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Total 186 results found since Jan 2013.
Correspondence Stoop to conquer: preventing stroke and dementia together
The timely editorial in The Lancet (Dec 3, p 2713)1 calls for a broadening of our approaches to dementia research. Treatment and prevention of cerebrovascular diseases appear to be the most obvious examples. Covert cerebrovascular disease can contribute to or trigger neurodegeneration. Alzheimer's and other neurodegenerative diseases are common in the elderly, most of whom do not develop dementia. However, if an individual has a component of vascular disease, which occurs in 80% of patients with Alzheimer's disease, it doubles the chances of developing dementia.
Source: LANCET - April 14, 2017 Category: Journals (General) Authors: Vladimir Hachinski Tags: Correspondence Source Type: research
Department of Error Department of Error
Breitenstein C, Grewe T, Fl öel A, et al. Intensive speech and language therapy in patients with chronic aphasia after stroke: a randomised, open-label, blinded-endpoint, controlled trial in a health-care setting. Lancet 2017; 389: 1528–38—In this Article, S Runge should have been listed as part of the FCET2EC study group as a non-author collaborator. This change has been made to the online version as of April 13, 2017, and the printed Article is correct.
Source: LANCET - April 14, 2017 Category: Journals (General) Tags: Department of Error Source Type: research
Articles Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials
Mean achieved SBP less than 120 mm Hg during treatment was associated with increased risk of cardiovascular outcomes except for myocardial infarction and stroke. Similar patterns were observed for DBP less than 70 mm Hg, plus increased risk for myocardial infarction and hospital admission for heart failure. Very low blood pressure achieved on treatment was associated with increased risks of several cardiovascular disease events. These data suggest that the lowest blood pressure possible is not necessarily the optimal target for high-risk patients, although it is not possible to rule out some effect of reverse causality.
Source: LANCET - April 5, 2017 Category: General Medicine Authors: Michael B öhm, Helmut Schumacher, Koon K Teo, Eva M Lonn, Felix Mahfoud, Johannes F E Mann, Giuseppe Mancia, Josep Redon, Roland E Schmieder, Karen Sliwa, Michael A Weber, Bryan Williams, Salim Yusuf Tags: Articles Source Type: research
Comment Bioprosthetic surgical and transcatheter heart valve thrombosis
Excellent outcomes of transcatheter aortic valve replacement (TAVR) have been experienced by patients with aortic stenosis at high and intermediate risk of surgery.1 Findings from large randomised trials1,2 have shown survival with TAVR that is similar to or improved compared with bioprosthetic surgical aortic valve replacement (SAVR), and very low stroke rates have been observed with new-generation devices. Investigators of echocardiographic follow-up studies3 have consistently reported low transvalvular gradients up to 5 years after TAVR and SAVR, with slightly greater aortic valve areas after TAVR than after SAVR.
Source: LANCET - March 19, 2017 Category: General Medicine Authors: Jeroen J Bax, Gregg W Stone Tags: Comment Source Type: research
Correspondence Risk of mortality and stroke after atrial fibrillation
Jeff Healey and colleagues (Sept 17, p 1161)1 should take credit for their study about mortality and stroke 1 year after a diagnosis of atrial fibrillation. The main findings of the study were the almost two-times higher mortality in South America (17%) and Africa (20%) compared with North America, western Europe, and Australia (10%), and the higher stroke frequency in Africa (8%) and China (7%) compared with the aforementioned regions (3%).
Source: LANCET - March 3, 2017 Category: Journals (General) Authors: Constantinos Mihas, Anargiros Mariolis, Konstantinos P Letsas, Maria Kantzanou Tags: Correspondence Source Type: research
Correspondence Risk of mortality and stroke after atrial fibrillation – Authors' reply
On behalf our colleagues, we would like to thank Zitian Huo and Constantinos Mihas and colleagues for their interest in our Article and for their questions. We agree with Mihas and colleagues that it would be informative to examine regional differences in haemorrhagic stroke. However, given the large size of our study,1 we needed to minimise the burden of data collection to keep costs affordable. As a result, we did not collect any data on stroke subtypes. The decision not to collect these data was also influenced by the fact that not all participating regions in this study had equal access to advanced neurological imaging...
Source: LANCET - March 3, 2017 Category: Journals (General) Authors: Jeff S Healey, Jonas Oldgren, RE-LY Atrial Fibrillation and Cohort Study Investigators Tags: Correspondence Source Type: research
Comment Does intensity matter in aphasia rehabilitation?
