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Total 3153 results found since Jan 2013.

Coated-platelets predict stroke at 30 days following TIA
Conclusions: These findings suggest a role for coated-platelets in risk stratification for stroke at 30 days after TIA.
Source: Neurology - July 10, 2017 Category: Neurology Authors: Kirkpatrick, A. C., Vincent, A. S., Dale, G. L., Prodan, C. I. Tags: All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Standard operating procedures improve acute neurologic care in a sub-Saharan African setting
Conclusions: Implementing SOPs is a realistic, low-cost option for improving process quality of neurologic emergency management in under-resourced settings. Classification of evidence: This study provides Class IV evidence that, for patients with suspected neurologic emergencies in sub-Saharan Africa, neurologic SOPs increase the rate of performance of guideline-recommended procedures.
Source: Neurology - July 10, 2017 Category: Neurology Authors: Jaiteh, L. E. S., Helwig, S. A., Jagne, A., Ragoschke-Schumm, A., Sarr, C., Walter, S., Lesmeister, M., Manitz, M., Blass, S., Weis, S., Schlund, V., Bah, N., Kauffmann, J., Fousse, M., Kangankan, S., Ramos Cabrera, A., Kronfeld, K., Ruckes, C., Liu, Y., Tags: ARTICLE Source Type: research

Teaching NeuroImages: Abnormal cervical and cerebral vasculature in 22q11 deletion syndrome
A 12-day-old girl with a postnatal microarray diagnosis of 22q11.2 deletion syndrome was transferred for surgical repair of truncus arteriosus. Neurologic examination at the time of transfer was unremarkable. Brain MRI on day of life 9 demonstrated an absent left internal carotid flow void. Magnetic resonance angiography of the head (figure, A) and neck (figure, B) was subsequently obtained prior to cardiac repair. Patients with 22q11 deletion syndromes may have abnormal cervical vessel development.1 Children with congenital heart disease have an elevated stroke risk, particularly for periprocedural stroke.2 Understanding ...
Source: Neurology - July 3, 2017 Category: Neurology Authors: Mithal, D. S., Kurz, J. E. Tags: All Cerebrovascular disease/Stroke, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke, All Genetics RESIDENT AND FELLOW SECTION Source Type: research

Rapid transitions in the epidemiology of stroke and its risk factors in China from 2002 to 2013
Conclusions: In 2002–2013, the incidence of stroke in China increased rapidly. Combined with a high prevalence, a trend toward a younger age, and stable mortality, this finding suggests that additional clinical and behavioral interventions for metabolic and lifestyle risk factors are necessary to prevent stroke, particularly in certain populations.
Source: Neurology - July 3, 2017 Category: Neurology Authors: Guan, T., Ma, J., Li, M., Xue, T., Lan, Z., Guo, J., Shen, Y., Chao, B., Tian, G., Zhang, Q., Wang, L., Liu, Y. Tags: All Cerebrovascular disease/Stroke, Prevalence studies, Incidence studies, Risk factors in epidemiology ARTICLE Source Type: research

Tenecteplase in ischemic stroke offers improved recanalization: Analysis of 2 trials
Conclusions: Tenecteplase may offer greater recanalization efficacy compared to alteplase, possibly exaggerated in patients with complete vessel occlusions on baseline CTA.
Source: Neurology - July 3, 2017 Category: Neurology Authors: Bivard, A., Huang, X., Levi, C. R., Spratt, N., Campbell, B. C. V., Cheripelli, B. K., Kalladka, D., Moreton, F. C., Ford, I., Bladin, C. F., Davis, S. M., Donnan, G. A., Muir, K. W., Parsons, M. W. Tags: CT, MRI, All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Long-term unmet needs and associated factors in stroke or TIA survivors: An observational study
Conclusions: Survivors of stroke/TIA reported considerable unmet needs ≥2 years after discharge, particularly in secondary prevention. The factors associated with unmet needs could help guide policy decisions, particularly for tailoring care and support services provided after discharge.
Source: Neurology - July 3, 2017 Category: Neurology Authors: Olaiya, M. T., Cadilhac, D. A., Kim, J., Nelson, M. R., Srikanth, V. K., Andrew, N. E., Bladin, C. F., Gerraty, R. P., Fitzgerald, S. M., Phan, T., Frayne, J., Thrift, A. G., On behalf of the STANDFIRM (Shared Team Approach Between Nurses and Doctors for Tags: Outcome research, Medical care, Stroke prevention, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Proatlantal intersegmental artery with internal carotid artery stenosis
A 56-year-old man presented with vertigo of 4 days duration. Neurologic examination was unremarkable. CT angiograms revealed a right internal carotid artery (ICA) stenosis and an ipsilateral proatlantal intersegmental artery (PIA, type 1). The PIA arose from the ICA, ran upward, then took a dorsal course, and continued as the vertebral artery, serving as the major contributor of the posterior circulation (figure, A–C). Catheter-based angiogram showed ICA stenosis of 60% (figure, D). He chose drug therapy and remained asymptomatic on follow-up. Such combination can lead to TIA of the vertebrobasilar system; treatment ...
Source: Neurology - July 3, 2017 Category: Neurology Authors: Yu, W., Feng, Z., Zhao, C., Fu, C. Tags: CT, All Clinical Neurology, All Cerebrovascular disease/Stroke NEUROIMAGES Source Type: research

