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Source: European Heart Journal

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Total 237 results found since Jan 2013.

Prediction of individual life-years gained without cardiovascular events from lipid, blood pressure, glucose, and aspirin treatment based on data of more than 500  000 patients with Type 2 diabetes mellitus
ConclusionCardiovascular disease-free life expectancy and effects of lifelong prevention in terms of CVD-free life-years gained can be estimated for people with T2DM using readily available clinical characteristics. Predictions of individual-level treatment effects facilitate translation of trial results to individual patients.
Source: European Heart Journal - January 9, 2019 Category: Cardiology Source Type: research

Clinical and haemodynamic outcomes of balloon-expandable transcatheter mitral valve implantation: a 7-year experience
ConclusionTranscatheter mitral valve implantation using balloon-expandable valves in selected patients with bioprosthesis or annuloplasty failure or severe MAC was associated with a low rate of peri-procedural complications and acceptable long-term outcomes.
Source: European Heart Journal - May 19, 2018 Category: Cardiology Source Type: research

Left ventricular stroke volume in severe aortic stenosis and preserved left ventricular ejection fraction: prognostic relevance
Source: European Heart Journal - May 16, 2018 Category: Cardiology Source Type: research

Ten-year association of coronary artery calcium with atherosclerotic cardiovascular disease (ASCVD) events: the multi-ethnic study of atherosclerosis (MESA)
ConclusionsCoronary artery calcium is associated strongly and in a graded fashion with 10-year risk of incident ASCVD as it is for CHD, independent of standard risk factors, and similarly by age, gender, and ethnicity. While 10-year event rates in those with CAC  = 0 were almost exclusively below 5%, those with CAC ≥ 100 were consistently above 7.5%, making these potentially valuable cutpoints for the consideration of preventive therapies. Coronary artery calcium strongly predicts risk with the same magnitude of effect in all races, age groups, an d both sexes, which makes it among the most useful markers for predicting ASCVD risk.
Source: European Heart Journal - April 23, 2018 Category: Cardiology Source Type: research

Clinical impact of direct stenting and interaction with thrombus aspiration in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: Thrombectomy Trialists Collaboration
ConclusionDirect stenting rates were higher in patients randomized to thrombus aspiration. Clinical outcomes and myocardial reperfusion measures did not differ significantly between DS and conventional stenting and there was no interaction with thrombus aspiration.
Source: European Heart Journal - April 21, 2018 Category: Cardiology Source Type: research

‘Ten Commandments’ of the EHRA Guide for the Use of NOACs in AF
Non-vitamin K antagonist oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with atrial fibrillation (AF), and have emerged as the preferred choice, particularly in patients newly started on anticoagulation. Both physicians and patients are becoming more accustomed to the use of these drugs in clinical practice. However, many unresolved questions on how to optimally use these agents in specific clinical situations remain. In 2013, the first “EHRA Practical Guide” was published to provide practical guidance for situations; an update was published in 2015. Below ...
Source: European Heart Journal - April 21, 2018 Category: Cardiology Source Type: research

Safety and efficacy of dual vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: a systematic review and meta-analysis of randomized clinical trials
ConclusionCompared with TAT, DAT shows a reduction in TIMI major or minor bleeding by 47% with comparable outcomes of MACE. Our findings support the concept that DAT may be a better option than TAT in many patients with AF following PCI.
Source: European Heart Journal - April 13, 2018 Category: Cardiology Source Type: research

The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation
AbstractThe current manuscript is the second update of the original Practical Guide, published in 2013 [Heidbuchelet al. European Heart Rhythm Association Practical Guide on the use of new oral anticoagulants in patients with non-valvular atrial fibrillation.Europace 2013;15:625 –651; Heidbuchelet al. Updated European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist anticoagulants in patients with non-valvular atrial fibrillation. Europace 2015;17:1467 –1507]. Non-vitamin K antagonist oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in pati...
Source: European Heart Journal - March 19, 2018 Category: Cardiology Source Type: research

Predicting the development of in-hospital cardiogenic shock in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention: the ORBI risk score
ConclusionThe ORBI risk score provides a readily useable and efficient tool to identify patients at high-risk of developing CS during hospitalization following STEMI, which may aid in further risk-stratification and thus potentially facilitate pre-emptive clinical decision making.
Source: European Heart Journal - March 15, 2018 Category: Cardiology Source Type: research

Prediction of ischaemic stroke in non-valvular atrial fibrillation if advanced echocardiography plays the game
Abstract
Source: European Heart Journal - February 9, 2018 Category: Cardiology Source Type: research

