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Total 3153 results found since Jan 2013.

Biological age is better than chronological as predictor of 3-month outcome in ischemic stroke
Conclusions: B-age, estimated by DNA methylation, is an independent predictor of ischemic stroke outcome regardless of chronological years.
Source: Neurology - August 21, 2017 Category: Neurology Authors: Soriano-Tarraga, C., Mola-Caminal, M., Giralt-Steinhauer, E., Ois, A., Rodriguez-Campello, A., Cuadrado-Godia, E., Gomez-Gonzalez, A., Vivanco-Hidalgo, R. M., Fernandez-Cadenas, I., Cullell, N., Roquer, J., Jimenez-Conde, J. Tags: All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology, All Genetics ARTICLE Source Type: research

Child Neurology: Childhood basilar artery occlusion and stroke
Stroke is one of the major causes of childhood mortality. Pediatric arterial ischemic stroke (PAIS) has an annual estimated rate as high as 3.3 cases per 100,000 children (with the vertebrobasilar territory involved in up to 36% of cases); however, the incidence of isolated childhood basilar artery occlusion (BAO) and stroke (BAS) is unknown.1 Adult BAO carries up to a 90% mortality rate, while death or severe neurologic deficits may be seen in 50% of children with BAO/BAS.1,2 The following case report describes a 12-year-old boy with BAO leading to BAS. Clinical symptoms, differential diagnoses, associated comorbidities, ...
Source: Neurology - August 14, 2017 Category: Neurology Authors: Lobbous, M., Williams, S., Rashid, S. Tags: Childhood stroke, Stroke in young adults, All Cerebrovascular disease/Stroke, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke RESIDENT AND FELLOW SECTION Source Type: research

Long-term antithrombotic treatment in intracranial hemorrhage survivors with atrial fibrillation
Conclusions: In observational studies, anticoagulation with VKA is associated with a lower rate of IS than APA or no-ATM without increasing ICH recurrence significantly. A randomized controlled trial is needed to determine the net clinical benefit of anticoagulation in ICH survivors with AF.
Source: Neurology - August 14, 2017 Category: Neurology Authors: Korompoki, E., Filippidis, F. T., Nielsen, P. B., Del Giudice, A., Lip, G. Y. H., Kuramatsu, J. B., Huttner, H. B., Fang, J., Schulman, S., Marti-Fabregas, J., Gathier, C. S., Viswanathan, A., Biffi, A., Poli, D., Weimar, C., Malzahn, U., Heuschmann, P., Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Cardiac, Embolism, Intracerebral hemorrhage ARTICLE Source Type: research

Clinical Reasoning: Two see or not two see--Is it really double vision?
A 57-year-old right-handed woman presented to the emergency department with complaints of double vision and intractable nausea that began abruptly 2 days earlier. Her visual symptoms were characterized as seeing overlapping or separate horizontally or diagonally displaced objects. She had no history of headaches or stroke. Her cerebrovascular risk factors included hypertension, type II diabetes, coronary artery disease, and cigarette smoking. Her medications included clopidogrel, lisinopril, paroxetine, and oxycodone. Her family history was notable for late-onset ischemic heart disease in her parents with no first-degree r...
Source: Neurology - August 7, 2017 Category: Neurology Authors: Murphy, R. R., Al Sawaf, A., Rose, D. R., Goldstein, L. B., Smith, C. D. Tags: Clinical neurology examination, Diplopia (double vision), Visual fields, Visual processing, All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research

Pearls & Oy-sters: An uncommon initial presentation of thyrotoxicosis
Venous thrombosis is common in patients with thyrotoxicosis, with the cerebral venous system being frequently involved.
Source: Neurology - August 7, 2017 Category: Neurology Authors: Grewal, P. K., Villamar, M. F., Raslau, F. D., Dobbs, M. R. Tags: Stroke in young adults, Endocrine, All Cerebrovascular disease/Stroke, Cerebral venous thrombosis RESIDENT AND FELLOW SECTION Source Type: research

Teaching NeuroImages: Artery of Percheron aneurysm masquerading as ICH spot sign
A 50-year-old Japanese woman presented with left thalamic intracerebral hemorrhage (ICH). CT angiography demonstrated an ICH spot sign and intracranial vasculopathy consistent with Moyamoya disease (figure 1). Conventional angiography demonstrated that the spot sign was actually a pseudoaneurysm arising from the artery of Percheron (figure 2). Intracranial aneurysms may complicate Moyamoya disease and occur at the circle of Willis, distal peripheral arteries, or Moyamoya vessels at a ratio of 3:1:1.1 Aneurysms in thalamo-perforating arteries are rare2 and an artery of Percheron aneurysm in Moyamoya disease has not been rep...
Source: Neurology - August 7, 2017 Category: Neurology Authors: Moughamian, A. J., Morshed, R. A., Colorado, R. A., Liner, Z., Cooke, D., Hemphill, J. C. Tags: All Cerebrovascular disease/Stroke, Intracerebral hemorrhage RESIDENT AND FELLOW SECTION Source Type: research

