Query: stroke

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Total 2232 results found since Jan 2013.

Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke
Conclusions: Global SVD burden is associated with increased BBB leakage in both acutely ischemic and nonischemic area. Our results support that SVD score has construct validity, and confirm a relation between SVD and BBB disruption also in patients with acute stroke.
Source: Neurology - November 20, 2017 Category: Neurology Authors: Arba, F., Leigh, R., Inzitari, D., Warach, S. J., Luby, M., Lees, K. R., On behalf of the STIR/VISTA Imaging Collaboration Tags: MRI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Association between percent decline in serum total homocysteine and risk of first stroke
Conclusions: Percent lowering in tHcy was significantly associated with a reduction in first stroke risk in Chinese adults with hypertension, and if further confirmed, may serve as a useful indicator for folic acid treatment efficacy on stroke prevention. Clinicaltrials.gov identifier: NCT00794885.
Source: Neurology - November 13, 2017 Category: Neurology Authors: Huang, X., Li, Y., Li, P., Li, J., Bao, H., Zhang, Y., Wang, B., Sun, N., Wang, J., He, M., Yin, D., Tang, G., Chen, Y., Cui, Y., Huang, Y., Hou, F. F., Qin, X., Huo, Y., Cheng, X. Tags: Stroke prevention, All Clinical trials ARTICLE Source Type: research

Increasing prevalence of vascular risk factors in patients with stroke: A call to action
Conclusions: Despite numerous guidelines and prevention initiatives, prevalence of hypertension, diabetes, dyslipidemia, smoking, and drug abuse in AIS increased across the 2004–2014 period. Proportion of patients with carotid stenosis, CRF, and multiple risk factors also increased. Enhanced risk factor modification strategies and implementation of evidence-based recommendations are needed for optimal stroke prevention.
Source: Neurology - November 6, 2017 Category: Neurology Authors: Otite, F. O., Liaw, N., Khandelwal, P., Malik, A. M., Romano, J. G., Rundek, T., Sacco, R. L., Chaturvedi, S. Tags: Stroke prevention, Embolism, Prevalence studies, Risk factors in epidemiology, Infarction ARTICLE Source Type: research

Teaching NeuroImages: Bilateral hypertrophic olivary degeneration following posterior circulation stroke
A 40-year-old comatose man was brought to the hospital with a history of posterior circulation stroke 4 months earlier due to hypertension. On examination, he had spastic quadriplegia, bilateral extensor plantar reflex, and palatal myoclonus. MRI revealed enlarged olives (figure 1) and chronic infarcts involving midbrain and pons (figure 2) suggestive of hypertrophic olivary degeneration seen after 4 months of insult. Hypertrophic olivary degeneration is a transsynaptic degeneration involving interconnecting fibers of inferior olivary nucleus, red nucleus, and contralateral dentate nucleus forming the 3 corners of the Guil...
Source: Neurology - October 30, 2017 Category: Neurology Authors: Venkatesh, M., Prasad, V. R. S., Basha, S. U., Priya, G. H. J. Tags: MRI, Coma, All Cerebrovascular disease/Stroke, All Education, Infarction RESIDENT AND FELLOW SECTION Source Type: research

COL4A2 is associated with lacunar ischemic stroke and deep ICH: Meta-analyses among 21,500 cases and 40,600 controls
Conclusions: These results provide evidence of shared genetic determinants and suggest common pathophysiologic mechanisms of distinct ischemic and hemorrhagic cerebral SVD stroke phenotypes, offering new insights into the causal mechanisms of cerebral SVD.
Source: Neurology - October 23, 2017 Category: Neurology Authors: Rannikmäe, K., Sivakumaran, V., Millar, H., Malik, R., Anderson, C. D., Chong, M., Dave, T., Falcone, G. J., Fernandez-Cadenas, I., Jimenez-Conde, J., Lindgren, A., Montaner, J., O'Donnell, M., Pare, G., Radmanesh, F., Rost, N. S., Slowik, A., So& Tags: All Cerebrovascular disease/Stroke, Infarction, Intracerebral hemorrhage, All Genetics, Association studies in genetics ARTICLE Source Type: research

