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The VGVAPG Peptide Regulates the Production of Nitric Oxide Synthases and Reactive Oxygen Species in Mouse Astrocyte Cells In Vitro.
Abstract The products of elastin degradation, namely elastin-derived peptides (EDPs), are detectable in the cerebrospinal fluid of healthy individuals and in patients after ischemic stroke, and their number increases with age. Depending on their concentrations, both nitric oxide (NO) and reactive oxygen species (ROS) take part either in myocardial ischemia reperfusion injury or in neurovascular protection after ischemic stroke. The aim of our study was to determine the impact of VGVAPG peptide on ROS and NO production and expression of endothelial nitric oxide synthase (eNos), inducible nitric oxide synthase (iNos...
Source: Neurochemical Research - February 13, 2019 Category: Neuroscience Authors: Szychowski KA, Gmiński J Tags: Neurochem Res Source Type: research

Peroxisome Proliferator-activated Receptor-γ Agonist Pioglitazone Ameliorates White Matter Lesion and Cognitive Impairment in Hypertensive Rats.
CONCLUSIONS: Long-term treatment of pioglitazone has beneficial effect on hypertension-induced WML and cognition decline, which may partly through its effect on attenuation of arteriolar remodeling, endothelial activation, and brain inflammation. PMID: 25611692 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - January 22, 2015 Category: Neuroscience Authors: Lan LF, Zheng L, Yang X, Ji XT, Fan YH, Zeng JS Tags: CNS Neurosci Ther Source Type: research