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Total 1148 results found since Jan 2013.

Biochemical aspirin resistance in acute stroke patients and its association with clinical factors: a  prospective pilot study
CONCLUSIONS: Patients aged 76 and more can be more likely aspirin resistant than younger patients. We believe that especially in the elderly with congestive heart failure there is a strong need for further investigations in this field, including searching for alternative antiplatelet therapies.PMID:34628792 | DOI:10.5114/fn.2021.109434
Source: Folia Neuropathologica - October 11, 2021 Category: Pathology Authors: Micha ł Morton Katarzyna Kubiak-Balcerewicz Anna Sarnowska Urszula Fiszer Source Type: research

Estimated glucose disposal rate and risk of stroke and mortality in type 2 diabetes: a nationwide cohort study
Insulin resistance contributes to the development of type 2 diabetes (T2D) and is also a cardiovascular risk factor. The aim of this study was to investigate the potential association between insulin resistanc...
Source: Cardiovascular Diabetology - October 6, 2021 Category: Cardiology Authors: Alexander Zabala, Vladimer Darsalia, Marcus Lind, Ann-Marie Svensson, Stefan Franz én, Björn Eliasson, Cesare Patrone, Magnus Jonsson and Thomas Nyström Tags: Original investigation Source Type: research

Ten-year all-cause death following percutaneous or surgical revascularization in patients with prior cerebrovascular disease: insights from the SYNTAX Extended Survival study
ConclusionPrior CEVD was associated with a significantly increased risk of 10  year all-cause death which was similar in patients treated with PCI or CABG. These results do not support preferential referral for PCI rather than CABG in patients with prior CEVD.Trial registration: SYNTAX: ClinicalTrials.gov reference: NCT00114972. SYNTAX Extended Survival: ClinicalTrials.gov reference: NCT03417050.Graphic abstract
Source: Clinical Research in Cardiology - October 1, 2021 Category: Cardiology Source Type: research

The Exosomal MicroRNA Profile Is Responsible for the Mesenchymal Stromal Cell Transplantation-Induced Improvement of Functional Recovery after Stroke in Rats
Conclusion: We confirmed that MSC transplantation repaired stroke-induced functional impairments in rats by regulating various pathways associated with nervous system protection and MSC differentiation through the deregulation of exosomal miRNAs.Neuroimmunomodulation
Source: Neuroimmunomodulation - September 17, 2021 Category: Allergy & Immunology Source Type: research

Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia
Autophagy. 2021 Sep 14:1-21. doi: 10.1080/15548627.2021.1973339. Online ahead of print.ABSTRACTCerebral ischemia is a pathology involving a cascade of cellular mechanisms, leading to the deregulation of proteostasis, including macroautophagy/autophagy, and finally to neuronal death. If it is now accepted that cerebral ischemia induces autophagy, the effect of thrombolysis/energy recovery on proteostasis remains unknown. Here, we investigated the effect of thrombolysis by PLAT/tPA (plasminogen activator, tissue) on autophagy and neuronal death. In two in vitro models of hypoxia reperfusion and an in vivo model of thromboemb...
Source: Autophagy - September 14, 2021 Category: Cytology Authors: Audrey M Thiebaut Izaskun Buendia Vanessa Ginet Eloise Lemarchand Mehdi Boutagouga Boudjadja Yannick Hommet Laurent Lebouvier Charlotte Lechevallier Mike Maillasson Elodie Hedou Nicole D églon Franck Oury Marina Rubio Joan Montaner Julien Puyal Denis Viv Source Type: research

Emergency Medical Service Workers Battle a Hurricane, and COVID-19, To Bring Health Care To New Orleans
As Hurricane Ida pounded the coast of New Orleans with downpours and 150-mile-per-hour winds on the afternoon of Aug. 29, New Orleans Emergency Medical Services had to reverse course after spending 18 months running around the city at full speed battling COVID-19: staying put. For 13 hours and 41 minutes, as the storm’s worst shook their community, the workers hunkered down at their base, keeping themselves safe to be ready to protect others from whatever came next. However, the deluge of 9-1-1 calls didn’t come to a halt as EMS waited out the storm. So, after EMS workers were given the go-ahead to rush back in...
Source: TIME: Health - September 7, 2021 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized climate change COVID-19 healthscienceclimate Source Type: news

