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independent origin for M.3243A & gt;G mitochondrial mutation in three venezuelan cases of melas syndrome
Clin Biochem. 2022 Sep 18:S0009-9120(22)00221-1. doi: 10.1016/j.clinbiochem.2022.09.007. Online ahead of print.ABSTRACTMitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a multisystem and progressive neurodegenerative mitochondrial disease, caused by point nucleotide changes in the mtDNA where 80% of cases have the mutation m.3243A>G in the MT-TL1 gene. In this work, we described the clinical, biochemical and molecular analysis of three Venezuelan patients affected with MELAS syndrome. All cases showed lactic acidosis, cortical cerebral atrophy on magnetic resonance imaging and ...
Source: Clinical Biochemistry - September 21, 2022 Category: Biochemistry Authors: Ingrid Florez Irune Pirrone Liliana Casique Carmen Luisa Dom ínguez Antonieta Mahfoud Tania Rodr íguez Daniel Rodr íguez Marisel De Lucca Jos é Luis Ramírez Source Type: research

Ischemic Stroke in a Child after a Probable Scorpion Sting
We report a 2-year-old Venezuelan boy presenting with acute pancreatitis and pulmonary edema without an identifiable cause 48 hours after his initial symptoms. We administered antivenom therapy when an undetected scorpion sting was suspected. Despite some initial clinical improvement with respect to his acute pancreatitis, pulmonary edema, and coagulation abnormalities, our patient experienced an ischemic stroke. Fortunately, our patient did demonstrate some neurological improvement. Although acute pancreatitis and pulmonary edema are known end-organ damage manifestations of the sting of Tityus in the Americas, our particu...
Source: Am J Trop Med Hyg - November 29, 2021 Category: Infectious Diseases Authors: Laura Naranjo Fernando Carrillo-Villase ñor Gina D'Suze Carlos Sevcik Nathan Gundacker Amy Rao Carlos Franco-Paredes Jos é Antonio Suárez Source Type: research

Intrinsic capacity and its associations with incident dependence and mortality in 10/66 Dementia Research Group studies in Latin America, India, and China: A population-based cohort study
ConclusionsIn this study we observed a high prevalence of DICs, particularly in older age groups. Those affected had substantially increased risks of dependence and death. Most needs for care arose in those with DIC yet to become frail. Our findings provide some support for the strategy of optimising intrinsic capacity in pursuit of healthy ageing. Implementation at scale requires community-based screening and assessment, and a stepped-care intervention approach, with redefined roles for community healthcare workers and efforts to engage, train, and support them in these tasks. ICOPE might be usefully integrated into commu...
Source: PLoS Medicine - September 14, 2021 Category: Internal Medicine Authors: Martin J. Prince Source Type: research

Cardiometabolic risk factors in Venezuela. The EVESCAM study: a national cross-sectional survey in adults
Cardiovascular disease (CVD) is the leading global cause of death [1]. High adiposity, hypertension, high cholesterol, and hyperglycemia are their most important risk factors. Between 1980 and 2010, the mortality burden of cardiometabolic risk factors (CMRF) shifted from high-income to low and middle-income countries [2]. In Latin America, coronary heart disease and stroke cause 42.5% and 28.8% of the CVD mortality, respectively [3]. But, it is necessary to identify the magnitude of the CMRF not only in each region but in each country.
Source: Primary Care Diabetes - August 3, 2020 Category: Primary Care Authors: Ramfis Nieto-Mart ínez, Juan P. González-Rivas, Eunice Ugel, Maritza Duran, Eric Dávila, Ramez Constantino, Alberto García, Jeffrey I. Mechanick, María Inés Marulanda Tags: Original research Source Type: research

Neuroimaging and Neurolaw: Drawing the Future of Aging
Vincenzo Tigano1, Giuseppe Lucio Cascini2, Cristina Sanchez-Castañeda3, Patrice Péran4 and Umberto Sabatini5* 1Department of Juridical, Historical, Economic and Social Sciences, University of Magna Graecia, Catanzaro, Italy 2Department of Experimental and Clinical Medicine, University of Magna Graecia, Catanzaro, Italy 3Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain 4ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France 5Department of Medical and Surgical Sciences, University of Magna Graecia, Catanzaro, ...
Source: Frontiers in Endocrinology - April 7, 2019 Category: Endocrinology Source Type: research

Overfed and Underfed: Global Food Extremes
The international community of nations has made commitments to eliminate hunger, achieve food security and improved nutrition by 2030 and also to promote and protect health through nutritious diet, healthy eating and increased physical activity. Credit: IPSBy Joseph ChamieNEW YORK, Jun 12 2017 (IPS)Global food extremes of chronic undernourishment and obesity have brought about a bipolar world of hundreds of millions of underfed and overfed people. Of the world’s population of 7.5 billion the proportions suffering from chronic undernourishment and those afflicted by obesity are similar, approximately 11 percent or togethe...
Source: IPS Inter Press Service - Health - June 12, 2017 Category: International Medicine & Public Health Authors: Joseph Chamie Tags: Development & Aid Food & Agriculture Global Headlines Health Poverty & SDGs Regional Categories Source Type: news

In Depth A fish back from the dead
Deprive a human of oxygen for 5 minutes or more and she will turn blue, pass out, and may die. Suffocate the embryo of a Venezuelan annual killifish, however, and it survives for months, emerging unscathed to complete its development. At a recent meeting, researchers offered a look at the killifish's bag of tricks, assessing the interplay between temperature and oxygen levels in determining whether this fish's embryos enter a state of dormancy to survive their ephemeral ponds drying up, and, more recently, cataloging the RNAs involved in this decision and the embryo's survival. By exploring the extremes of vertebrate physi...
Source: ScienceNOW - January 29, 2016 Category: Science Authors: Elizabeth Pennisi Tags: Physiology Source Type: news

Cost-Effectiveness of Apixaban Versus Other New Oral Anticoagulants And Warfarin for Stroke Prevention In Atrial Fibrillation In Venezuela
Apixaban (5 mg BID), dabigatran (150mg), and rivaroxaban (20 mg once daily) are 3 novel oral anticoagulants (NOACs) currently approved for stroke prevention in patients with atrial fibrillation (AF). Although warfarin remains the standard of care in Venezuela.
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: Y Fernández Ávila, KC Garcia, S Garrido Lecca, BM Donato, A Juarez-Garcia Source Type: research

I Go Red for Mis Abuelas
By Chef Hamlet Garcia Five years ago I became a national volunteer spokesperson for the American Heart Association's Go Red for Women campaign. To this day, many people ask me why I support this cause and not others. The answer is that I carry this cause in my heart. I was raised under the guidance and care of two great women. They both had simple, strong personalities with a tempered focus in their actions. They were heads of families, paternal and maternal, and for me they became much more than that: They were teachers, friends and even confidantes. My "Nona" (grandmother) Alcira, the mother of my mother, certainly wa...
Source: Healthy Living - The Huffington Post - February 24, 2015 Category: Consumer Health News Source Type: news