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Total 160 results found since Jan 2013.

Safety and efficacy of GABAA α5 antagonist S44819 in patients with ischaemic stroke: a multicentre, double-blind, randomised, placebo-controlled trial
Publication date: March 2020Source: The Lancet Neurology, Volume 19, Issue 3Author(s): Hugues Chabriat, Claudio L Bassetti, Ute Marx, Marie-Laure Audoli-Inthavong, Aurore Sors, Estelle Lambert, Marine Wattez, Dirk M Hermann, Katharina ALTHAUS, Sergi AMARO, Hee-Joon BAE, Zbigniew BAK, Leonardo BARBARINI, Pietro BASSI, Rodrigo BAZAN, Daniel BERECZKI, Tomasz BERKOWICZ, Joerg BERROUSCHOT, Dylan BLACQUIERE, Waldemar BROLASummaryBackgroundS44819, a selective GABAA α5 receptor antagonist, reduces tonic post-ischaemic inhibition of the peri-infarct cortex. S44819 improved stroke recovery in rodents and increased cortical excitabi...
Source: The Lancet Neurology - February 19, 2020 Category: Neurology Source Type: research

Validity of an enhanced EQ-5D-5L measure with an added cognitive dimension in patients with stroke.
CONCLUSIONS: The EQ-5D-5L+C, which includes a cognitive domain that is highly significant for stroke patients, showed increased content validity and good discriminative ability, without losing internal consistency. PMID: 32070131 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - February 19, 2020 Category: Rehabilitation Authors: de Graaf JA, Kuijpers M, Visser-Meily J, Kappelle LJ, Post M Tags: Clin Rehabil Source Type: research

Dutch 'walking-bike' helps disabled people gain mobility, sit tall
Lindsey Main from Massachusetts was an active woman who enjoyed yoga, running and walking her dog, until she suffered a stroke in January 2018 and lost mobility.
Source: Reuters: Health - February 6, 2020 Category: Consumer Health News Tags: healthNews Source Type: news

Reasons for discontinuation of novel oral anticoagulant therapy in patients with atrial fibrillation.
Conclusion: DOAC discontinuation rates varied significantly and appeared related to drug-specific side effects, patient-initiated discontinuation, and bleeding. We observed longer-term administration of apixaban, suggesting that this drug is better tolerated than dabigatran or rivaroxaban. PMID: 32011180 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - February 5, 2020 Category: Research Tags: Curr Med Res Opin Source Type: research

ICDs Have Come a Long Way in 40 Years
Michel Mirowski and his colleagues gave the field of implantable cardioverter-defibrillators (ICDs) a pretty good start, but what's more impressive is how far the technology has advanced since that first human ICD implant in February 1980. In the past 40 years we've seen ICDs become dramatically smaller, longer lasting, more capable, more personalized, subcutaneous (non-transvenous), and even MRI-firendly. And that's not to mention the advanced data connectivity and monitoring capabilities that the latest technologies offer. So without further ado, let's take a look at the current ICD landscape and the companie...
Source: MDDI - February 4, 2020 Category: Medical Devices Authors: Amanda Pedersen Tags: Implants Source Type: news

Opportunistic screening versus usual care for diagnosing atrial fibrillation in general practice: a cluster randomised controlled trial.
CONCLUSION: Opportunistic screening with a single-lead ECG at the discretion of the GP did not result in a higher yield of newly detected cases of AF in patients aged ≥65 years in the community than usual care. For higher participation rates in future studies, more rigorous screening methods are needed. PMID: 31988084 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - January 27, 2020 Category: Primary Care Authors: Kaasenbrood F, Hollander M, de Bruijn SH, Dolmans CP, Tieleman RG, Hoes AW, Rutten FH Tags: Br J Gen Pract Source Type: research

