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Combined Aerobic and Resistance Training for Cardiorespiratory Fitness, Muscle Strength, and Walking Capacity after Stroke: A Systematic Review and Meta-Analysis
Cardiorespiratory fitness, measured as peak oxygen consumption, is a potent predictor of stroke risk. Muscle weakness is the most prominent impairment after stroke and is directly associated with reduced walking capacity. There is a lack of recommendations for optimal combined aerobic training and resistance training for those patients. The purpose of this study was to systematically review and quantify the effects of exercise training on cardiorespiratory fitness, muscle strength, and walking capacity after stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - November 12, 2019 Category: Neurology Authors: Junghoon Lee, Audrey J. Stone Source Type: research

Pitfall of Light Transmission Aggregometry-Based Assessment of Platelet Function in Acute Ischemic Stroke Patients
This study aimed to clarify why LTA failed to estimate platelet function in acute ischemic stroke patients. Methods: Using LTA, we evaluated the platelet aggregation abilities of citrated blood samples from 22 acute noncardiogenic ischemic stroke patients prior to treatment and compared them with those of 65 heathy volunteer controls. Platelet counts and mean platelet volumes (MPV) of citrated blood and platelet-rich plasma (PRP) prepared for LTA were evaluated simultaneously.
Source: Journal of Stroke and Cerebrovascular Diseases - November 12, 2019 Category: Neurology Authors: Eriko Sugawara, Mie Shimizu, Masahiro Yamamoto, Yosuke Kudo, Fumiaki Tanaka, Ken Johkura Source Type: research

What Proportion of Patients Admitted with Stroke or Transient Ischemic Attack May Be Suitable for Newer Cholesterol-Lowering Treatment?
Protein convertase subtilisin –kexin type 9 (PCSK9) inhibitors effectively clear low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C). We evaluated stroke admissions potentially eligible for more intensive cholesterol treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - November 12, 2019 Category: Neurology Authors: Vafa Alakbarzade, Anthony C. Pereira Source Type: research

Contrast Extravasation is Predictive of Poor Clinical Outcomes in Patients Undergoing Endovascular Therapy for Acute Ischemic Stroke in the Anterior Circulation
To investigate whether contrast extravasation on dual-energy computed tomography (DECT) in patients with acute ischemic stroke (AIS) after endovascular therapy (EVT) are related to hemorrhagic transformation (HT) and poor short-term clinical outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2019 Category: Neurology Authors: Zhongyun Chen, Yingbo Zhang, Yingying Su, Yijia Sun, Yanbo He, Hongbo Chen Source Type: research

A Case of Wallenberg's Syndrome Presenting with Spontaneous Thrombosis of a Vertebral Artery Aneurysm
Complete spontaneous thrombosis of intracranial aneurysms is uncommon. Although this type of thrombosis is largely asymptomatic, in rare cases it can be accompanied by parent artery occlusion and ischemic stroke. There are limited reports of complete thrombosis of an unruptured aneurysm of the internal carotid artery and middle cerebral artery. Furthermore, there are no reports of occlusion of the vertebral artery caused by thrombosis of an aneurysm. The mechanisms of spontaneous thrombosis are not established.
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2019 Category: Neurology Authors: Misaki Kamogawa, Takashi Koide, Ryogo Kikuchi, Akiyoshi Nakamura, Asako Tagawa, Hiromichi Miyazaki Tags: Case Report Source Type: research

Gastrodin Attenuates Neuronal Apoptosis and Neurological Deficits after Experimental Intracerebral Hemorrhage
This study investigated the effect of gastrodin on neuronal apoptosis and neurological deficits in rat ICH model. Methods: In vitro experiments were performed using hematoma lysate-induced cell damage model in primary cortical neurons. Rat ICH model was produced by a caudatum injection of collagenase.
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2019 Category: Neurology Authors: Xi-chang Liu, Chang-zhu Wu, Xiao-fei Hu, Ting-ling Wang, Xiao-ping Jin, Shao-fa Ke, En Wang, Gang Wu Source Type: research

Impaired Endothelial Function in Embolic Stroke of Undetermined Source
This study aimed to clarify the endothelial function of patients with ESUS.
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2019 Category: Neurology Authors: Yuka Shirai, Sono Toi, Utako Adachi, Kazuo Kitagawa Source Type: research

