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Drug: Insulin
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Total 1988 results found since Jan 2013.
Investigation of Pancreatic-beta cells Role in the Biological Process of Ageing
CONCLUSION: Aging accelerates beta cell senescence by generating premature cell senescence, which is mostly mediated by high glucose levels. Despite higher plasma glucose levels, hepatic gluconeogenesis accelerates and adipose tissue lipolysis rises, resulting in an increase in free fatty acid levels in the blood and worsening insulin resistance throughout the body.PMID:37608675 | DOI:10.2174/1871530323666230822095932
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 23, 2023 Category: Endocrinology Authors: Rishabh Chaudhary Janvi Khanna Manni Rohilla Sumeet Gupta Seema Bansal Source Type: research
Hyperosmolar Hyperglycemic State
Hyperosmolar hyperglycemic state (HHS) is an underrecognized diabetic emergency with high morbidity and mortality. Many features of HHS overlap with those of diabetic ketoacidosis but key differentiators for HHS are serum osmolality greater than 320 mOsm/kg, lack of metabolic acidosis, and minimal to no presence of ketones. HHS is often triggered by an underlying illness —most commonly infection but may also be triggered by stroke, acute coronary syndrome, and other acute illnesses. Treatment guidelines recommend aggressive volume-repletion of osmotic losses in addition to insulin therapy, plus treatment of the underlying cause.
Source: Emergency Medicine Clinics of North America - August 18, 2023 Category: Emergency Medicine Authors: Spencer S. Lovegrove, Sarah B. Dubbs Source Type: research
Role of GLP-1 receptor agonist in diabetic cardio-renal disorder: Recent updates of clinical and pre-clinical evidence
Curr Diabetes Rev. 2023 Aug 9. doi: 10.2174/1573399820666230809152148. Online ahead of print.ABSTRACTCardiovascular complications and renal disease is the growing cause of mortality in patients with diabetes. The subversive complications of diabetes such as hyperglycemia, hyperlipidemia and insulin resistance lead to an increase in the risk of myocardial infarction (MI), stroke, heart failure (HF) as well as chronic kidney disease (CKD). Among the commercially available anti-hyperglycemic agents, incretin-based medications appear to be safe and effective in the treatment of type 2 diabetes mellitus (T2DM) and associated ca...
Source: Current Diabetes Reviews - August 10, 2023 Category: Endocrinology Authors: Sanket Seksaria Bhaskar Jyoti Dutta Mandeep Kaur Ghanshyam Das Gupta Surendra H Bodakhe Amrita Singh Source Type: research
Triglyceride-glucose index predicts death in patients with stroke younger than 65
ConclusionElevated TGI independently predicts death at 3 months and 12 months in patients under 65 with ischemic stroke. Regulating TGI is expected to be an approach to enhance prognosis in young individuals affected by ischemic stroke.
Source: Frontiers in Neurology - August 3, 2023 Category: Neurology Source Type: research
How do patients with Type 2 Diabetes Mellitus value the importance of outcomes? An overview of reviews
CONCLUSION: We provide standardised, reliable utility values (or associated disutilities) for T2DM, acute, microvascular and macrovascular complications, related comorbidities and treatments that may support judgements when making clinical recommendations, designing decision support tools, and developing interventions and economic analysis.PMID:37516195 | DOI:10.1016/j.jval.2023.07.003
Source: Cancer Control - July 29, 2023 Category: Cancer & Oncology Authors: Ena Nino-de-Guzman Javier Bracchiglione Adrian Vasquez-Mejia Gimon de Graaf Claudio Rocha Calderon Pablo Alonso-Coello Source Type: research
Do Non-Functional Adrenal Adenomas Affect Metabolic Profile and Carotid Intima-Media Thickness? A Single Centre Study from Poland
Conclusions: Patients diagnosed with NFAIs, despite normal cortisol inhibition in the 1 mg dexamethasone test, still presented a number of metabolic abnormalities. The assessment of IMT may proove valuable in indicate the presence of early vascular remodelling in asymptomatic patients. The underlying mechanisms of these findings are still unknown, hence further studies are required.PMID:37510727 | PMC:PMC10380859 | DOI:10.3390/jcm12144612
Source: Atherosclerosis - July 29, 2023 Category: Cardiology Authors: Magdalena Szychli ńska Magdalena Rzeczkowska Katarzyna Gontarz-Nowak Wojciech Matuszewski El żbieta Bandurska-Stankiewicz Source Type: research
When It ’ s This Hot, What Should You Eat?
As temperatures continue to climb in what could become the northern hemisphere’s hottest summer on record, the summer of 2023 is all about finding any way to stay cool. And that includes turning to foods that will hopefully provide a little relief. While not a panacea for the heat, body-cooling foods and no-cook diets could help to lower body temperature and make record-breaking heat waves a little more bearable..
Living safely in consistently hot climates means staying hydrated, especially with chilled drinks or fruits. But there are other, more physiologically based—and even surprising—ways to make your...
Source: TIME: Health - July 20, 2023 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized climate change Diet & Nutrition healthscienceclimate Source Type: news
Mets-IR as a predictor of cardiovascular events in the middle-aged and elderly population and mediator role of blood lipids
Conclusionets-IR is associated with an increased risk of cardiovascular disease/stroke/cardiac issues, with LDL-C mediating these relationships. Improving insulin sensitivity and lipid regulation may be essential and effective preventive measures for cardiovascular events.
