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Total 66 results found since Jan 2013.

Effect of Electroacupuncture on Relieving Central Post-Stroke Pain by Inhibiting Autophagy in the Hippocampus.
CONCLUSION: EA may inhibit autophagy in the hippocampus by reducing β-catenin/COX-2 protein expression and effectively alleviating CPSP. SIGNIFICANCE: Statement Previous studies have found that EA can reduce the expression of NK-1R in damaged rats by inhibition of COX-2 and β-catenin loops, which controls the activation of glial cells in the damaged area and the apoptosis of neuronal cells, and alleviated pain. In the male SD rat model, we evaluated this effect that EA inhibits autophagy in the hippocampus by reducing β-catenin/COX-2 protein expression in the brain tissue. In addition, we assessed expression levels...
Source: Brain Research - January 24, 2020 Category: Neurology Authors: Zheng L, Li XY, Huang FZ, Zhang XT, Tang HB, Li YS, Kevin Zhang W, Li XJ, Tian GH Tags: Brain Res Source Type: research

Selective serotonin reuptake inhibitors (SSRIs) for stroke recovery.
CONCLUSIONS: We found no reliable evidence that SSRIs should be used routinely to promote recovery after stroke. Meta-analysis of the trials at low risk of bias indicate that SSRIs do not improve recovery from stroke. We identified potential improvements in disability only in the analyses which included trials at high risk of bias. A further meta-analysis of large ongoing trials will be required to determine the generalisability of these findings. PMID: 31769878 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - November 26, 2019 Category: General Medicine Authors: Legg LA, Tilney R, Hsieh CF, Wu S, Lundström E, Rudberg AS, Kutlubaev MA, Dennis M, Soleimani B, Barugh A, Hackett ML, Hankey GJ, Mead GE Tags: Cochrane Database Syst Rev Source Type: research

Treatments for Poststroke Motor Deficits and Mood Disorders: A Systematic Review for the 2019 U.S. Department of Veterans Affairs and U.S. Department of Defense Guidelines for Stroke Rehabilitation.
Conclusion: Cardiorespiratory training, repetitive task training, and transcranial direct current stimulation may improve ADLs in adults with stroke. Cognitive behavioral therapy, exercise, and SSRIs may reduce symptoms of poststroke depression, but use of SSRIs to prevent depression or improve motor function was not supported. Primary Funding Source: U.S. Department of Veterans Affairs, Veterans Health Administration. PMID: 31739315 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - November 19, 2019 Category: Internal Medicine Authors: D'Anci KE, Uhl S, Oristaglio J, Sullivan N, Tsou AY Tags: Ann Intern Med Source Type: research

MAMBO: Measuring ambulation, motor, and behavioral outcomes with post-stroke fluoxetine in Tanzania: Protocol of a phase II clinical trial
Sub-Saharan Africa has a high stroke incidence and post-stroke morbidity. An inexpensive pharmacological treatment for stroke recovery would be beneficial to patients in the region. Fluoxetine, currently on the World Health Organization Essential Medicines List, holds promise as a treatment for motor recovery after ischemic stroke, but its effectiveness is controversial and untested in this context in Sub-Saharan Africa.
Source: Journal of the Neurological Sciences - November 6, 2019 Category: Neurology Authors: AndreC. Vogel, Kigocha Okeng'o, Faraja Chiwanga, Seif Sharif Ismail, Deus Buma, Lindsay Pothier, Farrah J. Mateen Source Type: research

Economic burden associated with inadequate antidepressant medication management among patients with depression and known cardiovascular diseases: insights from a united states based retrospective claims database analysis.
Conclusions: Among post-MI and post-stroke patients, inadequate MDD care was associated with a significantly higher economic burden. PMID: 31665949 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - November 2, 2019 Category: Health Management Tags: J Med Econ Source Type: research

Study shows how serotonin and a popular anti-depressant affect the gut ’s microbiota
In this study, we were interested in finding out why they might do so,” said Hsiao, UCLA assistant professor of integrative biology and physiology, and of microbiology, immunology and molecular genetics in the  UCLA College; and of digestive diseases in the David Geffen School of Medicine at UCLA.Hsiao and her research group reported in the journal Cell in 2015 that in mice, a specific mixture of bacteria, consisting mainly of  Turicibacter sanguinis and Clostridia, produces molecules that signal to gut cells to increase production of serotonin. When Hsiao’s team raised mice without the bacteria, more than 50% of t...
Source: UCLA Newsroom: Health Sciences - September 6, 2019 Category: Universities & Medical Training Source Type: news

