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Source: International Journal of Stroke

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Total 572 results found since Jan 2013.

Celebrating 10 years of the International Journal of Stroke!
International Journal of Stroke,Volume 10, Issue 8, Page 1167-1167, December 2015.
Source: International Journal of Stroke - November 18, 2015 Category: Neurology Source Type: research

Effect of atorvastatin co ‐treatment on inhibition of platelet activation by clopidogrel in patients with ischemic stroke
International Journal of Stroke,Volume 10, Issue 8, Page E90-E91, December 2015.
Source: International Journal of Stroke - November 18, 2015 Category: Neurology Source Type: research

Celebrating 10 years of the International Journal of Stroke!
International Journal of Stroke,Volume 10, Issue 8, Page 1167-1167, December 2015.
Source: International Journal of Stroke - November 18, 2015 Category: Neurology Authors: Geoffrey A Donnan Source Type: research

The iScore predicts total healthcare costs early after hospitalization for an acute ischemic stroke
ConclusionsThe ischemic Stroke risk score can be useful as a predictor of healthcare utilization and costs early after hospitalization for an acute ischemic stroke.
Source: International Journal of Stroke - October 27, 2015 Category: Neurology Authors: Emmanuel M. Ewara, Wanrudee Isaranuwatchai, Dawn M. Bravata, Linda S. Williams, Jiming Fang, Jeffrey S. Hoch, Gustavo Saposnik, Tags: Research Source Type: research

Exercise after Stroke
International Journal of Stroke,Volume 10, Issue S5, Page 38-40, December 2015.
Source: International Journal of Stroke - October 23, 2015 Category: Neurology Source Type: research

Severe cerebral white matter lesions in ischemic stroke patients are associated with less time spent at home and early institutionalization
International Journal of Stroke,Volume 10, Issue 8, Page 1192-1196, December 2015.
Source: International Journal of Stroke - October 21, 2015 Category: Neurology Source Type: research

Design of Randomized, double‐blind, Evaluation in secondary Stroke Prevention comparing the EfficaCy and safety of the oral Thrombin inhibitor dabigatran etexilate vs. acetylsalicylic acid in patients with Embolic Stroke of Undetermined Source (RE‐SPECT ESUS)
DiscussionAcetylsalicylic acid is the most common antithrombotic given to patients with embolic strokes of undetermined source to reduce recurrence risk. This trial will determine whether anticoagulation with dabigatran is more effective than acetylsalicylic acid, and acceptably safe.
Source: International Journal of Stroke - September 30, 2015 Category: Neurology Authors: Hans‐Christoph Diener, J. Donald Easton, Christopher B. Granger, Lisa Cronin, Christine Duffy, Daniel Cotton, Martina Brueckmann, Ralph L. Sacco, Tags: Protocol Source Type: research

Design of Randomized, double ‐blind, Evaluation in secondary Stroke Prevention comparing the EfficaCy and safety of the oral Thrombin inhibitor dabigatran etexilate vs. acetylsalicylic acid in patients with Embolic Stroke of Undetermined Source (RE‐SPECT ESUS)
International Journal of Stroke,Volume 10, Issue 8, Page 1309-1312, December 2015.
Source: International Journal of Stroke - September 30, 2015 Category: Neurology Source Type: research

Neurothrombectomy trial results: stroke systems, not just devices, make the difference
The overwhelming benefit demonstrated in the four recent randomized trials comparing intra‐arterial therapies to medical management alone will have a transformative effect on the emergent management of strokes throughout the world. New generation neurothrombectomy devices were critical to trial success, but not the sole driver of patient outcomes in these trials. Patients in the positive trials were treated at hospitals with complex, efficient, resource‐rich, team‐based stroke systems in place. To ensure attainment of trial results in actual practice, patients should receive treatment at facilities certified as havin...
Source: International Journal of Stroke - September 24, 2015 Category: Neurology Authors: J. Mocco, Kyle M. Fargen, Mayank Goyal, Elad I. Levy, Peter J. Mitchell, Bruce C. V. Campbell, Charles B. L. M. Majoie, Diederik W. J. Dippel, Pooja Khatri, Michael D. Hill, Jeffery L. Saver Tags: Leading opinion Source Type: research