Response to: “Arrhythmia paradox in patients with familial hypercholesterolemia”
We read the letter by Mirzaee and Cameron with great interest. We recently assessed the prognostic impact of clinically diagnosed familial hypercholesterolemia (FH) on long-term adverse cardiovascular outcomes in patients undergoing percutaneous coronary intervention for chronic and acute coronary syndromes. In our cohort, patients with probable or definite FH according to the Dutch Lipid Clinic Network faced a significant, approximate 2-fold increased risk for subsequent atherothrombotic events (death, myocardial infarction, or stroke) during a 6-year period of follow-up compared with patients with possible or unlikely FH.
Source: Journal of Clinical Lipidology - December 24, 2019 Category: Lipidology Authors: Maximilian Tscharre, Kurt Huber Tags: Letter to Editor Source Type: research

The Dutch Audit for Carotid Interventions; Transparency in Quality of Carotid Artery Surgery in the Netherlands
We describe the initiation and design of the DACI and the results of interventions in patients with a symptomatic carotid artery stenosis.
Source: European Journal of Vascular and Endovascular Surgery - December 1, 2019 Category: Surgery Authors: Eleonora G. Karthaus, Anco C. Vahl, Laurien S. Kuhrij, Bernard H. Elsman, Robert H. Geelkerken, Michel W. Wouters, Jaap F. Hamming, Gert Jan de Borst Source Type: research

Trends in mortality, cardiovascular complications, and risk factors in type 2 diabetes.
CONCLUSION: Despite highly organised diabetes care, excess incident cardiovascular events and mortality due to T2DM did not decrease over the study period. Life expectancy of T2DM patients is significantly reduced and risk factor control is suboptimal. This suggests there is considerable room for improvement of diabetes care in the Netherlands. PMID: 31814586 [PubMed - in process]
Source: The Netherlands Journal of Medicine - December 1, 2019 Category: General Medicine Authors: Heintjes EM, Houben E, Beekman-Hendriks WL, Lighaam E, Cremers SM, Penning-van Beest FJA, Stehouwer CDA, Herings RMC Tags: Neth J Med Source Type: research

Diagnostic and (new) therapeutic options for resistant hypertension: a short review.
Abstract Hypertension is a major risk factor for ischaemic heart disease and stroke. Despite the availability of numerous pharmacological treatment options, blood pressure (BP) targets are often not achieved. The inability to reach BP levels below 140/90 mmHg despite the use of three or more antihypertensive drugs is defined as resistant hypertension (RH). The etiology for RH is multifactorial. First, BP should be appropriately measured. In order to improve BP control, lifestyle modification should be recommended, adherence should be carefully assessed to exclude pseudo-resistance, and efforts should be made to ex...
Source: The Netherlands Journal of Medicine - December 1, 2019 Category: General Medicine Authors: Feyz L, Peeters L, Daemen J, Versmissen J Tags: Neth J Med Source Type: research

Safety and efficacy of balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension in the Netherlands.
CONCLUSIONS: BPA performed in a CTEPH expert centre is an effective and safe treatment in patients with inoperable CTEPH. PMID: 31782109 [PubMed - as supplied by publisher]
Source: Netherlands Heart Journal - November 28, 2019 Category: Cardiology Authors: van Thor MCJ, Lely RJ, Braams NJ, Ten Klooster L, Beijk MAM, Heijmen RH, van den Heuvel DAF, Rensing BJWM, Snijder RJ, Vonk Noordegraaf A, Nossent EJ, Meijboom LJ, Symersky P, Mager JJ, Bogaard HJ, Post MC Tags: Neth Heart J Source Type: research

Management and outcomes of real-world use of non-vitamin-K oral anticoagulants (NOACs) in patients with atrial fibrillation: experience of a  dedicated NOAC clinic.
CONCLUSIONS: We observed low rates of bleeding and adverse drug reactions. However, rates of mortality and discontinuation were relatively high. These results could possibly be explained by the real-world nature of the data including higher-risk patients. PMID: 31773474 [PubMed - as supplied by publisher]
Source: Netherlands Heart Journal - November 26, 2019 Category: Cardiology Authors: de Veer AJWM, Bennaghmouch N, Wijffels MCEF, Ten Berg JM Tags: Neth Heart J Source Type: research

