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Total 229 results found since Jan 2013.

Validity of the Utrecht scale for evaluation of rehabilitation-participation restrictions scale in a hospital-based stroke population 3 months after stroke
Conclusions:The USER-P-R shows good measurement properties and provides additional patient-reported information, proving its usefulness as an instrument to evaluate participation after 3 months in a hospital-based stroke population.PMID:34315356 | DOI:10.1080/10749357.2021.1956047
Source: Topics in Stroke Rehabilitation - July 28, 2021 Category: Neurology Authors: Joris A de Graaf Eline J Volkers Vera P M Schepers Johanna M A Visser-Meily Marcel W M Post Source Type: research

City Heat is Worse if You ’re Not Rich or White. The World’s First Heat Officer Wants to Change That
Jane Gilbert knows she doesn’t get the worst of the sticky heat and humidity that stifles Miami each summer. She lives in Morningside, a coastal suburb of historically preserved art deco and Mediterranean-style single-family homes. Abundant trees shade the streets and a bay breeze cools residents when they leave their air conditioned cars and homes. “I live in a place of privilege and it’s a beautiful area,” says Gilbert, 58, over Zoom in early June, shortly after beginning her job as the world’s first chief heat officer, in Miami Dade county. “But you don’t have to go far to see t...
Source: TIME: Science - July 7, 2021 Category: Science Authors: Ciara Nugent Tags: Uncategorized climate change feature Londontime Source Type: news

People display tell-tale signs of a looming stroke up to 10 YEARS before it happens
Dutch researchers say stroke patients experience a more rapid mental decline and decreased ability to perform every day tasks, such as banking and cooking.
Source: the Mail online | Health - July 7, 2021 Category: Consumer Health News Source Type: news

Influence of Onset to Imaging Time on Radiological Thrombus Characteristics in Acute Ischemic Stroke
Conclusion: In our population of acute ischemic stroke patients, we found no clear association between onset-to-imaging time and radiological thrombus characteristics. This suggests that elapsed time from stroke onset plays a limited role in the interpretation of radiological thrombus characteristics and their effect on treatment results, at least in the early time window.
Source: Frontiers in Neurology - June 18, 2021 Category: Neurology Source Type: research

Call Characteristics of Patients Suspected of Transient Ischemic Attack (TIA) or Stroke During Out-of-Hours Service: A Comparison Between Men and Women
Conclusion: Overall, patient and call characteristics are mostly comparable between men and women, and these only modestly assist in identifying TIA/stroke. There were no gender differences in allocated urgencies after telephone triage in patients with TIA/stroke.
Source: Frontiers in Neurology - June 14, 2021 Category: Neurology Source Type: research

Sensors, Vol. 21, Pages 4066: Wearable Activity Monitoring in Day-to-Day Stroke Care: A Promising Tool but Not Widely Used
In conclusion, although the concept of remote activity monitoring was perceived as useful, it was not widely adopted by physical therapists involved in stroke care. To date, skills, beliefs, and attitudes of individual therapists determine the current use of wearable technology.
Source: Sensors - June 12, 2021 Category: Biotechnology Authors: Hanneke E. M. Braakhuis Johannes B. J. Bussmann Gerard M. Ribbers Monique A. M. Berger Tags: Communication Source Type: research

Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of VEXAS patients
Novel features of VEXAS include interstitial nephritis, cardiac involvement, stroke, and intestinal perforation related to treatment with tocilizumab. Early diagnosis could prevent unnecessary diagnostic procedures, and provide better prognostic information and more suitable treatment options.
Source: Journal of Allergy and Clinical Immunology - May 25, 2021 Category: Allergy & Immunology Authors: Caspar I. van der Made, Judith Potjewijd, Annemiek Hoogstins, Huub P.J. Willems, A.J. Kwakernaak, Ruud G.L. de Sevaux, Paul L.A. van Daele, Annet Simons, Marloes Heijstek, David B. Beck, Mihai G. Netea, Pieter van Paassen, A.E. Hak, Lars T. van der Veken, Source Type: research