Is acute reperfusion therapy safe in acute ischemic stroke patients who harbor unruptured intracranial aneurysm?
ConclusionOur findings suggest that neither intravenous thrombolysis nor combination of intravenous and intra‐arterial thrombolysis increases the risk of aneurysmal hemorrhage in acute ischemic stroke patients who harbor unruptured intracranial aneurysms less than 10 mm in diameter. Their listing in exclusion criteria for intravenous thrombolysis should be reconsidered to assure appropriate use of acute reperfusion therapy in this group of patients.
Source: International Journal of Stroke - September 17, 2015 Category: Neurology Authors: Ashkan Mowla, Karanbir Singh, Sandhya Mehla, Mohammad K. Ahmed, Peyman Shirani, Haris Kamal, Chandan Krishna, Robert N. Sawyer, Marilou Ching, Adnan H. Siddiqui, Elad I. Levy, Kenneth V. Snyder, Annemarie Crumlish, L. N. Hopkins Tags: Research Source Type: research

Adverse outcome after incident stroke hospitalization for Indigenous and non‐Indigenous Australians in the Northern Territory
ConclusionIndigenous stroke patients have higher prevalence of comorbidities than non‐Indigenous stroke patients, which explained part of the disparity in both case fatality and long‐term survival but did not explain the disparity in stroke recurrence at all.
Source: International Journal of Stroke - September 9, 2015 Category: Neurology Authors: Vincent YF. He, John R. Condon, Jiqiong You, Yuejen Zhao, James N. Burrow Tags: Research Source Type: research

Effect of helicopter transport on neurological outcomes in a mouse model of embolic stroke with reperfusion: AIR‐MICE pilot study
ConclusionsThis study shows that helicopter emergency medical services do not have an inherent adverse effect on outcome in a mouse model of ischemic stroke with reperfusion. These results endorse the safety of the practice of using helicopter emergency medical services in stroke patients. The observed potential synergistic effect of helicopter‐induced factors, such as vibration and changes in altitude, with reperfusion merits further exploration in animal experimental models and in stroke patients.
Source: International Journal of Stroke - September 1, 2015 Category: Neurology Authors: Enrique C. Leira, Asgar Zaheer, Thomas Schnell, James C. Torner, Heena M. Olalde, Andrew A. Pieper, Santiago Ortega‐Gutierrez, Nandakumar Nagaraja, Nancy L. Marks, Harold P. Adams Tags: Research Source Type: research

The correlation between admission blood glucose and intravenous rt‐PA‐induced arterial recanalization in acute ischemic stroke: a multi‐centre TCD study
ConclusionHyperglycemia is associated with low rate of complete recanalization and poor clinical outcome in intravenous recombinant tissue‐plasminogen activator‐treated patients. Further studies are needed to evaluate whether lowering hyperglycemia is beneficial in the management of acute stroke patients.
Source: International Journal of Stroke - September 1, 2015 Category: Neurology Authors: Maher Saqqur, Ashfaq Shuaib, Andrei V. Alexandrov, Joseph Sebastian, Khurshid Khan, Ken Uchino Tags: Research Source Type: research

Stroke preparedness in children: translating knowledge into behavioral intent: a systematic review and meta‐analysis
ConclusionChildren are a potentially attractive target population for improvement in stroke knowledge and behavioral intent, both in the short and long term. Our findings may support the implementation of large‐scale stroke educational initiatives targeting children.
Source: International Journal of Stroke - September 1, 2015 Category: Neurology Authors: Cassandra Ottawa, Luciano A. Sposato, Fadl Nabbouh, Gustavo Saposnik, Tags: Systematic Review Source Type: research

Acute Stroke or Transient Ischemic Attack Treated with Aspirin or Ticagrelor and Patient Outcomes (SOCRATES) trial: rationale and design
International Journal of Stroke,Volume 10, Issue 8, Page 1304-1308, December 2015.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Source Type: research

A systematic review and meta ‐analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke
International Journal of Stroke,Volume 10, Issue 8, Page 1168-1178, December 2015.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Source Type: research

