Query: stroke

Filtered By:
Source: The American Journal of Cardiology

This page shows you your search results in order of date.

Order by Relevance | Date

Total 386 results found since Jan 2013.

Edwards SAPIEN Versus Medtronic Aortic Bioprosthesis In Women Undergoing Transcatheter Aortic Valve Implantation (From the Win-TAVI Registry)
We sought to analyze outcomes of women receiving balloon-expandable valves (BEV) or self-expanding valves (SEV) in contemporary transcatheter aortic valve implantation (TAVI). WIN TAVI (Women's INternational Transcatheter Aortic Valve Implantation) is the first all-female TAVI registry to study the safety and performance of TAVI in women. We compared women treated with BEV (n=408, 46.9%) versus those treated with SEV (n  = 461, 53.1%). The primary efficacy endpoint was the (VARC-2) composite of 1-year all-cause death, stroke, myocardial infarction, hospitalization for valve-related symptoms or heart failure or valve-related dysfunction.
Source: The American Journal of Cardiology - November 8, 2019 Category: Cardiology Authors: Cristina Giannini, Anna Sonia Petronio, Julinda Mehilli, Samantha Sartori, Jaya Chandrasekhar, Michela Faggioni, Thierry Lef èvre, Patrizia Presbitero, Piera Capranzano, Didier Tchetche, Alessandro Iadanza, Gennaro Sardella, Nicolas M. Van Mieghem, Emanu Source Type: research

Meta-Analysis Comparing Results of Transcatheter versus Surgical Aortic-Valve Replacement in Patients with Severe Aortic Stenosis
Transcatheter aortic-valve replacement (TAVR) has emerged as a promising strategy for treating patients with severe aortic stenosis. We aimed to compare TAVR with surgical aortic-valve replacement (SAVR) and determine the performance of TAVR over time and within several subgroups. We included 8 randomized trials comparing TAVR vs. SAVR. Compared with SAVR, TAVR was associated with a lower rate of all-cause mortality or disabling stroke at 30-day (odds ratio [OR], 0.72; P=0.004), 1-year (OR, 0.83; P=0.01) and 2-year (OR, 0.86; P=0.02), but not at long-term follow-up (rate ratio [RR], 1.02 [CI, 0.92 to 1.13]; P=0.67).
Source: The American Journal of Cardiology - November 7, 2019 Category: Cardiology Authors: Xinlin Zhang, Tingyu Wang, Rongfang Lan, Qing Dai, Lina Kang, Lian Wang, Yong Wang, Wei Xu, Biao Xu Source Type: research

Incidence and Outcomes of Acute Ischemic Stroke Following Percutaneous Coronary Interventions in Men Versus Women
Comparative data on the incidence and outcomes of stroke after percutaneous coronary interventions (PCI) between men and women are limited. We identified hospitalizations for PCI in the National-Inpatient-Sample between January 1st 2003 and December 31st 2016. We compared the incidence of post-PCI stroke and in-hospital complications, mortality, and cost of post-PCI strokes between men and women. Among 8,753,574 weighted hospitalizations for PCI, 49,097 (0.56%) were complicated with ischemic stroke.
Source: The American Journal of Cardiology - November 7, 2019 Category: Cardiology Authors: Mohamad Alkhouli, Fahad Alqahtani, Mohamed Farouk Elsisy, Akram Kawsara, Mirvat Alasnag Source Type: research

Detecting Atrial Fibrillation in Patients with an Embolic Stroke of Undetermined Source (From the DAF-ESUS registry)
Atrial fibrillation (AF) causes a substantial proportion of embolic strokes of undetermided source (ESUS). Effective detection of subclinical AF (SCAF) has important therapeutic implications. We conducted a prospective study to determine the prevalence of SCAF in patients with ESUS through of a 21-day Holter monitoring. In an early-monitoring group, Holter was initiated immediately after hospital discharge. The results were compared with a previous cohort of patients in whom the Holter was initiated at least one week after hospital discharge (late-monitoring group).
Source: The American Journal of Cardiology - November 6, 2019 Category: Cardiology Authors: Jos é Manuel Rubio Campal, M Araceli García Torres, Pepa Sánchez Borque, Inmaculada Navas Vinagre, Ivana Zamarbide Capdepón, Ángel Miracle Blanco, Loreto Bravo Calero, Rafael Sáez Pinel, José Tuñón Fernández, José María Serratosa Fernández Source Type: research

Safety and Efficacy of Direct Oral Anticoagulants Versus Warfarin in Patients with Chronic Kidney Disease and Atrial Fibrillation
This study evaluated and compared the safety outcomes of DOACs versus warfarin in patients with non-valvular AF and concomitant CKD. Patients in our health system with AF prescribed oral anticoagulants during 2010 to 2017 were identified. All-cause mortality, bleeding, and hemorrhagic and ischemic stroke were evaluated based on degree of renal impairment and method of anticoagulation.
Source: The American Journal of Cardiology - October 31, 2019 Category: Cardiology Authors: Amber Makani, Samir Saba, Sandeep K. Jain, Aditya Bhonsale, Michael S. Sharbaugh, Floyd Thoma, Yisi Wang, Oscar C. Marroquin, Joon S. Lee, N.A. Mark Estes, Suresh R. Mulukutla Source Type: research

Pharmacoinvasive Strategy Versus Primary Percutaneous Coronary Intervention For ST-Segment Elevation Myocardial Infarction In Patients ≥ 70 Years of Age
This study compared efficacy and safety of PI with primary percutaneous coronary intervention (pPCI). Data from 2841 patients (mean age: 78.1±5.6 years, fema le: 36.1%) included in a prospective multicenter registry, and who underwent either PI (n=269) or pPCI (n=2572), were analyzed. The primary endpoint was in-hospital major adverse cardiovascular events (MACE) defined as the composite of all-cause mortality, non-fatal MI, stroke and definite stent thr ombosis.
Source: The American Journal of Cardiology - October 11, 2019 Category: Cardiology Authors: Vincent Auffret, Cl ément Laurin, Guillaume Leurent, Romain Didier, Emmanuelle Filippi, Jean-Philippe Hacot, Amer Zabalawi, Gilles Rouault, Djamel Saouli, Philippe Druelles, Isabelle Coudert, Bertrand Boulanger, Emilie Bot, Josiane Treuil, Marc Bedossa, Source Type: research