Prediction of Outcome in Embolic Strokes of Undetermined Source
Predicting outcome after stroke is a major goal and research field. The Embolic Stroke of Undetermined Source (ESUS) is a recently introduced clinical construct, and the prediction of outcome in this population has to be further explored. The aim of the study was to evaluate the prognostic validity and accuracy of the Acute Stroke Registry and Analysis of Lausanne (ASTRAL) score in patients with ESUS.
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2019 Category: Neurology Authors: Simona Lattanzi, Alessandra Pulcini, Tommaso Corradetti, Claudia Rinaldi, Maria Luisa Zedde, Giuseppe Ciliberti, Mauro Silvestrini Source Type: research

Silencing of Tenascin-C Inhibited Inflammation and Apoptosis Via PI3K/Akt/NF- κB Signaling Pathway in Subarachnoid Hemorrhage Cell Model
Tenascin-C (TNC) is upregulated in serum and cerebrospinal fluid after subarachnoid hemorrhage (SAH) and the deficiency of TNC could alleviate neuronal apoptosis and neuroinflammation after SAH. However, the specific mechanism of TNC regulating neuronal apoptosis and neuroinflammation after SAH is not well recognized. The aim of this study was to investigate whether PI3K/Akt/ NF- κB signaling pathway is involved in the regulation of TNC on early brain injury after SAH.
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2019 Category: Neurology Authors: Xiaopeng Tong, Jinjing Zhang, Miaoxin Shen, Junyang Zhang Source Type: research

An Epidemiological Model for First Stroke in Saudi Arabia
The Kingdom of Saudi Arabia has a young but ageing population, leading to concerns for planning for future growth in the number of strokes to provide necessary care. An understanding of the expected evolution of stroke incidence is therefore necessary to plan infrastructure changes. Our aim was to predict the number of first strokes occurring in Saudi Arabia over a 10-year period.
Source: Journal of Stroke and Cerebrovascular Diseases - November 6, 2019 Category: Neurology Authors: Fahmi Al-Senani, Mohamed Al-Johani, Mohammad Salawati, Adel Alhazzani, Lewis B. Morgenstern, Valeska Seguel Ravest, Matthieu Cuche, Simon Eggington Source Type: research

Medullary Compression Due to Ectatic Vertebral Artery —Case Report and Review of Literature
Medullary compression syndrome due to anomalous course of blood vessels is a rare disease most commonly seen in the adult population. The offending vessels causing this syndrome are mostly posterior inferior cerebellar artery or the vertebral artery. The symptoms of this syndrome vary from most common hypertension to various other neurologic deficits like hemiplegia, dysesthesia, and dysarthria. Intractable dizziness is a rare symptom of this disease. The definite management plan for this disease is microvascular decompression.
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2019 Category: Neurology Authors: Raja K. Kutty, Yasuhiro Yamada, Katsumi Takizawa, Yoko Kato Tags: Case Report Source Type: research

Vision, Aphasia, Neglect Assessment for Large Vessel Occlusion Stroke
Vision, Aphasia, Neglect (VAN) is a large vessel occlusion (LVO) screening tool that was initially tested in a small study where emergency department (ED) nurses were trained to perform VAN assessment on stroke code patients. We aimed to validate the VAN assessment in a larger inpatient dataset.
Source: Journal of Stroke and Cerebrovascular Diseases - November 5, 2019 Category: Neurology Authors: Digvijaya Navalkele, Farhaan Vahidy, Sarah Kendrick, Angela Traylor, Micelle Haydel, Stacy Drury, Sheryl Martin-Schild Source Type: research

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Associated With a Novel In-Frame Mutation in the NOTCH3 Gene in a Japanese Patient
Here, we report a case involving a 67-year-old Japanese woman with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) associated with a novel in-frame complex rearrangement in the NOTCH3 gene. The patient had gradually developed cognitive impairment since the occurrence of an ischemic stroke at the age of 53 years. Her mother had a history of stroke and dementia. Fluid-attenuated inversion recovery magnetic resonance imaging of the brain showed hyperintense lesions in the bilateral temporal poles, external capsules, and periventricular white matter accompanied by multiple c...
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2019 Category: Neurology Authors: Yuho Takeshi, Satoshi Suda, Takashi Shimoyama, Junya Aoki, Kentaro Suzuki, Seiji Okubo, Ikuko Mizuta, Toshiki Mizuno, Kazumi Kimura Tags: Case Report Source Type: research