Older age and duration of exposure to type 2 diabetes in selective screening of asymptomatic carotid artery stenosis for primary stroke prevention —A single institution experience
Carotid artery disease is a well-known cause of stroke. In Malaysia, stroke is the third most common cause of death [1]. To our knowledge, there is still limited information regarding stroke and its associated risk factors. Strokes from ischemic infarction of the brain is due to narrowing or occlusion from local thrombosis or embolization of a proximal thrombus. The incidence of ischemic stroke from carotid artery stenosis in an asymptomatic western population is approximately 2.7% according to a report from Netherlands by Hartog et al.
Source: Primary Care Diabetes - November 17, 2019 Category: Primary Care Authors: Lenny Suryani Safri, Henry Tan Chor Lip, M. Iqbal Saripan, Tan Jih Huei, K. Krishna, Mohamad Azim Md Idris, Hanafiah Harunarashid Tags: Original research Source Type: research

Determinants of extended door-to-needle time in acute ischemic stroke and its influence on in-hospital mortality: results of a nationwide Dutch clinical audit
Intravenous thrombolysis (IVT) plays a prominent role in the treatment of acute ischemic stroke (AIS). The sooner IVT is administered, the higher the odds of a good outcome. Therefore, registering the in-hospi...
Source: BMC Neurology - November 4, 2019 Category: Neurology Authors: Laurien S. Kuhrij, Perla J. Marang-van de Mheen, Renske M. van den Berg-Vos, Frank-Erik de Leeuw and Paul J. Nederkoorn Tags: Research article Source Type: research

Systematic review of subjective memory measures to inform assessing memory limitations after stroke and stroke-related aphasia.
Conclusions: This literature domain currently provides an unclear picture as to how memory limitations affect participation in stroke and stroke-related aphasia. IMPLICATIONS FOR REHABILITATION A broad range of subjective memory measures have been used to determine stroke survivors' perceptions of their everyday memory issues. Because of psychometric weaknesses such as inadequate reliability and cross-cultural validity among subjective memory measures, there remains a need to carefully review a given measure's properties to determine if it is appropriate for use with a given stroke survivor. Stroke survivors with aphasia h...
Source: Disability and Rehabilitation - September 27, 2019 Category: Rehabilitation Authors: Salis C, Murray L, Vonk JMJ Tags: Disabil Rehabil Source Type: research

Balloon Guide Catheter in Endovascular Treatment for Acute Ischemic Stroke: Results from the MR CLEAN Registry
ConclusionsIn clinical practice, use of a BGC was associated with higher reperfusion grade and early improvement of neurologic deficits, but had no positive effect on long-term functional outcome.
Source: Journal of Vascular and Interventional Radiology - September 19, 2019 Category: Radiology Source Type: research

Young Stroke Survivors Face Increased Long-Term Death Risk Young Stroke Survivors Face Increased Long-Term Death Risk
A national Dutch study in more than 15,000 adults younger than 50 who survived at least 30 days following a first stroke suggests higher mortality risks over time for these patients.Medscape Medical News
Source: Medscape Cardiology Headlines - May 29, 2019 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Association Between Stroke and Mortality in Young Adults
This cohort study uses Dutch registry and population data to estimate associations between incident stroke occurring between ages 18 and 49 years and short- and long-term all-cause mortality stratified by age, sex, and stroke subtype.
Source: JAMA - Journal of the American Medical Association - May 23, 2019 Category: General Medicine Source Type: research

Development and validity of an innovative test to assess guideline-consistent clinical reasoning by physical therapists in stroke rehabilitation.
CONCLUSION: The script concordance test has good construct validity. Greater self-reported guideline knowledge, successful completion of the post-bachelor Dutch Neurorehabilitation course, as well as systematic participation in professional development activities facilitate important factors that enhance specialization. The script concordance test is a valid feedback tool for physical therapists to support professional development in the domain of stroke rehabilitation. PMID: 31099400 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - May 19, 2019 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Anxiety in Patients With Acute Ischemic Stroke: Risk Factors and Effects on Functional Status
Conclusion: Depressive symptoms are the major correlates of PSA while more severe PSA is associated with poorer ADL and health-related QOL. Acute lesions involving CHWM may correlate with PSA in ischemic stroke patients with mild-to-moderate neurologic deficits, supporting a lesion-location hypothesis in PSA.IntroductionAnxiety is prevalent after stroke and occurs in about one-quarter of stroke survivors (1, 2). Poststroke anxiety (PSA) may have a negative impact on quality of life (QOL) of stroke survivors, affecting their rehabilitation (3). Furthermore, one prospective study found that severe anxiety symptoms were assoc...
Source: Frontiers in Psychiatry - April 17, 2019 Category: Psychiatry Source Type: research