Source: Frontiers in Endocrinology - July 17, 2023 Category: Endocrinology Source Type: research
Glyoxal in hyperglycaemic ischemic stroke – a cohort study
Hyperglycaemia is frequent in acute ischemic stroke and denotes a bad prognosis, even in the absence of pre-existing diabetes. However, in clinical trials treatment of elevated glucose levels with insulin did ...
Source: Cardiovascular Diabetology - July 12, 2023 Category: Cardiology Authors: Sina Rhein, Julica Inderhees, Oliver Herrmann, Alaa Othman, Kimberly Begemann, Thomas Fleming, Peter P. Nawroth, Karel D. Klika, Rakad Isa, Inke R. K önig, Georg Royl and Markus Schwaninger Tags: Research Source Type: research
Overexpressing Glyoxalase 1 Attenuates Acute Hyperglycemia-Exacerbated Neurological Deficits of Ischemic Stroke in Mice
This study investigated the therapeutic effects of the overexpression of glyoxalase 1 (GLO1), a detoxifying enzyme of glycotoxins, on acute hyperglycemia-aggravated ischemic brain injury. In present study, AAV-mediated GLO1 overexpression reduced infarct volume and edema level but did not improve neurofunctional recovery in the mice with MCAO. AAV-GLO1 infection significantly enhanced neurofunctional recovery in the MCAO mice with acute hyperglycemia but not in the mice with normoglycemia. MG-modified proteins expression significantly increased in the ipsilateral cortex of the MCAO mice with acute hyperglycemia. AAV-GLO1 i...
Source: Translational Research : the journal of laboratory and clinical medicine - July 7, 2023 Category: Laboratory Medicine Authors: Kuan-Jung Lu Chih-Hao Yang Joen-Rong Sheu Chi-Li Chung Tanasekar Jayakumar Chieh-Min Chen Cheng-Ying Hsieh Source Type: research
Overexpressing Glyoxalase 1 Attenuates Acute Hyperglycemia –Exacerbated Neurological Deficits of Ischemic Stroke in Mice
This study investigated the therapeutic effects of the overexpression of glyoxalase 1 (GLO1), a detoxifying enzyme of glycot oxins, on acute hyperglycemia–aggravated ischemic brain injury. In present study, AAV-mediated GLO1 overexpression reduced infarct volume and edema level but did not improve neurofunctional recovery in the mice with MCAO.
Source: Translational Research - July 5, 2023 Category: Research Authors: Kuan-Jung Lu, Chih-Hao Yang, Joen-Rong Sheu, Chi-Li Chung, Tanasekar Jayakumar, Chieh-Min Chen, Cheng-Ying Hsieh Source Type: research
Mitochondrial aspartate/glutamate carrier AGC1 regulates cardiac function via Drp1-mediated mitochondrial fission in doxorubicin-induced cardiomyopathy
This study investigated the therapeutic effects of the overexpression of glyoxalase I (GLO1), a detoxifying enzyme of gly cotoxins, on acute hyperglycemia–aggravated ischemic brain injury. In the present study, adeno-associated viral (AAV)-mediated GLO1 overexpression reduced infarct volume and edema level but did not improve neurofunctional recovery in the mice with middle cerebral artery occlusion (MCAO).
Source: Translational Research - July 5, 2023 Category: Research Authors: Kuan-Jung Lu, Chih-Hao Yang, Joen-Rong Sheu, Chi-Li Chung, Tanasekar Jayakumar, Chieh-Min Chen, Cheng-Ying Hsieh Source Type: research
Sex differences in the association between stroke risk factors and pre-clinical predictors of stroke in the childhood determinants of Adult Health study
CONCLUSIONS: Smoking, SBP and glucose affect carotid structure and function more in women than men with some of this risk due to co-occurring risk factors.PMID:37391336 | DOI:10.1016/j.atherosclerosis.2023.06.077
Source: Atherosclerosis - June 30, 2023 Category: Cardiology Authors: Mohammad Shah Marie-Jeanne Buscot Jing Tian Hoang T Phan Thomas H Marwick Terence Dwyer Alison Venn Seana Gall Source Type: research
Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats
CONCLUSIONS: Overall, the XO inhibitor febuxostat exerted protective effects against NASH and atherosclerosis in SHRSP5/Dmcr rats.PMID:37376883 | DOI:10.32725/jab.2023.009
Source: Atherosclerosis - June 28, 2023 Category: Cardiology Authors: Mai Kakimoto Moe Fujii Ikumi Sato Koki Honma Hinako Nakayama Sora Kirihara Taketo Fukuoka Shang Ran Satoshi Hirohata Kazuya Kitamori Shusei Yamamoto Shogo Watanabe Source Type: research
Insulin Regulation of Hepatic Lipid Homeostasis
Compr Physiol. 2023 Jun 26;13(3):4785-4809. doi: 10.1002/cphy.c220015.ABSTRACTThe incidence of obesity, insulin resistance, and type II diabetes (T2DM) continues to rise worldwide. The liver is a central insulin-responsive metabolic organ that governs whole-body metabolic homeostasis. Therefore, defining the mechanisms underlying insulin action in the liver is essential to our understanding of the pathogenesis of insulin resistance. During periods of fasting, the liver catabolizes fatty acids and stored glycogen to meet the metabolic demands of the body. In postprandial conditions, insulin signals to the liver to store exc...
Source: Atherosclerosis - June 26, 2023 Category: Cardiology Authors: Kahealani Uehara Dominic Santoleri Anna E Garcia Whitlock Paul M Titchenell Source Type: research
