclusion: The important factor for the poorer outcome and gender differences in hypertensive patients with acute ischemic stroke is mainly due to stroke severity and thrombolysis may play a major role in neutralizing this effect.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Thomas I Nathaniel, Jordan Gainey, Leah Wormack, Chibueze Ubah, Leanne Brechtel, Amber Frazier Tags: Poster Abstract Presentations Source Type: research

Abstract P114: White Coat Effect is Common Among Stroke Survivors Session Title: Onsite Poster Competition I With Reception
Background and Purpose: Among stroke survivors, uncontrolled hypertension is a major risk factor for recurrent stroke. Blood pressure (BP) medication titration often relies on office BP measures, which may be inaccurate due to the white coat effect (WCE). We sought to determine the prevalence of the WCE in stroke survivors and to determine whether clinical and demographic factors were associated with WCE.Methods: We followed ischemic and hemorrhagic stroke and transient ischemic attack patients with prior hypertension presenting to our stroke clinic for a BP study. Sitting BP was obtained by a medical assistant using an of...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Adriana Morell, Munachi Okpala, Sean Savitz, Anjail Z Sharrief Tags: Poster Abstract Presentations Source Type: research

Abstract P119: Hypertension Trends in Florida Stroke Patients. The Florida Puerto Rico Collaboration to Reduce Stroke Disparities Session Title: Onsite Poster Competition I With Reception
Conclusions: In our large Stroke Registry we observed higher prevalence of HTN in women, blacks and AIS. We also observe a decreasing trend over the past 7 years, especially among women and minorities (blacks and Hispanics). These findings provide an opportunity to design and implement interventions to reduce disparities in HTN and improve stroke outcome.
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Marialaura Simonetto, Nirav H Shah, Kefeng Wang, Maria A Ciliberti–Vargas, Carolina Gutierrez, Chuanhui Dong, Jorge Sanchez, Dianne Foster, Jose’ G Romano, Ralp L Sacco, Tatȷana Rundek Tags: Poster Abstract Presentations Source Type: research

Vitamin D, Hypertension, and Ischemic Stroke Editorial Commentary
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Ronen Levi-Vardi, Yoram Yagil Tags: Epidemiology, Genetic, Association Studies, High Blood Pressure, Ischemic Stroke Editorial Commentaries Source Type: research

Vitamin D, Hypertension, and Ischemic Stroke in 116 655 Individuals From the General PopulationNovelty and Significance Epidemiology/Population
Observational studies indicate that low concentrations of plasma 25-hydroxyvitamin D (25(OH)D) are associated with high blood pressure, hypertension, and ischemic stroke. However, whether these associations are causal remain unknown. A total of 116 655 white individuals of Danish descent from the general population were genotyped for genetic variants in DHCR7 and CYP2R1 affecting plasma 25(OH)D concentrations; 35 517 had plasma 25(OH)D measurements. Primary outcomes were blood pressure, hypertension, and ischemic stroke. Median follow-up for incident ischemic stroke was 9.3 years (range, 1 day–33.6 years). DHCR7/CYP2R1 a...
Source: Hypertension - August 9, 2017 Category: Cardiology Authors: Shoaib Afzal, Borge G. Nordestgaard Tags: Risk Factors, Genetic, Association Studies, High Blood Pressure, Hypertension Original Articles Source Type: research

Polymerization-Incompetent Uromodulin in the Pregnant Stroke-Prone Spontaneously Hypertensive RatNovelty and Significance Uromodulin in Hypertensive Pregnancy
The kidney is centrally involved in blood pressure regulation and undergoes extensive changes during pregnancy. Hypertension during pregnancy may result in an altered urinary peptidome that could be used to indicate new targets of therapeutic or diagnostic interest. The stroke-prone spontaneously hypertensive rat (SHRSP) is a model of maternal chronic hypertension. Capillary electrophoresis-mass spectrometry was conducted to interrogate the urinary peptidome in SHRSP and the control Wistar–Kyoto strain at three time points: prepregnancy and gestational days 12 and 18. The comparison within and between the Wistar–Kyoto ...
Source: Hypertension - April 12, 2017 Category: Cardiology Authors: Sheon Mary, Heather Yvonne Small, Justyna Siwy, William Mullen, Ashok Giri, Christian Delles Tags: Animal Models of Human Disease, Proteomics, Hypertension Original Articles Source Type: research