Smoking cessation and outcome after ischemic stroke or TIA
Conclusion: Cessation of cigarette smoking after an ischemic stroke or TIA was associated with significant health benefits over 4.8 years in the IRIS trial cohort.
Source: Neurology - October 16, 2017 Category: Neurology Authors: Epstein, K. A., Viscoli, C. M., Spence, J. D., Young, L. H., Inzucchi, S. E., Gorman, M., Gerstenhaber, B., Guarino, P. D., Dixit, A., Furie, K. L., Kernan, W. N., For the IRIS Trial Investigators Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Some light in the shadows of atrial fibrillation and stroke: To look or not to look
In ischemic stroke, the diagnostic workup determines the best preventive strategy. However, cryptogenic stroke accounts for about 20%–40% of all strokes.1 For these patients, the best preventive treatment remains unknown, and most guidelines recommend risk factor modification and antiplatelet therapy. Given the substantial recurrence rate for cryptogenic stroke, this is not a comfortable situation: just try to tell your stroke patients, "After all these tests, I do not have any clue why you had a stroke"; and about the treatment, "Just take an aspirin and cross fingers you do not have another one."
Source: Neurology - October 9, 2017 Category: Neurology Authors: Ustrell, X., Tagawa, M. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Cardiac, Embolism EDITORIALS Source Type: research

Outcome after stroke thrombolysis in patients >80 years treated within 3 hours vs >3-4.5 hours
Conclusions: In this observational study, unselected patients >80 years of age treated with IVT after 3 hours vs earlier had a slightly higher rate of SICH and similar unadjusted functional outcome but poorer adjusted outcome. The absolute difference between the treatment groups is small, and elderly patients should not be denied IVT in the later time window solely because of age without other contraindications.
Source: Neurology - October 9, 2017 Category: Neurology Authors: Ahmed, N., Lees, K. R., Ringleb, P. A., Bladin, C., Collas, D., Toni, D., Ford, G. A., And the SITS Investigators Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Quality improvement in neurology: Stroke and Stroke Rehabilitation Quality Measurement Set update
Stroke is the fifth leading cause of death in the United States and the second leading cause of disability worldwide.1,2 "On average, every 40 seconds, someone in the United States has a stroke, and someone dies of one approximately every 4 minutes."3 Each year, nearly 800,000 people experience stroke, with up to 185,000 experiencing recurrent stroke events.3 Strokes occur at any age, and risk increases with age.4 Nearly half of older stroke survivors experience moderate to severe disability.5
Source: Neurology - October 9, 2017 Category: Neurology Authors: Latorre, J. G. S., Flanagan, S., Phipps, M. S., Shenoy, A. M., Bennett, A., Seidenwurm, D. Tags: All Imaging, All Cerebrovascular disease/Stroke, All Rehabilitation, All Practice Management SPECIAL ARTICLE Source Type: research

Effect of informed consent on patient characteristics in a stroke thrombolysis trial
Conclusions: Patients recruited by proxy consent were older, had more severe strokes, and had higher prevalence of aphasia than those with capacity to give personal consent. Variations in the manner of consent across countries may influence trial results. Clinicaltrials.gov and Clinicaltrialsregister.eu identifiers: NCT01525290 (clinicaltrials.gov); 2011-005906-32 (clinicaltrialsregister.eu).
Source: Neurology - September 25, 2017 Category: Neurology Authors: Thomalla, G., Boutitie, F., Fiebach, J. B., Simonsen, C. Z., Nighoghossian, N., Pedraza, S., Lemmens, R., Roy, P., Muir, K. W., Heesen, C., Ebinger, M., Ford, I., Cheng, B., Cho, T.-H., Puig, J., Thijs, V., Endres, M., Fiehler, J., Gerloff, C. Tags: MRI, All Clinical trials, All Cerebrovascular disease/Stroke, Clinical trials Methodology/study design, All Ethics in Neurology/Legal issues ARTICLE Source Type: research

Incidence and management of seizures after ischemic stroke: Systematic review and meta-analysis
Conclusions: The burden of stroke-related seizures and epilepsy due to ischemic stroke is substantial. Further studies are required to determine risk factors for epilepsy following ischemic stroke and optimal secondary prevention.
Source: Neurology - September 18, 2017 Category: Neurology Authors: Wang, J. Z., Vyas, M. V., Saposnik, G., Burneo, J. G. Tags: All Cerebrovascular disease/Stroke, Incidence studies, All Epilepsy/Seizures ARTICLE Source Type: research

