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Source: American Heart Journal

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Total 491 results found since Jan 2013.

Association of Frailty and Cognitive Impairment with benefits of Oral anticoagulation in patients with atrial fibrillation
ConclusionThose with cognitive impairment or frailty in AF had higher predicted risk for stroke and higher observed mortality, yet were less likely to be treated with OAC. Despite this, the benefits of OAC were similar in patients with and without cognitive impairment or frailty.
Source: American Heart Journal - January 30, 2019 Category: Cardiology Source Type: research

Differences in statin utilization and lipid lowering by race, ethnicity, and HIV status in a real-world cohort of persons with human immunodeficiency virus and uninfected persons
ConclusionsAmong PWH with statin indication(s), blacks and Hispanics were less likely than whites to have been prescribed a statin. These racial/ethnic disparities were less pronounced among uninfected persons. There were significant differences in type of statin used for PWH compared to uninfected matched controls. Future efforts addressing disparities in CVD prevention among PWH are warranted.
Source: American Heart Journal - January 25, 2019 Category: Cardiology Source Type: research

Radial versus femoral vascular access in ST-elevation myocardial infarction: Are the results of femoral operators unfairly represented in observational research?
ConclusionDefault femoral operators achieved comparable outcomes when compared to default radial operators. The less favorable outcomes observed in FA cases may result from its selective use by radial operators in high risk cases.
Source: American Heart Journal - January 16, 2019 Category: Cardiology Source Type: research

C-reactive protein and prognosis after percutaneous coronary intervention and bypass graft surgery for left Main coronary artery disease: Analysis from the EXCEL trial
Conclusions: In patients with LMCAD undergoing revascularization, elevated baseline CRP levels were strongly associated with subsequent death, MI and stroke at 3 years, irrespective of the mode of revascularization. Further studies are warranted to determine whether anti-inflammatory therapies may improve the prognosis of high-risk patients with LMCAD following revascularization.
Source: American Heart Journal - January 12, 2019 Category: Cardiology Source Type: research

Comparative effectiveness and safety of statins as a class and of specific statins for primary prevention of cardiovascular disease: A systematic review, meta-analysis and network meta-analysis of randomized trials with 94,283 participants
ConclusionsAll statins showed statistically significant risk reduction of CVD and all-cause mortality in primary prevention populations while increasing the risk for some harm risks. However, the benefit-harm profile differed by statin type. A quantitative assessment of the benefit-harm balance is thus needed since meta-analyses alone are insufficient to inform whether statins provide net benefit.
Source: American Heart Journal - January 11, 2019 Category: Cardiology Source Type: research

Rationale and design for AMPLATZER™ amulet™ left atrial appendage Occluder IDE randomized controlled trial (amulet IDE trial)
Publication date: Available online 21 December 2018Source: American Heart JournalAuthor(s): Dhanunjaya Lakkireddy, Stephan Windecker, David Thaler, Lars Sondergaard, John Carroll, Michael R Gold, Hongfei Guo, Kyle J Brunner, James B Hermiller, Hans-Christoph Diener, Boris Schmidt, Lee MacDonald, Moussa Mansour, Brijeshwar Maini, Joseph LevineAbstractAimsThe Amulet IDE Trial is an ongoing, prospective, randomized, multi-national trial, designed to evaluate the safety and effectiveness of the AMPLATZER™ Amulet™ Left Atrial Appendage Occluder for stroke prevention in comparison to the WATCHMAN Left Atrial Appendage Closur...
Source: American Heart Journal - December 21, 2018 Category: Cardiology Source Type: research

Differences in Statin Utilization and Lipid-Lowering by Race, Ethnicity, and HIV Status in a Real-World Cohort of Persons with Human Immunodeficiency Virus and Uninfected Persons
ConclusionsAmong PWH with statin indication(s), Blacks and Hispanics were less likely than whites to have been prescribed a statin. These racial/ethnic disparities were less pronounced among uninfected persons. There were significant differences in type of statin utilized for PWH compared to uninfected matched controls. Future efforts addressing disparities in CVD prevention among PWH are warranted.
Source: American Heart Journal - December 21, 2018 Category: Cardiology Source Type: research