Evaluation of Response Processes to the Danish Version of the Dutch Multifactor Fatigue Scale in Stroke Using the Three-Step Test-Interview
In conclusion, findings elucidate the interpretative processes involved in responding to DMFS post-stroke, strengthen the evidence base of validity, and guide revisions to mitigate potential problems in item performance.
Source: Frontiers in Human Neuroscience - May 6, 2021 Category: Neuroscience Source Type: research

Endovascular treatment for calcified cerebral emboli in patients with acute ischemic stroke
CONCLUSIONS: While patients with CCE had significantly lower reperfusion rates and less improvement on the NIHSS after EVT, CCE were not significantly associated with worse functional outcome or higher mortality rates. Therefore, EVT should still be considered in this specific group of patients.PMID:33799302 | DOI:10.3171/2020.9.JNS201798
Source: Journal of Neurosurgery - April 2, 2021 Category: Neurosurgery Authors: Agnetha A E Bruggeman Manon Kappelhof Nerea Arrarte Terreros Manon L Tolhuisen Praneeta R Konduri Nikki Boodt Heleen M M van Beusekom Hajo M Hund Aladdin Taha Aad van der Lugt Yvo B W E M Roos Adriaan C G M van Es Wim H van Zwam Alida A Postma Diederik W Source Type: research

Prediction of long-term recurrent ischemic stroke: the added value of non-contrast CT, CT perfusion, and CT angiography
ConclusionData from CT imaging significantly improved the discriminatory performance and reclassification in predicting ischemic stroke recurrence beyond a model incorporating clinical risk factors only.
Source: Neuroradiology - March 17, 2021 Category: Radiology Source Type: research

Validation of automated Alberta Stroke Program Early CT Score (ASPECTS) software for detection of early ischemic changes on non-contrast brain CT scans
ConclusionThe performance of automated ASPECTS is comparable to expert readers and could support readers in the detection of early ischemic changes.
Source: Neuroradiology - March 17, 2021 Category: Radiology Source Type: research

MR CLEAN-LATE, a multicenter randomized clinical trial of endovascular treatment of acute ischemic stroke in The Netherlands for late arrivals: study protocol for a randomized controlled trial
Endovascular therapy (EVT) for acute ischemic stroke due to proximal occlusion of the anterior intracranial circulation, started within 6  h from symptom onset, has been proven safe and effective. Recently, EVT...
Source: Trials - February 24, 2021 Category: General Medicine Authors: F. A. V. ( Anne) Pirson, Wouter H. Hinsenveld, Robert-Jan B. Goldhoorn, Julie Staals, Inger R. de Ridder, Wim H. van Zwam, Marianne A. A. van Walderveen, Geert J. Lycklama à Nijeholt, Maarten Uyttenboogaart, Wouter J. Schonewille, Aad van der Lugt, Diede Tags: Study protocol Source Type: research

Decision-Making on Referral to Primary Care Physiotherapy After Inpatient Stroke Rehabilitation
Worldwide, stroke is a leading cause of death and disability.1 Although incidence rates are expected to increase over the next few decades, survival rates are expected to improve. Consequently, more stroke survivors will have to learn to live with the consequences. After acute stroke care or rehabilitation, returning home is one of the primary goals for stroke survivors.2 In the Netherlands, 65 % of stroke survivors return home immediately after acute hospital care.3 The remaining 35% continue inpatient rehabilitation in a rehabilitation center (RC) or geriatric rehabilitation center (GRC) before returning home.
Source: Journal of Stroke and Cerebrovascular Diseases - February 23, 2021 Category: Neurology Authors: Marieke Geerars, Roderick Wondergem, Martijn F. Pisters Source Type: research

Patient Reported Outcomes Measurements Information System in Stroke Patients in Full and Shortened Format
Conclusion: PROMIS better reflects the overall health status of stroke patients beyond functional outcome as measured by the mRS. Simplification of the questionnaire with a single question per PROMIS domain could potentially replace the full questionnaire, but needs further validation.
Source: Frontiers in Neurology - January 22, 2021 Category: Neurology Source Type: research