Aphasia is a serious acquired communication disability, that affects approximately 30% of stroke survivors.1 It is chronic in nature: 50% of people diagnosed with aphasia have persistent communication problems 1 year after stroke.2 Aphasia compromises an individual's ability to undertake many activities of daily living, resulting in reduced mood and quality of life.3,4 In addition to the personal cost of aphasia, health-care costs for people with aphasia are the highest in stroke care.5 Therefore, the recent identification of recovery from aphasia as one of the top ten research priorities related to life after stroke is unsurprising.
Source: LANCET - February 27, 2017 Category: Journals (General) Authors: Linda Worrall, Abby Foster Tags: Comment Source Type: research
Articles Intensive speech and language therapy in patients with chronic aphasia after stroke: a randomised, open-label, blinded-endpoint, controlled trial in a health-care setting
3 weeks of intensive speech and language therapy significantly enhanced verbal communication in people aged 70 years or younger with chronic aphasia after stroke, providing an effective evidence-based treatment approach in this population. Future studies should examine the minimum treatment intensity required for meaningful treatment effects, and determine whether treatment effects cumulate over repeated intervention periods.
Source: LANCET - February 27, 2017 Category: Journals (General) Authors: Caterina Breitenstein, Tanja Grewe, Agnes Fl öel, Wolfram Ziegler, Luise Springer, Peter Martus, Walter Huber, Klaus Willmes, E Bernd Ringelstein, Karl Georg Haeusler, Stefanie Abel, Ralf Glindemann, Frank Domahs, Frank Regenbrecht, Klaus-Jürgen Schlenc Tags: Articles Source Type: research
Perspectives Towards a smart medical home
Julia is nudged awake at 0615 h, her optimum waking time as determined by patterns of her vital signs and body movements, which are all measured by her mattress as she sleeps. Although prone to orthostatic hypotension, the floor-based hallway sensors do not detect any unsteadiness as she walks to the bathroom. Upon sitting on the toilet, a rapid assessment of her blood pressure, cardiac stroke volume, bodyweight, urine, and stool assays takes place. When she looks in the mirror, a reminder of her medications appear.
Source: LANCET - January 27, 2017 Category: Journals (General) Authors: Evan D Muse, Paddy M Barrett, Steven R Steinhubl, Eric J Topol Tags: Perspectives Source Type: research
Obituary Wenner Dudley Johnson
Pioneering heart surgeon. He was born in Madison, WI, USA, on April 3, 1930, and died following a stroke in Milwaukee, WI, USA, on Oct 24, 2016, aged 86 years.
Source: LANCET - January 20, 2017 Category: Journals (General) Authors: Geoff Watts Tags: Obituary Source Type: research
Correspondence Hypertension control and cardiovascular disease
On the basis of Omran's theory of epidemiological transition, Jacques Blacher and colleagues (July 30, p 530)1 provocatively propose six strategies to reduce the burden of hypertensive cardiovascular disease. Notably, missing from their list are strategies to minimise blood pressure variability. In several large randomised trials, such as ALLHAT2 and ASCOT,3 blood pressure variability has been identified as a powerful independent risk factor for stroke and cardiovascular events.4 –6 Of note, not all antihypertensive drugs are equally effective in reducing blood pressure variability.
Source: LANCET - January 13, 2017 Category: Journals (General) Authors: Franz H Messerli, Urs Fischer, Stefano F Rimoldi, Sripal Bangalore Tags: Correspondence Source Type: research
Correspondence The INTERSTROKE study on risk factors for stroke
In a large case-control study in 32 countries, O'Donnell and colleagues (Aug 20, p 761) 1 sought to quantify the importance of potentially modifiable risk factors for stroke in different regions of the world. They found that ten potentially modifiable risk factors are collectively associated with about 90% of the population attributable risks of stroke in each major region of the world.
Source: LANCET - January 6, 2017 Category: Journals (General) Authors: Xianwei Zeng, Aijun Deng, Yi Ding Tags: Correspondence Source Type: research
Correspondence The INTERSTROKE study on risk factors for stroke – Authors' reply
Xianwei Zeng and collagues suggest our analysis of the INTERSTROKE study1 overestimated the population attributable for ten risk factors of stroke due to the selection of variables included. Although we did not include a variable for metabolic syndrome, we did include the key domains for metabolic syndrome, namely obesity, diabetes, hypertension, and apolipoproteins. Our analysis also included a measure of dietary quality, namely modified alternative healthy index (mAHEI). Variables for health education and hormones were not included, because these were not measured, although certain hormones could be measured in future an...
Source: LANCET - January 6, 2017 Category: Journals (General) Authors: Martin O'Donnell, Salim Yusuf Tags: Correspondence Source Type: research