Age and the fuzzy edges of embolic stroke of undetermined source: Implications for trials
After an acute ischemic stroke, clinicians pursue further diagnostic assessment to identify the most plausible causes and tailor secondary prevention strategies. Available treatments with a high level of evidence for reducing recurrence stroke risk might include long-term oral anticoagulation in patients with a major-risk cardioembolic source (atrial fibrillation, prosthetic valves, etc), carotid endarterectomy in minor ischemic stroke related to moderate to severe internal carotid artery atherosclerotic stenosis, and best-practice medical management in those with lacunar stroke due to cerebral small vessel disease.1 Howev...
Source: Neurology - August 7, 2017 Category: Neurology Authors: Charidimou, A. Tags: Stroke in young adults, All Clinical trials, All Cerebrovascular disease/Stroke, Embolism, Infarction EDITORIALS Source Type: research

Determining the optimal target blood pressure after thrombectomy: High or low?
The management of patients with acute ischemic stroke has changed dramatically with modern mechanical thrombectomy (MT) techniques and improved patient selection using CT angiography.1 Although the benefit of early recanalization in large vessel occlusion (LVO) seems clear, the optimal periprocedural management remains uncertain. Unresolved issues include the method of analgesia and sedation, reversal and application of adjunctive periprocedural anticoagulation, glycemic control, ventilatory management, and perhaps most important, blood pressure (BP) control.
Source: Neurology - August 7, 2017 Category: Neurology Authors: Wartenberg, K. E., Mayer, S. A. Tags: EDITORIALS Source Type: research

Age- and sex-specific analysis of patients with embolic stroke of undetermined source
Conclusions: Age, but not sex, is a strong predictor of stroke recurrence and death in ESUS. The risk is 3- and 8-fold higher in patients >80 years compared with those <60 years of age, respectively. The age distribution in the ongoing ESUS trials may potentially influence their power to detect a significant treatment association.
Source: Neurology - August 7, 2017 Category: Neurology Authors: Ntaios, G., Lip, G. Y. H., Vemmos, K., Koroboki, E., Manios, E., Vemmou, A., Rodriguez-Campello, A., Cuadrado-Godia, E., Roquer, J., Arnao, V., Caso, V., Paciaroni, M., Diez-Tejedor, E., Fuentes, B., Perez Lucas, J., Arauz, A., Ameriso, S. F., Pertierra, Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Embolism ARTICLE Source Type: research

Blood pressure levels post mechanical thrombectomy and outcomes in large vessel occlusion strokes
Conclusions: High maximum SBP levels following MT are independently associated with increased likelihood of 3-month mortality and functional dependence in LVO patients. Moderate BP control is also related to lower odds of 3-month mortality in comparison to permissive hypertension.
Source: Neurology - August 7, 2017 Category: Neurology Authors: Goyal, N., Tsivgoulis, G., Pandhi, A., Chang, J. J., Dillard, K., Ishfaq, M. F., Nearing, K., Choudhri, A. F., Hoit, D., Alexandrov, A. W., Arthur, A. S., Elijovich, L., Alexandrov, A. V. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Blood pressure reduction and noncontrast CT markers of intracerebral hemorrhage expansion
Conclusions: NCCT signs reliably identify ICH patients at high risk of hematoma growth. However, we found no evidence that patients with these markers specifically benefit from intensive BP reduction. Clinicaltrials.gov identifier: NCT01176565.
Source: Neurology - August 7, 2017 Category: Neurology Authors: Morotti, A., Boulouis, G., Romero, J. M., Brouwers, H. B., Jessel, M. J., Vashkevich, A., Schwab, K., Afzal, M. R., Cassarly, C., Greenberg, S. M., Martin, R. H., Qureshi, A. I., Rosand, J., Goldstein, J. N., On behalf of ATACH-II and NETT investigators Tags: CT, All Cerebrovascular disease/Stroke, Intracerebral hemorrhage ARTICLE Source Type: research

Severity assessment in maximally treated ICH patients: The max-ICH score
Conclusions: Care limitations significantly influenced the validity of common prognostication models resulting in overestimation of poor outcome. The max-ICH score demonstrated increased predictive validity with minimized confounding by care limitations, making it a useful tool for severity assessment in ICH patients.
Source: Neurology - July 31, 2017 Category: Neurology Authors: Sembill, J. A., Gerner, S. T., Volbers, B., Bobinger, T., Lücking, H., Kloska, S. P., Schwab, S., Huttner, H. B., Kuramatsu, J. B. Tags: Other cerebrovascular disease/ Stroke, Prognosis, All Cerebrovascular disease/Stroke, Intracerebral hemorrhage ARTICLE Source Type: research

Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study
Conclusions: This study provides support that T2D may be causally associated with large artery stroke.
Source: Neurology - July 31, 2017 Category: Neurology Authors: Larsson, S. C., Scott, R. A., Traylor, M., Langenberg, C. C., Hindy, G., Melander, O., Orho-Melander, M., Seshadri, S., Wareham, N. J., Markus, H. S., For the METASTROKE Collaboration and NINDS Stroke Genetics Network (SiGN) Tags: Risk factors in epidemiology, Infarction ARTICLE Source Type: research

Carotid artery web and ischemic stroke: A case-control study
Source: Neurology - July 31, 2017 Category: Neurology Tags: CORRECTIONS Source Type: research

Physical activity, but not body mass index, predicts less disability before and after stroke
Source: Neurology - July 31, 2017 Category: Neurology Tags: CORRECTIONS Source Type: research