Continuing or Temporarily Stopping Prestroke Antihypertensive Medication in Acute StrokeNovelty and Significance Stroke
Over 50% of patients are already taking blood pressure–lowering therapy on hospital admission for acute stroke. An individual patient data meta-analysis from randomized controlled trials was undertaken to determine the effect of continuation versus temporarily stopping preexisting antihypertensive medication in acute stroke. Key databases were searched for trials against the following inclusion criteria: randomized design; stroke onset ≤48 hours; investigating the effect of continuation versus stopping prestroke antihypertensive medication; and follow-up of ≥2 weeks. Two randomized controlled trials were identified a...
Source: Hypertension - April 12, 2017 Category: Cardiology Authors: Lisa J. Woodhouse, Lisa Manning, John F. Potter, Eivind Berge, Nikola Sprigg, Joanna Wardlaw, Kennedy R. Lees, Philip M. Bath, Thompson G. Robinson Tags: High Blood Pressure, Hypertension, Intracranial Hemorrhage, Ischemic Stroke Original Articles Source Type: research

Role of Tumor Necrosis Factor-{alpha} and Natural Killer Cells in Uterine Artery Function and Pregnancy Outcome in the Stroke-Prone Spontaneously Hypertensive Rat Pregnancy and Hypertension
Women with chronic hypertension are at increased risk of maternal and fetal morbidity and mortality. We have previously characterized the stroke-prone spontaneously hypertensive rat (SHRSP) as a model of deficient uterine artery function and adverse pregnancy outcome compared with the control Wistar–Kyoto. The activation of the immune system plays a role in hypertension and adverse pregnancy outcome. Therefore, we investigated the role of tumor necrosis factor-α in the SHRSP phenotype in an intervention study using etanercept (0.8 mg/kg SC) at gestational days 0, 6, 12, and 18 in pregnant SHRSP compared with ve...
Source: Hypertension - October 12, 2016 Category: Cardiology Authors: Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T. J., Graham, D., Delles, C. Tags: Animal Models of Human Disease, Basic Science Research, Inflammation, Hypertension, Preeclampsia Pregnancy and Hypertension Source Type: research

Role of Tumor Necrosis Factor-{alpha} and Natural Killer Cells in Uterine Artery Function and Pregnancy Outcome in the Stroke-Prone Spontaneously Hypertensive RatNovelty and Significance Pregnancy and Hypertension
Women with chronic hypertension are at increased risk of maternal and fetal morbidity and mortality. We have previously characterized the stroke-prone spontaneously hypertensive rat (SHRSP) as a model of deficient uterine artery function and adverse pregnancy outcome compared with the control Wistar–Kyoto. The activation of the immune system plays a role in hypertension and adverse pregnancy outcome. Therefore, we investigated the role of tumor necrosis factor-α in the SHRSP phenotype in an intervention study using etanercept (0.8 mg/kg SC) at gestational days 0, 6, 12, and 18 in pregnant SHRSP compared with vehicle-tre...
Source: Hypertension - October 12, 2016 Category: Cardiology Authors: Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T. J., Graham, D., Delles, C. Tags: Animal Models of Human Disease, Basic Science Research, Inflammation, Hypertension, Preeclampsia Original Articles Source Type: research

Independent and Joint Effect of Brachial-Ankle Pulse Wave Velocity and Blood Pressure Control on Incident Stroke in Hypertensive Adults Epidemiology/Population
This report included 3310 hypertensive adults, a subset of the China Stroke Primary Prevention Trial (CSPPT) with baseline measurements for baPWV. During a median follow-up of 4.5 years, 111 participants developed first stroke. The risk of stroke was higher among participants with baPWV in the highest quartile than among those in the lower quartiles (6.3% versus 2.4%; hazard ratio, 1.66; 95% confidence interval, 1.06–2.60). Similarly, the participants with inadequate hypertension control had a higher risk of stroke than those with adequate control (5.1% versus 1.8%; hazard ratio, 2.32; 95% confidence interval, 1.49&n...
Source: Hypertension - June 8, 2016 Category: Cardiology Authors: Song, Y., Xu, B., Xu, R., Tung, R., Frank, E., Tromble, W., Fu, T., Zhang, W., Yu, T., Zhang, C., Fan, F., Zhang, Y., Li, J., Bao, H., Cheng, X., Qin, X., Tang, G., Chen, Y., Yang, T., Sun, N., Li, X., Zhao, L., Hou, F. F., Ge, J., Dong, Q., Wang, B., Xu, Tags: Hypertension, Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research