Sex-specific stroke incidence over time in the Greater Cincinnati/Northern Kentucky Stroke Study
Conclusions: Decreases in stroke incidence over time are driven by a decrease in ischemic stroke in men. Contrary to previous study periods, stroke incidence rates were similar by sex in 2010. Future research is needed to understand why the decrease in ischemic stroke incidence is more pronounced in men.
Source: Neurology - September 4, 2017 Category: Neurology Authors: Madsen, T. E., Khoury, J., Alwell, K., Moomaw, C. J., Rademacher, E., Flaherty, M. L., Woo, D., Mackey, J., De Los Rios La Rosa, F., Martini, S., Ferioli, S., Adeoye, O., Khatri, P., Broderick, J. P., Kissela, B. M., Kleindorfer, D. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Incidence studies, Risk factors in epidemiology ARTICLE Source Type: research

Validating and comparing stroke prognosis scales
Conclusions: Our comparative analyses confirm differences in the prognostic accuracy of stroke scales. However, even the best performing scale had prognostic accuracy that may not be sufficient as a basis for clinical decision-making.
Source: Neurology - September 4, 2017 Category: Neurology Authors: Quinn, T. J., Singh, S., Lees, K. R., Bath, P. M., Myint, P. K., On behalf of the VISTA Collaborators Tags: Outcome research, Prognosis, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Individualized risk prediction of major bleeding in secondary stroke prevention: Are we there yet?
In most patients diagnosed with a TIA or ischemic stroke, secondary stroke prevention relies on antiplatelet therapy unless anticoagulation is indicated. Aspirin has the largest evidence base and reduces the risk of early recurrent ischemic stroke without a major risk of early hemorrhagic complications.1 Because antiplatelet therapy typically continues for many years, clinicians and patients need an estimation of the annual bleeding risk to accurately assess future risk. In a meta-analysis of 25 randomized trials of antiplatelet therapy in primary or secondary prevention of cardiovascular disease, aspirin increased the abs...
Source: Neurology - August 28, 2017 Category: Neurology Authors: Lemmens, R., Al-Shahi Salman, R. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Risk factors in epidemiology, Infarction EDITORIALS Source Type: research

Predicting major bleeding in patients with noncardioembolic stroke on antiplatelets: S2TOP-BLEED
Conclusions: The S2TOP-BLEED score can be used to estimate 3-year major bleeding risk in patients with a TIA or ischemic stroke who use antiplatelet agents, based on readily available characteristics. The discriminatory performance may be improved by identifying stronger predictors of major bleeding.
Source: Neurology - August 28, 2017 Category: Neurology Authors: Hilkens, N. A., Algra, A., Diener, H.-C., Reitsma, J. B., Bath, P. M., Csiba, L., Hacke, W., Kappelle, L. J., Koudstaal, P. J., Leys, D., Mas, J.-L., Sacco, R. L., Amarenco, P., Sissani, L., Greving, J. P., For the Cerebrovascular Antiplatelet Trialists' Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Risk factors in epidemiology, Infarction ARTICLE Source Type: research

Activity limitations and subjective well-being after stroke
Conclusions: Activity limitations were not associated with stroke survivors' subjective well-being after adjustment for other factors. While some predictors of well-being after stroke were identified, the determinants of well-being remained largely unexplained.
Source: Neurology - August 28, 2017 Category: Neurology Authors: Zahuranec, D. B., Skolarus, L. E., Feng, C., Freedman, V. A., Burke, J. F. Tags: Quality of life, All Cerebrovascular disease/Stroke, All Rehabilitation ARTICLE Source Type: research

Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke
Conclusions: Higher serum MMP-9 levels in the acute phase of ischemic stroke were associated with increased risk of mortality and major disability, suggesting that serum MMP-9 could be an important prognostic factor for ischemic stroke.
Source: Neurology - August 21, 2017 Category: Neurology Authors: Zhong, C., Yang, J., Xu, T., Xu, T., Peng, Y., Wang, A., Wang, J., Peng, H., Li, Q., Ju, Z., Geng, D., Zhang, Y., He, J., For the CATIS Investigators Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Cohort studies ARTICLE Source Type: research