Generalizability of the FOURIER Trial to Routine Clinical Care: Do Trial Participants Represent Patients in Everyday Practice?
ConclusionsOne in seven ASCVD patients in practice would have qualified for FOURIER. The excluded and under-represented populations were at a particularly low or high cardiovascular risk. Statin therapy was under-used and physicians may need to evaluate adherence before adding PCSK9i.
Source: American Heart Journal - December 19, 2018 Category: Cardiology Source Type: research

Yao generalizability of FOURIER to routine practice
ConclusionsOne in seven ASCVD patients in practice would have qualified for FOURIER. The excluded and under-represented populations were at a particularly low or high cardiovascular risk. Statin therapy was under-used and physicians may need to evaluate adherence before adding PCSK9i.
Source: American Heart Journal - December 16, 2018 Category: Cardiology Source Type: research

Immediate unselected coronary angiography versus delayed triage in survivors of out-of-hospital cardiac arrest without ST-segment elevation: Design and rationale of the TOMAHAWK trial
ConclusionThe TOMAHAWK trial will address the unresolved issue of timing and general indication of angiography after OHCA without ST-segment elevation.
Source: American Heart Journal - December 12, 2018 Category: Cardiology Source Type: research

Outcomes of Apixaban versus warfarin in patients with atrial fibrillation and multi-morbidity: Insights from the ARISTOTLE trial
ConclusionsMulti-morbidity is prevalent among the population with AF; efficacy and safety of apixaban is preserved in this subgroup supporting extension of trial results to the most complex AF patients.Clinical trial registrationClinicalTrials.gov (NCT00412984).
Source: American Heart Journal - November 23, 2018 Category: Cardiology Source Type: research

An international cluster-randomized quality improvement trial to increase the adherence to evidence-based therapies for acute ischemic stroke and transient ischemic attack patients: Rationale and design of the BRIDGE STROKE Trial
Publication date: January 2019Source: American Heart Journal, Volume 207Author(s): Maria Julia Machline-Carrion, Eliana Vieira Santucci, Lucas Petri Damiani, Cecilia Bahit, Germán Málaga, Octávio Marques Pontes-Neto, Sheila Cristina Ouriques Martins, Viviane Flumignan Zétola, Karina Normilio-Silva, Gabriel Rodrigues de Freitas, Alessandra Gorgulho, Antônio De Salles, Beatriz Gonzales Pacheco da Silva, Juliana Yamashita Santos, Isabella de Andrade Jesuíno, Priscila Regina Torres Bueno, Alexandre Biasi Cavalcanti, Hélio Penna Guimarães, Ying Xian, Janet Prvu BettgerBackgroundTranslating evidence into clinical practic...
Source: American Heart Journal - November 9, 2018 Category: Cardiology Source Type: research

Characterization of cardiovascular clinical events and impact of event adjudication on the treatment effect of darapladib versus placebo in patients with stable coronary heart disease – Insights from the STABILITY trial
ConclusionThe primary outcome results of the STABILITY trial were consistent whether using investigator-reported or CEC-adjudicated events. The proportion of investigator-reported events confirmed by CEC varied by type of event. These results should help improve event identification in clinical trials to optimize ascertainment and adjudication.
Source: American Heart Journal - November 8, 2018 Category: Cardiology Source Type: research

Stroke prevention in atrial fibrillation: Closing the gap
Publication date: Available online 25 October 2018Source: American Heart JournalAuthor(s): Sean D. Pokorney, Bernard J. Gersh, Azhar Ahmad, Sana M. Al-Khatib, Melanie Blank, Megan Coylewright, Peter DiBattiste, Jeff S. Healey, Olaf Hedrich, Elaine M. Hylek, Eva Kline-Rogers, Eric D. Peterson, Phil Mendys, Michael J. Mirro, Gerald Naccarelli, Parashar Patel, Christian T. Ruff, Howard Rutman, Norman Stockbridge, Robert Temple
Source: American Heart Journal - October 25, 2018 Category: Cardiology Source Type: research

Blood Pressure Differences Between Home Monitoring and Daytime Ambulatory Values and their Reproducibility in Treated Hypertensive Stroke and TIA Patients
ConclusionsDaytime ambulatory systolic and diastolic blood pressure values were significantly lower than home monitored values at both time points. Differences between the two methods were not reproducible for individuals. Using the same threshold value for both out-of-office measurement methods may not be appropriate in patients with cerebrovascular disease.
Source: American Heart Journal - October 20, 2018 Category: Cardiology Source Type: research