Morning and Evening Home Blood Pressure and Risks of Incident Stroke and Coronary Artery Disease in the Japanese General Practice Population: The Japan Morning Surge-Home Blood Pressure Study Epidemiology/Population
Our aim is to determine the optimal time schedule for home blood pressure (BP) monitoring that best predicts stroke and coronary artery disease in general practice. The Japan Morning Surge-Home Blood Pressure (J-HOP) study is a nationwide practice-based study that included 4310 Japanese with a history of or risk factors for cardiovascular disease, or both (mean age, 65 years; 79% used antihypertensive medication). Home BP measures were taken twice daily (morning and evening) over 14 days at baseline. During a mean follow-up of 4 years (16 929 person-years), 74 stroke and 77 coronary artery disease events occurred. Morning ...
Source: Hypertension - June 8, 2016 Category: Cardiology Authors: Hoshide, S., Yano, Y., Haimoto, H., Yamagiwa, K., Uchiba, K., Nagasaka, S., Matsui, Y., Nakamura, A., Fukutomi, M., Eguchi, K., Ishikawa, J., Kario, K., on behalf of the J-HOP Study Group Tags: Hypertension Epidemiology/Population Source Type: research

Mid- to Late-Life Trajectories of Blood Pressure and the Risk of Stroke: The Rotterdam Study Epidemiology/Population
Hypertension is a major modifiable risk factor for stroke. Associations of blood pressure with incident stroke are mostly based on single or average blood pressure levels. However, this approach does not take into account long-term trajectories of blood pressure, which can vary considerably in the elderly. Within the population-based Rotterdam Study, we examined trajectories of systolic blood pressure in 6745 participants (60.0% women) over an age-range from 55 to 106 years and jointly modeled their risk of stroke and competing causes of death using joint latent class mixed modeling. Four trajectories were identified. Clas...
Source: Hypertension - May 11, 2016 Category: Cardiology Authors: Portegies, M. L. P., Mirza, S. S., Verlinden, V. J. A., Hofman, A., Koudstaal, P. J., Swanson, S. A., Ikram, M. A. Tags: Epidemiology, High Blood Pressure, Mortality/Survival, Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research

Medication Adherence and the Risk of Cardiovascular Mortality and Hospitalization Among Patients With Newly Prescribed Antihypertensive Medications Epidemiology/Population
This study evaluated the effect of antihypertensive medication adherence on specific cardiovascular disease mortality (ischemic heart disease [IHD], cerebral hemorrhage, and cerebral infarction). Our study used data from a 3% sample cohort that was randomly extracted from enrollees of Korean National Health Insurance. Study subjects were aged ≥20 years, were diagnosed with hypertension, and started newly prescribed antihypertensive medication in 2003 to 2004. Adherence to antihypertensive medication was estimated as the cumulative medication adherence. Subjects were divided into good (cumulative medication adherence, &g...
Source: Hypertension - February 10, 2016 Category: Cardiology Authors: Kim, S., Shin, D. W., Yun, J. M., Hwang, Y., Park, S. K., Ko, Y.-J., Cho, B. Tags: Cardiovascular Disease, Primary Prevention, Compliance/Adherence, Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research

Evidence to Maintain the Systolic Blood Pressure Treatment Threshold at 140 mm Hg for Stroke Prevention: The Northern Manhattan Study Epidemiology/Population
In 2014, the Eighth Joint National Committee revised the target maximum systolic blood pressure (SBP) from 140 to 150 mm Hg in patients aged ≥60 years without diabetes mellitus or chronic kidney disease. The evidence from cohort studies supporting this change was sparse, particularly among US minority populations. In the Northern Manhattan Study, 1750 participants aged ≥60 years and free of stroke, diabetes mellitus, and chronic kidney disease had SBP measured at baseline and were annually followed up for incident stroke. Mean age at baseline was 72±8 years, 63% were women, 48% Hispanic, 25% non-Hispanic white...
Source: Hypertension - February 10, 2016 Category: Cardiology Authors: Dong, C., Della-Morte, D., Rundek, T., Wright, C. B., Elkind, M. S. V., Sacco, R. L. Tags: Epidemiology Epidemiology/Population Source Type: research