Fluoxetine adjunct to therapeutic exercise promotes motor recovery in rats with cerebral ischemia: roles of nucleus accumbens.
In conclusion, the NAc may play an important role in driving physical motivation, which was possibly related to motor recovery after stroke. Fluoxetine may hasten the effectiveness of therapeutic exercise, possibly via regulating 5-HT and its receptors in the NAc. PMID: 31369829 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - July 29, 2019 Category: Neurology Authors: Hua Y, Ce L, Jian H, Wang YY, Liu PL, Gao BY, Chen C, Dong-Sheng X, Zhang B, Bai YL Tags: Brain Res Bull Source Type: research

Pharmacological interventions and rehabilitation approach for enhancing brain self-repair and stroke recovery.
Abstract Neuroplasticity is a natural process occurring in the brain for entire life. Stroke is the leading cause of long term disability and huge medical and financial problem throughout the world. Research conducted over the past decade focused mainly on neuroprotection in the acute phase of stroke while very little studies targets chronic stage. Recovery after stroke depends on the ability of our brain to reestablish structural and functional organization of neurovascular networks. Combining adjuvant therapies and drugs may enhance the repair processes and restore impaired brain functions. Currently, there are ...
Source: Current Neuropharmacology - July 25, 2019 Category: Drugs & Pharmacology Authors: Szelenberger R, Kostka J, Saluk-Bijak J, Miller E Tags: Curr Neuropharmacol Source Type: research

Pharmacological Enhancement of Stroke Recovery
AbstractPurpose of ReviewThis review aims to discuss the recent literature relating to drugs for stroke recovery and to identify some of the challenges in conducting translational research for stroke recovery.Recent FindingsAdvances in our understanding of neural repair mechanisms in pre-clinical stroke models have provided insights into potential targets for drugs that enhance the repair/recovery process. Few drugs that act on serotonergic and dopaminergic systems have been tested in humans with mixed results. The FOCUS trial, a phase III study of early administration of fluoxetine for stroke recovery, failed to replicate...
Source: Current Neurology and Neuroscience Reports - May 30, 2019 Category: Neuroscience Source Type: research

Fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ERS-mediated neurons apoptosis in the hippocampus.
Abstract Existing evidence from clinical and animal experiments all indicated that fluoxetine, selective serotonin-reuptake inhibitor (SSRI) and anti-depressant drug, has neuroprotection and improve functional outcomes after stroke. Endoplasmic reticulum stress (ERS) inducing apoptosis after cerebral ischemia reperfusion injury was demonstrated in our previous. This trial was examined whether fluoxetine mitigates ERS-induced neuron apoptosis. Male sprague-dawley rats of cerebral ischemia reperfusion injury was produced via middle cerebral artery occlusion (MCAO) strategy, with ischemia for 90 min and reperfusion...
Source: Behavioural Brain Research - May 16, 2019 Category: Neurology Authors: Xu F, Zhang G, Yin J, Zhang Q, Ge MY, Peng L, Wang S, Li Y Tags: Behav Brain Res Source Type: research

Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
This study was carried out in accordance with the recommendations of the “Institutional Animal Care and Use Committee of China Medical University.” The protocol was approved by the “Institutional Animal Care and Use Committee of China Medical University.”Author ContributionsXWu and GW conceived and designed the experiments. YLi, RD, XR, WR, HYa, and YT performed the experiments. HYu, XZ, JY and XWa helped to analyze and interpret the data. GW drafted the manuscript. XWu, EX, YLu, and GZ provided critical revisions. All the authors reviewed and approved the final manuscript.FundingThe present stu...
Source: Frontiers in Psychiatry - April 30, 2019 Category: Psychiatry Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

A commonly-used antidepressant doesn ' t improve recovery after stroke
The antidepressant fluoxetine works no better than placebo to reduce disability after a stroke, lowering hopes that had been raised by other smaller studies. After a six month trial including more than 3,000 adult stroke patients recruited at 103 UK hospitals, researchers concluded that fluoxetine should not be used to promote recovery from stroke-related disability, or routinely prescribed to prevent depression after stroke. Several smaller studies and animal trials had found promising results from the use of fluoxetine after stroke. However, this trial of fluoxetine 20mg daily for six months found no improvement in funct...
Source: Current Awareness Service for Health (CASH) - February 18, 2019 Category: Consumer Health News Source Type: news