Spasticity and Range of Motion Over Time in Stroke Patients Who Received Multiple-Dose Botulinum Toxin Therapy
This study examined how the effects of botulinum toxin therapy changed over time by sequential evaluation of clinical improvements in spasticity and contracture in 24 chronic-stage stroke patients on repeated botulinum toxin therapy who were receiving fewer rehabilitation interventions.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2019 Category: Neurology Authors: Takanori Ro, Tetsuo Ota, Tsukasa Saito, Ou Oikawa Source Type: research

Is Door-to-Needle Time Reduced for Emergency Medical Services Transported Stroke Patients Routed Directly to the Computed Tomography Scanner on Emergency Department Arrival?
A nationally recommended practice to accelerate thrombolytic therapy for acute ischemic stroke is to route emergency medical services (EMS)-transported stroke patients directly to the computed tomography (CT) scanner on arrival. We evaluated door-to-needle time with direct-to-CT routing versus emergency department (ED)-bed first routing.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2019 Category: Neurology Authors: Bryan Sloane, Nichole Bosson, Nerses Sanossian, Jeffrey L. Saver, Lorrie Perez, Marianne Gausche-Hill Source Type: research

Mechanical Revascularization in the Era of the Field Assessment Stroke Triage for Emergency Destination (FAST-ED): A Retrospective Cohort Assessment in a Community Stroke Practice
Endovascular mechanical revascularization has become the mainstay acute stroke management secondary to emergent large vessel occlusions. In patients who can benefit from mechanical revascularization, the ability to intervene in a timely manner directly correlates with improved outcomes. The field assessment for stroke triage (FAST-ED) prehospital triage tool, is one of many stroke severity scales designed to decrease time to diagnosis in the field and optimize patient triage to comprehensive stroke centers.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2019 Category: Neurology Authors: Kevin Carr, Yi Yang, Allison Roach, Ravishankar Shivashankar, David Pasquale, Yafell Serulle Source Type: research

Edaravone Administration Confers Neuroprotection after Experimental Intracerebral Hemorrhage in Rats via NLRP3 Suppression
Intracerebral hemorrhage (ICH) is one of the leading causes of disability and mortality in adult, which lacks effective therapies. Edaravone has showed its neuroprotective effects after ischemia stroke, but its effects and possible mechanisms after ICH are poorly understood. Here, we investigated whether edaravone confers neuroprotection after ICH in rats and explored the potential mechanisms involved.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2019 Category: Neurology Authors: Hongping Miao, Yongxiang Jiang, Junjun Geng, Bo Zhang, Gang Zhu, Jun Tang Source Type: research

Early Management of Transient Ischemic Attack in Emergency Departments in France
Emergency departments play a key role in the diagnosis and treatment of transient ischemic attacks, but limited data are available about the early management of such patients in emergency wards. Therefore, we aimed to evaluate emergency physicians ’ management of transient ischemic attack and analyze variations factors.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2019 Category: Neurology Authors: Julie Gennesseaux, Guillaume Giordano Orsini, Sophie Lefour, Serge Bakchine, Quentin Marion, Coralie Barbe, St éphane Gennai Source Type: research

Effects of Bihemispheric Transcranial Direct Current Stimulation on Upper Extremity Function in Stroke Patients: A randomized Double-Blind Sham-Controlled Study
Transcranial direct current stimulation (tDCS) is a treatment used in the rehabilitation of stroke patients aiming to improve functionality of the plegic upper extremity. Currently, tDCS is not routinely used in post stroke rehabilitation. The aim of this study was to establish the effects of bihemspheric tDCS combined with physical therapy (PT) and occupational therapy (OT) on upper extremity motor function.
Source: Journal of Stroke and Cerebrovascular Diseases - November 4, 2019 Category: Neurology Authors: Dilek Cetinkaya Alisar, Selin Ozen, Seyhan Sozay Source Type: research