Comparison between EQ-5D-5L and PROMIS-10 to evaluate health-related quality of life 3 months after stroke: a cross-sectional multicenter study.
CONCLUSIONS: Both EQ-5D-5L and PROMIS-10 prove to be useful instruments to evaluate HRQoL in patients who are living at home 3 months after stroke. CLINICAL REHABILITATION IMPACT: It depends on the setting and underlying goal which patient-reported outcome measure is preferred to evaluate HRQoL 3 months after stroke. The PROMIS-10 should be preferred to detect differences in less affected stroke patients, whereas the EQ-5D-5L provides slightly more information in more affected stroke patients. PMID: 33448750 [PubMed - as supplied by publisher]
Source: European Journal of Physical and Rehabilitation Medicine - January 15, 2021 Category: Rehabilitation Authors: de Graaf JA, Visser-Meily JM, Schepers VP, Baars A, Kappelle LJ, Passier PE, Wermer MJ, de Wit DC, Post MW Tags: Eur J Phys Rehabil Med Source Type: research

Effect of Heparinized Flush Concentration on Safety and Efficacy During Endovascular Thrombectomy for Acute Ischemic Stroke: Results from the  MR CLEAN Registry
ConclusionEffect of heparin in flush fluids should not be ignored by clinicians or researchers as higher concentrations may be associated with higher rates of ICH. The observed variation in protocols regarding heparin concentrations between EVT centers should encourage further studies, ideally in a controlled way, resulting in recommendations on heparin use in flush fluids in future guidelines.
Source: CardioVascular and Interventional Radiology - January 3, 2021 Category: Radiology Source Type: research

Effect of intravenous thrombolysis in stroke depends on pattern of intracranial internal carotid artery calcification
The pattern of intracranial internal carotid artery calcification (ICAC) has been identified as an effect modifier of endovascular treatment in patients with acute ischemic stroke, but it is unclear whether it modifies the effect of intravenous thrombolysis. The purpose of this study was to evaluate the association between intravenous thrombolysis and 90-day clinical outcome, follow-up infarct volume, intracranial hemorrhage and recanalization across different patterns of ICAC.
Source: Atherosclerosis - November 22, 2020 Category: Cardiology Authors: Frans Kauw, Pim A. de Jong, Richard A.P. Takx, Hugo W.A.M. de Jong, L. Jaap Kappelle, Birgitta K. Velthuis, Jan W. Dankbaar, Dutch acute stroke study (DUST) investigators Source Type: research

Peripheral Artery Disease in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy; Results From the MR CLEAN Registry
Conclusion: In the absence of an association between the presence of PAD and collateral scores or outcomes after EVT, it may be questioned whether PAD leads to RIPC in patients with acute ischemic stroke due to large vessel occlusion.
Source: Frontiers in Neurology - October 6, 2020 Category: Neurology Source Type: research

Long-Term Mortality Among ICU Patients With Stroke Compared With Other Critically Ill Patients
Conclusions: Stroke patients who need intensive care treatment have a high short-term mortality risk, but this alters favorably with increasing duration of survival time after ICU admission in patients with both ischemic stroke and intracerebral hemorrhage, especially compared with other populations of critically ill patients such as sepsis or severe community-acquired pneumonia patients.
Source: Critical Care Medicine - September 12, 2020 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Stroke prevention in patients with atrial fibrillation and comorbidities: evidence and common sense.
PMID: 32897488 [PubMed - as supplied by publisher]
Source: Netherlands Heart Journal - September 7, 2020 Category: Cardiology Authors: de Groot JR Tags: Neth Heart J Source Type: research

Smoking Does Not Alter Treatment Effect of Intravenous Thrombolysis in Mild to Moderate Acute Ischemic Stroke —A Dutch String-of-Pearls Institute (PSI) Stroke Study
Conclusions: In patients with mild to moderate AIS admitted within 12 h of symptom onset, smoking did not modify treatment effect of thrombolysis.
Source: Frontiers in Neurology - July 30, 2020 Category: Neurology Source Type: research