Antidepressant-like effects of paeoniflorin on post-stroke depression in a rat model.
CONCLUSIONS: Observed results suggested that paeoniflorin could ameliorate the symptoms and improve the functional capability of PSD rats, similar to the effect of fluoxetine. ABBREVIATIONS: PSD: post-stroke depression; CUMS: chronic unpredictable mild stress stimulation; MCAO: middle cerebral artery occlusion; OFT: open field test; SPT: sucrose preference test, NDS: neurological deficit score, BBT: beam balance test; BDNF: brain-derived neurotrophic factor protein; p-CREB: phosphorylated Cyclic-AMP responsive element binding protein. PMID: 30759063 [PubMed - as supplied by publisher]
Source: Neurological Research - February 15, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Efficacy and mechanism of acupuncture for ischemic poststroke depression: Study protocol for a multicenter single-blinded randomized sham-controlled trial
Conclusion: The present research is designed to investigate efficacy and mechanism of traditional acupuncture therapy on ischemic PSD, also to explore the correlation between cerebra metabolic and serologic factors, and ischemic PSD. With this research, we are looking forward to find out an appropriate alternative nondrug therapy for PSD people to alleviate the adverse effects and drug dependence caused by antidepressants.
Source: Medicine - February 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Stable isotope labeling derivatization and magnetic dispersive solid phase extraction coupled with UHPLC-MS/MS for the measurement of brain neurotransmitters in post-stroke depression rats administrated with gastrodin.
Abstract Synchronous measurement of brain neurotransmitters and blood drug metabolism by dual sites in vivo microdialysis can provide very important information for several neurological disorders such as post-stroke depression (PSD). In this work, d0/d3-6-N-methyl-rhodamine 6G-N-hydroxysuccinimidyl formate (d0/d3-MRSF) were firstly designed, synthesized and used as stable isotope labeling derivatization reagents for the determination of multiple neurotransmitters by ultra-high performance liquid chromatography-tandem mass spectrometry. The light d0-MRSF was used to label neurotransmitters in real samples and the ...
Source: Analytica Chimica Acta - January 23, 2019 Category: Chemistry Authors: Zhao XE, He Y, Zhu S, Xu Y, You J, Bai Y, Liu H Tags: Anal Chim Acta Source Type: research

Fluoxetine does not assist recovery following stroke, research suggests
Daily fluoxetine in patients who have had a stroke does not improve functional outcomes at six months, results of a randomised trial published in The Lancet have shown.
Source: Clinical Pharmacist - January 21, 2019 Category: Drugs & Pharmacology Source Type: research

Fluoxetine and its metabolite norfluoxetine induce microglial apoptosis
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - January 5, 2019 Category: Neuroscience Authors: Kamaldeep S. Dhami, Matthew A. Churchward, Glen. B. Baker, Kathryn G. Todd Tags: Original Article Source Type: research

Therapeutic effect observation on acupuncture plus medication for post-stroke depression
ConclusionAcupuncture plus medication is an effective method for post-stroke depression, and it can further improve the patient's bad mood.
Source: Journal of Acupuncture and Tuina Science - December 22, 2018 Category: Complementary Medicine Source Type: research

Fluoxetine and recovery after stroke
Publication date: Available online 5 December 2018Source: The LancetAuthor(s): H Bart van der Worp
Source: The Lancet - December 5, 2018 Category: General Medicine Source Type: research

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial
Publication date: Available online 5 December 2018Source: The LancetAuthor(s): Martin Dennis, Gillian Mead, John Forbes, Catriona Graham, Maree Hackett, Graeme J Hankey, Allan House, Stephanie Lewis, Erik Lundström, Peter Sandercock, Karen Innes, Carol Williams, Jonathan Drever, Aileen Mcgrath, Ann Deary, Ruth Fraser, Rosemary Anderson, Pauli Walker, David Perry, Connor McgillSummaryBackgroundResults of small trials indicate that fluoxetine might improve functional outcomes after stroke. The FOCUS trial aimed to provide a precise estimate of these effects.MethodsFOCUS was a pragmatic, multicentre, parallel group, double-b...
Source: The Lancet - December 5, 2018 Category: General Medicine Source Type: research