Stroke and Systemic Embolism and other Adverse Outcomes of Heart Failure with Preserved and Reduced Ejection Fraction in Patients with Atrial Fibrillation (From the COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation CODE-AF)
It is unknown whether heart failure (HF) with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) carry a similar risk of stroke or systemic embolism (SE) and other outcomes in patients with non-valvular atrial fibrillation (AF). A prospective, multicenter outpatient registry with echocardiographic data which enrolled 10,589 patients from June 2016 to May 2019 was analyzed. In this registry, 935 (8.8%) patients had HF, and the proportions of patients with HFpEF and HFrEF were 43.2% and 56.8%, respectively.
Source: The American Journal of Cardiology - October 10, 2019 Category: Cardiology Authors: Seyong Chung, Tae-Hoon Kim, Jae-Sun Uhm, Myung-Jin Cha, Jung-Myung Lee, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jun Kim, Hyung Wook Park, Eue-Keun Choi, Jin-Bae Kim, Chang-Soo Kim, Young Soo Lee, Jaemin Shim, Boyoung Joung Source Type: research

Effectiveness of Only Aspirin or Clopidogrel Following Percutaneous Left Atrial Appendage Closure
Percutaneous left atrial appendage closure (LAAC) offers a feasible option for stroke prevention in patients with atrial fibrillation (AF), but the optimal antithrombotic treatment strategy for patients with strict contraindications to oral anticoagulation (OAC) remains uncertain. We sought to evaluate short- and long-term outcome after percutaneous LAAC in these very patients discharged on single antiplatelet therapy (SAPT) alone. All consenting AF patients who underwent LAAC from February 2009 to August 2018 in Turku University Hospital, Finland, were enrolled into a prospectively maintained registry.
Source: The American Journal of Cardiology - September 26, 2019 Category: Cardiology Authors: Jussi-Pekka Pouru, Samuli Jaakkola, Juha Lund, Fausto Biancari, Antti Saraste, K. E. Juhani Airaksinen Source Type: research

Meta-Analysis Evaluating the Safety and Efficacy of Transcarotid Transcatheter Aortic Valve Implantation
We performed a systemic review and meta-analysis of studies evaluating transcarotid vascular access for transcatheter aortic valve implantation (TAVI). Published studies evaluating transcarotid vascular access for TAVI were included in this analysis. Outcomes of interest included thirty-day mortality, stroke/TIA, new pacemaker implantation, acute kidney injury (AKI), major vascular complication, major bleeding, and myocardial infarction. Pooled estimate for 30-day mortality was 5.3% (95% CI: 4.0%-6.8%; I2=4%), stroke/TIA was 3.4% (95% CI: 2.4%-4.6%; I2=0%), new pacemaker implantation was 15.3% (95% CI: 10.8%-19.7%; I2=72%)...
Source: The American Journal of Cardiology - September 25, 2019 Category: Cardiology Authors: Muhammad Shariq Usman, Wasiq Faraz Rawasia, Tariq Jamal Siddiqi, Firzah Abdul Mujeeb, Shahrukh Nadeem, Mohamad Alkhouli Source Type: research

Atrial Septal Defect and the Risk of Ischemic Stroke in the Perioperative Period of Noncardiac Surgery
Stroke is a serious complication of non-cardiac surgery. Congenital defects of the interatrial septum may be a potent risk factor for perioperative stroke. The aim of the present study was to determine the association between atrial septal defect (ASD) or patent foramen ovale (PFO) and in-hospital perioperative ischemic stroke after non-cardiac surgery in a large nationwide cohort of patients hospitalized in the United States. Patients undergoing noncardiac surgery between 2004 and 2014 were identified using the Healthcare Cost and Utilization Project's National Inpatient Sample.
Source: The American Journal of Cardiology - July 15, 2019 Category: Cardiology Authors: Nathaniel R. Smilowitz, Varun Subashchandran, Jeffrey S. Berger Source Type: research

Usefulness of CHA2DS2-VASc Score to Predict Stroke Risk Independent of Atrial
We examined whether a CHA2DS2-VASc score predicts stroke risk among individuals without hospital-diagnosed AF and quantified the magnitude of the association in comparison to AF patients. We used data from population-based medical registries (1995 –2005) covering all Danish hospitals to identify patients diagnosed with AF (n=122,980). We matched ≤5 non-AF individuals (n=612,723) to each AF patient on the individual risk factors included in the CHA2DS2-VASc score.
Source: The American Journal of Cardiology - July 15, 2019 Category: Cardiology Authors: Anne Gulbech Ording, Erzs ébet Horváth-Puhó, Paolo Prandoni, Michelle Zippora Leisner, Dóra Körmendiné Farkas, Flemming Hald Steffensen, Morten Olsen, Henrik Toft Sørensen, Morten Schmidt Source Type: research

Usefulness of CHA2DS2-VASc Score to Predict Stroke Risk Independent of Atrial Fibrillation
We examined whether a CHA2DS2-VASc score predicts stroke risk among individuals without hospital-diagnosed AF and quantified the magnitude of the association in comparison to AF patients. We used data from population-based medical registries (1995 to 2005) covering all Danish hospitals to identify patients diagnosed with AF (n  = 122,980). We matched ≤5 non-AF individuals (n = 612,723) to each AF patient on the individual risk factors included in the CHA2DS2-VASc score.
Source: The American Journal of Cardiology - July 15, 2019 Category: Cardiology Authors: Anne Gulbech Ording, Erzs ébet Horváth-Puhó, Paolo Prandoni, Michelle Zippora Leisner, Dóra Körmendiné Farkas, Flemming Hald Steffensen, Morten Olsen, Henrik Toft Sørensen, Morten Schmidt Source Type: research