Biological age is better than chronological as predictor of 3-month outcome in ischemic stroke
Conclusions: B-age, estimated by DNA methylation, is an independent predictor of ischemic stroke outcome regardless of chronological years.
Source: Neurology - August 21, 2017 Category: Neurology Authors: Soriano-Tarraga, C., Mola-Caminal, M., Giralt-Steinhauer, E., Ois, A., Rodriguez-Campello, A., Cuadrado-Godia, E., Gomez-Gonzalez, A., Vivanco-Hidalgo, R. M., Fernandez-Cadenas, I., Cullell, N., Roquer, J., Jimenez-Conde, J. Tags: All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology, All Genetics ARTICLE Source Type: research

Child Neurology: Childhood basilar artery occlusion and stroke
Stroke is one of the major causes of childhood mortality. Pediatric arterial ischemic stroke (PAIS) has an annual estimated rate as high as 3.3 cases per 100,000 children (with the vertebrobasilar territory involved in up to 36% of cases); however, the incidence of isolated childhood basilar artery occlusion (BAO) and stroke (BAS) is unknown.1 Adult BAO carries up to a 90% mortality rate, while death or severe neurologic deficits may be seen in 50% of children with BAO/BAS.1,2 The following case report describes a 12-year-old boy with BAO leading to BAS. Clinical symptoms, differential diagnoses, associated comorbidities, ...
Source: Neurology - August 14, 2017 Category: Neurology Authors: Lobbous, M., Williams, S., Rashid, S. Tags: Childhood stroke, Stroke in young adults, All Cerebrovascular disease/Stroke, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke RESIDENT AND FELLOW SECTION Source Type: research

Age and the fuzzy edges of embolic stroke of undetermined source: Implications for trials
After an acute ischemic stroke, clinicians pursue further diagnostic assessment to identify the most plausible causes and tailor secondary prevention strategies. Available treatments with a high level of evidence for reducing recurrence stroke risk might include long-term oral anticoagulation in patients with a major-risk cardioembolic source (atrial fibrillation, prosthetic valves, etc), carotid endarterectomy in minor ischemic stroke related to moderate to severe internal carotid artery atherosclerotic stenosis, and best-practice medical management in those with lacunar stroke due to cerebral small vessel disease.1 Howev...
Source: Neurology - August 7, 2017 Category: Neurology Authors: Charidimou, A. Tags: Stroke in young adults, All Clinical trials, All Cerebrovascular disease/Stroke, Embolism, Infarction EDITORIALS Source Type: research

Age- and sex-specific analysis of patients with embolic stroke of undetermined source
Conclusions: Age, but not sex, is a strong predictor of stroke recurrence and death in ESUS. The risk is 3- and 8-fold higher in patients >80 years compared with those <60 years of age, respectively. The age distribution in the ongoing ESUS trials may potentially influence their power to detect a significant treatment association.
Source: Neurology - August 7, 2017 Category: Neurology Authors: Ntaios, G., Lip, G. Y. H., Vemmos, K., Koroboki, E., Manios, E., Vemmou, A., Rodriguez-Campello, A., Cuadrado-Godia, E., Roquer, J., Arnao, V., Caso, V., Paciaroni, M., Diez-Tejedor, E., Fuentes, B., Perez Lucas, J., Arauz, A., Ameriso, S. F., Pertierra, Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Embolism ARTICLE Source Type: research

Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study
Conclusions: This study provides support that T2D may be causally associated with large artery stroke.
Source: Neurology - July 31, 2017 Category: Neurology Authors: Larsson, S. C., Scott, R. A., Traylor, M., Langenberg, C. C., Hindy, G., Melander, O., Orho-Melander, M., Seshadri, S., Wareham, N. J., Markus, H. S., For the METASTROKE Collaboration and NINDS Stroke Genetics Network (SiGN) Tags: Risk factors in epidemiology, Infarction ARTICLE Source Type: research

Body mass index in early life and stroke in adult life: What is the risk?
The article "BMI increase through puberty and adolescence is associated with risk of adult stroke" by Ohlsson et al.1 explores the relationship between body mass index (BMI) when a person is young (adolescence) and risk of stroke when the person is older (adults). Previous studies2,3 have shown that rate of stroke is decreasing in older adults but increasing in younger adults. This finding coincides with an increasing BMI in children and young adults. The researchers wanted to ask: Does an increased BMI during puberty and adolescence increase the risk for stroke later in life? The authors also explored whether the cha...
Source: Neurology - July 24, 2017 Category: Neurology Authors: Jones, S. H., Karceski, S. C. Tags: Stroke prevention, Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Infarction, Intracerebral hemorrhage PATIENT PAGES Source Type: research