Ameliorative effect of Xiaoyao - jieyu - san on post-stroke depression and its potential mechanisms
AbstractA stroke is a severe life-threatening disease with high fatality and disability rate. This investigation aimed to study the effect ofXiaoyao-jieyu-san (XYJY) on post-stroke depression (PSD) and its potential mechanisms. PSD rats were prepared using middle cerebral artery embolization (MCAO) and chronic unpredictable mild stress (CUMS), and divided into six groups (n = 10)—sham; MCAO; MCAO + CUMS (PSD); PSD + fluoxetine (1.84 mg/kg/day, 4 weeks); and PSD + XYJY (450 mg/kg/day and 900 mg/kg/day, 4 weeks). Body weight recording, despair swimming test, and sucrose preference test were performed a...
Source: Journal of Natural Medicines - September 7, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of Fluoxetine on Poststroke Dysphagia: A Clinical Retrospective Study
To investigate whether fluoxetine improves poststroke dysphagia and to detect the potential relationship between serum brain-derived neurotrophic factor (BDNF) levels and fluoxetine effects.
Source: Journal of Stroke and Cerebrovascular Diseases - August 30, 2018 Category: Neurology Authors: Jianting Huang, Xuanwei Liu, Xun Luo, Chunzhi Tang, Mingzhu Xu, Lisa Wood, Yulong Wang, Qing Mei Wang Source Type: research

Potassium 2-(1-hydroxypentyl)-benzoate improves depressive-like behaviors in rat model
In this study, we demonstrated that PHPB improved depressive-like behaviors induced by chronic unpredictable mild stress (CUMS) in rats. Male SD rats were subjected to the stress for five weeks. PHPB (30 and 100 mg/kg) or fluoxetine (FLX 10 mg/kg, as positive control) was administered orally from the third week in CUMS procedure. The behavioral tests were applied and then the biochemical studies were carried out. PHPB or FLX treatment rescued the behavioral deficiency in CUMS-exposed rats. Meanwhile, PHPB normalized the enhanced level of serum corticosterone, improved hippocampal and serum BDNF levels, as well as...
Source: Acta Pharmaceutica Sinica B - August 21, 2018 Category: Cancer & Oncology Source Type: research

Efficacy and tolerability of pharmacotherapy for post-stroke depression: a network meta-analysis.
Conclusions: Paroxetine is probably the best option to consider for patients with PSD. To get a quicker relief of depression, duloxetine might be useful for its rapid onset of antidepressant action. The tolerability was comparable among all the antidepressants. But more high-quality RCTs are needed. PMID: 29805769 [PubMed]
Source: Oncotarget - May 31, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Clinical effects and safety of electroacupuncture for the treatment of post-stroke depression: a systematic review and meta-analysis of randomised controlled trials.
CONCLUSION: There was no significant difference between EA and antidepressants in the severity of depression, however EA caused fewer adverse events than antidepressants. Additional larger scale RCTs with rigorous study design are required. PMID: 29776950 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine - May 18, 2018 Category: Complementary Medicine Authors: Li XB, Wang J, Xu AD, Huang JM, Meng LQ, Huang RY, Xu J Tags: Acupunct Med Source Type: research

The efficacy comparison of citalopram, fluoxetine, and placebo on motor recovery after ischemic stroke: a double-blind placebo-controlled randomized controlled trial.
CONCLUSION: There was no significant difference between citalopram and fluoxetine in facilitating post-stroke motor recovery in ischemic stroke patients. However, compared with a placebo, both drugs improved post-stroke motor function. PMID: 29783900 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - May 1, 2018 Category: Rehabilitation Authors: Asadollahi M, Ramezani M, Khanmoradi Z, Karimialavijeh E Tags: Clin Rehabil Source Type: research