An African cardiology summitThe World Heart Federation African Summit on Best Practices in Policy and Access to Care in 2017 concluded with the Khartoum Action Plan, to improve cardiovascular on the African continent
The World Heart Federation (WHF) is the umbrella organization of continental and national cardiac societies and heart foundations globally, reporting to the World Health Organization (WHO). The WHF is dedicated to the global fight against CVD, including heart disease, stroke, and rheumatic heart disease (RHD). Building on the first Global Summit on Circulatory Health, held at the 2016 World Congress of Cardiology and Cardiovascular Health in Mexico City, the second Summit held in Singapore July 2017 focused on building a civil society movement for circulatory health.
Source: European Heart Journal - February 6, 2018 Category: Cardiology Source Type: research

Blood pressure and cardiovascular outcomes in patients with diabetes and high cardiovascular risk
ConclusionsIn patients with diabetes and elevated CV risk, even after extensive adjustment for underlying disease burden, there was a persistent association for low DBP with subclinical myocardial injury and risk of MI.
Source: European Heart Journal - January 31, 2018 Category: Cardiology Source Type: research

The winding path towards rationale anti-thrombotic therapy to prevent stroke in patients with atrial fibrillation
This editorial refers to ‘Characteristics of patients with atrial fibrillation prescribed antiplatelet monotherapy compared with those on anticoagulants: insights from the GARFIELD-AF registry’††, by F.W.A. Verheugtet al., on page 464.
Source: European Heart Journal - January 9, 2018 Category: Cardiology Source Type: research

Innovative strategies to improve adherence to non-vitamin K antagonist oral anticoagulants for stroke prevention in atrial fibrillation
Abstract
Source: European Heart Journal - January 6, 2018 Category: Cardiology Source Type: research

Telemonitoring-based feedback improves adherence to non-vitamin K antagonist oral anticoagulants intake in patients with atrial fibrillation
ConclusionTelemonitoring resulted in high NOAC adherence due to the notion of being watched, as evidenced by the rapid decline during the observation period. Feedback further optimized adherence. Telemonitoring with or without feedback may be a cost-effective approach in high-risk patients deemed poorly adherent.
Source: European Heart Journal - January 2, 2018 Category: Cardiology Source Type: research

Characteristics of patients with atrial fibrillation prescribed antiplatelet monotherapy compared with those on anticoagulants: insights from the GARFIELD-AF registry
ConclusionPrescribing AP monotherapy in newly diagnosed AF has declined, but even nowadays a substantial proportion of AP-treated patients with AF have no indication for AP.Clinical Trial RegistrationURL:http://www.clinicaltrials.gov. Unique identifier: NCT01090362.
Source: European Heart Journal - December 20, 2017 Category: Cardiology Source Type: research

Traumatic injury: another unjustified reason to stop oral anticoagulation for atrial fibrillation
This editorial refers to ‘Resumption of oral anticoagulation following traumatic injury and risk of stroke and bleeding in patients with atrial fibrillation: a nationwide cohort study’††, by L. Staerket al., on page 1698.
Source: European Heart Journal - December 13, 2017 Category: Cardiology Source Type: research

External applicability of the COMPASS trial: an analysis of the reduction of atherothrombosis for continued health (REACH) registry
ConclusionCOMPASS-Eligible patients represent a substantial fraction of stable CAD/PAD patients encountered in routine clinical practice in the large international REACH registry suggesting good external applicability. COMPASS-Eligible patients experienced a higher rate of the primary outcome compared with COMPASS participants in the aspirin alone treatment arm.
Source: European Heart Journal - November 23, 2017 Category: Cardiology Source Type: research

Cholesterol variability: a marker for increased risk or a risk factor?
This editorial refers to ‘Cholesterol variability and the risk of mortality, myocardial infarction, and stroke: a nationwide population-based study’†, by M.K. Kimet al., on page3560.
Source: European Heart Journal - November 13, 2017 Category: Cardiology Source Type: research

A Swiss National Strategy for 2017 –2024
A Swiss National Strategy for Cardiovascular disease, Stroke, and Diabetes for the next 7  years has been produced through a joint initiative of 26 National Cardiovascular Societies and the Swiss Heart Foundation 
Source: European Heart Journal - November 7, 2017 Category: Cardiology Source Type: research