Meta-Regression to Identify Patients Deriving the Greatest Benefit from Dual Antiplatelet Therapy After Stroke or Transient Ischemic Attack Without Thrombolytic or Thrombectomy Treatment
The patient's profile drawing the greatest benefit from dual antiplatelet therapy (DAPT) after a non-cardioembolic, ischemic cerebrovascular event is not well characterized. Aim of this meta-regression analysis was to compare DAPT versus single antiplatelet therapy (SAPT) in patients with stroke or transient ischemic attack (TIA). We searched randomized trials evaluating clinical outcome with aspirin plus a P2Y12 inhibitor versus SAPT in patients with non-cardioembolic stroke or TIA. Primary endpoint was the incidence of recurrent stroke; safety outcome measure was major bleeding.
Source: The American Journal of Cardiology - May 25, 2019 Category: Cardiology Authors: Giuseppe Patti, Alessandro Sticchi, Antonio Bisignani, Francesco Pelliccia, Vincenzo Pasceri, Giulio Speciale, Maria Penco Source Type: research

Relation of Fontan Baffle Stroke Volume to Fontan Failure and Lower Exercise Capacity in Patients With an Atriopulmonary Fontan
Fontan failure remains a significant problem, especially in patients with an atriopulmonary Fontan. Fontan baffle volume change during the cardiac cycle (Fontan baffle stroke volume) may affect outcomes in Fontan circulation. Assuming that increased Fontan baffle stroke volume is associated with increased energy loss in the baffle, we hypothesized that higher baffle stroke volume is associated with worse exercise capacity and increased incidence of Fontan failure. Patients from 6 centers with an atriopulmonary or lateral tunnel Fontan operation were included if they had a cardiac magnetic resonance (CMR) study and an adequ...
Source: The American Journal of Cardiology - April 9, 2019 Category: Cardiology Authors: Tarek Alsaied, Jelle P.G. van der Ven, Saeed Juggan, Lynn A. Sleeper, Nina Azcue, Lucia J Kroft, Andrew J. Powell, Willem A. Helbing, Rahul H. Rathod Source Type: research

Comparison of Stroke Risk Stratification Scores for Atrial Fibrillation
Several stroke risk stratification scores have been developed to guide clinical decision making in patients with non valvular atrial fibrillation (AF). The aim of this study was to compare the performance of the CHADS2, CHA2DS2-VASc and R2CHADS2 risk scores to predict stroke.This retrospective cohort study was based on electronic medical records from Clalit Health Services (CHS), the largest payer provider healthcare organization in Israel. Data of CHS members with AF diagnosis between 2004- 2015 were extracted.
Source: The American Journal of Cardiology - March 13, 2019 Category: Cardiology Authors: Meytal Avgil Tsadok, Adi Berliner Senderey, Orna Reges, Morton Leibowitz, Maya Leventer-Roberts, Moshe Hoshen, Moti Haim Source Type: research

Medication-taking Behaviors and Perceptions Among Adults with Heart Failure (From the REasons for Geographic And Racial Differences in Stroke REGARDS Study)
We examined medication-taking behaviors and perceptions among individuals with HF with a particular focus on BBs. A mailed survey on medication use was administered to US adults with HF enrolled in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study.
Source: The American Journal of Cardiology - February 23, 2019 Category: Cardiology Authors: Matthew T. Mefford, Alysse Sephel, Melissa K. Van Dyke, Ligong Chen, Raegan W. Durant, Todd M. Brown, Matthew Fifolt, Juan Maya, Parag Goyal, Monika M. Safford, Emily B. Levitan Source Type: research

Thoracoscopic Left Atrial Appendage Occlusion for Stroke Prevention Compared with Long-Term Warfarin Therapy in Patients With Nonvalvular Atrial Fibrillation
In their recent paper, Fu et al. conclude that thoracoscopic left atrial appendage (LAA) occlusion is superior to warfarin for a composite outcome of stroke, systemic embolism and mortality.1 We suggest considering their results with caution.
Source: The American Journal of Cardiology - February 8, 2019 Category: Cardiology Authors: Sophie Weiwei Gao, Emilie Prudence Belley-C ôté, Kevin John Um, Richard Paul Whitlock Tags: Reader's Comments Source Type: research

Relation of Left Atrial Appendage Morphology Determined by Computed Tomography to Prior Stroke or to Increased Risk of Stroke in Patients With Atrial Fibrillation
This study aimed to assess inter-observer and intra-observer agreements in LAA morphology and its real value in stroke prediction. A total of 2264 atrial fibrillation (AF) patients who underwent computed tomography (CT) to explore the LAA anatomy were enrolled.
Source: The American Journal of Cardiology - January 23, 2019 Category: Cardiology Authors: Lingmin Wu, Erpeng Liang, Siyang Fan, Lihui Zheng, Zhongpeng Du, Shangyu Liu, Feng Hu, Xiaohan Fan, Gang Chen, Ligang Ding, Yan Yao Source Type: research