The Spectrum of Nontraumatic Convexity Subarachnoid Hemorrhage
Background: Nontraumatic convexity subarachnoid hemorrhage (cSAH) is a nonaneurysmal variant that is associated with diverse etiologies. Methods: With IRB approval, we retrospectively reviewed consecutive nontraumatic cSAH from July 1, 2006 to July 1, 2016. Data were abstracted on demographics, medical history, neuroimaging, etiology, and clinical presentation. Results: We identified 94 cases of cSAH. The cases were classified according to the following etiologies: reversible cerebral vasoconstriction syndrome (RCVS) 17 (18%), cerebral amyloid angiopathy (CAA) 15 (16%), posterior reversible encephalopathy syndrome 16 (17%)...
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2019 Category: Neurology Authors: Rachel Forman, James J. Conners, Sarah Y. Song, Sayona John, Rajeev Garg, Jennifer Harris, Vivien H. Lee Source Type: research

Incidence of Unreliable Automated Computed Tomography Perfusion Maps
Despite the increasing national adoption of automated computed tomography perfusion (CTP) to select thrombectomy patients 6 hours after last known well, reliability issues have been anecdotally reported. Unreliable diagnostic tests add time and confusion to a process that requires efficiency. Our study aims to critically assess an automated CTP program in a contemporary cohort of patients presenting with large vessel occlusion (LVO) in the extended time window by evaluating the rate of unreliable automated CTP maps and whether this influences clinical outcomes.
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2019 Category: Neurology Authors: Zachary Bulwa, Hormuzdiyar Dasenbrock, Nicholas Osteraas, Laurel Cherian, R. Webster Crowley, Michael Chen Source Type: research

S-Nitrosoglutathione Mimics the Beneficial Activity of Endothelial Nitric Oxide Synthase-Derived Nitric Oxide in a Mouse Model of Stroke
Background: The nitric oxide (NO)-producing activity of endothelial nitric oxide synthase (eNOS) plays a significant role in maintaining endothelial function and protecting against the stroke injury. However, the activity of the eNOS enzyme and the metabolism of major NO metabolite S-nitrosoglutathione (GSNO) are dysregulated after stroke, causing endothelial dysfunction. We investigated whether an administration of exogenous of GSNO or enhancing the level of endogenous GSNO protects against neurovascular injury in wild-type (WT) and eNOS-null (endothelial dysfunction) mouse models of cerebral ischemia-reperfusion (IR).
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2019 Category: Neurology Authors: Mushfiquddin Khan, Tajinder S. Dhammu, Fei Qiao, Pavan Kumar, Avtar K. Singh, Inderjit Singh Source Type: research

Vision, Aphasia, Neglect Assessment to Predict Neurosurgical Intervention in Patients with Nontraumatic Intracerebral Hemorrhage
The Vision, Aphasia, and Neglect (VAN) screening tool is a simple bedside test developed to identify patients with large vessel occlusion stroke. In the setting of intracerebral hemorrhage (ICH), there are very few bedside predictors of need for neurosurgical interventions other than age and Glasgow Coma Scale (GCS). We aimed to assess the utility of the VAN screening tool in predicting the need for neurosurgical intervention in patients with ICH.
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2019 Category: Neurology Authors: Digvijaya Navalkele, Farhaan Vahidy, Sarah Kendrick, Angela Traylor, Micelle Haydel, Stacy Drury, Sheryl Martin-Schild Source Type: research

Cerebral Infarction after Transcatheter Aortic Valve Implantation in Japan: Retrospective Analysis at a Single High-Volume Center
Perioperative cerebral infarction is one of the concerning complications after transcatheter aortic valve implantation in patients with aortic stenosis. Several studies have reported on this complication; however, those included only Caucasians and analyzed a small number of cases. Here, we report on the characteristics and risk factors of symptomatic cerebral infarction after transcatheter aortic valve implantation in a single, high-volume center in Japan.
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2019 Category: Neurology Authors: Takashi Iizuka, Koichi Oki, Kentaro Hayashida, Kazushi Minami, Yoshikane Izawa, Shinichi Takahashi, Hideyuki Shimizu, Keiichi Fukuda, Jin Nakahara Source Type: research