A meta-analysis of continuous positive airway pressure therapy in prevention of cardiovascular events in patients with obstructive sleep apnoea
ConclusionCPAP therapy might reduce MACE and stroke among subjects with CPAP time exceeding 4  h/night. Additional randomized trials mandating adequate CPAP time adherence are required to confirm this impression.
Source: European Heart Journal - October 24, 2017 Category: Cardiology Source Type: research

Effect of statins and non-statin LDL-lowering medications on cardiovascular outcomes in secondary prevention: a meta-analysis of randomized trials
ConclusionReduction of MVE is proportional to the magnitude of LDL-C lowering across a broad spectrum of on-treatment levels in secondary prevention. Statin intensification and add-on treatment with PCSK9 inhibitors or ezetimibe are associated with significant reduction of cardiovascular morbidity in this very high-risk population.
Source: European Heart Journal - October 23, 2017 Category: Cardiology Source Type: research

Improved outcomes in patients with ST-elevation myocardial infarction during the last 20  years are related to implementation of evidence-based treatments: experiences from the SWEDEHEART registry 1995–2014
ConclusionGradual implementation of new and established evidence-based treatments in STEMI patients during the last 20  years has been associated with prolonged survival and lower risk of recurrent ischaemic events, although a plateauing is seen since around 2008.
Source: European Heart Journal - August 29, 2017 Category: Cardiology Source Type: research

The role of cardiologists in stroke prevention and treatment: position paper of the European Society of Cardiology Council on Stroke
Source: European Heart Journal - August 28, 2017 Category: Cardiology Source Type: research

Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study
ConclusionAt one year, clinical outcomes with the SYNTAX-II strategy were associated with improved clinical results compared to the PCI performed in comparable patients from the original SYNTAX-I trial. Longer term follow-up is awaited and a randomized clinical trial with contemporary CABG is warranted.ClinicalTrials.gov IdentifierNCT02015832
Source: European Heart Journal - August 26, 2017 Category: Cardiology Source Type: research

2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS)Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteriesEndorsed by: the European Stroke Organization (ESO)The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS)
GuidelinesPeripheral arterial diseasesCarotid artery diseaseVertebral artery diseaseUpper extremity artery diseaseMesenteric artery diseaseRenal artery diseaseLower extremity artery diseaseMultisite artery disease
Source: European Heart Journal - August 26, 2017 Category: Cardiology Source Type: research

Questions and answers on diagnosis and management of patients with Peripheral Arterial Diseases: a companion document of the 2017 ESC Guidelines for the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS)Endorsed by: the European Stroke Organisation (ESO)The Task Force for the Diagnosis and Treatment of Peripheral Arterial Diseases of the European Society of Cardiology (ESC) and of the European Society for Vascular Surgery (ESVS)
GuidelinesQuestions and answersPeripheral arterial diseasesCarotid artery diseaseVertebral artery diseaseUpper extremity artery diseaseMesenteric artery diseaseRenal artery diseaseLower extremity artery diseaseMultisite artery disease
Source: European Heart Journal - August 26, 2017 Category: Cardiology Source Type: research

How to use Mendelian randomization to anticipate the results of randomized trials
This editorial refers to ‘Differential effects ofPCSK9 variants on risk of coronary disease and ischaemic stroke ’††, by J.C. Hopewellet al., on page 354. 
Source: European Heart Journal - August 16, 2017 Category: Cardiology Source Type: research

Uncommon cause of dyspnoea after percutaneous closure of the left atrial appendage
A 69-year-old female with persistent atrial fibrillation and history of recurrent strokes presented with progressive shortness of breath. Three years ago, percutaneous closure of the left atrial appendage (LAA) for stroke prophylaxis was performed using an Amplatzer Amulet® device (St. Jude Medical, MN, USA).
Source: European Heart Journal - August 1, 2017 Category: Cardiology Source Type: research

Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement
ConclusionsTransthyretin cardiac amyloidosis is prevalent in 16% of patients with severe calcific AS undergoing TAVR and is associated with a severe AS phenotype of low-flow low-gradient with mildly reduced ejection fraction. Average tissue Doppler mitral annular S ’ of <  6 cm/s may be a sensitive measure that should prompt a confirmatory99mTc-PYP scan and subsequent testing for ATTR-CA. Prospective assessment of outcomes after TAVR is needed in patients with and without ATTR-CA.
Source: European Heart Journal - August 1, 2017 Category: Cardiology Source Type: research

Insomnia and myocardial infarction
Insomnia associated with increased risk of infarction and stroke according to study 
Source: European Heart Journal - July 14, 2017 Category: Cardiology Source Type: research