Allopurinol and Cardiovascular Outcomes in Adults With Hypertension Epidemiology/Population
Allopurinol lowers blood pressure in adolescents and has other vasoprotective effects. Whether similar benefits occur in older individuals remains unclear. We hypothesized that allopurinol is associated with improved cardiovascular outcomes in older adults with hypertension. Data from the United Kingdom Clinical Research Practice Datalink were used. Multivariate Cox-proportional hazard models were applied to estimate hazard ratios for stroke and cardiac events (defined as myocardial infarction or acute coronary syndrome) associated with allopurinol use over a 10-year period in adults aged >65 years with hypertension. A ...
Source: Hypertension - February 10, 2016 Category: Cardiology Authors: MacIsaac, R. L., Salatzki, J., Higgins, P., Walters, M. R., Padmanabhan, S., Dominiczak, A. F., Touyz, R. M., Dawson, J. Tags: Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research

Long-Term Stroke Risk Due to Partial White-Coat or Masked Hypertension Based on Home and Ambulatory Blood Pressure Measurements: The Ohasama Study Epidemiology/Population
In conclusion, impacts of partial WCHT as well as partial masked hypertension for long-term stroke risk were comparable to those of complete masked hypertension or sustained hypertension. We need both home and 24-h ambulatory blood pressure measurements to evaluate stroke risk accurately.
Source: Hypertension - December 9, 2015 Category: Cardiology Authors: Satoh, M., Asayama, K., Kikuya, M., Inoue, R., Metoki, H., Hosaka, M., Tsubota-Utsugi, M., Obara, T., Ishiguro, A., Murakami, K., Matsuda, A., Yasui, D., Murakami, T., Mano, N., Imai, Y., Ohkubo, T. Tags: Epidemiology, Cerebrovascular Disease/Stroke Epidemiology/Population Source Type: research

Achieved Blood Pressure and Outcomes in the Secondary Prevention of Small Subcortical Strokes Trial Clinical Trial
Abstract— Studies suggest a J-shaped association between blood pressure and cardiovascular events in the setting of intensive systolic blood pressure control; whether there is a similar association with stroke remains less well established. The Secondary Prevention of Small Subcortical Strokes was a randomized trial to evaluate higher (130–149 mm Hg) versus lower (<130 mm Hg) systolic blood pressure targets in participants with recent lacunar infarcts. We evaluated the association of mean achieved blood pressure, 6 months after randomization, and recurrent stroke, major vascular events, and all-cause mortali...
Source: Hypertension - December 9, 2015 Category: Cardiology Authors: Odden, M. C., McClure, L. A., Sawaya, B. P., White, C. L., Peralta, C. A., Field, T. S., Hart, R. G., Benavente, O. R., Pergola, P. E. Tags: Clinical Studies, Cerebrovascular Disease/Stroke Clinical Trial Source Type: research

Abstract P012: Mycophenolate Mofetil Prevents Cerebrovascular Injury in Stroke-prone Spontaneously Hypertensive Rats Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
The stroke-prone spontaneously hypertensive rat strain (SHR-A3) develops hypertensive end-organ injury, including strokes and progressive kidney disease, as a result of naturally occurring genetic variations. Our recent work identifies genetic variants in immune signaling pathways that contribute to susceptibility to end organ injury. These variants are present in SHR-A3 animals, but absent in SHR lines that resist end organ injury. To test the hypothesis that a dysregulated immune response promotes stroke susceptibility, 20-week old male SHR-A3 rats were salt loaded (1% NaCl in drinking water) and treated daily with the i...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Dhande, I. S., Zhu, Y., Doris, P. A. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research

Abstract P013: Meta-analysis of Poor Outcomes and Permissive Hypertension after Acute Ischemic Stroke Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Conclusion: Use of antihypertensive therapy in acute period of ischemic stroke does not have an effect on disability or all-cause mortality.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Ivanov, A., Mohamed, A., Korniyenko, A. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research

Abstract P157: Tractography of White Matter Connections Predicts for Vascular Cognitive Impairment in Hypertensive Patients Session Title: Cerebrovascular Disease and Stroke
In this study, we used DTI and cognitive assessment (CA), in order to identify a regional pattern of fractional anisotropy (FA) changes that could predict for VCI in hypertensive patients (HT).We have examined 15 HT (moderate to severe, with antihypertensive medications) vs 15 normotensive (NT), subjecting them to DTI and CA. HT had significant higher SBP (138±4 vs 118±3 in NT) and DBP (87±2 vs 75±2 in NT) (p<0.001), displayed a significant LV hypertrophic remodeling (LVM/BSA 112±5 vs 83±3 for NT) (p<0.0001), with a significant moderate increase in albuminuria (15.7±2....
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Carnevale, L., Selvetella, G., Cugino, D., Grillea, G., Lembo, G., Carnevale, D. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research