Effects of increasing IV tPA-treated stroke mimic rates at CT-based centers on clinical outcomes
Conclusions: Thrombolysis of stroke mimics is increasing at our CT-based spoke hospitals and not at our MRI-based hub hospitals. Caution should be used in interpreting clinical outcomes based on large stroke databases when stroke diagnosis at discharge is unclear. Inadvertent reporting of treated stroke mimics as strokes will artificially elevate overall favorable clinical outcomes with additional downstream costs to patients and the health care system.
Source: Neurology - July 24, 2017 Category: Neurology Authors: Burton, T. M., Luby, M., Nadareishvili, Z., Benson, R. T., Lynch, J. K., Latour, L. L., Hsia, A. W. Tags: Outcome research, CT, MRI, DWI, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Comment: Does patient sex affect decision-making after hemorrhagic stroke?
Women do worse than men after both ischemic and hemorrhagic stroke, with evidence that sex bias in physician decision-making may contribute to this increased morbidity and mortality.1 Intracerebral hemorrhage (ICH) poses additional challenges, as the etiologies—amyloid angiopathy associated with prior cognitive decline, illicit drug use—carry their own assumptions. Guha et al.2 report findings from the Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study, a prospective, multicenter, triethnic, case-control study of ICH risk factors and outcomes. In almost 3,000 people, they examined comorbidities,...
Source: Neurology - July 24, 2017 Category: Neurology Authors: Brodtmann, A. Tags: All Cerebrovascular disease/Stroke, Intracerebral hemorrhage ARTICLE Source Type: research

Diagnosis of DWI-negative acute ischemic stroke: A meta-analysis
Conclusions: A small but significant percentage of patients with AIS have a negative DWI scan. Patients with neurologic deficits consistent with posterior circulation ischemia have 5 times the odds of having a negative DWI scan compared to patients with anterior circulation ischemia. AIS remains a clinical diagnosis and urgent reperfusion therapy should be considered even when an initial DWI scan is negative.
Source: Neurology - July 17, 2017 Category: Neurology Authors: Edlow, B. L., Hurwitz, S., Edlow, J. A. Tags: MRI, DWI, All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Structural MRI markers of brain aging early after ischemic stroke
Conclusions: Brain structure is likely to be compromised before ischemic stroke by vascular risk factors. Smaller hippocampal and total brain volumes and increased WMH load represent proxies for underlying vascular brain injury.
Source: Neurology - July 10, 2017 Category: Neurology Authors: Werden, E., Cumming, T., Li, Q., Bird, L., Veldsman, M., Pardoe, H. R., Jackson, G., Donnan, G. A., Brodtmann, A. Tags: MRI, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Alzheimer's disease, Vascular dementia ARTICLE Source Type: research

Coated-platelets predict stroke at 30 days following TIA
Conclusions: These findings suggest a role for coated-platelets in risk stratification for stroke at 30 days after TIA.
Source: Neurology - July 10, 2017 Category: Neurology Authors: Kirkpatrick, A. C., Vincent, A. S., Dale, G. L., Prodan, C. I. Tags: All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Rapid transitions in the epidemiology of stroke and its risk factors in China from 2002 to 2013
Conclusions: In 2002–2013, the incidence of stroke in China increased rapidly. Combined with a high prevalence, a trend toward a younger age, and stable mortality, this finding suggests that additional clinical and behavioral interventions for metabolic and lifestyle risk factors are necessary to prevent stroke, particularly in certain populations.
Source: Neurology - July 3, 2017 Category: Neurology Authors: Guan, T., Ma, J., Li, M., Xue, T., Lan, Z., Guo, J., Shen, Y., Chao, B., Tian, G., Zhang, Q., Wang, L., Liu, Y. Tags: All Cerebrovascular disease/Stroke, Prevalence studies, Incidence studies, Risk factors in epidemiology ARTICLE Source Type: research