Heart rate and ischemic stroke: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study
International Journal of Stroke,Volume 10, Issue 8, Page 1229-1235, December 2015.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Source Type: research

Acute Stroke or Transient Ischemic Attack Treated with Aspirin or Ticagrelor and Patient Outcomes (SOCRATES) trial: rationale and design
International Journal of Stroke,Volume 10, Issue 8, Page 1304-1308, December 2015.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: S. Claiborne Johnston , Pierre Amarenco , Gregory W. Albers , Hans Denison , J. Donald Easton , Peter Held , Jenny Jonasson , Kazuo Minematsu , Carlos A. Molina , Lawrence K. S. Wong Source Type: research

A systematic review and meta ‐analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke
International Journal of Stroke,Volume 10, Issue 8, Page 1168-1178, December 2015.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Joyce S. Balami , Brad A. Sutherland , Laurel D. Edmunds , Iris Q. Grunwald , Ain A. Neuhaus , Gina Hadley , Hasneen Karbalai , Kneale A. Metcalf , Gabriele C. DeLuca , Alastair M. Buchan Source Type: research

A systematic review and meta‐analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke
ConclusionsThere is clear evidence for improvement in functional independence with endovascular thrombectomy compared with standard medical care, suggesting that endovascular thrombectomy should be considered the standard effective treatment alongside thombolysis in eligible patients.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Joyce S. Balami, Brad A. Sutherland, Laurel D. Edmunds, Iris Q. Grunwald, Ain A. Neuhaus, Gina Hadley, Hasneen Karbalai, Kneale A. Metcalf, Gabriele C. DeLuca, Alastair M. Buchan Tags: Review Source Type: research

Acute Stroke or Transient Ischemic Attack Treated with Aspirin or Ticagrelor and Patient Outcomes (SOCRATES) trial: rationale and design
DiscussionThe SOCRATES trial fulfills an important clinical need by evaluating a potent antiplatelet agent as a superior alternative to current standard of care in patients presenting acutely with ischemic stroke or transient ischemic attack.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: S. Claiborne Johnston, Pierre Amarenco, Gregory W. Albers, Hans Denison, J. Donald Easton, Peter Held, Jenny Jonasson, Kazuo Minematsu, Carlos A. Molina, Lawrence K. S. Wong Tags: Protocol Source Type: research

Which stroke patients gain most from intermittent pneumatic compression: further analyses of the CLOTS 3 trial
ConclusionsIPC appears to reduce the risk of DVT and probably improves survival in all immobile stroke patients, other than the fifth with the best prognosis. It therefore seems reasonable to recommend that IPC should be considered in all immobile stroke patients, but that the final decision should be based on a judgment about the individual's prognosis. In some, their prognosis for survival with an acceptable quality of life will be so poor that use of IPC might be considered futile, while at the other end of the spectrum, patients' risk of DVT, and of dying from VTE, may not be high enough to justify the modest cost and ...
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Martin Dennis, Catriona Graham, Joel Smith, John Forbes, Peter Sandercock, Tags: Research Source Type: research

Heart rate and ischemic stroke: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study
ConclusionIn REGARDS, high resting heart rates were associated with an increased risk of ischemic stroke compared with low heart rates. Further research is needed to examine whether interventions aimed to reduce heart rate decrease stroke risk.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Wesley T. O'Neal, Waqas T. Qureshi, Suzanne E. Judd, James F. Meschia, Virginia J. Howard, George Howard, Elsayed Z. Soliman Tags: Research Source Type: research

One‐year case fatality rate following stroke in the Mashhad Stroke Incidence Study: a population‐based study of stroke in Iran
ConclusionDespite the younger age of stroke occurrence in Iran, the one‐year case fatality rate following stroke is similar to that reported in developed countries.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Ali Shoeibi, Maryam Salehi, Amanda G. Thrift, Moira K. Kapral, Mohammad Taghi Farzadfard, Amir Azarpazhooh, Parvaneh Layegh, Peyman Hashemi, Amin Amiri, Naghmeh Mokhber, Bahare Hassankhani, Mahmoud Reza Azarpazhooh Tags: Research Source Type: research