Long working hours as a risk factor for atrial fibrillation: a multi-cohort study
ConclusionIndividuals who worked long hours were more likely to develop atrial fibrillation than those working standard hours.
Source: European Heart Journal - July 13, 2017 Category: Cardiology Source Type: research

Safety and efficacy of a repositionable and fully retrievable aortic valve used in routine clinical practice: the RESPOND Study
ConclusionThe results of RESPOND confirm the safety and efficacy of TAVI with the Lotus Valve in routine clinical practice.Trial registrationClinicalTrials.gov #NCT 02031302.
Source: European Heart Journal - June 22, 2017 Category: Cardiology Source Type: research

Modern prevention: genetic testing, vascular imaging, machine learning, and drug safety
Traditionally, prevention has been divided into primary and secondary prevention. While the former focused on individuals considered healthy, the latter was designed to avoid future events in those who already had coronary artery disease, myocardial infarction, or stroke.1 However, this distinction is no longer useful, as many asymptomatic individuals do have atherosclerotic lesions such as plaques and calcifications upon modern imaging, and not all subjects with suspected symptoms have atherosclerotic vascular disease.2 –4 This Focus Issue on Prevention addresses these important issues. In a firstCurrent Opinion entitle...
Source: European Heart Journal - June 13, 2017 Category: Cardiology Source Type: research

NSAIDs and cardiac arrest Non-steroidal anti-inflammatory drug use is associated with increased risk of Out-of-hospital Cardiac Arrest: A nationwide Case-Time-Control study
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs worldwide. However, during the last 10  years, accumulating evidence of an increased cardiovascular risk associated with use of NSAIDs has emerged, and NSAIDs have been linked to several cardiovascular adverse events, such as myocardial infarction, heart failure, and stroke. Cardiac arrest is the ultimate and most dreaded adverse drug event… We aimed to assess the association between NSAID use and the risk of out-of-hospital cardiac arrest.
Source: European Heart Journal - June 13, 2017 Category: Cardiology Source Type: research

Final 5-year clinical and echocardiographic results for treatment of severe aortic stenosis with a self-expanding bioprosthesis from the ADVANCE Study
ConclusionFive-year results in real-world, elderly, high-risk patients undergoing TAVI with a self-expanding bioprosthesis provided evidence for continued valve durability with low rates of reinterventions and haemodynamic valve dysfunction.Trial registrationClinicalTrials.gov, NCT01074658.
Source: European Heart Journal - June 13, 2017 Category: Cardiology Source Type: research

SOURCE 3: 1-year outcomes post-transcatheter aortic valve implantation using the latest generation of the balloon-expandable transcatheter heart valve
ConclusionIn SOURCE 3, we observe a low complication rate and mortality at 1  year. Given the low incidence of higher degree paravalvular leakages, this variable did no longer affect outcome. Clinicaltrial.gov number: NCT02698956.
Source: European Heart Journal - June 12, 2017 Category: Cardiology Source Type: research

Corrigendum to: Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrial fibrillation: analysis of the CHARM-Preserved and I-Preserve trials
Eur Heart J (2017) 38 (10):742 –750.
Source: European Heart Journal - June 1, 2017 Category: Cardiology Source Type: research

Visit-to-visit variability of blood pressure and cardiovascular outcomes in patients with stable coronary heart disease. Insights from the STABILITY trial
ConclusionIn patients with stable coronary heart disease, higher visit-to-visit variabilities of both systolic and diastolic BP are strong predictors of increased risk of cardiovascular events, independently of mean BP.
Source: European Heart Journal - May 27, 2017 Category: Cardiology Source Type: research

Benefit of switching dual antiplatelet therapy after acute coronary syndrome: the TOPIC (timing of platelet inhibition after acute coronary syndrome) randomized study
ConclusionA switched DAPT is superior to an unchanged DAPT strategy to prevent bleeding complications without increase in ischaemic events following ACS.
Source: European Heart Journal - May 16, 2017 Category: Cardiology Source Type: research

Atrial fibrillation as a risk factor for cognitive decline and dementia
ConclusionIn adults aged 45 –85 years AF is associated with accelerated cognitive decline and higher risk of dementia even at ages when AF incidence is low. At least in part, this was explained by incident cardiovascular disease in patients with AF.
Source: European Heart Journal - April 29, 2017 Category: Cardiology Source Type: research

Prediction of adverse events after catheter-based procedures in adolescents and adults with congenital heart disease in the IMPACT registry
ConclusionThe factors predicting adverse events after cardiac catheterization in adolescents and adults with CHD are different than in the general population. Validation of this model in other national or multi-institutional datasets is the next step.
Source: European Heart Journal - April 18, 2017 Category: Cardiology Source Type: research