Abstract P158: Increased Circulating Cathepsin K in Patients with Chronic Heart Failure Session Title: Cerebrovascular Disease and Stroke
Conclusions: These data indicate that elevated levels of CatK are closely associated with the presence of CHF and that the measurement of circulating CatK provides a noninvasive method of documenting and monitoring the extent of cardiac remodeling and dysfunction in patients with CHF.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Cheng, X. W., Zhao, G., Han, X., Fang, E., Li, X., Zhou, D., Jiang, H., Li, Y., Cui, L. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research

Abstract P159: Effect of Pharmacological Kinin Receptor Activation on Brain Damage and Mortality in Experimental Cerebral Ischemia in Non-diabetic and Diabetic Mice Session Title: Cerebrovascular Disease and Stroke
Brain ischemia is a major complication of arterial diseases and has a poorer prognosis in diabetic patients. As activation of the kallikrein-kinin system has been shown to enhance cardiac and renal tolerance to ischemia we tested effect of kinin receptor activation by pharmacological agonists, selective B1R or B2R, in a mouse model of transient middle cerebral artery occlusion [C57bl6 male, 10 week-old, anaesthesia, occlusion 60 min (MCAO)]. Treatment with the B1R agonist NG29 (B1Rago) or the B2R agonist NG291 (B2Rago) was started at reperfusion using osmotic micropumps. Neurological deficit (ND) was evaluated at 1 and 2 d...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Desposito, D., Taveau, C., Zadigue, G., Adam, C., Bouby, N., Alhenc-Gelas, F., Roussel, R. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research

Abstract P160: Role of Uncoupling Protein 2 in Stroke Susceptibility of Stroke-prone Spontaneously Hypertensive Rat Session Title: Cerebrovascular Disease and Stroke
Mitochondrial dysfunction causes severe cellular derangements potentially underlying tissue injury and consequent diseases. Evidence of a direct involvement of mitochondrial dysfunction in hypertensive target organ damage is still poor.The gene encoding Uncoupling Protein 2 (UCP2), a inner mitochondrial membrane protein, maps inside stroke QTL/STR1 in stroke prone spontaneously hypertensive rat (SHRSP). We explored the role of UCP2 in stroke pathogenesis of SHRSP. Male SHRSP, stroke resistant SHR (SHRSR) and reciprocal STR1/congenic rats were fed with stroke permissive Japanese style diet (JD). A group of SHRSP received JD...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Rubattu, S., Cotugno, M., Bianchi, F., Di Castro, S., Stanzione, R., Busceti, C., Marchitti, S., Nicoletti, F., Volpe, M. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research

Abstract P161: Angiotensin Receptor Blockade Decreases Glutamate-induced Brain Inflammation Session Title: Cerebrovascular Disease and Stroke
Chronic Kidney Disease (CKD) is very frequently associated with brain inflammation and cell injury leading to cognitive loss. At present a combined treatment of related kidney and brain injury has never been proposed. We focused on glutamate-induced excitotoxicity and neuronal inflammation, and on the effects of candesartan, a renoprotective Angiotensin Receptor Blocker (ARB) ameliorating hypertension and diabetes-induced kidney damage, and with accompanying neuroprotective efficacy. Primary cerebellar granule cells (CGC) were exposed to 100 μM glutamate and pre-treated for one hour with candesartan at neuroprotective c...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Saavedra, J., Elkahloun, A. G., Hafko, R. Tags: Session Title: Cerebrovascular Disease and Stroke Source Type: research

Abstract P075: Stroke Volume and Visceral Fat Drive Differences in Blood Pressure Between Two Generations: A Population-Based Study of Adolescents and Their Parents Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception
Excess total body fat (TBF) and visceral fat (VF) are major risk factors of hypertension. Blood pressure (BP) increases with age, as do TBF and VF. Here we investigated whether TBF and VF contribute to BP differences between adolescents and adults. A population-based sample of adolescents (n=933, 12-18 years) and their parents (n=429, 38-65 years) was studied as part of the Saguenay Youth Study. In all participants, beat-by-beat values of SBP, DBP and underlying hemodynamic parameters (heart rate, stroke volume [SV] and total peripheral resistance) were obtained with a Finometer during a 52-minute protocol mimicking daily ...
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Syme, C. A., Abrahamowicz, M., Leonard, G., Perron, M., Richer, L., Veillette, S., Gaudet, D., Paus, T., Pausova, Z. Tags: Session Title: Poster Session 1- Trainee Onsite Poster Competition and Reception Source Type: research