Multi‐modal CT in acute stroke: wait for a serum creatinine before giving intravenous contrast? No!
ConclusionsThe incidence of CIN is low when MMCT is used routinely to assess acute stroke patients. In this population, CIN was a biochemical phenomenon that did not have clinical manifestations, cause chronic kidney disease, require dialysis, or negatively impact on 90‐day mRS outcomes. Renal profiling and waiting for a baseline serum‐creatinine are an unnecessary delay to emergency reperfusion treatment.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Timothy E. Ang, Andrew Bivard, Christopher Levi, Henry Ma, Chung Y. Hsu, Bruce Campbell, Geoffrey Donnan, Stephen M. Davis, Mark Parsons Tags: Research Source Type: research

A systematic review and meta ‐analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke
ConclusionsThere is clear evidence for improvement in functional independence with endovascular thrombectomy compared with standard medical care, suggesting that endovascular thrombectomy should be considered the standard effective treatment alongside thombolysis in eligible patients.
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Joyce S. Balami, Brad A. Sutherland, Laurel D. Edmunds, Iris Q. Grunwald, Ain A. Neuhaus, Gina Hadley, Hasneen Karbalai, Kneale A. Metcalf, Gabriele C. DeLuca, Alastair M. Buchan Tags: Review Source Type: research

Prognostic value of 24‐h ABPM in acute ischemic stroke for short‐, medium‐, and long‐term outcome: a systematic review and meta‐analysis
ConclusionsHigher systolic and diastolic blood pressure levels derived with ambulatory blood pressure monitoring were associated with poor outcome. The same was not found for higher casual blood pressure measurements on admission, and it is possible that ambulatory blood pressure monitoring conveys better prognostic information.
Source: International Journal of Stroke - August 19, 2015 Category: Neurology Authors: Nikolaos Kakaletsis, George Ntaios, Haralampos Milionis, Anna‐Bettina Haidich, Konstantinos Makaritsis, Christos Savopoulos, Eivind Berge, Apostolos I. Hatzitolios Tags: Review Source Type: research

Individual patient data meta‐analysis of antiplatelet regimens after noncardioembolic stroke or TIA: rationale and design
ConclusionsThis paper outlines inclusion criteria, outcome measures, baseline characteristics, and planned statistical analysis.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Authors: Jacoba P. Greving, Hans‐Christoph Diener, László Csiba, Werner Hacke, L. Jaap Kappelle, Peter J. Koudstaal, Didier Leys, Jean‐Louis Mas, Ralph L. Sacco, Juhani Sivenius, Ale Algra, Tags: Protocol Source Type: research

Statistical analysis plan for evaluating low‐ vs. standard‐dose alteplase in the ENhanced Control of Hypertension and Thrombolysis strokE stuDy (ENCHANTED)
ConclusionsWe have developed a predetermined statistical analysis plan for the ENhanced Control of Hypertension And Thrombolysis strokE stuDy alteplase dose arm which is to be followed to avoid analysis bias arising from prior knowledge of the study findings.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Authors: Craig S. Anderson, Mark Woodward, Hisatomi Arima, Xiaoying Chen, Richard I. Lindley, Xia Wang, John Chalmers, Tags: Protocol Source Type: research

Specialized stroke rehabilitation services in seven countries
International Journal of Stroke,Volume 10, Issue 8, Page 1236-1246, December 2015.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Source Type: research

Statistical analysis plan for evaluating low ‐ vs. standard‐dose alteplase in the ENhanced Control of Hypertension and Thrombolysis strokE stuDy (ENCHANTED)
International Journal of Stroke,Volume 10, Issue 8, Page 1313-1315, December 2015.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Source Type: research

Specialized stroke rehabilitation services in seven countries
International Journal of Stroke,Volume 10, Issue 8, Page 1236-1246, December 2015.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Authors: Birgitta Langhammer , Frank Becker , Katharina S. Sunnerhagen , Tong Zhang , Xiaoxia Du , Tamara Bushnik , Maria Panchenko , Ofer Keren , Samir Banura , Khamis Elessi , Fuad Luzon , Åsa Lundgren‐Nilsson , Xi Source Type: research