Relation of Admission Blood Pressure to In-hospital and 90-Day Outcomes in Patients Presenting with Transient Ischemic Attack
The association between admission blood pressure (BP) and outcomes in patients with transient ischemic attack (TIA) is not well defined. Patients in the United States national Get With The Guidelines-Stroke registry with a TIA were included. Admission systolic and diastolic BP was used to compute mean arterial pressure (MAP) and pulse pressure (PP). A subset of this cohort was linked to CMS claims data for post-discharge outcomes. The in-hospital outcomes of interest were: mortality, not discharged home, and inability to ambulate independently at discharge.
Source: The American Journal of Cardiology - January 10, 2019 Category: Cardiology Authors: Sripal Bangalore, Lee Schwamm, Eric E. Smith, Anne S. Hellkamp, Ying Xian, Phillip J. Schulte, Jeffrey L. Saver, Gregg C. Fonarow, Deepak L. Bhatt, for the Get With The Guidelines-Stroke Steering Committee and Investigators Source Type: research

Extremely low prevalence of Takotsubo cardiomyopathy and transient cardiac dysfunction in stroke patients with T-wave abnormalities
Stone et al. studied an important association about the presence of cerebral T-waves in 800 patients with ischemic stroke1. They demonstrated that about 17 (2.1%) patients presenting with stroke exhibited cerebral T-waves and of those, only 3 patients (18%) with T-wave abnormality have transient systolic dysfunction on echocardiography. Thus overall, only 0.0037% (3 of 800) patients developed Takotsubo cardiomyopathy (TC) in the study group of patients with stroke.1
Source: The American Journal of Cardiology - January 9, 2019 Category: Cardiology Authors: Lovely Chhabra, Nauman Khalid, Pooja Sareen Source Type: research

Meta-analysis of Stroke and Bleeding Risk in Patients with Various Atrial Fibrillation Patterns Receiving Oral Anticoagulants
Oral anticoagulation therapy (OAT) is a mainstay for stroke prevention in atrial fibrillation (AF) patients. However, whether the risks of stroke/systemic embolic events (SEE) and bleeding events are affected by the type, duration, and frequency of AF in patients receiving OAT has been previously debated. We aimed to determine the risk of stroke/SEE and bleeding events associated with paroxysmal AF compared to persistent or permanent AF among patients who received OAT. Comprehensive literature searches of the Cochrane Library, PubMed/MEDLINE, and EMBASE databases were conducted from inception to July 2018.
Source: The American Journal of Cardiology - December 19, 2018 Category: Cardiology Authors: Weifang Zhang, Youwen Xiong, Lingling Yu, Aizhen Xiong, Huihui Bao, Xiaoshu Cheng Source Type: research

Relation of Race, Apparent Disability, and Stroke Risk With Warfarin Prescribing for Atrial Fibrillation in Patients Receiving Maintenance Hemodialysis
We examined patterns of warfarin use, and associated factors, after AF diagnosis. This retrospective cohort analysis studied US Medicare patients receiving maintenance dialysis January 1, 2008-June 30, 2010. Demographics, comorbidity, and a durable medical equipment claims-based disability proxy score predicted warfarin prescription after AF diagnosis. The analysis included 8964 patients with non-valvular AF.
Source: The American Journal of Cardiology - November 24, 2018 Category: Cardiology Authors: James B. Wetmore, Yi Peng, David T. Gilbertson, Jiannong Liu Source Type: research

Relation of the CHA2DS2-VASc Score to Risk of Thrombotic and Embolic Stroke in Community-Dwelling Individuals Without Atrial Fibrillation (From The Atherosclerosis Risk in Communities ARIC Study)
Recent hospital-based cohort studies found the CHA2DS2-VASc score to be associated with ischemic stroke in individuals without atrial fibrillation (AF). Our aim was to determine the distribution of embolic and thrombotic strokes and association with the CHA2DS2-VASc score, among community-dwelling individuals without AF. We included participants from the Atherosclerosis Risk in Communities (ARIC) Study who attended visit 4 (1996-98) and had no prior AF, stroke, or anticoagulant use (n=10,671). During follow-up through 2008, incident AF cases (n=760) and participants who started warfarin were censored.
Source: The American Journal of Cardiology - November 6, 2018 Category: Cardiology Authors: Ryan J. Koene, M. Chadi Alraies, Faye L. Norby, Elsayed Z. Soliman, Ankit Maheshwari, Gregory Y.H. Lip, Alvaro Alonso, Lin Y. Chen Source Type: research

Comparison of Frequency of Ischemic Stroke in Patients With Versus Without Coronary Heart Disease and Without Atrial Fibrillation
We examined ischemic stroke risk in patients without atrial fibrillation who underwent coronary angiography between 2004 and 2012. Patients were stratified according to presence or absence of CAD and further stratified by extent of CAD (0 vessel disease [VD], 1 VD, 2 VD, 3 VD, and diffuse VD).
Source: The American Journal of Cardiology - October 30, 2018 Category: Cardiology Authors: Kevin Kris Warnakula Olesen, Kamilla Steensig, Morten Madsen, Troels Thim, Lisette Okkels Jensen, Bent Raungaard, John Eikelboom, Steen Dalby Kristensen, Hans Erik B øtker, Michael Maeng Source Type: research

Relation of CHA2DS2VASC Score with Hemorrhagic Stroke and Mortality in Patients Undergoing Fibrinolytic Therapy for ST Elevation Myocardial Infarction
Hemorrhagic stroke (HS) is a feared complication of Fibrinolytic therapy (FT). Risk assessment scores may help in risk stratification to reduce this complication. Patients (admissions) ≥18 years with a primary diagnosis of STEMI who received systemic thrombolysis were extracted from Nationwide Inpatient Sample database and stratified and compared based on CHA2DS2VASC score 0-3, 4-6 and 7-9 as low, intermediate and high risk respectively. The primary outcomes of interest were hem orrhagic stroke (HS) and mortality.
Source: The American Journal of Cardiology - October 18, 2018 Category: Cardiology Authors: Gbolahan O. Ogunbayo, Robert Pecha, Naoki Misumida, Dustin Hillerson, Ayman Elbadawi, Ahmed Abdel-latif, Claude S. Elayi, Adrian W. Messerli, Susan S. Smyth Source Type: research