Postreperfusion Blood Pressure Variability After Endovascular Thrombectomy Affects Outcomes in Acute Ischemic Stroke Patients With Poor Collateral Circulation
Conclusion: Postreperfusion BP management by decreasing BPV may have influence on improving clinical outcome in cases of poor collateral circulation among patients achieving successful recanalization after ERT. Introduction Endovascular recanalization therapy (ERT) has been adopted as standard stroke care in patients with acute ischemic stroke (1–6). Time to recanalization and degree of recanalization are the most important predictors of clinical outcomes after ERT (7). Before recanalization, an effort to reduce the time from symptom onset to reperfusion is critical for penumbral salvage. After recanalization...
Source: Frontiers in Neurology - April 12, 2019 Category: Neurology Source Type: research

Substitutions between dairy products and risk of stroke: Results from the EPIC-NL cohort.
In conclusion, whole-fat yoghurt as a substitution for low-fat yoghurt, cheese, butter, buttermilk or milk regardless of fat content was associated with a lower rate of ischemic stroke. PMID: 30868976 [PubMed - as supplied by publisher]
Source: The British Journal of Nutrition - March 14, 2019 Category: Nutrition Authors: Laursen ASD, Sluijs I, Boer JMA, Verschuren WMM, van der Schouw YT, Jakobsen MU Tags: Br J Nutr Source Type: research

Circle of Willis variations in migraine patients with ischemic stroke
ConclusionWe found no significant difference in the completeness of the CoW in acute stroke patients with migraine compared to those without.
Source: Brain and Behavior - February 16, 2019 Category: Neurology Authors: Arend M. Hamming, Marianne A. A. van Walderveen, Inge A. Mulder, Irene C. van der Schaaf, L. Jaap Kappelle, Birgitta K. Velthuis, Michel D. Ferrari, Gisela M. Terwindt, Marieke C. Visser, Wouter Schonewille, Ale Algra, Marieke J. H. Wermer, On Tags: ORIGINAL RESEARCH Source Type: research

Safety and Outcome of Endovascular Treatment for Minor Ischemic Stroke: Results From the Multicenter Clinical Registry of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands
Goal: Insufficient data is available about safety and efficacy of endovascular treatment (EVT) in patients with minor stroke symptoms because these patients were excluded from most randomized trials. We aimed to compare characteristics, functional outcome, and complications in patients with minor ischemic stroke National Institutes of Health Stroke Scale score ≤5 (NIHSS score ≤5) and moderate to severe ischemic stroke (NIHSS score ≥6) due to intracranial proximal artery occlusion of the anterior circulation who underwent EVT.
Source: Journal of Stroke and Cerebrovascular Diseases - December 6, 2018 Category: Neurology Authors: R.B. Goldhoorn, Maxim J.H.L. Mulder, Ivo G.H. Jansen, Wim H. van Zwam, Julie Staals, Aad van der Lugt, Diederik W.J. Dippel, Hester F. Lingsma, Jan Albert Vos, Jelis Boiten, Ido R. van den Wijngaard, Charles B.L.M. Majoie, Yvo B.W.E.M. Roos, Robert J. van Source Type: research

Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach ADULT BRAIN
CONCLUSIONS: Our study confirms that infarct location has an important impact on functional outcome of patients with stroke and should be considered in prediction models. After we adjusted for covariates, the left-hemispheric corticosubcortical fiber tracts seemed to be of higher functional importance compared with cortical lesions.
Source: American Journal of Neuroradiology - November 15, 2018 Category: Radiology Authors: Ernst, M., Boers, A. M. M., Forkert, N. D., Berkhemer, O. A., Roos, Y. B., Dippel, D. W. J., van der Lugt, A., van Oostenbrugge, R. J., van Zwam, W. H., Vettorazzi, E., Fiehler, J., Marquering, H. A., Majoie, C. B. L. M., Gellissen, S., on behalf of the M Tags: ADULT BRAIN Source Type: research