Statistical analysis plan for evaluating low ‐ vs. standard‐dose alteplase in the ENhanced Control of Hypertension and Thrombolysis strokE stuDy (ENCHANTED)
International Journal of Stroke,Volume 10, Issue 8, Page 1313-1315, December 2015.
Source: International Journal of Stroke - August 18, 2015 Category: Neurology Authors: Craig S. Anderson , Mark Woodward , Hisatomi Arima , Xiaoying Chen , Richard I. Lindley , Source Type: research

The Clinical Relevance of Microbleeds in Stroke study (CROMIS‐2): rationale, design, and methods
Background and rationaleThe increasing use of oral anticoagulants, mostly to prevent ischemic stroke due to atrial fibrillation in an ageing population, has been associated with a fivefold increased incidence of oral anticoagulant‐associated intracerebral hemorrhage: a rare, serious, and unpredictable complication. We hypothesize that cerebral microbleeds and other markers of cerebral small vessel disease on magnetic resonance imaging, and genetic polymorphisms (e.g. influencing cerebral small vessel integrity or anticoagulation stability), are associated with an increased risk of oral anticoagulant‐associated intracer...
Source: International Journal of Stroke - August 2, 2015 Category: Neurology Authors: Andreas Charidimou, Duncan Wilson, Clare Shakeshaft, Gareth Ambler, Mark White, Hannah Cohen, Tarek Yousry, Rustam Al‐Shahi Salman, Gregory Lip, Henry Houlden, Hans R. Jäger, Martin M. Brown, David J. Werring Tags: Protocol Source Type: research

Heart rate variability and baroreceptor sensitivity in acute stroke: a systematic review
BackgroundAutonomic nervous system dysfunction is common after acute stroke and is associated with elevated risk of cardiac arrhythmia and mortality. Heart rate variability and baroreceptor sensitivity have been investigated as parameters of autonomic nervous system dysfunction for the prediction of stroke outcome. SummaryWe performed a systematic literature review on heart rate variability and baroreceptor sensitivity as parameters for autonomic nervous function in acute stroke. Twenty‐two studies were included. Associations between heart rate variability or baroreceptor sensitivity and stroke severity, early and late c...
Source: International Journal of Stroke - July 23, 2015 Category: Neurology Authors: Laetitia Yperzeele, Robbert‐Jan van Hooff, Guy Nagels, Ann De Smedt, Jacques De Keyser, Raf Brouns Tags: Systematic review Source Type: research

What's new in stroke? Phase III randomized clinical trials of 2012–2014
ConclusionsThe diversity of interventions, high‐quality, and worldwide origins of recently published phase III randomized clinical trials reflects a vibrant international stroke research community. The current generation of stroke randomized clinical trials provides important guidance for stroke prevention and acute stroke care.
Source: International Journal of Stroke - July 14, 2015 Category: Neurology Authors: Robert G. Hart, Kuan H. Ng, Kanjana S. Perera, Ashkan Shoamanesh Tags: Review Source Type: research

Prevalence of stroke symptoms among stroke‐free residents: first national data from Lebanon
ConclusionsThis is the first study conducted in the Middle East, assessing self‐reported stroke symptoms among stroke‐free residents. Our study showed that almost one in eight residents without a history of stroke or transient ischemic attack has had stroke symptoms. Major vascular risk factors are associated with these symptoms, thus allowing for prevention strategies.
Source: International Journal of Stroke - July 14, 2015 Category: Neurology Authors: Rita Farah, Rouba Karen Zeidan, Mirna N. Chahine, Roland Asmar, Ramez Chahine, Pascale Salameh, Hassan Hosseini Tags: Research Source Type: research

Direct medical cost of stroke in Singapore
ConclusionThere is a considerable economic burden associated with stroke in Singapore. The type of stroke, length of poststroke period, and stroke complications and comorbidities are found to be associated with the total costs. Efforts to reduce inpatient costs and to allocate health resources to focus on the primary prevention of stroke should become a priority.
Source: International Journal of Stroke - July 14, 2015 Category: Neurology Authors: Charmaine Shuyu Ng, Matthias Paul Han Sim Toh, Jiaying Ng, Yu Ko Tags: Research Source Type: research