Thoracoscopic Left Atrial Appendage Occlusion for Stroke Prevention Compared with Long-Term Warfarin Therapy in Patients With Nonvalvular Atrial Fibrillation
Thoracoscopic left atrial appendage (LAA) occlusion is an alternative treatment for stroke prevention in patients with atrial fibrillation. Prospective study comparing thoracoscopic LAA occlusion and warfarin therapy is still lacking. The goal of this prospective cohort study was to assess the safety and efficacy of thoracoscopic LAA occlusion for stroke prevention in patients with nonvalvular atrial fibrillation (NVAF) compared with long-term warfarin therapy. 492 NVAF Patients were enrolled. 257 patients were treated with thoracoscopic LAA occlusion and 235 with long-term warfarin therapy.
Source: The American Journal of Cardiology - September 26, 2018 Category: Cardiology Authors: Mingjie Fu, Zheng Qin, Shuai Zheng, Yueping Li, Shiwei Yang, Yingxin Zhao, Chengping Hu, Kuo Zhou, Yujie Zhou, Xu Meng Source Type: research

Comparison of the Utility of Transesophageal Echocardiography in Patients With Acute Ischemic Stroke and Transient Ischemic Attack Stratified by Age Group ( < 60, 60-80, ≥80 Years)
The objective was to study the utility of transesophageal echocardiography (TEE) in affecting acute ischemic stroke treatment of older adults (age, ≥80 years). Patients hospitalized between January 2010 and February 2015 were included who had TEE ordered as part of their diagnostic workup at a tertiary medical center. We studied 515 hospitalized patients with acute stroke or transient ischemic attack who underwent TEE. The proportion of patie nts with important TEE findings was 35%. However, TEE changed management in only 2.5% of cases.
Source: The American Journal of Cardiology - September 17, 2018 Category: Cardiology Authors: Ryan C. Van Woerkom, Steven J. Lester, Bart M. Demaerschalk, Austin J. LaBanc, Megan L. Davis, Maria F. Coakley, Stephen S. Cha, Susan Wilansky Tags: Original Article Source Type: research

Underuse of oral anticoagulants in patients with ischemic stroke and atrial fibrillation in China
Anticoagulant therapy is an effective stroke prevention measure for people with atrial fibrillation (AF) who are at high risk of ischemic stroke. However, it is reported that oral anticoagulants (OACs) are generally underused in clinical practice. A better awareness of current usage of anticoagulant therapy would enable prevention of stroke secondary to AF. Therefore, we determined the nationwide prevalence of AF and the frequency of OACs use among patients with ischemic stroke in China. Based on the China National Stroke Screening Survey (CNSSS), a representative nationwide sample of 1,252,703 adults over 40 years old dur...
Source: The American Journal of Cardiology - September 13, 2018 Category: Cardiology Authors: Jian Guo, Tianjia Guan, Siyuan Fan, Baohua Chao, Longde Wang, Yuanli Liu Source Type: research

Lifetime Pattern of Atrial Fibrillation and the Risks of Stroke and Death in a Population-based Cohort of Men (From The Manitoba Follow-Up Study)
Atrial Fibrillation (AF) is associated with stroke and mortality. The arrhythmia can be sustained or intermittent. Prior studies that have used fixed covariates and short time horizons to examine the relationship between the pattern of AF and the occurrence of events have produced conflicting results. The Manitoba Follow-Up Study includes 3983 originally healthy men who have been followed with routine examinations since 1948. AF status during each visit was classified into the following patterns: free of AF, newly-diagnosed; intermittent AF – in sinus; intermittent AF – in AF; sustained AF.
Source: The American Journal of Cardiology - August 20, 2018 Category: Cardiology Authors: William F. McIntyre, Philip D. St John, Mahmoud Torabi, Robert B. Tate Source Type: research

Meta-Analysis Comparing the Frequency of Stroke After Transcatheter Versus Surgical Aortic Valve Replacement
Stroke is one of the most feared complications of aortic valve replacement. Although the outcomes of transcatheter aortic valve implantation (TAVI) improved substantially over time, concerns remained about a potentially higher incidence of stroke with TAVI compared with surgical replacement (SAVR). However, comparative data are sparse. We performed a meta-analysis comparing the incidence of stroke among patients undergoing TAVI versus SAVR. Of the 5067 studies screened, 28 eligible studies (22 propensity-score matched studies and 6 randomized trials) were analyzed.
Source: The American Journal of Cardiology - July 5, 2018 Category: Cardiology Authors: Kuldeep Shah, Zakeih Chaker, Tatiana Busu, Vinay Badhwar, Fahad Alqahtani, Muhammad Alvi, Amelia Adcock, Mohamad Alkhouli Source Type: research

Meta-Analysis Comparing The Frequency of Stroke After Transcatheter vs. Surgical Aortic Valve Replacement
Stroke is one of the most feared complication of aortic valve replacement. Although the outcomes of transcatheter aortic valve implantation (TAVI) improved substantially overtime, concerns remained about a potentially higher incidence of stroke with TAVI compared with surgical replacement (SAVR). However, comparative data are sparse. We performed a meta-analysis comparing the incidence of stroke amongst patients undergoing TAVI versus SAVR. Of the 5067 studies screened, 28 eligible studies (22 propensity-score matched studies and 6 randomized trials) were analyzed.
Source: The American Journal of Cardiology - July 5, 2018 Category: Cardiology Authors: Kuldeep Shah, Zakeih Chaker, Tatiana Busu, Vinay Badhwar, Fahad Alqahtani, Muhammad Alvi, Amelia Adcock, Mohamad Alkhouli Source Type: research