Psychometric properties of the Dutch SAQOL-39NL in a generic stroke population.
CONCLUSIONS: These data provide further evidence for the acceptability, internal consistency, and initial promising data on validity of the SAQOL-39NLg. Further research on structural validity and responsiveness to change is needed. PMID: 30380373 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - October 31, 2018 Category: Neurology Authors: Van Ewijk L, Ter Wal N, Okx G, Goossens P, Groeneveld I Tags: Top Stroke Rehabil Source Type: research

Why the uptake of eRehabilitation programs in stroke care is so difficult —a focus group study in the Netherlands
The uptake of eRehabilitation programs in stroke care is insufficient, despite the growing availability. The aim of this study was to explore which factors influence the uptake of eRehabilitation in stroke reh...
Source: Implementation Science - October 29, 2018 Category: Health Management Authors: B. Brouns, J. J. L. Meesters, M. M. Wentink, A. J. de Kloet, H. J. Arwert, T. P. M. Vliet Vlieland, L. W. Boyce and L. van Bodegom-Vos Tags: Research Source Type: research

Comparison of outcome in stroke patients admitted during working hours vs. off-hours; a single-center cohort study
Discussion and conclusionsThe overall outcome of stroke patients admitted to a large Dutch teaching hospital is not influenced by time of admission. When studying OH effects, adjustment for disease severity and poor prognostic findings on imaging is crucial before drawing conclusions on staffing and material.
Source: Journal of Neurology - October 5, 2018 Category: Neurology Source Type: research

Association of Low Urinary Sodium Excretion With Increased Risk of Stroke
We examined the association of urinary sodium excretion (UNaV) as an accurate estimate of intake with risk of stroke. We studied 7330 individuals free of cardiovascular events at baseline in the Prevention of Renal and Vascular End-stage Disease (PREVEND) study, a prospective, population-based cohort of Dutch men and women.
Source: Mayo Clinic Proceedings - September 20, 2018 Category: Internal Medicine Authors: Lyanne M. Kieneker, Michele F. Eisenga, Ron T. Gansevoort, Rudolf A. de Boer, Gerjan Navis, Robin P.F. Dullaart, Michel M. Joosten, Stephan J.L. Bakker Tags: Brief report Source Type: research

Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study
This study is registered with ClinicalTrials.gov, number NCT02513316.FindingsBetween Aug 4, 2011, and July 31, 2015, we recruited 1490 participants of whom follow-up data were available for 1447 (97%), over a mean period of 850 days (SD 373; 3366 patient-years). The symptomatic intracranial haemorrhage rate in patients with cerebral microbleeds was 9·8 per 1000 patient-years (95% CI 4·0–20·3) compared with 2·6 per 1000 patient-years (95% CI 1·1–5·4) in those without cerebral microbleeds (adjusted hazard ratio 3·67, 95% CI 1·27–10·60). Compared with the HAS-BLED score alone (C-index 0·41, 95% CI 0·29–0·5...
Source: The Lancet Neurology - July 10, 2018 Category: Neurology Source Type: research

Value of Quantitative Collateral Scoring on CT Angiography in Patients with Acute Ischemic Stroke ADULT BRAIN
CONCLUSIONS: Automated quantitative collateral scoring in patients with acute ischemic stroke is a reliable and user-independent measure of the collateral capacity on baseline CTA and has the potential to augment the triage of patients with acute stroke for endovascular therapy.
Source: American Journal of Neuroradiology - June 13, 2018 Category: Radiology Authors: Boers, A. M. M., Sales Barros, R., Jansen, I. G. H., Berkhemer, O. A., Beenen, L. F. M., Menon, B. K., Dippel, D. W. J., van der Lugt, A., van Zwam, W. H., Roos, Y. B. W. E. M., van Oostenbrugge, R. J., Slump, C. H., Majoie, C. B. L. M., Marquering, H. A. Tags: ADULT BRAIN Source Type: research