A Network Pharmacology Approach for Exploring the Mechanisms of < em > Panax notoginseng < /em > Saponins in Ischaemic Stroke
CONCLUSIONS: The ameliorative effects of PNS against IS were predicted to be associated with the regulation of the IGF1-PI3K-Akt signalling pathway. Ginsenoside Re and ginsenoside Rb1 may play an important role in the treatment of IS.PMID:34434246 | PMC:PMC8382556 | DOI:10.1155/2021/5582782
Source: Evidence-based Complementary and Alternative Medicine - August 26, 2021 Category: Complementary Medicine Authors: Cong Wang Hao Chen Shi-Tang Ma Bin-Bin Mao Yu Chen Hao-Nan Xu Hao Yu Source Type: research

Diabetes and Heart Failure: Multi-Omics Approaches
This article reviewed the recent omics-driven discoveries in the diagnosis and treatment of type 2 diabetes and heart failure with focus on the common molecular mechanisms.
Source: Frontiers in Physiology - August 6, 2021 Category: Physiology Source Type: research

The voltage-gated K < sup > + < /sup > channel Kv1.3 modulates platelet motility and α < sub > 2 < /sub > β < sub > 1 < /sub > integrin-dependent adhesion to collagen
Platelets. 2021 Aug 4:1-11. doi: 10.1080/09537104.2021.1942818. Online ahead of print.ABSTRACTKv1.3 is a voltage-gated K+-selective channel with roles in immunity, insulin-sensitivity, neuronal excitability and olfaction. Despite being one of the largest ionic conductances of the platelet surface membrane, its contribution to platelet function is poorly understood. Here we show that Kv1.3-deficient platelets display enhanced ADP-evoked platelet aggregation and secretion, and an increased surface expression of platelet integrin αIIb. In contrast, platelet adhesion and thrombus formation in vitro under arterial shear condit...
Source: Platelets - August 5, 2021 Category: Hematology Authors: Joy R Wright Sarah Jones Sasikumar Parvathy Leonard K Kaczmarek Ian Forsythe Richard W Farndale Jonathan M Gibbins Martyn P Mahaut-Smith Source Type: research

The dream of a good night's sleep for our dermatology patients
Are you getting adequate sleep? Chances are that you are not and the repercussions could be profound. Sleep deprivation has been associated with insulin resistance, diabetes mellitus, obesity, hypertension, obstructive sleep apnea, anxiety and depression, and an increased risk of myocardial infarction and stroke. Quality of life (QoL) may suffer by poor job performance, an increased risk of accidents, and family stress.1
Source: Journal of the American Academy of Dermatology - August 2, 2021 Category: Dermatology Authors: Warren R. Heymann Tags: A clinician's perspective Source Type: research

Midkine: a multifaceted driver of atherosclerosis
Clin Chim Acta. 2021 Jul 28:S0009-8981(21)00264-3. doi: 10.1016/j.cca.2021.07.024. Online ahead of print.ABSTRACTAtherosclerosis constitutes the pathological basis of life-threatening events, including heart attack and stroke. Midkine is a heparin-binding growth factor and forms a small protein family with pleiotrophin. Under inflammatory or hypoxic conditions, midkine expression is up-regulated. Upon binding to its receptors, midkine can activate multiple signal pathways to regulate cell survival and migration, epithelial-to-mesenchymal transition, and oncogenesis. Circulating midkine levels are significantly increased in...
Source: International Journal of Clinical Chemistry - July 31, 2021 Category: Chemistry Authors: Zi-Zhen Zhang Gang Wang Shan-Hui Yin Xiao-Hua Yu Source Type: research

Insulin Resistance is Significantly Related with Worse Clinical Outcomes in Non-Diabetic Acute Ischemic Stroke Patients Treated with Intravenous Thrombolysis
to investigate the relationship between insulin resistance (IR) and clinical outcomes in non-diabetic ischemic stroke patients treated with intravenous thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2020 Category: Neurology Authors: Xiaoli Yang, Chen Li, Jing Li, Duanlu Hou, Yufan Luo, Shufan Zhang, Zhi Jin, Liwei Shen, Ping Zhong, Danhong Wu Source Type: research