Tenecteplase in ischemic stroke offers improved recanalization: Analysis of 2 trials
Conclusions: Tenecteplase may offer greater recanalization efficacy compared to alteplase, possibly exaggerated in patients with complete vessel occlusions on baseline CTA.
Source: Neurology - July 3, 2017 Category: Neurology Authors: Bivard, A., Huang, X., Levi, C. R., Spratt, N., Campbell, B. C. V., Cheripelli, B. K., Kalladka, D., Moreton, F. C., Ford, I., Bladin, C. F., Davis, S. M., Donnan, G. A., Muir, K. W., Parsons, M. W. Tags: CT, MRI, All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Long-term unmet needs and associated factors in stroke or TIA survivors: An observational study
Conclusions: Survivors of stroke/TIA reported considerable unmet needs ≥2 years after discharge, particularly in secondary prevention. The factors associated with unmet needs could help guide policy decisions, particularly for tailoring care and support services provided after discharge.
Source: Neurology - July 3, 2017 Category: Neurology Authors: Olaiya, M. T., Cadilhac, D. A., Kim, J., Nelson, M. R., Srikanth, V. K., Andrew, N. E., Bladin, C. F., Gerraty, R. P., Fitzgerald, S. M., Phan, T., Frayne, J., Thrift, A. G., On behalf of the STANDFIRM (Shared Team Approach Between Nurses and Doctors for Tags: Outcome research, Medical care, Stroke prevention, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Total small vessel disease score and risk of recurrent stroke: Validation in 2 large cohorts
Conclusions: The total SVD score has predictive value for recurrent stroke after TIA/ischemic stroke. Prediction of recurrence in patients with nonlacunar events highlights the potential role of SVD in wider stroke etiology.
Source: Neurology - June 12, 2017 Category: Neurology Authors: Lau, K. K., Li, L., Schulz, U., Simoni, M., Chan, K. H., Ho, S. L., Cheung, R. T. F., Küker, W., Mak, H. K. F., Rothwell, P. M. Tags: MRI, Prognosis, All Cerebrovascular disease/Stroke, Infarction, Intracerebral hemorrhage ARTICLE Source Type: research

Prospective association between {beta}2-microglobulin levels and ischemic stroke risk among women
Conclusion: High levels of B2M were associated with an increased risk of ischemic stroke among women.
Source: Neurology - June 5, 2017 Category: Neurology Authors: Rist, P. M., Jimenez, M. C., Rexrode, K. M. Tags: All Cerebrovascular disease/Stroke, Case control studies, Risk factors in epidemiology ARTICLE Source Type: research

Endovascular therapy for ischemic stroke: Save a minute--save a week
Conclusions: Small reductions in endovascular delays lead to marked health benefits over patients' lifetimes. Services need to be optimized to reduce delays to endovascular therapy.
Source: Neurology - May 29, 2017 Category: Neurology Authors: Meretoja, A., Keshtkaran, M., Tatlisumak, T., Donnan, G. A., Churilov, L. Tags: Outcome research, Quality of life, All Cerebrovascular disease/Stroke, Models of care, Infarction ARTICLE Source Type: research

Diagnostic value of prehospital ECG in acute stroke patients
Conclusions: In a selected cohort of patients with stroke, the in-field recordings of the ECG detected a relevant rate of cardiac arrhythmia. The results can add to the in-hospital evaluation and should be considered in prehospital care of acute stroke.
Source: Neurology - May 15, 2017 Category: Neurology Authors: Bobinger, T., Kallmünzer, B., Kopp, M., Kurka, N., Arnold, M., Heider, S., Schwab, S., Köhrmann, M. Tags: All Cerebrovascular disease/Stroke, Cardiac, Critical care ARTICLE Source Type: research

Copeptin and NT-proBNP for prediction of all-cause and cardiovascular death in ischemic stroke
Conclusions: Copeptin and NT-proBNP may be useful independent prognostic markers of all-cause or CVD mortality in Chinese patients with AIS.
Source: Neurology - May 15, 2017 Category: Neurology Authors: Tu, W.-J., Ma, G.-Z., Ni, Y., Hu, X.-S., Luo, D.-Z., Zeng, X.-W., Liu, Q., Xu, T., Yu, L., Wu, B. Tags: Prognosis, All Cerebrovascular disease/Stroke, Cardiac ARTICLE Source Type: research