Cerebral Small Vessel Disease Burden and All-Cause Mortality: Mayo Clinic Florida Familial Cerebrovascular Diseases Registry
Goal: Cerebral small vessel disease (CSVD) leads to cognitive decline, gait disturbances, mood changes, and an increased risk of stroke. The goal of this study is to describe the relationship between a composite radiographic CSVD score and all-cause mortality. Materials and Methods: Data were collected from a prospective registry of patients with and without cerebrovascular disease from November 2010 through April 2018. The radiographic Total CSVD Score (tSVD) ranges from 0 (minimal disease) to 4 (severe disease), based on detection of lacunar infarcts, cerebral microbleeds, perivascular spaces, and subcortical or perivent...
Source: Journal of Stroke and Cerebrovascular Diseases - October 30, 2019 Category: Neurology Authors: Eric D. Goldstein, Mohammed K. Badi, Tasneem F. Hasan, Elizabeth R. Lesser, David O. Hodge, Michelle P. Lin, James F. Meschia Source Type: research

Multicenter prospective analysis of stroke patients taking oral anticoagulants: The PASTA registry - Study design and characteristics
The management of atrial fibrillation and deep venous thrombosis has evolved with the development of direct oral anticoagulants (DOAC), and oral anticoagulant (OAC) might influence the development or clinical course in both ischemic and hemorrhagic stroke. However, detailed data on the differences between the effects of the prior prescription of warfarin and DOAC on the clinical characteristics, neuroradiologic findings, and outcome of stroke are limited.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2019 Category: Neurology Authors: Satoshi Suda, Yasuyuki Iguchi, Shigeru Fujimoto, Yoshiki Yagita, Yu Kono, Masayuki Ueda, Kenichi Todo, Tomoyuki Kono, Takayuki Mizunari, Mineo Yamazaki, Takao Kanzawa, Seiji Okubo, Kimito Kondo, Nobuhito Nakajima, Takeshi Inoue, Takeshi Iwanaga, Makoto Na Source Type: research

Life Expectancy after Stroke Based On Age, Sex, and Rankin Grade of Disability: A Synthesis
Stroke is a leading cause of death and disability in the developed world. The major factor affecting long term survival (other than age) is known to be the severity of disability. Yet to our knowledge there are no studies reporting life expectancies stratified by both age and severity. Remaining life expectancy is a key measure of health.
Source: Journal of Stroke and Cerebrovascular Diseases - October 29, 2019 Category: Neurology Authors: Robert M. Shavelle, Jordan C. Brooks, David J. Strauss, Lynne Turner-Stokes Source Type: research

Successful Cesarean Section Deliveries in a Patient with a History of Developmental Venous Anomaly-Induced Hemorrhage
While hemorrhage can occur because of developmental venous anomalies (DVAs), there is no established opinion concerning their association with pregnancy and childbirth. In the present report, we discuss the case of a now 39-year-old woman with DVA in whom pregnancy and childbirth were successful. When she was 28, she experienced disturbance of consciousness and paralysis on the left side of the body, and brain computed tomography revealed cerebral hemorrhage coupled with subarachnoid hemorrhage.
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2019 Category: Neurology Authors: Yuko Nonaka, Shoji Yasuda, Nobutoshi Kumagai, Yoshinori Kakino, Jiro Nakagawa, Katsunobu Takenaka Tags: Case Report Source Type: research

Computed Tomography Angiogram Derived From Computed Tomography Perfusion Done With Low Iodine Volume Protocol Preserves Diagnostic Yield for Middle Cerebral Artery-M2 Occlusions
In this study, we test reliability for identifying M2 occlusions on CTA derived from CTP. Methods: Through a retrospective search of the institutional thrombectomy database, we identified 28 cases with M2-MCA occlusion, of which 24 met the inclusion criteria for analysis.
Source: Journal of Stroke and Cerebrovascular Diseases - October 26, 2019 Category: Neurology Authors: Kaustubh Limaye, Adam Bryant, Girish Bathla, Biyue Dai, Sami Al Kasab, Amir Shaban, Edgar A. Samaniego, David Hasan, Bruno Policeni, Enrique Leira, Colin Derdeyn, Santiago Ortega-Gutierrez Source Type: research