Chronic Fluoxetine Induces Activity Changes in Recovery From Poststroke Anxiety, Depression, and Cognitive Impairment
AbstractPoststroke depression (PSD) is a common outcome of stroke that limits recovery and is only partially responsive to chronic antidepressant treatment. In order to elucidate changes in the cortical-limbic circuitry associated with PSD and its treatment, we examined a novel mouse model of persistent PSD. Focal endothelin-1-induced ischemia of the left medial prefrontal cortex (mPFC) in male C57BL6 mice resulted in a chronic anxiety and depression phenotype. Here, we show severe cognitive impairment in spatial learning and memory in the stroke mice. The behavioral and cognitive phenotypes were reversed by chronic (4-wee...
Source: Neurotherapeutics - December 4, 2017 Category: Neurology Source Type: research

Gastrointestinal Hemorrhage Related to Fluoxetine in a Patient With Stroke
We report on a patient who developed massive gastrointestinal hemorrhage related to the use of fluoxetine in combination with aspirin and clopidogrel. A 58-year-old man was admitted with a posterior circulation infarct with significant weakness in all four limbs and dysarthria. Aspirin and clopidogrel were started. Fluoxetine was started for pharmacological neurostimulation to promote motor recovery and for low mood. He developed gastrointestinal hemorrhage a week after fluoxetine was started. Fluoxetine was suspended and investigations failed to reveal the source of the bleeding. He was then restarted on fluoxetine along ...
Source: American Journal of Physical Medicine and Rehabilitation - October 24, 2017 Category: Rehabilitation Tags: Case Reports Source Type: research

Neuroplasticity and behavioral effects of  fluoxetine after experimental stroke.
Neuroplasticity and behavioral effects of fluoxetine after experimental stroke. Restor Neurol Neurosci. 2017 Aug 24;: Authors: Sun Y, Sun X, Qu H, Zhao S, Xiao T, Zhao C Abstract The brain can undergo self-repair and has the ability to compensate for functions lost after a stroke. The plasticity of the ischemic brain is influenced by several factors including aging and pharmacotherapy. Fluoxetine is an antidepressant which enhances serotonergic neurotransmission through selective inhibition of neuronal reuptake of serotonin. In clinical practice, fluoxetine alleviates the symptoms of post-stroke depre...
Source: Restorative Neurology and Neuroscience - September 2, 2017 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

The risk of initiating fluoxetine for motor deficits after ischemic stroke in patients with bipolar disorder
Discussion Ayahuasca administration in controlled settings appear to be safe. Moreover, ayahuasca seem to have therapeutic effects for treatment-resistant psychiatric disorders that should be further investigated in randomized controlled clinical trials. However, medical complications and cases of prolonged psychotic reactions have been reported, and people with personal or family history of psychotic disorders should avoid ayahuasca intake.
Source: Revista de Psiquiatria Clinica - August 31, 2017 Category: Psychiatry Source Type: research

Effects of Central Nervous System Drugs on Recovery After Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
ConclusionsAdministration of SSRIs may improve gross motor function, reduce disability and enhance QOL for patients recovering from stroke.
Source: Clinical Drug Investigation - July 29, 2017 Category: Drugs & Pharmacology Source Type: research

The ms-smart trial in secondary progressive ms - current update
MS-SMART is an ongoing multicentre, multi-arm, double blind, placebo-controlled phase IIb randomised controlled trial to establish whether putative neuroprotective drugs (fluoxetine,riluzole,amiloride or placebo) can slow down the progression of brain volume loss in secondary progressive multiple sclerosis (SPMS) over 96 weeks using MRI-derived Percentage Brain Volume Change (PBVC) as the primary outcome. 360 patients have been screened so far, 328 (92%) consented and 272 randomized (65% of the total UK cohort–440). Patients will have outcome-data collected after 0,24,48 and 96 weeks. The trial is using a range of co...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 15, 2016 Category: Neurosurgery Authors: Chataway, J., Chandran, S., Miller, D., Connick, P., Giovannoni, G., Pavitt, S., Stallard, N., Hawkins, C., Sharrack, B., Plantone, D. Tags: Immunology (including allergy), Multiple sclerosis, Stroke, Radiology, Radiology (diagnostics) ABN Annual Meeting, 17-19 May 2016, The Brighton Centre, Brighton Source Type: research