Impact of the SYNTAX scores I and II in patients with diabetes and multivessel coronary disease: a pooled analysis of patient level data from the SYNTAX, PRECOMBAT, and BEST trials
ConclusionsDifferences in 5 years outcomes following PCI and CABG for patients with MVD and diabetes were influenced by anatomic complexity as measured by the SYNTAX score. The SYNTAX score II mortality prediction model showed similar performance regardless of the diabetes status.
Source: European Heart Journal - April 18, 2017 Category: Cardiology Source Type: research

Low-density lipoprotein cholesterol targeting with pitavastatin + ezetimibe for patients with acute coronary syndrome and dyslipidaemia: the HIJ-PROPER study, a prospective, open-label, randomized trial
ConclusionAlthough intensive lowering with standard pitavastatin plus ezetimibe showed no more cardiovascular benefit than standard pitavastatin monotherapy in ACS patients with dyslipidaemia, statin plus ezetimibe may be more effective than statin monotherapy in patients with higher cholesterol absorption; further confirmation is needed.Trial NoUMIN000002742, registered as an International Standard Randomized Controlled Trial.
Source: European Heart Journal - April 18, 2017 Category: Cardiology Source Type: research

Subclinical atrial fibrillation in need of more assertive evidence
<span class="paragraphSection"><strong>This editorial refers to ‘Duration of device-detected subclinical atrial fibrillation and occurrence of stroke in ASSERT’†<sup> †</sup>, by I.C. Van Gelder<span style="font-style:italic;">et al.</span>, on page<strong><a href="article.aspx?volume=&page=">1339<span></span></a></strong>.</strong></span>
Source: European Heart Journal - March 31, 2017 Category: Cardiology Source Type: research

Comparison of coronary artery calcification, carotid intima-media thickness and ankle-brachial index for predicting 10-year incident cardiovascular events in the general population
ConclusionCoronary artery calcification provides the best discrimination of risk compared with CIMT and ABI, particularly in the intermediate risk group, whereas CIMT may be an alternative measure for reassurance in the low risk group.
Source: European Heart Journal - March 30, 2017 Category: Cardiology Source Type: research

Female gender as a risk factor for stroke associated with atrial fibrillation
This editorial refers to ‘Revisiting sex differences in outcomes in non-valvular atrial fibrillation: a population-based cohort study’†, by C. Renouxet al., on page1473.
Source: European Heart Journal - March 27, 2017 Category: Cardiology Source Type: research

Hypo-attenuated leaflet thickening of transcatheter aortic valves: jeopardy or epiphenomenon?
<span class="paragraphSection"><strong>This editorial refers to ‘Transcatheter aortic valve thrombosis: the relation between hypo-attenuated leaflet thickening, abnormal valve haemodynamics, and stroke’<sup> †</sup>, by E.M. Vollema<span style="font-style:italic;">et al.</span>, on page<strong><a href="article.aspx?volume=&page=">1207<span></span></a></strong>.</strong></span>
Source: European Heart Journal - March 27, 2017 Category: Cardiology Source Type: research

Foreign body granuloma as an unexpected long-term finding after percutaneous closure of a patent foramen ovale
A 67-year-old man was referred to our hospital for catheter ablation of atrial fibrillation. Eight years earlier, prior to diagnosis of atrial fibrillation, the patient suffered an ischaemic stroke. A patent foramen ovale (PFO) was diagnosed and the patient underwent percutaneous PFO closure by implantation of a Premere device (20  mm, St. Jude Medical). One month ago, the patient had another middle-cerebral artery infarction, which was considered cardioembolic due to insufficient anticoagulation. However, transthoracic echocardiography (TTE) obtained on current admission demonstrated a suspicious mass in the left atrium...
Source: European Heart Journal - March 24, 2017 Category: Cardiology Source Type: research

Long-term symptom improvement and patient satisfaction following catheter ablation of supraventricular tachycardia: insights from the German ablation registry
Conclusion</div>Ablation therapy for SVT is a safe procedure bringing symptomatic improvement and satisfaction to three quarters of patients after 1 year. Even in patients with arrhythmia recurrence, a high satisfaction level and adherence to the ablating institution could be documented. Strikingly high mortality and stroke rates in follow-up were observed in AFL patients, who apparently need consistent long-term anticoagulation and more medical attention.</span>
Source: European Heart Journal - March 17, 2017 Category: Cardiology Source Type: research