CT Scanning in Suspected Stroke or Head Trauma: Is it Worth Going the Extra Mile and Including the Chest to Screen for COVID-19 Infection? ADULT BRAIN
CONCLUSIONS: The sensitivity of additional chest CT is fairly high. However, a negative result does not exclude COVID-19. The positive predictive value is poor. Correlation of chest CT results with epidemiologic history and clinical presentation, along with real-time reverse transcriptase polymerase chain reaction, is needed for confirmation.
Source: American Journal of Neuroradiology - July 12, 2020 Category: Radiology Authors: Kwee, R. M., Krdzalic, J., Fasen, B. A. C. M., de Jaegere, T. M. H., for the COVID-19 CT Investigators South-East Netherlands (CISEN) Study Group Tags: ADULT BRAIN Source Type: research

Association of PAI-1 rs1799889 Polymorphism with Susceptibility to Ischemic Stroke: a Huge Meta-Analysis based on 44 Studies.
CONCLUSIONS: This meta-analysis result suggested that PAI-1 rs1799889 polymorphism was associated with an increased risk of ischemic stroke, especially in Asian and Mixed populations. PMID: 32422114 [PubMed - in process]
Source: Acta Medica: Hradec Kralove - May 20, 2020 Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research

Counselled Patients with Stroke Still Experience Sexual and Relational Problems 1 –5 Years After Stroke Rehabilitation
AbstractTo describe sexual functioning/satisfaction and relational satisfaction of patients with stroke who received sexual counselling during their rehabilitation 1 –5 years thereafter. All adult patients with stroke admitted to one Dutch Rehabilitation Centre between January 2010 and January 2014 with at least two consultations with a sexologist were invited to participate in this cross-sectional survey study. Patients were asked to complete a questionnaire on sexual functioning, relational satisfaction (Maudsley Marital Questionnaire, 0–80; low–high dissatisfaction), health-related quality of life (HRQoL) short-f...
Source: Sexuality and Disability - April 27, 2020 Category: Disability Source Type: research

Radiology workload in clinical implementation of thrombectomy for acute ischemic stroke: experience from The Netherlands
ConclusionOur study estimated the number of stroke patients undergoing CTA for suspected LVO and those eligible for thrombectomy in relation to the population. Numbers were essentially the same throughout the week, and during office and on-call hours. Our data can be used to make adequate staffing plans.
Source: Neuroradiology - April 4, 2020 Category: Radiology Source Type: research

Effectiveness of AbobotulinumtoxinA in Post-stroke Upper Limb Spasticity in Relation to Timing of Treatment
Conclusions: In this observational, routine-practice study, patients in all groups displayed a benefit from abobotulinumtoxinA treatment, supporting the effectiveness of treatment for patients at various disease stages. Although the data revealed some trends in favor of early vs. late treatment, we did not find strong evidence for a significant benefit of early vs. late start of treatment in terms of reduction in MAS scores.
Source: Frontiers in Neurology - February 27, 2020 Category: Neurology Source Type: research

Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Hugues Chabriat, Claudio L Bassetti, Ute Marx, Marie-Laure Audoli-Inthavong, Aurore Sors, Estelle Lambert, Marine Wattez, Dirk M Hermann, Katharina ALTHAUS, Sergi AMARO, Hee-Joon BAE, Zbigniew BAK, Leonardo BARBARINI, Pietro BASSI, Rodrigo BAZAN, Daniel BERECZKI, Tomasz BERKOWICZ, Joerg BERROUSCHOT, Dylan BLACQUIERE, Waldemar BROLASummaryBackgroundS44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical excitabi...
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Validity of an enhanced EQ-5D-5L measure with an added cognitive dimension in patients with stroke.
CONCLUSIONS: The EQ-5D-5L+C, which includes a cognitive domain that is highly significant for stroke patients, showed increased content validity and good discriminative ability, without losing internal consistency. PMID: 32070131 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - February 18, 2020 Category: Rehabilitation Authors: de Graaf JA, Kuijpers M, Visser-Meily J, Kappelle LJ, Post M Tags: Clin Rehabil Source Type: research