Editorial Board
Source: Journal of Stroke and Cerebrovascular Diseases - October 25, 2019 Category: Neurology Source Type: research

Masthead
Source: Journal of Stroke and Cerebrovascular Diseases - October 25, 2019 Category: Neurology Source Type: research

Retraction notice to “An Open-Label Trial Comparing Alendronate and Alphacalcidol in Reducing Falls and Hip Fractures in Disabled Stroke Patients” Journal of Stroke and Cerebrovascular Diseases, Volume 20, Issue 1, January-February 2011, Pages 41-46
Available online: 3 July 2010
Source: Journal of Stroke and Cerebrovascular Diseases - October 25, 2019 Category: Neurology Authors: Yoshihiro Sato, Jun Iwamoto, Yoshiaki Honda Tags: Retraction notice Source Type: research

Table of Contents
Source: Journal of Stroke and Cerebrovascular Diseases - October 25, 2019 Category: Neurology Source Type: research

Metabolomics of Aerobic Exercise in Chronic Stroke Survivors: A Pilot Study
Understanding the metabolic response to exercise may aid in optimizing stroke management. Therefore, the purpose of this pilot study was to evaluate plasma metabolomic profiles in chronic stroke survivors following aerobic exercise training.
Source: Journal of Stroke and Cerebrovascular Diseases - October 25, 2019 Category: Neurology Authors: Monica C. Serra, Carolyn J. Accardi, Chunyu Ma, Younja Park, ViLinh Tran, Dean P. Jones, Charlene E. Hafer-Macko, Alice S. Ryan Source Type: research

Comparison of Risk Scores for the Prediction of the Overall Cardiovascular Risk in Patients with Ischemic Stroke: The Athens Stroke Registry
Stratification of overall vascular risk in patients with ischemic stroke is important as it may guide management decisions. Currently available schemes have only modest prognostic accuracy. The TRA2 °P score aids in vascular risk stratification in patients with previous myocardial infarction (MI).
Source: Journal of Stroke and Cerebrovascular Diseases - October 25, 2019 Category: Neurology Authors: Georgios Georgiopoulos, George Ntaios, Kimon Stamatelopoulos, Efstathios Manios, Eleni Korompoki, Evangelia Vemmou, Haralampos Milionis, Stefano Masi, Gregory Y.H. Lip, Konstantinos Vemmos Source Type: research

Incidence of Convexal Subarachnoid Hemorrhage in the Elderly: The Mayo Clinic Study of Aging
Nontraumatic convexal subarachnoid hemorrhages in the elderly can be a manifestation of cerebral amyloid angiopathy associated with a high risk of future intracerebral hemorrhage. The incidence in the elderly population is unknown. Our objectives were to: 1) determine the incidence of convexal subarachnoid hemorrhage in a population-based study, and, 2) to compare apopolipoprotein-E genotype and amyloid positron emission tomographic (PET) imaging for those with versus without hemorrhage.
Source: Journal of Stroke and Cerebrovascular Diseases - October 24, 2019 Category: Neurology Authors: Micah Yost, Catherine Arnold Fiebelkorn, Alejandro A. Rabinstein, James Klaas, Jeremiah A. Aakre, Robert D. Brown, Michelle M. Mielke, David S. Knopman, Val Lowe, Ronald C. Petersen, Clifford R. Jack, Prashanthi Vemuri, Jonathan Graff-Radford Source Type: research

Association Between Troponin Levels and Visceral Infarction in Patients with Acute Ischemic Stroke
Visceral infarctions appear to be more common in patients with embolic stroke subtypes, but their relation to troponin elevation remains uncertain.
Source: Journal of Stroke and Cerebrovascular Diseases - October 23, 2019 Category: Neurology Authors: Shobana Ramasamy, Praneil Patel, Ajay Gupta, Peter M. Okin, Santosh Murthy, Babak B. Navi, Hooman Kamel, Alexander E. Merkler Source Type: research