Risks and benefits of clopidogrel-aspirin in minor stroke or TIA: Time course analysis of CHANCE
Conclusions: Clopidogrel–aspirin treatment may have a benefit of reducing stroke risk outweighing the potential risk of increased bleeding especially within the first 2 weeks compared with aspirin alone in patients with minor stroke or TIA. Clinicaltrials.gov identifier: NCT00979589. Classification of evidence: This study provides Class II evidence that for patients with minor stroke or TIA, the reduction of stroke risk from clopidogrel plus aspirin within the first 2 weeks outweighs the risk of bleeding compared with aspirin alone.
Source: Neurology - May 15, 2017 Category: Neurology Authors: Pan, Y., Jing, J., Chen, W., Meng, X., Li, H., Zhao, X., Liu, L., Wang, D., Johnston, S. C., Wang, Y., Wang, Y., On behalf of the CHANCE investigators Tags: All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement) ARTICLE Source Type: research

Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers
Conclusions: Folic acid supplementation could reduce the stroke risk in regions without folic acid fortification, particularly in trials using a relatively low dosage of folic acid and with low vitamin B12 levels.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Zhao, M., Wu, G., Li, Y., Wang, X., Hou, F. F., Xu, X., Qin, X., Cai, Y. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), All epidemiology ARTICLE Source Type: research

Racial differences in statin adherence following hospital discharge for ischemic stroke
Conclusions: Compared with white adults, black adults were more likely to be nonadherent to statins following hospitalization for ischemic stroke.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Albright, K. C., Zhao, H., Blackburn, J., Limdi, N. A., Beasley, T. M., Howard, G., Bittner, V., Howard, V. J., Muntner, P. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Probable REM sleep behavior disorder and risk of stroke: A prospective study
Conclusions: Presence of pRBD was associated with a higher risk of developing stroke, including both ischemic and hemorrhagic types. Future studies with clinically confirmed RBD and a longer follow-up would be appropriate to further investigate this association.
Source: Neurology - May 8, 2017 Category: Neurology Authors: Ma, C., Pavlova, M., Liu, Y., Liu, Y., Huangfu, C., Wu, S., Gao, X. Tags: All Cerebrovascular disease/Stroke, All Sleep Disorders, Cohort studies ARTICLE Source Type: research

Integrity of normal-appearing white matter and functional outcomes after acute ischemic stroke
Conclusions: FA decrease in NAWM contralateral to the acute infarct is associated with worse mRS category at 90 days after stroke. These data suggest that white matter integrity may contribute to functional recovery after stroke.
Source: Neurology - May 1, 2017 Category: Neurology Authors: Etherton, M. R., Wu, O., Cougo, P., Giese, A.-K., Cloonan, L., Fitzpatrick, K. M., Kanakis, A. S., Boulouis, G., Karadeli, H. H., Lauer, A., Rosand, J., Furie, K. L., Rost, N. S. Tags: MRI, Other cerebrovascular disease/ Stroke, Volumetric MRI, Metabolic disease (inherited) ARTICLE Source Type: research

Fine particulate matter exposure and incidence of stroke: A cohort study in Hong Kong
Conclusion: Long-term PM2.5 exposure was associated with higher risk of incident ischemic stroke, but the association with incident hemorrhagic stroke was less clear.
Source: Neurology - May 1, 2017 Category: Neurology Authors: Qiu, H., Sun, S., Tsang, H., Wong, C.-M., Lee, R. S.-y., Schooling, C. M., Tian, L. Tags: All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Physical activity, but not body mass index, predicts less disability before and after stroke
Conclusions: Physical inactivity predicts a higher risk of being dependent both before and after stroke.
Source: Neurology - May 1, 2017 Category: Neurology Authors: Rist, P. M., Capistrant, B. D., Mayeda, E. R., Liu, S. Y., Glymour, M. M. Tags: All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Is fabrys disease a risk factor for stroke in young patients? (p1.252)
Conclusions:Although as much as 40% of young patients with ischemic stroke have no clear etiology, extensive investigation for possibly treatable causes is warranted and should include Fabry’s Disease.Disclosure: Dr. Ikuta has nothing to disclose. Dr. Scavasine has nothing to disclose. Dr. Canever has nothing to disclose. Dr. Zamproni has nothing to disclose. Dr. Lange has nothing to disclose. Dr. Germiniani has nothing to disclose. Dr. Zetola has nothing to disclose. Dr. Werneck has nothing to disclose. Dr. Novak has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ikuta, C., Scavasine, V., Canever, M., Zamproni, L., Lange, M., Germiniani, F., Zetola, V., Werneck, L., Novak, E. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