Older age and duration of exposure to type 2 diabetes in selective screening of asymptomatic carotid artery stenosis for primary stroke prevention —A single institution experience
Carotid artery disease is a well-known cause of stroke. In Malaysia, stroke is the third most common cause of death [1]. To our knowledge, there is still limited information regarding stroke and its associated risk factors. Strokes from ischemic infarction of the brain is due to narrowing or occlusion from local thrombosis or embolization of a proximal thrombus. The incidence of ischemic stroke from carotid artery stenosis in an asymptomatic western population is approximately 2.7% according to a report from Netherlands by Hartog et al.
Source: Primary Care Diabetes - November 16, 2019 Category: Primary Care Authors: Lenny Suryani Safri, Henry Tan Chor Lip, M. Iqbal Saripan, Tan Jih Huei, K. Krishna, Mohamad Azim Md Idris, Hanafiah Harunarashid Tags: Original research Source Type: research

Determinants of extended door-to-needle time in acute ischemic stroke and its influence on in-hospital mortality: results of a nationwide Dutch clinical audit
Intravenous thrombolysis (IVT) plays a prominent role in the treatment of acute ischemic stroke (AIS). The sooner IVT is administered, the higher the odds of a good outcome. Therefore, registering the in-hospi...
Source: BMC Neurology - November 4, 2019 Category: Neurology Authors: Laurien S. Kuhrij, Perla J. Marang-van de Mheen, Renske M. van den Berg-Vos, Frank-Erik de Leeuw and Paul J. Nederkoorn Tags: Research article Source Type: research

Systematic review of subjective memory measures to inform assessing memory limitations after stroke and stroke-related aphasia.
Conclusions: This literature domain currently provides an unclear picture as to how memory limitations affect participation in stroke and stroke-related aphasia. IMPLICATIONS FOR REHABILITATION A broad range of subjective memory measures have been used to determine stroke survivors' perceptions of their everyday memory issues. Because of psychometric weaknesses such as inadequate reliability and cross-cultural validity among subjective memory measures, there remains a need to carefully review a given measure's properties to determine if it is appropriate for use with a given stroke survivor. Stroke survivors with aphasia h...
Source: Disability and Rehabilitation - September 26, 2019 Category: Rehabilitation Authors: Salis C, Murray L, Vonk JMJ Tags: Disabil Rehabil Source Type: research

Balloon Guide Catheter in Endovascular Treatment for Acute Ischemic Stroke: Results from the MR CLEAN Registry
ConclusionsIn clinical practice, use of a BGC was associated with higher reperfusion grade and early improvement of neurologic deficits, but had no positive effect on long-term functional outcome.
Source: Journal of Vascular and Interventional Radiology - September 19, 2019 Category: Radiology Source Type: research

Safety and Outcome of Endovascular Treatment for Minor Ischemic Stroke: Results From the Multicenter Clinical Registry of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands
Goal: Insufficient data is available about safety and efficacy of endovascular treatment (EVT) in patients with minor stroke symptoms because these patients were excluded from most randomized trials. We aimed to compare characteristics, functional outcome, and complications in patients with minor ischemic stroke National Institutes of Health Stroke Scale score ≤5 (NIHSS score ≤5) and moderate to severe ischemic stroke (NIHSS score ≥6) due to intracranial proximal artery occlusion of the anterior circulation who underwent EVT.
Source: Journal of Stroke and Cerebrovascular Diseases - December 6, 2018 Category: Neurology Authors: R.B. Goldhoorn, Maxim J.H.L. Mulder, Ivo G.H. Jansen, Wim H. van Zwam, Julie Staals, Aad van der Lugt, Diederik W.J. Dippel, Hester F. Lingsma, Jan Albert Vos, Jelis Boiten, Ido R. van den Wijngaard, Charles B.L.M. Majoie, Yvo B.W.E.M. Roos, Robert J. van Source Type: research