Update on pharmacotherapy for stroke and traumatic brain injury recovery during rehabilitation
This article evaluates whether specific drugs are able to facilitate motor recovery after stroke or improve the level of consciousness, cognitive, or behavioral symptoms after traumatic brain injury. Recent findings: After stroke, serotonin reuptake inhibitors can enhance restitution of motor functions in depressed as well as in nondepressed patients. Erythropoietin and progesterone administered within hours after moderate to severe traumatic brain injury failed to improve the outcome. A single dose of zolpidem can transiently improve the level of consciousness in patients with vegetative state or minimally conscious stat...
Source: Current Opinion in Neurology - November 8, 2016 Category: Neurology Tags: TRAUMA AND REHABILITATION: Edited by Bruce H. Dobkin Source Type: research

Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients.
Authors: Buga AM, Ciobanu O, Bădescu GM, Bogdan C, Weston R, Slevin M, DiNapoli M, Popa-Wagner A Abstract Despite the fact that a high proportion of elderly stroke patients develop mood disorders, the mechanisms underlying late-onset neuropsychiatric and neurocognitive symptoms have so far received little attention in the field of neurobiology. In rodents, aged animals display depressive symptoms following stroke, whereas young animals recover fairly well. This finding has prompted us to investigate the expression of serotonin receptors 2A and 2B, which are directly linked to depression, in the brains of aged and ...
Source: Oncotarget - March 27, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Effect of using fluoxetine at different time windows on neurological functional prognosis after ischemic stroke.
CONCLUSIONS: In patients with ischemic stroke, early administration of fluoxetine may improve the neurological functional prognosis. PMID: 26923613 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - March 1, 2016 Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

Effects of Fluoxetine on Neural Functional Prognosis after Ischemic Stroke: A Randomized Controlled Study in China
We investigated the effects of fluoxetine on the short-term and long-term neural functional prognoses after ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 25, 2016 Category: Neurology Authors: Yi-Tao He, Bing-Shan Tang, Zhi-Li Cai, Si-Ling Zeng, Xin Jiang, Yi Guo Source Type: research

Should This Patient With Ischemic Stroke Receive Fluoxetine?
You admit T.R., a 75-year-old man, to your inpatient rehabilitation unit 10 days after a stroke. He has a medical history of hypertension and type II diabetes. On the day of his admission to the neurology service, he experienced a sudden onset of severe left-sided weakness with a facial droop and slurring of speech. His husband was driving them both to a social event at the time and detoured immediately to the emergency department, where the patient received tissue plasminogen activator (tPA) for a large, right middle cerebral artery thrombosis seen on magnetic resonance imaging.
Source: PM and R - December 1, 2015 Category: Rehabilitation Authors: Heidi Schambra, Brian Im, Michael W. O'Dell Tags: Point/Counterpoint Source Type: research

Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model Basic Sciences
Conclusions— There is a gradient of diminishing responsiveness to motor training over the first week after stroke. Fluoxetine can overcome this gradient and maintain maximal levels of responsiveness to training even 7 days after stroke.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Ng, K. L., Gibson, E. M., Hubbard, R., Yang, J., Caffo, B., O'Brien, R. J., Krakauer, J. W., Zeiler, S. R. Tags: Animal models of human disease, Behavioral Changes and Stroke, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Antidepressant may help stroke patients with rehabilitation
Stephen FellerBALTIMORE, Sept. 2 (UPI) -- The antidepressant drug Prozac prolonged the amount of time after stroke that rehabilitation could restore movement and coordination in a study of mice.
Source: Health News - UPI.com - September 2, 2015 Category: Consumer Health News Source Type: news

Selective serotonin reuptake inhibitors to improve outcome in acute ischemic stroke: possible mechanisms and clinical evidence
ConclusionIn addition to the need of comprehensive‐clinical evidence, further elucidation of the beneficial mechanisms whereby SSRIs may improve structural and functional recovery from ischemic‐brain damage is needed to form a basis for translation into clinical practice. Several clinical studies have indicated that selective serotonin reuptake Inhibitors (SSRIs) administered after acute ischemic stroke can improve clinical recovery independently of depression. However, data from confirmatory trials in large study populations are lacking and the underlying mechanisms are incompletely understood. This review summarizes...
Source: Brain and Behavior - September 1, 2015 Category: Neurology Authors: Timo Siepmann, Ana Isabel Penzlin, Jessica Kepplinger, Ben Min‐Woo Illigens, Kerstin Weidner, Heinz Reichmann, Kristian Barlinn Tags: Review Source Type: research