Longitudinal Relationship Between Intramuscular Fat in the Quadriceps and Gait Independence in Convalescent Stroke Patients
In stroke patients, secondary changes in the skeletal muscles, including decreased muscle mass and increased intramuscular fat, have been examined after stroke onset.1 These changes are greater on the paretic side than on the non-paretic side.2,3 In chronic stroke survivors, these secondary changes in skeletal muscles are associated with decreased muscle strength,4 gait independence,5 and aerobic exercise capacity.6 Furthermore, Ryan et al.2 have reported that increased intramuscular fat in stroke patients is associated with decreased insulin sensitivity.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2020 Category: Neurology Authors: Taisei Ishimoto, Yusuke Taniguchi, Naoki Akazawa Source Type: research

Poor glycemic control and posterior circulation ischemic stroke
Conclusions Poor glycemic control may be associated with an increased risk of thrombotic infarction that occurs preferentially in the posterior circulation of the brain.
Source: Neurology Clinical Practice - April 7, 2019 Category: Neurology Authors: Kuroda, J., Matsuo, R., Yamaguchi, Y., Sato, N., Kamouchi, M., Hata, J., Wakisaka, Y., Ago, T., Kitazono, T., on behalf of the Fukuoka Stroke Registry Investigators Tags: Infarction Research Source Type: research

Microembolic Signals is Associated With Insulin Resistance Among Acute Ischemic Stroke Patients
This study aims to investigate the clinical correlation between intracranial MES and IR in AIS patients.
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2019 Category: Neurology Authors: Xuyou Zhou, Dongmei Zhang, Yong Zhou, Fang Wang, Xiangyang Zhu Source Type: research

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease Clinical Sciences
Conclusions—Our Mendelian randomization study provides evidence to suggest that T2D may be causally associated with CSVD, in particular with lacunar stroke and FA.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Junfeng Liu, Loes Rutten-Jacobs, Ming Liu, Hugh S. Markus, Matthew Traylor Tags: Genetic, Association Studies, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Growth Hormone Improves Cognitive Function After Experimental Stroke Basic Sciences
Conclusions—These findings provide compelling preclinical evidence for the usage of GH as a potential therapeutic tool in the recovery phase of patients after stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Lin Kooi Ong, Wei Zhen Chow, Clifford TeBay, Murielle Kluge, Giovanni Pietrogrande, Katarzyna Zalewska, Patricia Crock, N. David Aberg, Andrew Bivard, Sarah J. Johnson, Frederick R. Walker, Michael Nilsson, Jorgen Isgaard Tags: Angiogenesis, Basic Science Research, Growth Factors/Cytokines, Cognitive Impairment, Neurogenesis Original Contributions Source Type: research

Pancreatic {beta}-Cell Function and Prognosis of Nondiabetic Patients With Ischemic Stroke Clinical Sciences
Conclusions—In this large-scale registry, β-cell dysfunction was associated with an increased risk of 12-month poor prognosis in nondiabetic patients with ischemic stroke.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Yuesong Pan, Weiqi Chen, Jing Jing, Huaguang Zheng, Qian Jia, Hao Li, Xingquan Zhao, Liping Liu, Yongjun Wang, Yan He, Yilong Wang Tags: Diabetes, Type 2, Secondary Prevention, Ischemic Stroke Original Contributions Source Type: research

Smoking cessation and outcome after ischemic stroke or TIA
Conclusion: Cessation of cigarette smoking after an ischemic stroke or TIA was associated with significant health benefits over 4.8 years in the IRIS trial cohort.
Source: Neurology - October 16, 2017 Category: Neurology Authors: Epstein, K. A., Viscoli, C. M., Spence, J. D., Young, L. H., Inzucchi, S. E., Gorman, M., Gerstenhaber, B., Guarino, P. D., Dixit, A., Furie, K. L., Kernan, W. N., For the IRIS Trial Investigators Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Infarction ARTICLE Source Type: research

Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study
Conclusions: This study provides support that T2D may be causally associated with large artery stroke.
Source: Neurology - July 31, 2017 Category: Neurology Authors: Larsson, S. C., Scott, R. A., Traylor, M., Langenberg, C. C., Hindy, G., Melander, O., Orho-Melander, M., Seshadri, S., Wareham, N. J., Markus, H. S., For the METASTROKE Collaboration and NINDS Stroke Genetics Network (SiGN) Tags: Risk factors in epidemiology, Infarction ARTICLE Source Type: research

Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke Clinical Sciences
We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke.Methods—We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62% women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990–1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders.Results—During a mean follow-up of 10.2 years, 99 individuals developed ischemic stroke. After adjustment for age, sex, and potentia...
Source: Stroke - June 26, 2017 Category: Neurology Authors: Hamidreza Saber, Jayandra J. Himali, Alexa S. Beiser, Ashkan Shoamanesh, Aleksandra Pikula, Ronenn Roubenoff, Jose R. Romero, Carlos S. Kase, Ramachandran S. Vasan, Sudha Seshadri Tags: Risk Factors, Ischemic Stroke Original Contributions Source Type: research

Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke Clinical Sciences
Conclusions—Insulin resistance was associated with an increased risk of death, stroke recurrence, and poor outcome but not dependence in nondiabetic patients with acute ischemic stroke.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Jing Jing, Yuesong Pan, Xingquan Zhao, Huaguang Zheng, Qian Jia, Donghua Mi, Weiqi Chen, Hao Li, Liping Liu, Chunxue Wang, Yan He, David Wang, Yilong Wang, Yongjun Wang Tags: Prognosis, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Sex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study Epidemiology
ConclusionsBoth HOMA‐IR and the McAuley index demonstrate strong associations with CHD but not stroke risk in blacks. The logHOMA‐IR and CHD association was present in men, but not in women.
Source: JAHA:Journal of the American Heart Association - February 2, 2017 Category: Cardiology Authors: Effoe, V. S., Wagenknecht, L. E., Echouffo Tcheugui, J. B., Chen, H., Joseph, J. J., Kalyani, R. R., Bell, R. A., Wu, W.-C. H., Casanova, R., Bertoni, A. G. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Original Research Source Type: research

Pioglitazone for Secondary Stroke Prevention Clinical Sciences
Conclusions—Pioglitazone reduces recurrent stroke and major vascular events in ischemic stroke patients with insulin resistance, prediabetes, and diabetes mellitus.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Meng Lee, Jeffrey L. Saver, Hung-Wei Liao, Chun-Hsien Lin, Bruce Ovbiagele Tags: Cardiovascular Disease, Diabetes, Type 2, Secondary Prevention, Meta Analysis, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Post-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke Stroke
This study aimed to estimate the association between post–glucose load measures of insulin resistance and prognosis of nondiabetic patients with ischemic stroke.Methods and ResultsData were derived from the ACROSS‐China (Abnormal Glucose Regulation in Patients with Acute Stroke across China) registry. Patients with ischemic stroke without a history of diabetes mellitus were included. Two post–glucose load measures of insulin sensitivity, the insulin sensitivity indices ISI(composite) and the ISI0,120, were calculated. Outcomes included stroke recurrence, all‐cause death, and poor functional outcome at 12 months. A...
Source: JAHA:Journal of the American Heart Association - January 20, 2017 Category: Cardiology Authors: Pan, Y., Jing, J., Chen, W., Zheng, H., Jia, Q., Mi, D., Li, H., Zhao, X., Liu, L., Wang, C., Gaisano, H. Y., He, Y., Wang, Y., Tags: Ischemic Stroke Original Research Source Type: research

Resistive Training and Molecular Regulators of Vascular-Metabolic Risk in Chronic Stroke
Peroxisome proliferator-activated receptor (PPAR)- γ coactivator (PGC-1α) gene and Sirtuin-1 (SIRT-1) respond to physiological stimuli and regulate insulin resistance. Inflammatory markers tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), and the soluble forms of intracellular adhesion molecule (sICAM-1) and vas cular CAM-1 (sVCAM-1) are associated with increased risk of diabetes and coronary heart disease. Resistive training (RT) reduces hyperinsulinemia and improves insulin action in chronic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - December 8, 2016 Category: Neurology Authors: Alice S. Ryan, Guoyan Li, Charlene Hafer-Macko, Frederick M. Ivey Source Type: research

Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice Basic Sciences
Conclusions— Treatment with exendin-4 could be a potentially useful therapeutic option for treatment of acute ischemic stroke with transient hyperglycemia.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Kuroki, T., Tanaka, R., Shimada, Y., Yamashiro, K., Ueno, Y., Shimura, H., Urabe, T., Hattori, N. Tags: Treatment, Blood-Brain Barrier, Ischemic Stroke Basic Sciences Source Type: research

Decrease in Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-1 Ratio in the First Week of Stroke Is Related to Positive Outcomes
High insulin-like growth factor-1 (IGF-1), measured once during acute stroke, is associated with greater survival rates and lower stroke severity. However, information is lacking regarding how IGF-1 availability, determined by IGF-1's ratio to insulin-like growth factor binding protein-3 (IGFBP-3), relates to recovery and how the response of IGF-1 during the first week of stroke relates to outcomes. The purpose of this study was to determine the following: (1) the relationship between percent change in IGF-1 and IGF-1 ratio during the first week of stroke and stroke outcomes; and (2) the difference in percent change in IGF...
Source: Journal of Stroke and Cerebrovascular Diseases - April 20, 2016 Category: Neurology Authors: Anna E. Mattlage, Michael A. Rippee, Janice Sandt, Sandra A. Billinger Source Type: research

A Diagnostic Score for Insulin Resistance in Nondiabetic Patients with Ischemic Stroke or Transient Ischemic Attack
We sought to develop an instrument to screen for insulin resistance in nondiabetic patients with recent ischemic stroke or transient ischemic attack (TIA).
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2016 Category: Neurology Authors: Jin Xu, Catherine M. Viscoli, Gary A. Ford, Mark Gorman, Walter N. Kernan, IRIS Trial Investigators Source Type: research

Tackling insulin resistance may reduce recurrence after stroke
Giving pioglitazone to stroke survivors with insulin resistance but no overt diabetes reduces their risk of having a recurrent vascular event, shows the randomised Insulin Resistance Intervention after Stroke trial.
Source: MedWire News - February 19, 2016 Category: Consumer Health News Tags: Stroke Source Type: news

D-4F Decreases White Matter Damage After Stroke in Mice Basic Sciences
Conclusions— D-4F treatment initiated 2 h after MCAo decreases neuroinflammation and white matter damage and improves functional outcome after stroke. D-4F-induced increase in IGF1 may contribute to D-4F–induced neurite/axonal outgrowth after stroke.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Cui, X., Chopp, M., Zacharek, A., Cui, C., Yan, T., Ning, R., Chen, J. Tags: Treatment, Ischemic Stroke Basic Sciences Source Type: research

Deficiency of Brain ATP-Binding Cassette Transporter A-1 Exacerbates Blood-Brain Barrier and White Matter Damage After Stroke Basic Sciences
Conclusions— We demonstrate that brain ABCA1 deficiency increases BBB leakage, WM/axonal damage, and functional deficits after stroke. Concomitant reduction of insulin-like growth factor 1 and upregulation of matrix metalloproteinase-9 may contribute to brain ABCA1 deficiency–induced BBB and WM/axonal damage in the ischemic brain.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Cui, X., Chopp, M., Zacharek, A., Karasinska, J. M., Cui, Y., Ning, R., Zhang, Y., Wang, Y., Chen, J. Tags: Acute Cerebral Infarction, Behavioral Changes and Stroke Basic Sciences Source Type: research

Imaging of a Clinically Relevant Stroke Model: Glucose Hypermetabolism Revisited Basic Sciences
Conclusions— The increased uptake of [2-18F]-2-fluoro-2-deoxy-d-glucose in cerebral ischemia most likely reflects hypermetabolism of glucose meeting increased energy needs of ischemic and hypoperfused brain tissue, and it occurs under both anaerobic and aerobic conditions measured by local lactate production. Infarct-related systemic hyperglycemia could serve to facilitate glucose supply to the ischemic brain. Glycemic control by insulin treatment could negatively influence this mechanism.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Arnberg, F., Grafstrom, J., Lundberg, J., Nikkhou-Aski, S., Little, P., Damberg, P., Mitsios, N., Mulder, J., Lu, L., Soderman, M., Stone-Elander, S., Holmin, S. Tags: Acute Stroke Syndromes, Brain Circulation and Metabolism Basic Sciences Source Type: research