Psychometric properties of the Dutch SAQOL-39NL in a generic stroke population.
CONCLUSIONS: These data provide further evidence for the acceptability, internal consistency, and initial promising data on validity of the SAQOL-39NLg. Further research on structural validity and responsiveness to change is needed. PMID: 30380373 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - October 31, 2018 Category: Neurology Authors: Van Ewijk L, Ter Wal N, Okx G, Goossens P, Groeneveld I Tags: Top Stroke Rehabil Source Type: research

Increased Risk of Pregnancy Complications After Stroke Clinical Sciences
Background and Purpose—The study goal was to investigate the prevalence of pregnancy complications and pregnancy loss in women before, during, and after young ischemic stroke/transient ischemic attack.Methods—In the FUTURE study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation), a prospective young stroke study, we assessed the occurrence of pregnancy, miscarriages, and pregnancy complications in 223 women aged 18 to 50 years with a first-ever ischemic stroke/transient ischemic attack. Pregnancy complications (gestational hypertension, diabetes mellitus, preeclampsia, ...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Mayte E. van Alebeek, Myrthe de Vrijer, Renate M. Arntz, Noortje A.M.M. Maaijwee, Nathalie E. Synhaeve, Hennie Schoonderwaldt, Maureen J. van der Vlugt, Ewoud J. van Dijk, Roel de Heus, Loes C.A. Rutten-Jacobs, Frank-Erik de Leeuw Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Utility-Weighted Modified Rankin Scale as Primary Outcome in Stroke Trials Clinical Sciences
Conclusions—The UW-mRS as primary outcome does not capture individual variation in utility values and may reduce the statistical power of a randomized trial.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Simone A. Dijkland, Daphne C. Voormolen, Esmee Venema, Bob Roozenbeek, Suzanne Polinder, Juanita A. Haagsma, Daan Nieboer, Vicky Chalos, Albert J. Yoo, Jennifer Schreuders, Aad van der Lugt, Charles B.L.M. Majoie, Yvo B.W.E.M. Roos, Wim H. van Zwam, Rober Tags: Quality and Outcomes, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Associations Between Collateral Status and Thrombus Characteristics and Their Impact in Anterior Circulation Stroke Clinical Sciences
Conclusions—Patients with lower thrombus burden and higher thrombus perviousness scores had higher collateral score. The positive effect of thrombus perviousness on clinical outcome was only present in patients with moderate and high collateral scores.Clinical Trial Registration—URL: http://www.trialregister.nl. Unique identifier: NTR1804 and URL: http://www.controlled-trials.com Unique identifier: ISRCTN10888758.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Heitor C. Alves, Kilian M. Treurniet, Bruna G. Dutra, Ivo G. H. Jansen, Anna M.M. Boers, Emilie M.M. Santos, Olvert A. Berkhemer, Diederik W.J. Dippel, Aad van der Lugt, Wim H. van Zwam, Robert J. van Oostenbrugge, Hester F. Lingsma, Yvo B.W.E.M. Roos, Al Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research

Circulating Endothelial Markers in Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations Clinical Sciences
Background and Purpose—Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a monogenic small vessel disease, caused by C-terminal truncating TREX1 mutations, that can be considered a model for stroke and vascular dementia. The pathophysiology of RVCL-S is largely unknown, but systemic endothelial involvement has been suggested, leading to pathology in the brain and other highly vascularized organs. Here, we investigated circulating endothelial markers to confirm endothelial involvement and identify biomarkers for disease activity.Methods—We measured circulating levels of von W...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Nadine Pelzer, Roel Bijkerk, Marlies E.J. Reinders, Anton Jan van Zonneveld, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Jeroen Eikenboom, Gisela M. Terwindt Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Genetics, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

The Longer-term Unmet Needs after Stroke Questionnaire: Cross-Cultural Adaptation, Reliability, and Concurrent Validity in a Dutch Population
Unmet needs are common after stroke. We aimed to translate the 22-item Longer-term Unmet Needs after Stroke (LUNS) Questionnaire and validate it in a Dutch stroke population.
Source: Journal of Stroke and Cerebrovascular Diseases - September 26, 2017 Category: Neurology Authors: Iris Groeneveld, Henk Arwert, Paulien Goossens, Thea Vliet Vlieland Source Type: research