Research in mice shows potential value of antidepressant in some stroke victims
Working with mice, researchers have added to evidence that a commonly prescribed antidepressant called fluoxetine helps stroke victims improve movement and coordination, and possibly why.
Source: ScienceDaily Headlines - August 31, 2015 Category: Science Source Type: news

The FOCUS, AFFINITY and EFFECTS trials studying the effect(s) of fluoxetine in patients with a recent stroke: a study protocol for three multicentre randomised controlled trials
DiscussionIf fluoxetine is safe and effective in promoting functional recovery, it could be rapidly, widely and affordably implemented in routine clinical practice and reduce the burden of disability due to stroke.Trial registrationFOCUS: ISRCTN83290762 (23/05/2012), AFFINITY: ACTRN12611000774921 (22/07/2011). EFFECTS: ISRCTN13020412 (19/12/2014).
Source: Trials - August 20, 2015 Category: Journals (General) Authors: Gillian MeadMaree HackettErik LundströmVeronica MurrayGraeme HankeyMartin Dennis Source Type: research

Fluoxetine enhanced neurogenesis is not translated to functional outcome in stroke rats
Publication date: 31 August 2015 Source:Neuroscience Letters, Volume 603 Author(s): Xiaoyu Sun, Xuan Sun, Tingting Liu, Mei Zhao, Shanshan Zhao, Ting Xiao, Jukka Jolkkonen, Chuansheng Zhao Fluoxetine is widely used in clinical practice. It regulates hippocampal neurogenesis, however, the effect of fluoxetine on neurogenesis in the subventricular zone (SVZ) remains controversial. We aimed to study the effect of fluoxetine on neurogenesis in the SVZ and subgranular zone (SGZ) of dentate gyrus (DG) in relation to behavioral recovery after stroke in rats. Adult male Wistar rats were randomly assigned to four groups: ...
Source: Neuroscience Letters - July 25, 2015 Category: Neuroscience Source Type: research

Interventions for post-stroke fatigue.
CONCLUSIONS: There was insufficient evidence on the efficacy of any intervention to treat or prevent fatigue after stroke. Trials to date have been small and heterogeneous, and some have had a high risk of bias. Some of the interventions described were feasible in people with stroke, but their efficacy should be investigated in RCTs with a more robust study design and adequate sample sizes. PMID: 26133313 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 2, 2015 Category: Journals (General) Authors: Wu S, Kutlubaev MA, Chun HY, Cowey E, Pollock A, Macleod MR, Dennis M, Keane E, Sharpe M, Mead GE Tags: Cochrane Database Syst Rev Source Type: research

Effectiveness and safety of Wuling capsule for post stroke depression: A systematic review.
CONCLUSION: Wuling capsule appeared to present certain antidepressant effect compared to no treatment control. With a combination of several Western medicines, Wuling capsule could be helpful in strengthening efficacy and reducing the incidence of adverse events as an alternative choice in the treatment of PSD. However, due to the limited number of included trials and relatively moderate methodological quality in the majority of studies, further large scale and rigorously designed trials are warranted to confirm the effectiveness and safety of Wuling capsule for post stroke depression. PMID: 24906594 [PubMed - as supplied by publisher]
Source: Complementary Therapies in Medicine - June 1, 2014 Category: Complementary Medicine Authors: Peng L, Zhang X, Kang DY, Liu XT, Hong Q Tags: Complement Ther Med Source Type: research

Treating post-stroke depression with Xingnao Jieyu capsules or fluoxetine
The occurrence of post-stroke depression results from the effects of biological, psychological, and social factors, likely involving neurotransmitters, neuroendocrine effects, nerve anatomy, neurotrophic factors, neural regeneration, inflammatory reactions, and social psyche factors. Synaptotagmin promotes neurotransmitter release, regulates the transfer of synaptic vesicle to synaptic active zones, and is a key factor in information transfer among neurons. The Xingnao Jieyu capsule has been shown to effectively relieve neurologic impairments and lessen depression...
Source: Health News from Medical News Today - August 16, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Xingnao Jieyu capsules are similar to fluoxetine for post-stroke depression
(Neural Regeneration Research) Xingnao Jieyu capsules are similar to fluoxetine for post- stroke depression.
Source: EurekAlert! - Medicine and Health - August 14, 2013 Category: Global & Universal Source Type: news