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Drug: Citalopram

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Total 35 results found since Jan 2013.

Impact of prestroke physical activity and citalopram treatment on poststroke depressive symptoms: a secondary analysis of data from the TALOS randomised controlled trial in Denmark
Conclusions A higher prestroke physical activity level was associated with fewer depressive symptoms 1 and 6 months after stroke. Citalopram treatment did not seem to modify this association. Trial registration numbers NCT01937182 (ClinicalTrials.gov) and 2013-002253-30 (EUDRACT).
Source: BMJ Open - March 30, 2023 Category: General Medicine Authors: Vestergaard, S. B., Damsbo, A. G., Blauenfeldt, R. A., Johnsen, S. P., Andersen, G., Mortensen, J. K. Tags: Open access, Neurology Source Type: research

Effect of transcranial magnetic stimulation in combination with citalopram on patients with post-stroke depression
ConclusionOur study found TMS in combination with citalopram is conducive to improving depression status and neuropsychological function, which holds great promise for treating PSD.
Source: Frontiers in Human Neuroscience - October 7, 2022 Category: Neuroscience Source Type: research

Clinical efficacy of Danzhi Xiaoyao Powder in the treatment of post-stroke depression: A protocol for randomized, double-blind clinical study
This study will evaluate the clinical efficacy of Danzhi Xiaoyao Powder in the treatment of PSD. The results of this study will provide reliable evidence for the clinical use of Xiaoyao Powder in the treatment of PSD. Trial registration: Open Science Framework Registration number: DOI 10.17605/OSF.IO/5V926
Source: Medicine - October 22, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

The Efficacy and Tolerability of Selective Serotonin Reuptake Inhibitors for Motor Recovery in Non-depressed Patients After Acute Stroke: A Meta-Analysis
Conclusions: Fluoxetine and citalopram can promote motor recovery in non-depressed patients with acute stroke, but it is necessary to pay attention to the possible AEs of fluoxetine, such as hyponatremia, seizure and fracture.Systematic Review Registration: PROSPERO, identifier [CRD42021227452].
Source: Frontiers in Neurology - October 20, 2021 Category: Neurology Source Type: research

Prevention of depression in adults with long-term physical conditions
CONCLUSIONS: Based on evidence of very low certainty, our results may indicate the benefit of pharmacological interventions, during or directly after preventive treatment. Few trials examined short-term outcomes up to six months, nor the follow-up effects at six to 12 months, with studies suffering from great numbers of drop-outs and inconclusive results. Generalisation of results is limited as study populations and treatment regimes were very heterogeneous. Based on the results of this review, we conclude that for adults with long-term physical conditions, there is only very uncertain evidence regarding the implementation...
Source: Cochrane Database of Systematic Reviews - March 5, 2021 Category: General Medicine Authors: Hanna Kampling Harald Baumeister J ürgen Bengel Oskar Mittag Source Type: research

A Review of Pharmacologic Neurostimulant Use During Rehabilitation and Recovery After Brain Injury.
CONCLUSIONS: The pharmacologic agent with the most supporting literature is amantadine used for cognitive improvement after TBI. Other neurostimulants with positive, despite more limited, evidence include methylphenidate, modafinil, levodopa, and citalopram. Caution is warranted with other neurostimulants given higher rates of adverse effects or lack of benefit observed in clinical trials. PMID: 33435717 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - January 12, 2021 Category: Drugs & Pharmacology Authors: Kakehi S, Tompkins DM Tags: Ann Pharmacother Source Type: research

Prestroke Physical Activity and Poststroke Cognitive Performance
Conclusion: Higher prestroke PA was associated with a better cognitive performance as measured by the SDMT at 1 and 6 months poststroke. We found no significant association between prestroke PA and functional outcome. Our results are encouraging and support further investigations of PA as a protective measure against poststroke cognitive impairment.Cerebrovasc Dis
Source: Cerebrovascular Diseases - November 11, 2020 Category: Neurology Source Type: research

Does citalopram effectively treat post-stroke depression?: A protocol for systematic review and meta analysis
Conclusions: The results of this study may present helpful evidence to determine whether citalopram is an effective management for patients with PSD. PROSPERO registration number: PROSPERO CRD42020171015.
Source: Medicine - June 26, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Considerations and Current Trends in the Management of the Geriatric Patient on a Consultation –Liaison Service
AbstractPurpose of ReviewTo provide consultation –liaison psychiatrists with an updated resource that can assist in the treatment and management of geriatric patients.Recent FindingsThe current available literature has not shown any differences in efficacy between haloperidol and second-generation antipsychotics in patients with delirium. When considering relative advantages of forms of antipsychotic administration, there is no support for a superior safety profile of oral compared to intramuscular or intravenous administration. A recent meta-analysis of four randomized controlled trials concluded that when melatonin was...
Source: Current Psychiatry Reports - April 12, 2020 Category: Psychiatry Source Type: research

Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
This study was carried out in accordance with the recommendations of the “Institutional Animal Care and Use Committee of China Medical University.” The protocol was approved by the “Institutional Animal Care and Use Committee of China Medical University.”Author ContributionsXWu and GW conceived and designed the experiments. YLi, RD, XR, WR, HYa, and YT performed the experiments. HYu, XZ, JY and XWa helped to analyze and interpret the data. GW drafted the manuscript. XWu, EX, YLu, and GZ provided critical revisions. All the authors reviewed and approved the final manuscript.FundingThe present stu...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Serotonergic Regulation and Cognition after Stroke: The Role of Antidepressant Treatment and Genetic Variation
Conclusion: There was no difference in cognition between citalopram and placebo-treated patients according to the genotype group. Our results indicate, however, that low expression SERT genotype may contribute to reduced cognitive function post stroke as placebo-treated patients with low SERT expression tended to score lower on the SDMT. The significant difference in SDMT scores between low and high expression patients was present only in the placebo-treated group, thereby warranting further exploration of the potential effect of early citalopram treatment on cognitive functioning. Our results are preliminary and need repl...
Source: Cerebrovascular Diseases - March 7, 2019 Category: Neurology Source Type: research

Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - January 5, 2019 Category: Neuroscience Authors: Kamaldeep S. Dhami, Matthew A. Churchward, Glen. B. Baker, Kathryn G. Todd Tags: Original Article Source Type: research

Efficacy and Safety of Citalopram for the Treatment of Poststroke Depression: A Meta ­Analysis
To objectively evaluate the efficacy and safety of citalopram versus other antidepressant drugs in poststroke depression (PSD) treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - September 7, 2018 Category: Neurology Authors: Min Cui, Chao Yun Huang, Fang Wang Tags: Review Article Source Type: research