Effect of Antiplatelet Therapy (Aspirin  + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke
The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes. We analysed prospectively collected data from the Norfolk and Norwich University Hospital Stroke Register. The sample population consisted of 3,572 participants (mean age 74.96 ± 12.67) with ischemic stroke, who were consecutively admitted between 2003 and 2015. Patients were placed on one of three antiplatelet regimens at hospital discharge; aspirin monotherapy, aspirin plus dipyridamole and clopidogrel.
Source: The American Journal of Cardiology - July 2, 2018 Category: Cardiology Authors: Raphae S. Barlas, Yoon K. Loke, Mamas A. Mamas, Joao H Bettencourt-Silva, Isobel Ford, Allan B. Clark, Kristian M. Bowles, Anthony K. Metcalf, John F. Potter, Phyo K. Myint Source Type: research

Effect of Antiplatelet Therapy (Aspirin  + Dipyridamole vs Clopidogrel) on Mortality Outcome in Ischemic Stroke
The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes. We analysed prospectively collected data from the Norfolk and Norwich University Hospital Stroke Register (NNUHSR). The sample population consisted of 3,572 participants (mean age 74.96 ± 12.67) with ischemic stroke, who were consecutively admitted between 2003-2015. Patients were placed on one of three antiplatelet regimens at hospital discharge; aspirin monotherapy, aspirin plus dipyridamole and clopidogrel.
Source: The American Journal of Cardiology - July 2, 2018 Category: Cardiology Authors: Raphae S. Barlas, Yoon K. Loke, Mamas A. Mamas, Joao H Bettencourt-Silva, Isobel Ford, Allan B. Clark, Kristian M. Bowles, Anthony K. Metcalf, John F. Potter, Phyo K. Myint Source Type: research

Willingness to be Re-initiated on a Statin (From the REasons for Geographic And Racial Differences in Stroke REGARDS Study)
Guidelines recommend attempting to re-initiate statins in patients who discontinue treatment. Prior experiences while taking a statin, including side effects, may reduce a person's willingness to re-initiate treatment. We determined the percentage of adults who are willing to re-initiate statin therapy after treatment discontinuation. Factors associated with willingness to re-initiate a statin were also examined. A statin questionnaire was administered and study examination conducted among black and white US adults enrolled in the nationwide REasons for Geographic And Racial Differences in Stroke (REGARDS) study between 2013 and 2017.
Source: The American Journal of Cardiology - June 2, 2018 Category: Cardiology Authors: Matthew T. Mefford, Gabriel S. Tajeu, Rikki M. Tanner, Lisandro D. Colantonio, Keri L. Monda, Ricardo Dent, Michael E. Farkouh, Robert S. Rosenson, Monika M. Safford, Paul Muntner Source Type: research

Willingness to be Reinitiated on a Statin (from the REasons for Geographic and Racial Differences in Stroke Study)
Guidelines recommend attempting to reinitiate statins in patients who discontinue treatment. Previous experiences while taking a statin, including side effects, may reduce a patient ’s willingness to reinitiate treatment. We determined the percentage of adults who are willing to reinitiate statin therapy after treatment discontinuation. Factors associated with willingness to reinitiate a statin were also examined. A statin questionnaire was administered and study examination conducted in black and white US adults enrolled in the nationwide REasons for Geographic And Racial Differences in Stroke study from 2013 to 2017.
Source: The American Journal of Cardiology - June 2, 2018 Category: Cardiology Authors: Matthew T. Mefford, Gabriel S. Tajeu, Rikki M. Tanner, Lisandro D. Colantonio, Keri L. Monda, Ricardo Dent, Michael E. Farkouh, Robert S. Rosenson, Monika M. Safford, Paul Muntner Source Type: research

Risk of Cardioembolic Stroke in Cancer Patients with Atrial Fibrillation
In a recent article in the journal, Elbadawi et al1 find that the risk of cerebrovascular accidents (CVA) in cancer patients with atrial fibrillation (AF) was lower than in non-cancer patients with AF. At first glance this may appear surprising in light of the higher risk of stroke of cancer patients generally2,3, particularly those with aggressive subtypes and/or metastatic disease. However, recent studies in patients with AF and cancer4,5 show no increase in stroke risk, seemingly indicating that the risk of cardioembolic stroke specifically is not higher than in cancer-free pacients.
Source: The American Journal of Cardiology - April 18, 2018 Category: Cardiology Authors: Marc Sorigue, Edurne Sarrate, Mireia Franch-Sarto, Juan-Manuel Sancho, Elisa Orna Source Type: research

Risk of Cardioembolic Stroke in Patients With Cancer and Atrial Fibrillation
In a recent article in the journal, Elbadawi et al1 find that the risk of cerebrovascular accidents (CVA) in patients with cancer and atrial fibrillation (AF) was lower than in patients with AF without cancer. At first glance, this may appear surprising in light of the higher stroke risk of patients with cancer in general,2,3 particularly those with aggressive subtypes and/or metastatic disease. However, recent studies in patients with AF and cancer4,5 show no increase in stroke risk, seemingly indicating that the risk of cardioembolic stroke specifically is not higher than in patients without cancer.
Source: The American Journal of Cardiology - April 18, 2018 Category: Cardiology Authors: Marc Sorigue, Edurne Sarrate, Mireia Franch-Sarto, Juan-Manuel Sancho, Elisa Orna Source Type: research

Risk of Cardioembolic Stroke in Cancer Patients with Atrial Fibrillation
In a recent article in the journal, Elbadawi et al1 find that the risk of cerebrovascular accidents (CVA) in cancer patients with atrial fibrillation (AF) was lower than in non-cancer patients with AF. At first glance this may appear surprising in light of the higher risk of stroke of cancer patients generally2,3, particularly those with aggressive subtypes and/or metastatic disease. However, recent studies in patients with AF and cancer4,5 show no increase in stroke risk, seemingly indicating that the risk of cardioembolic stroke specifically is not higher than in cancer-free pacients.
Source: The American Journal of Cardiology - April 18, 2018 Category: Cardiology Authors: Marc Sorigue, Edurne Sarrate, Mireia Franch-Sarto, Juan-Manuel Sancho, Elisa Orna Source Type: research