Transcranial Magnetic Stimulation-EEG Biomarkers of Poststroke Upper-Limb Motor Function
Motor evoked potentials obtained with transcranial magnetic stimulation (TMS) can provide valuable information to inform stroke neurophysiology and recovery but are difficult to obtain in all stroke survivors due to high stimulation thresholds.
Source: Journal of Stroke and Cerebrovascular Diseases - October 19, 2019 Category: Neurology Authors: Brenton Hordacre, Rukmini Ghosh, Mitchell R. Goldsworthy, Michael C. Ridding Source Type: research

Association between Angiotensin-Converting Enzyme Inhibitors and Post-Stroke Aspiration Pneumonia
This study aimed to re-evaluate the preventive effect of ACEIs on post-stroke AP, compared with that of angiotensin II receptor blockers (ARBs).
Source: Journal of Stroke and Cerebrovascular Diseases - October 18, 2019 Category: Neurology Authors: Ryosuke Kumazawa, Taisuke Jo, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga Source Type: research

Stroke Patients' Status Post-Acute Phase of Illness. How Is It and How Ought It to Be: Ain Shams University Experience
Stroke is a leading cause of disability worldwide with a great impact on quality of life. Ain Shams University Hospital is a tertiary center for neurology and a pioneer in offering comprehensive stroke service in the region.
Source: Journal of Stroke and Cerebrovascular Diseases - October 15, 2019 Category: Neurology Authors: Tamer Roushdy, Alia H. Mansour, Heba M. Khafaga, Abdulrahman Sayed, Mohamed Fathy, Salwa Eltawil, Tamer Emara Source Type: research

Risk Stratification for Endovascular Treatment in Acute Anterior Circulation Occlusive Stroke
Objective: To develop and validate a novel scoring system for risk stratification in acute anterior circulation large vessel occlusion stroke patients undergoing endovascular treatment. Methods: Subjects were included from a multicenter registry on acute ischemic stroke undergoing thrombectomy in China. Two thirds of the patients were used as the derivation group and the other one third of the patients as the validation group. Multivariable logistic regression was used to generate the scoring system.
Source: Journal of Stroke and Cerebrovascular Diseases - October 15, 2019 Category: Neurology Authors: Yunyun Xiong, Huaiming Wang, Meng Zhang, Zhiming Zhou, Wei Wang, Xinfeng Liu, Marc Fisher Source Type: research

Extreme Gradient Boosting Model Has a Better Performance in Predicting the Risk of 90-Day Readmissions in Patients with Ischaemic Stroke
Ischemic stroke readmission within 90 days of hospital discharge is an important quality of care metric. The readmission rates of ischemic stroke patients are usually higher than those of patients with other chronic diseases. Our aim was to identify the ischemic stroke readmission risk factors and establish a 90-day readmission prediction model for first-time ischemic stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - October 15, 2019 Category: Neurology Authors: Yuan Xu, Xinlei Yang, Hui Huang, Chen Peng, Yanqiu Ge, Honghu Wu, Jiajing Wang, Gang Xiong, Yingping Yi Source Type: research

Neurological Deficits in Stroke Patients that May Impede the Capacity to Provide Informed Consent for Endovascular Treatment Trials
We assessed the occurrence of neurological deficits that may impede the capacity to provide consent for trial participation in patients with an acute stroke, who are eligible for endovascular treatment (EVT).
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2019 Category: Neurology Authors: Paula M. Janssen, Vicky Chalos, Sophie A. van den Berg, Erwin J.O. Kompanje, Paul J. Nederkoorn, Bart H. van der Worp, Wim H. van Zwam, Diederik W.J. Dippel, MR CLEAN Registry Investigators Source Type: research

Stroke Mortality Rates and Trends in Romania, 1994-2017
Background and Aim: Romanian national level stroke mortality data is relatively scarce. The current study investigated stroke mortality rates and trends in Romania. Methods: All individual deaths registered in Romania during 1994-2017 were analyzed using an anonymized database, based on death certificates. Stroke crude mortality rates (CMR) and age-standardized mortality rates (ASMR) were calculated and expressed per 100,000 persons-year. Results: Between 1994 and 2017, 6,281,873 persons died in Romania, stroke being registered as the underlying cause of death in 959,319 cases.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2019 Category: Neurology Authors: Sorin Ioacara, Cristina Tiu, Cristina Panea, Horia Nicolae, Elisabeta Sava, Sorina Martin, Simona Fica Source Type: research