Clinical Effects of Phosphodiesterase 3A Mutations in Inherited Hypertension With Brachydactyly Genetics
Autosomal-dominant hypertension with brachydactyly is a salt-independent Mendelian syndrome caused by activating mutations in the gene encoding phosphodiesterase 3A. These mutations increase the protein kinase A–mediated phosphorylation of phosphodiesterase 3A resulting in enhanced cAMP-hydrolytic affinity and accelerated cell proliferation. The phosphorylated vasodilator-stimulated phosphoprotein is diminished, and parathyroid hormone-related peptide is dysregulated, potentially accounting for all phenotypic features. Untreated patients die prematurely of stroke; however, hypertension-induced target-organ damage is ...
Source: Hypertension - September 9, 2015 Category: Cardiology Authors: Toka, O., Tank, J., Schachterle, C., Aydin, A., Maass, P. G., Elitok, S., Bartels-Klein, E., Hollfinger, I., Lindschau, C., Mai, K., Boschmann, M., Rahn, G., Movsesian, M. A., Muller, T., Doescher, A., Gnoth, S., Muhl, A., Toka, H. R., Wefeld-Neuenfeld, Y Tags: Cerebrovascular disease/stroke, Clinical Studies Genetics Source Type: research

Ethnic Differences in Associations Between Blood Pressure and Stroke in South Asian and European Men Epidemiology/Population
We report findings from a UK cohort study of 1375 European and 1074 South Asian men, not receiving antihypertensive medication, aged 40 to 69 years at baseline (1988–1991). Assessment included BP, blood tests, anthropometry, and questionnaires. Incident stroke was established at 20 years from death certification, hospital and primary care records, and participant report. South Asians had higher systolic BP, diastolic BP, and mean arterial pressure than Europeans, and similar pulse pressure. Associations between systolic BP or diastolic BP and stroke were stronger in South Asians than Europeans, after adjustment for a...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Eastwood, S. V., Tillin, T., Chaturvedi, N., Hughes, A. D. Tags: Cerebrovascular disease/stroke, Risk Factors, Epidemiology Epidemiology/Population Source Type: research

Neuron-Specific Tumor Necrosis Factor Receptor-Associated Factor 3 Is a Central Regulator of Neuronal Death in Acute Ischemic Stroke Nervous System
Neuronal death after ischemic stroke involves multiple pathophysiological events, as well as a complex molecular mechanism. Inhibiting a single therapeutic target that is involved in several ischemic signaling cascades may be a promising strategy for stroke management. Here, we report the versatile biological roles of tumor necrosis factor receptor–associated factor 3 (TRAF3) in ischemic stroke. Using several genetically manipulated mouse strains, we also demonstrated that TRAF3 inhibition can be neuroprotective. TRAF3 expression, which is robustly induced in response to ischemia/reperfusion (I/R) injury, was detecte...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Gong, J., Li, Z.-Z., Guo, S., Zhang, X.-J., Zhang, P., Zhao, G.-N., Gao, L., Zhang, Y., Zheng, A., Zhang, X.-F., Xiang, M., Li, H. Tags: Apoptosis, Ischemic biology - basic studies, Acute Cerebral Infarction, Oxidant stress Nervous System Source Type: research

Stages in Discovery: Angiotensin-Converting Enzyme Type 2 and Stroke Editorial Commentaries
Source: Hypertension - June 10, 2015 Category: Cardiology Authors: Pena-Silva, R. A., Heistad, D. D. Tags: ACE/Angiotension receptors, Cerebrovascular disease/stroke, Other hypertension, Acute Cerebral Infarction, Neuroprotectors Editorial Commentaries Source Type: research

Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke Renin-Angiotensin System
The angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis represents a promising target for inducing stroke neuroprotection. Here, we explored stroke-induced changes in expression and activity of endogenous angiotensin-converting enzyme 2 and other system components in Sprague–Dawley rats. To evaluate the clinical feasibility of treatments that target this axis and that may act in synergy with stroke-induced changes, we also tested the neuroprotective effects of diminazene aceturate, an angiotensin-converting enzyme 2 activator, administered systemically post stroke. Among rats that underwent experimental ...
Source: Hypertension - June 10, 2015 Category: Cardiology Authors: Bennion, D. M., Haltigan, E. A., Irwin, A. J., Donnangelo, L. L., Regenhardt, R. W., Pioquinto, D. J., Purich, D. L., Sumners, C. Tags: ACE/Angiotension receptors, Animal models of human disease, Other Treatment, Acute Cerebral Infarction, Neuroprotectors Renin-Angiotensin System Source Type: research

Acetaminophen Use and Risk of Myocardial Infarction and Stroke in a Hypertensive Cohort Epidemiology/Population
Recent data suggest that self-reported acetaminophen use is associated with increased risk of cardiovascular events and that acetaminophen causes a modest blood pressure rise. There are no randomized trials or studies using verified prescription data of this relationship. We aimed to assess the relationship between verified acetaminophen prescription data and risk of myocardial infarction or stroke in patients with hypertension. We performed a retrospective data analysis using information contained within the UK Clinical Research Practice Datalink. Multivariable Cox proportional hazard models were used to estimate hazard r...
Source: Hypertension - April 8, 2015 Category: Cardiology Authors: Fulton, R. L., Walters, M. R., Morton, R., Touyz, R. M., Dominiczak, A. F., Morrison, D. S., Padmanabhan, S., Meredith, P. A., McInnes, G. T., Dawson, J. Tags: Clinical Studies Epidemiology/Population Source Type: research

Common Carotid Intima-Media Thickness Relates to Cardiovascular Events in Adults Aged
Although atherosclerosis starts in early life, evidence on risk factors and atherosclerosis in individuals aged <45 years is scarce. Therefore, we studied the relationship between risk factors, common carotid intima-media thickness (CIMT), and first-time cardiovascular events in adults aged <45 years. Our study population consisted of 3067 adults aged <45 years free from symptomatic cardiovascular disease at baseline, derived from 6 cohorts that are part of the USE-IMT initiative, an individual participant data meta-analysis of general-population–based cohort studies evaluating CIMT measurements. Information...
Source: Hypertension - March 11, 2015 Category: Cardiology Authors: Eikendal, A. L. M., Groenewegen, K. A., Anderson, T. J., Britton, A. R., Engstrom, G., Evans, G. W., de Graaf, J., Grobbee, D. E., Hedblad, B., Holewijn, S., Ikeda, A., Kitagawa, K., Kitamura, A., Lonn, E. M., Lorenz, M. W., Mathiesen, E. B., Nijpels, G., Tags: Risk Factors, Imaging, Acute myocardial infarction, Acute Stroke Syndromes, Epidemiology Epidemiology/Population Source Type: research

Epidermal Growth Factor Receptor Is Critical For Angiotensin II-Mediated Hypertrophy in Cerebral Arterioles Renin-Angiotensin System
We examined the molecular mechanism of Ang II–mediated cerebrovascular remodeling that involves the epidermal growth factor receptor (EGFR) pathway. Mutant EGFR mice (waved-2), their heterozygous control (wild-type [WT]), and C57BL/6J mice were infused with Ang II (1000 ng kg–1 min–1) or saline via osmotic minipumps for 28 days (n=8 per group). Eight of the Ang II–infused C57BL/6J mice were cotreated with AG1478 (12 mg/kg per day, IP), a specific EGFR tyrosine kinase inhibitor. Systolic arterial pressure was measured by a tail-cuff method. Pressure and diameter of cerebral arterioles were measured t...
Source: Hypertension - March 11, 2015 Category: Cardiology Authors: Chan, S.-L., Umesalma, S., Baumbach, G. L. Tags: Cerebrovascular disease/stroke, Hypertrophy, Other Vascular biology Renin-Angiotensin System Source Type: research

Prolonged Corrected QT Interval Is Predictive of Future Stroke Events Even in Subjects Without ECG-Diagnosed Left Ventricular Hypertrophy Heart
In conclusion, prolonged QTc interval was associated with stroke risk even among patients without ECG-LVH in the general population.
Source: Hypertension - February 11, 2015 Category: Cardiology Authors: Ishikawa, J., Ishikawa, S., Kario, K. Tags: Risk Factors, Hypertrophy, Electrocardiology, Epidemiology Heart Source Type: research