A rare cause of stroke in young: PHACE syndrome (P1.253)
Conclusions:Neurocutaneous syndromes are typically diagnosed in childhood and can be a rare cause of stroke in young. Our patient suffered an ischemic stroke secondary to sequelae of undiagnosed PHACE syndrome. Early identification of neurocutaneous syndromes allows for proper surveillance, evaluation, and preventative education for development of complications.Disclosure: Dr. Fitzgerald has nothing to disclose. Dr. Chandra has nothing to disclose. Dr. Dannenbaum has nothing to disclose. Dr. Sharrief has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Fitzgerald, K., Chandra, S., Dannenbaum, M., Sharrief, A. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

MELAS Syndrome: How Stroke-like are the Stroke episodes? (P1.255)
Conclusions:Patients with MELAS syndrome may present with recurrent strokes in the arterial territory rather than SLEs. Clinicians should entertain the possibility of a mitochondrial disease in young patients with cryptogenic stroke and pursue appropriate diagnostic evaluations and treatment.Disclosure: Dr. Liaw has nothing to disclose. Dr. Lewis has nothing to disclose. Dr. Saini has nothing to disclose. Dr. Gultekin has nothing to disclose. Dr. Koch has nothing to disclose. Dr. Asdaghi has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Liaw, N., Lewis, R., Saini, V., Gultekin, S. H., Koch, S., Asdaghi, N. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

D-Lactate and Intestinal Fatty-Acid Binding Protein are elevated in serum in patients with acute ischemic stroke (P1.258)
Conclusions:D-Lactate and IFABP were significantly elevated in patients with AIS, but concentrations were not associated with stroke severity. This provides, for the first time, indirect evidence of disruption of the intestinal barrier in patients with AIS.Disclosure: Dr. Camara-Lemarroy has nothing to disclose. Dr. Escobedo-Zúñiga has nothing to disclose. Dr. Guzman-De la Garza has nothing to disclose. Dr. Castro-Garza has nothing to disclose. Dr. Vargas-Villarreal has nothing to disclose. Dr. Góngora-Rivera has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Camara-Lemarroy, C., Escobedo-Zuniga, N., la Garza, F. G.-D., Castro-Garza, J., Vargas-Villarreal, J., Gongora-Rivera, F. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Relationship between admission serum bilirubin and severity of acute ischaemic stroke in a nigerian tertiary hospital (p1.259)
Conclusion:Patients with higher physiologic range of serum bilirubin had more severe stroke (higher NIHSS values), suggesting that higher bilirubin values at stroke onset might be a reflection of oxidative intensity.Disclosure: Dr. Ademiluyi has nothing to disclose. Dr. Sanya has nothing to disclose. Dr. Wahab has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ademiluyi, B., Sanya, E., Wahab, K. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Association between nasogastric tubes, pneumonia, and clinical outcomes in acute stroke patients
Conclusions: Early NGT does not increase PSP incidence, mortality, or poor functional outcomes and can be used safely in acute stroke patients.
Source: Neurology - September 26, 2016 Category: Neurology Authors: Kalra, L., Hodsoll, J., Irshad, S., Smithard, D., Manawadu, D., On behalf of the STROKE-INF Investigators Tags: Outcome research, Medical care, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Class III ARTICLE Source Type: research

Better outcomes for hospitalized patients with TIA when in stroke units: An observational study
Conclusions: Hospitalized patients with TIA managed in SUs had better survival at 180 days than those treated in alternate wards, potentially through better management, but further research is needed.
Source: Neurology - May 30, 2016 Category: Neurology Authors: Cadilhac, D. A., Kim, J., Lannin, N. A., Levi, C. R., Dewey, H. M., Hill, K., Faux, S., Andrew, N. E., Kilkenny, M. F., Grimley, R., Thrift, A. G., Grabsch, B., Middleton, S., Anderson, C. S., Donnan, G. A., On behalf of the Australian Stroke Clinical Reg Tags: Outcome research, All Cerebrovascular disease/Stroke, Models of care, Cohort studies ARTICLE Source Type: research