Clinical Reasoning: Acute onset facial droop in a 36-year-old pregnant woman
A 36-year-old woman, G1P0, 22 weeks pregnant, presented to the emergency department for evaluation of acute onset facial droop. Her medical history included ulcerative colitis, primary sclerosing cholangitis, and heterozygosity for the prothrombin G20210A mutation. She was on 10,000 units of subcutaneous heparin twice daily for a previous deep vein thrombosis secondary to her prothrombin mutation; she was noncompliant with prescribed aspirin.
Source: Neurology - June 12, 2017 Category: Neurology Authors: George, I. C., Youn, T. S., Marcolini, E. G., Greer, D. M. Tags: Other cerebrovascular disease/ Stroke, Autoimmune diseases, Critical care, All Demyelinating disease (CNS) RESIDENT AND FELLOW SECTION Source Type: research

Imaging-based selection of patients for acute stroke treatment: Is it ready for prime time?
Historically, brain imaging in acute stroke has sought to exclude brain hemorrhage in order to allow therapy aiming at recanalization of the occluded intracranial artery. The National Institute of Neurological Disorders and Stroke study, published in 1995, found a clinical benefit of IV thrombolysis in acute stroke after exclusion of brain hemorrhage based on noncontrast CT (NCCT).1 More than 20 years later, the decision at most centers whether to give thrombolysis within the first 4.5 hours remains based on NCCT; often, the bolus of recombinant tissue plasminogen activator (rt-PA) is administered in the CT scanner suite e...
Source: Neurology - June 12, 2017 Category: Neurology Authors: Carrera, E., Wintermark, M. Tags: CT, MRI, Infarction EDITORIALS Source Type: research

Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core volume
Conclusions: We found no significant difference between the accuracy of CT perfusion and ASPECTS to predict hyperacute MRI lesion volume in ischemic stroke.
Source: Neurology - June 12, 2017 Category: Neurology Authors: Demeestere, J., Garcia-Esperon, C., Garcia-Bermejo, P., Ombelet, F., McElduff, P., Bivard, A., Parsons, M., Levi, C. Tags: CT, MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

MR perfusion lesions after TIA or minor stroke are associated with new infarction at 7 days
Conclusions: Our results showed that 30% of the acute focal PWI lesions detected after a TIA are associated with a new BI at 1 week. Those new BIs may result from the progression of the initial ischemic injury.
Source: Neurology - June 12, 2017 Category: Neurology Authors: Lee, J., Inoue, M., Mlynash, M., Mann, S. K., Cereda, C. W., Ke, M., Albers, G. W., Olivot, J. M. Tags: Stroke prevention, MRI ARTICLE Source Type: research

Total small vessel disease score and risk of recurrent stroke: Validation in 2 large cohorts
Conclusions: The total SVD score has predictive value for recurrent stroke after TIA/ischemic stroke. Prediction of recurrence in patients with nonlacunar events highlights the potential role of SVD in wider stroke etiology.
Source: Neurology - June 12, 2017 Category: Neurology Authors: Lau, K. K., Li, L., Schulz, U., Simoni, M., Chan, K. H., Ho, S. L., Cheung, R. T. F., Küker, W., Mak, H. K. F., Rothwell, P. M. Tags: MRI, Prognosis, All Cerebrovascular disease/Stroke, Infarction, Intracerebral hemorrhage ARTICLE Source Type: research

Evaluating the safety of {beta}-interferons in MS: A series of nested case-control studies
Conclusions: Among patients with RRMS, IFN-β was associated with a 1.8- and 1.6-fold increase in the risk of stroke and migraine and 1.3-fold increases in depression and hematologic abnormalities.
Source: Neurology - June 12, 2017 Category: Neurology Authors: de Jong, H. J. I., Kingwell, E., Shirani, A., Cohen Tervaert, J. W., Hupperts, R., Zhao, Y., Zhu, F., Evans, C., van der Kop, M. L., Traboulsee, A., Gustafson, P., Petkau, J., Marrie, R. A., Tremlett, H., On behalf of the British Columbia Multiple Scleros Tags: Patient safety, Multiple sclerosis, All epidemiology, Case control studies ARTICLE Source Type: research

Prospective association between {beta}2-microglobulin levels and ischemic stroke risk among women
Conclusion: High levels of B2M were associated with an increased risk of ischemic stroke among women.
Source: Neurology - June 5, 2017 Category: Neurology Authors: Rist, P. M., Jimenez, M. C., Rexrode, K. M. Tags: All Cerebrovascular disease/Stroke, Case control studies, Risk factors in epidemiology ARTICLE Source Type: research

Endovascular thrombectomy: Time is still brain
The "Time is brain" concept should be familiar to anyone who cares for patients with acute ischemic stroke. IV tissue plasminogen activator (tPA) reduces disability after stroke when administered within 4.5 hours of symptom onset, but the benefit of IV tPA is time-dependent.1 Earlier treatment improves functional outcomes. Quantified many ways, studies provide estimates in terms of functional outcome at 90 days, neurons saved, and days of disability-free life gained.1–3 As a result, door-to-needle time, defined as the time from hospital arrival to the initiation of IV tPA, has become an important quality metric for s...
Source: Neurology - May 29, 2017 Category: Neurology Authors: Mullen, M. T., Chaturvedi, S. Tags: Outcome research, Quality of life, All Cerebrovascular disease/Stroke, Models of care, Infarction EDITORIALS Source Type: research