Alcohol Intoxication as a Stroke Mimic and the Incidence of Acute Alcohol Intoxication in Stroke
We describe alcohol intoxication as a stroke mimic and the frequency of acute alcohol intoxication among stroke patients.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2019 Category: Neurology Authors: Laurien T. Hassing, Merelijne A. Verschoof, Hille Koppen Source Type: research

Novel Definition of Stroke “Good Responders” Predicts 90-Day Outcome after Thrombolysis
Identifying predictors of good response in thrombolytic-treated stroke is important to clinical care, resource allocation, and research design. We developed a simple, novel measure of “Good Responders” to assess if 2 short-term variables could predict 90-day outcomes after thrombolysis in stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - October 14, 2019 Category: Neurology Authors: Alyssa E. Bautista, Dawn M. Meyer, Brett C. Meyer Source Type: research

A Cross-Sectional Analysis of Differences in Physical Activity Levels between Stroke Belt and Non-Stroke Belt US Adults
Background: The Stroke Belt is a region of the United States with elevated stroke incidence and prevalence of stroke risk factors. Physical inactivity is an important stroke risk factor, but little is known about whether current physical activity levels differ between Stroke Belt and non-Stroke Belt states. In this nationally representative study, we determined whether unadjusted and adjusted physical activity levels differ between the Stroke Belt region and the rest of the United States. Methods: Using 2017 Behavioral Risk Factor Surveillance System data, we conducted bivariate analyses to obtain unadjusted physical activ...
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2019 Category: Neurology Authors: Phoebe Tran, Lam Tran, Liem Tran Source Type: research

Race-Ethnic Disparities in 30-Day Readmission After Stroke Among Medicare Beneficiaries in the Florida Stroke Registry
Objective: To examine racial/ethnic disparities in 30-day all-cause readmission after stroke. Methods: Thirty-day all-cause readmission was compared by race/ethnicity among Medicare fee-for-service beneficiaries discharged for ischemic stroke from hospitals in the Florida Stroke Registry from 2010 to 2013. We fit a Cox proportional hazards model that censored for death and adjusted for age, sex, length of stay, discharge home, and comorbidities to assess racial/ethnic differences in readmission.
Source: Journal of Stroke and Cerebrovascular Diseases - October 11, 2019 Category: Neurology Authors: Hannah Gardener, Erica C. Leifheit, Judith H. Lichtman, Kefeng Wang, Yun Wang, Carolina M. Gutierrez, Maria A. Ciliberti-Vargas, Chuanhui Dong, Mary Robichaux, Jose G. Romano, Ralph L. Sacco, Tatjana Rundek, FL-PR CReSD Investigators and Collaborators Source Type: research

Embolic Stroke of Undetermined Source in Saudi Arabia: Prevalence, Patient Characteristics, and Outcomes
Background: Embolic stroke of undetermined source (ESUS) is a newly introduced clinical construct to better characterize cryptogenic stroke. It is associated with considerable morbidity and mortality and a high recurrence rate. It has not previously been investigated in Saudi stroke patients. We aimed to conduct a descriptive analysis of ESUS in Saudi Arabia, including its frequency among patients with acute stroke, characteristics, and outcomes. Methods: We reviewed all ischemic stroke patients admitted to the stroke unit at King Abdulaziz Medical City-Riyadh, Saudi Arabia, from February 2016 to July 2018.
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2019 Category: Neurology Authors: Ali M. Al Khathaami, Bayan Al Bdah, Abdulmjeed Alnosair, Rayan Alrebdi, Shorug Alwayili, Sulaiman Alhamzah, Abdulkarim Al Turki, Nasser Alotaibi Source Type: research

Even Faster Door-to-Alteplase Times and Associated Outcomes in Acute Ischemic Stroke
We report a single-center, retrospective assessment of the safety and efficacy of alteplase treatment within 45 minutes. Methods: Five hundred and eighty-six patients were treated with alteplase in our emergency departments (EDs) between January 2014 and October 2016; 368 patients were included for analysis.
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2019 Category: Neurology Authors: Sarah Jung, Jamie M. Rosini, Jason T. Nomura, Richard J. Caplan, Jonathan Raser-Schramm Source Type: research