Effectiveness and Safety of Direct Oral Anticoagulants and Warfarin, Stratified by Stroke Risk in Patients With Atrial Fibrillation
The objective of the study was to examine how the comparative effectiveness and safety of direct oral anticoagulants (DOACs) and warfarin differ across subgroups of patients with atrial fibrillation defined by stroke risk (CHA2DS2-VASc score ≤3, 4 to 5, ≥6). Using Medicare claims data, we identified patients newly diagnosed with atrial fibrillation in 2013 to 2014 who initiated warfarin (n=12,354), apixaban (n=2,358), dabigatran (n=1,415), or rivaroxaban (n=5,139), and categorized them according to their CHA2DS2-VASc score (≤3, 4 to 5, ≥6).
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Inmaculada Hernandez, Yuting Zhang, Samir Saba Source Type: research

Usefulness of Proneurotensin to Predict Cardiovascular and All-Cause Mortality in a United States Population (From the REasons for Geographic and Racial Differences in Stroke Study)
Cardiovascular disease is a leading cause of death. Proneurotensin is a biomarker associated with the development of cardiovascular disease, cardiovascular mortality, and all-cause mortality. We assessed the association of fasting proneurotensin with mortal events by sex and race (black-white) in a United States (US) population. Using a case-cohort sub-population of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, fasting proneurotensin was measured on a 1046-person subcohort and 651 participants with incident coronary heart disease (CHD).
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Nicholas Wettersten, Mary Cushman, Virginia J. Howard, Oliver Hartmann, Gerasimos Filippatos, Neil Beri, Paul Clopton, George Howard, Monika M. Safford, Suzanne E. Judd, Andreas Bergmann, Joachim Struck, Alan Maisel Source Type: research

Effectiveness and Safety of Direct Oral Anticoagulants and Warfarin, Stratified by Stroke Risk in Patients with Atrial Fibrillation
The objective of the study was to examine how the comparative effectiveness and safety of direct oral anticoagulants (DOACs) and warfarin differ across subgroups of atrial fibrillation (AF) patients defined by stroke risk (CHA2DS2-VASc score ≤3, 4-5, ≥6). Using claims data from a 5% random sample of Medicare beneficiaries, we identified patients newly diagnosed with AF in 2013-2014 who initiated warfarin (n=12,354), apixaban (n=2,358), dabigatran (n=1,415) or rivaroxaban (n=5,139), and categorized them according to their CHA2DS2-VAS c score (≤3, 4-5, ≥6).
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Inmaculada Hernandez, Yuting Zhang, Samir Saba Source Type: research

Usefulness of Proneurotensin to Predict Cardiovascular and All-Cause Mortality in a United States Population (From the REasons for Geographic and Racial Differences in Stroke Study)
Cardiovascular disease is a leading cause of death. Proneurotensin is a biomarker associated with the development of cardiovascular disease, cardiovascular mortality, and all-cause mortality. We assessed the association of fasting proneurotensin with mortal events by sex and race (black-white) in a United States (US) population. Using a case-cohort sub-population of the REasons for Geographic And Racial Differences in Stroke (REGARDS) study, fasting proneurotensin was measured on a 1046-person subcohort and 651 participants with incident coronary heart disease (CHD).
Source: The American Journal of Cardiology - March 28, 2018 Category: Cardiology Authors: Nicholas Wettersten, Mary Cushman, Virginia J. Howard, Oliver Hartmann, Gerasimos Filippatos, Neil Beri, Paul Clopton, George Howard, Monika M. Safford, Suzanne E. Judd, Andreas Bergmann, Joachim Struck, Alan Maisel Source Type: research

Meta-analysis of Randomized Controlled Trials on Patent Foramen Ovale Closure Versus Medical Therapy for Secondary Prevention of Cryptogenic Stroke
The optimal management of patients with cryptogenic stroke (CS) and patent foramen ovale (PFO) remains controversial. We conducted a meta-analysis to assess the effect of PFO closure for secondary prevention of stroke on patients with CS. We searched the literature for randomized control trials assessing the recurrence of stroke after PFO closure compared with medical therapy (antiplatelet and/or anticoagulation). Five randomized control trials with a total of 3,440 patients were included. The mean age was 45.2  ± 9.7 years and follow-up duration ranged from 2.0 to 5.9 years.
Source: The American Journal of Cardiology - March 2, 2018 Category: Cardiology Authors: Aiman Smer, Mohsin Salih, Toufik Mahfood Haddad, Raviteja Guddeti, Abdulghani Saadi, Alok Saurav, Ram Belbase, Mohamed Ayan, Mahmoud Traina, Venkata Alla, Michael Del Core Source Type: research

Meta-Analysis of Randomized Controlled Trials on Patent Foramen Ovale Closure Versus Medical Therapy for Secondary Prevention of Cryptogenic Stroke
The optimal management of patients with cryptogenic stroke (CS) and patent foramen ovale (PFO) remains controversial. We conducted a meta-analysis to assess the effect of PFO closure for secondary prevention of stroke in patients with CS. We searched the literature for randomized clinical trials (RCTs) assessing the recurrence of stroke after PFO closure when compared to medical therapy (antiplatelet and/or anticoagulation). Five RCTs with a total of 3440 patients were included. The mean age was 45.2 ±9.7 years and follow-up duration ranged from 2 to 5.9 years.
Source: The American Journal of Cardiology - March 2, 2018 Category: Cardiology Authors: Aiman Smer, Mohsin Salih, Toufik Mahfood Haddad, Raviteja Guddeti, Abdulghani Saadi, Alok Saurav, Ram Belbase, Mohamed Ayan, Mahmoud Traina, Venkata Alla, Michael Del Core Source Type: research