Cardiovascular Disease Is the Main Cause of Long-Term Excess Mortality After Ischemic Stroke in Young Adults Ischemic Stroke in Young Adults
Adults with stroke at a young age (18–50 years) remain at an increased risk of death for decades. It is unclear what cause underlies this long-term excess mortality and whether this is sex and time specific. Therefore, we investigated sex-specific temporal changes in cause of death after transient ischemic attack or ischemic stroke in young adults aged 18 to 50 years. We included all 845 consecutive 30-day survivors, of a first-ever transient ischemic attack (n=261) or ischemic stroke (n=584), admitted to our hospital between 1980 and 2010. Survival status was assessed at April 1, 2013. Observed cause-specific mortal...
Source: Hypertension - February 11, 2015 Category: Cardiology Authors: Rutten-Jacobs, L. C. A., Arntz, R. M., Maaijwee, N. A. M., Schoonderwaldt, H. C., Dorresteijn, L. D., van Dijk, E. J., de Leeuw, F.-E. Tags: Acute Cerebral Infarction Ischemic Stroke in Young Adults Source Type: research

Systolic and Diastolic Blood Pressure Changes in Relation With Myocardial Infarction and Stroke in Patients With Coronary Artery Disease Clinical Trials
In conclusion, in patients with coronary artery disease and initially free from congestive heart failure, a BP reduction from baseline over the examined BP range had little effect on the risk of MI and predicted a lower risk of stroke. An increase in systolic BP from baseline increased the risk of stroke and MI. The relationships of BP with risk were much steeper for stroke than for MI. A treatment-induced BP reduction over the explored range seems to be safe in patients with coronary artery disease. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00153101.
Source: Hypertension - December 10, 2014 Category: Cardiology Authors: Verdecchia, P., Reboldi, G., Angeli, F., Trimarco, B., Mancia, G., Pogue, J., Gao, P., Sleight, P., Teo, K., Yusuf, S. Tags: Secondary prevention, Clinical Studies, Other Stroke Treatment - Medical Clinical Trials Source Type: research

Origin of the Y Chromosome Influences Intrarenal Vascular Responsiveness to Angiotensin I and Angiotensin (1-7) in Stroke-Prone Spontaneously Hypertensive Rats Renin-Angiotensin System and Y Chromosome
This study demonstrates that the origin of the Y chromosome significantly impacts the renal vascular responsiveness and therefore may influence the long-term renal regulation of blood pressure.
Source: Hypertension - November 12, 2014 Category: Cardiology Authors: Sampson, A. K., Andrews, K. L., Graham, D., McBride, M. W., Head, G. A., Thomas, M. C., Chin-Dusting, J. P. F., Dominiczak, A. F., Jennings, G. L. Tags: Cardio-renal physiology/pathophysiology, ACE/Angiotension receptors, Animal models of human disease, Other hypertension, Functional genomics, Genetics of cardiovascular disease Renin-Angiotensin System and Y Chromosome Source Type: research

Healthy Lifestyle Factors and Risk of Cardiovascular Events and Mortality in Treatment-Resistant Hypertension: The Reasons for Geographic and Racial Differences in Stroke Study Epidemiology/Population
In conclusion, healthy lifestyle factors, particularly physical activity and nonsmoking, are associated with a lower risk for cardiovascular events and mortality among individuals with apparent treatment-resistant hypertension.
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Diaz, K. M., Booth, J. N., Calhoun, D. A., Irvin, M. R., Howard, G., Safford, M. M., Muntner, P., Shimbo, D. Tags: Other hypertension, Epidemiology Epidemiology/Population Source Type: research

Brachial-Ankle Pulse Wave Velocity Is a Strong Predictor for Mortality in Patients With Acute Stroke Epidemiology/Population
This study suggested that measurement of baPWV during the acute phase of stroke might be useful in identifying patients at a higher risk for mortality.
Source: Hypertension - July 9, 2014 Category: Cardiology Authors: Kim, J., Song, T.-J., Song, D., Lee, K. J., Kim, E. H., Lee, H. S., Nam, C. M., Nam, H. S., Kim, Y. D., Heo, J. H. Tags: Cerebrovascular disease/stroke, Pathophysiology, Other diagnostic testing, Acute Cerebral Infarction Epidemiology/Population Source Type: research