Association of Computed Tomography Ischemic Lesion Location With Functional Outcome in Acute Large Vessel Occlusion Ischemic Stroke Clinical Sciences
Conclusions—The association between follow-up noncontrast computed tomography ILV and outcome as assessed with mRS 3 months after stroke is strengthened by accounting for the mRS relevance of the affected brain areas. Future prediction models should account for the ILV in brain areas of high mRS relevance.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Marielle Ernst, Anna M.M. Boers, Annette Aigner, Olvert A. Berkhemer, Albert J. Yoo, Yvo B. Roos, Diederik W.J. Dippel, Aad van der Lugt, Robert J. van Oostenbrugge, Wim H. van Zwam, Jens Fiehler, Henk A. Marquering, Charles B.L.M. Majoie Tags: Ischemic Stroke Original Contributions Source Type: research

Prediction of Clinical Outcome After Acute Ischemic Stroke Brief Report
Conclusions—Follow-up imaging after 3 days improves outcome prediction compared with prediction based on baseline variables alone. CTA recanalization and CTP reperfusion do not outperform noncontrast CT at this time point.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00880113.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Jan W. Dankbaar, Alexander D. Horsch, Andor F. van den Hoven, L. Jaap Kappelle, Irene C. van der Schaaf, Tom van Seeters, Birgitta K. Velthuis Tags: Computerized Tomography (CT), Prognosis, Ischemic Stroke Brief Reports Source Type: research

Letter by Freeman Regarding Article, “Baseline Blood Pressure Effect on the Benefit and Safety of Intra-Arterial Treatment in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands)” Letter to the Editor
Source: Stroke - July 24, 2017 Category: Neurology Authors: William D. Freeman Tags: Treatment, Ischemic Stroke Letters to the Editor Source Type: research

Response by Mulder et al to Letter Regarding Article, “Baseline Blood Pressure Effect on the Benefit and Safety of Intra-Arterial Treatment in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands)” Letter to the Editor
Source: Stroke - July 24, 2017 Category: Neurology Authors: Maxim J.H.L. Mulder, Hester F. Lingsma, Diederik W.J. Dippel Tags: High Blood Pressure, Revascularization, Cerebrovascular Disease/Stroke, Ischemic Stroke Letters to the Editor Source Type: research

Ethnic Disparities in Ischemic Stroke, Intracerebral Hemorrhage, and Subarachnoid Hemorrhage Incidence in The Netherlands Clinical Sciences
Conclusions— Our findings suggest that Surinamese have an increased risk, whereas Moroccans have a reduced risk for all the various stroke subtypes. Among other ethnic minorities, the risk seems to depend on the stroke subtype and sex. These findings underscore the need to identify the root causes of these ethnic differences to assist primary and secondary prevention efforts.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Agyemang, C., van Oeffelen, A. A. M., Norredam, M., Kappelle, L. J., Klijn, C. J. M., Bots, M. L., Stronks, K., Vaartjes, I. Tags: Cerebrovascular disease/stroke Clinical Sciences Source Type: research

The Dutch String‐of‐Pearls Stroke Study: Protocol of a large prospective multicenter genetic cohort study
BackgroundIn the last couple of years, genome‐wide association studies have largely altered the scope in genetic research in diseases in which both environmental and genetic risk factors contribute to the disease. To date, the genetic risk loci identified in stroke have lagged behind those in other complex diseases, possibly because of the heterogeneity of stroke phenotypes. Sufficiently large cohorts with well‐defined and detailed phenotyping of stroke patients are needed to identify additional genetic risk loci. DesignThe String‐of‐Pearls Institute is a unique partnership between all eight University Medical Cent...
Source: International Journal of Stroke - August 1, 2014 Category: Neurology Authors: Paul J. Nederkoorn, Ewoud J. Dijk, Peter J. Koudstaal, Gert‐Jan Luijckx, Robert J. Oostenbrugge, Marieke C. Visser, Marieke J. H. Wermer, Ynte M. Ruigrok, Ale Algra, L. Jaap Kappelle, Tags: Protocols Source Type: research