Stroke and Cardiovascular Events After Ablation or Antiarrhythmic Drugs for Treatment of Patients With Atrial Fibrillation
Catheter ablation and antiarrhythmic drugs (AADs) are the most common rhythm-control strategies for atrial fibrillation (AF). Data comparing the rate of stroke and cardiovascular events between the treatment strategies are limited. Therefore, this observational study uses claims data to compare rate of cardiovascular hospitalization and stroke for patients with AF treated with ablation or AADs. Patients in the MarketScan dataset with AF between January 2010 and December 2014 were categorized in the ablation group if an atrial catheter ablation was performed, or in the AAD group if a relevant AAD was prescribed for AF but n...
Source: The American Journal of Cardiology - February 12, 2018 Category: Cardiology Authors: Moussa Mansour, E. Kevin Heist, Rahul Agarwal, T. Jared Bunch, Edward Karst, Jeremy N. Ruskin, Srijoy Mahapatra Source Type: research

Effect on Risk of Stroke and Acute Myocardial Infarction of Nonselective Nonsteroidal Anti-Inflammatory Drugs in Patients With Rheumatoid Arthritis
There are still debates on the association of increased cardiovascular risk with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with rheumatoid arthritis (RA) because of inconsistent results. Therefore, our study aims to evaluate the transient effects of selective and nonselective NSAIDs on the risk of stroke and acute myocardial infarction (AMI) in patients with RA. We conducted a case-crossover study of 5,921 stroke or AMI patients with co-morbidity of RA. All cases were identified from the Taiwan National Health Insurance Database between January 1, 2006, and December 31, 2011, according to the Int...
Source: The American Journal of Cardiology - February 12, 2018 Category: Cardiology Authors: Yih-Ru Chen, Fang-I Hsieh, Chi-Ching Chang, Nai-Fang Chi, Hsin-Chiao Wu, Hung-Yi Chiou Source Type: research

Stroke and Cardiovascular Events After Ablation or Antiarrhythmic Drugs for Treatment of Patients With Atrial Fibrillation
Catheter ablation and antiarrhythmic drugs (AADs) are the most common rhythm-control strategies for atrial fibrillation (AF). Data comparing the rate of stroke and cardiovascular events between the treatment strategies are limited. Therefore, this observational study uses claims data to compare rate of cardiovascular hospitalization and stroke for patients with AF treated with ablation or AADs. Patients in the MarketScan dataset with AF between January 2010 and December 2014 were categorized in the ablation group if an atrial catheter ablation was performed, or in the AAD group if a relevant AAD was prescribed for AF but n...
Source: The American Journal of Cardiology - February 12, 2018 Category: Cardiology Authors: Moussa Mansour, E. Kevin Heist, Rahul Agarwal, T. Jared Bunch, Edward Karst, Jeremy N. Ruskin, Srijoy Mahapatra Source Type: research

Effect on Risk of Stroke and Acute Myocardial Infarction of Nonselective Nonsteroidal Anti-Inflammatory Drugs in Patients with Rheumatoid Arthritis
There are still debates on the association of increased cardiovascular risk with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in rheumatoid arthritis (RA) patients because of inconsistent results. Therefore, our study aims to evaluate the transient effects of selective and nonselective NSAIDs on the risk of stroke and acute myocardial infarction (AMI) in patients with RA. We conducted a case-crossover study of 5,921 stroke or AMI patients with comorbidity of RA. All cases were identified from the Taiwan National Health Insurance Database between January 1, 2006, through December 31, 2011 according to the Intern...
Source: The American Journal of Cardiology - February 12, 2018 Category: Cardiology Authors: Yih-Ru Chen, Fang-I Hsieh, Chi-Ching Chang, Nai-Fang Chi, Hsin-Chiao Wu, Hung-Yi Chiou Source Type: research

Stroke and Cardiovascular Events after Ablation or Anti-Arrhythmic Drugs for Treatment of Patients with Atrial Fibrillation
Catheter ablation and anti-arrhythmic drugs (AADs) are the most common rhythm-control strategies for atrial fibrillation (AF). Data comparing the rate of stroke and cardiovascular events between the treatment strategies are limited. Therefore, this observational study uses claims data to compare rate of cardiovascular hospitalization and stroke for patients with AF treated with ablation or AADs. Patients in the MarketScan dataset with AF between January 2010 and December 2014 were categorized in the ablation group if an atrial catheter ablation was performed, or in the AAD group if a relevant AAD was prescribed for AF but ...
Source: The American Journal of Cardiology - February 12, 2018 Category: Cardiology Authors: Moussa Mansour, E. Kevin Heist, Rahul Agarwal, T. Jared Bunch, Edward Karst, Jeremy N. Ruskin, Srijoy Mahapatra Source Type: research

Usefulness of the CHA2DS2-VASc and HAS-BLED Scores in Predicting the Risk of Stroke Versus Intracranial Bleeding in Patients with Atrial Fibrillation (From the FibStroke Study)
CHA2DS2-VASc and HAS-BLED scores stratify the risk of thromboembolic and bleeding events respectively in patients with atrial fibrillation (AF). There is only little information on how they differentiate which of the 2 clinically most important complications (ischemic stroke, IS or an intracranial bleeding, IB) the patient is more prone to suffer. We evaluated both scores in patients suffering either of these major complications. The FibStroke Study collected data on all patients with AF suffering either an ischemic stroke or an intracranial bleeding event between 2003-2012 in 4 Finnish hospital districts.
Source: The American Journal of Cardiology - February 12, 2018 Category: Cardiology Authors: Samuli Jaakkola, Tuomas O. Kiviniemi, Ilpo Nuotio, Juha Hartikainen, Pirjo Mustonen, Antti Palom äki, Jussi Jaakkola, Antti Ylitalo, Päivi Hartikainen, K.E. Juhani Airaksinen Source Type: research