Innovative Magnetic Resonance Imaging Markers of Hereditary Cerebral Amyloid Angiopathy at 7 Tesla Brief Report
Background and Purpose—The aim of the present study is to explore whether using 7 Tesla magnetic resonance imaging, additional brain changes can be observed in hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D) patients as compared with the established magnetic resonance imaging features of sporadic cerebral amyloid angiopathy.Methods—The local institutional review board approved this prospective cohort study. In all cases, informed consent was obtained. This prospective parallel cohort study was conducted between 2012 and 2014. We performed T2*-weighted magnetic resonance imaging performed at 7 Tesla...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Emma A. Koemans, Ellis S. van Etten, Anna M. van Opstal, Gerda Labadie, Gisela M. Terwindt, Marieke J.H. Wermer, Andrew G. Webb, Edip M. Gurol, Steven M. Greenberg, Mark A. van Buchem, Jeroen van der Grond, Sanneke van Rooden Tags: Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Vascular Disease Brief Reports Source Type: research

Fish consumption and risk of stroke, coronary heart disease, and cardiovascular mortality in a Dutch population with low fish intake
Fish consumption and risk of stroke, coronary heart disease, and cardiovascular mortality in a Dutch population with low fish intake, Published online: 22 May 2018; doi:10.1038/s41430-018-0190-2Fish consumption and risk of stroke, coronary heart disease, and cardiovascular mortality in a Dutch population with low fish intake
Source: European Journal of Clinical Nutrition - May 22, 2018 Category: Nutrition Authors: L. M. Hengeveld J. Praagman J. W. J. Beulens I. A. Brouwer Y. T. van der Schouw I. Sluijs Source Type: research

Wake-Up Stroke versus Stroke with Known Onset Time: Clinical and Multimodality CT Imaging Characteristics
Conclusions: There are only minor differences between clinical and imaging characteristics of WUS patients and patients who arrive in the hospital within the time criteria for intravenous or endovascular treatment. Therefore, CT imaging may help to identify WUS patients who would benefit from treatment and rule out those patients with severe ischemia and poor collaterals.Cerebrovasc Dis 2018;45:236 –244
Source: Cerebrovascular Diseases - May 17, 2018 Category: Neurology Source Type: research

Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study
This study is registered with ClinicalTrials.gov, number NCT02513316. Findings Between Aug 4, 2011, and July 31, 2015, we recruited 1490 participants of whom follow-up data were available for 1447 (97%), over a mean period of 850 days (SD 373; 3366 patient-years). The symptomatic intracranial haemorrhage rate in patients with cerebral microbleeds was 9·8 per 1000 patient-years (95% CI 4·0–20·3) compared with 2·6 per 1000 patient-years (95% CI 1·1–5·4) in those without cerebral microbleeds (adjusted hazard ratio 3·67, 95% CI 1·27–10·60). Compared with the HAS-BLED score alone (C-index 0·41, 95% CI 0·29–0...
Source: The Lancet Neurology - May 16, 2018 Category: Neurology Source Type: research

Accuracy of CT Angiography for Differentiating Pseudo-Occlusion from True Occlusion or High-Grade Stenosis of the Extracranial ICA in Acute Ischemic Stroke: A Retrospective MR CLEAN Substudy INTERVENTIONAL
CONCLUSIONS: On CTA, extracranial ICA pseudo-occlusions can be differentiated from true carotid occlusions.
Source: American Journal of Neuroradiology - May 15, 2018 Category: Radiology Authors: Kappelhof, M., Marquering, H. A., Berkhemer, O. A., Borst, J., van der Lugt, A., van Zwam, W. H., Vos, J. A., Lycklama a Nijeholt, G., Majoie, C. B. L. M., Emmer, B. J., on behalf of the MR CLEAN Investigators Tags: INTERVENTIONAL Source Type: research

Haemorrhagic stroke related to the use of 4-fluoroamphetamine
We report on two patients who presented with headache and mild hypertension after 4-FA use. Patient A developed one-sided weakness and decreased consciousness after a few hours. A computed tomography scan showed a left-sided intracerebral haemorrhage. Because of life-threatening cerebral herniation, haematoma evacuation was performed. Postoperatively, she suffered from a right-sided hemiparalysis and severe aphasia, requiring clinical rehabilitation. Patient B had a subarachnoid haemorrhage without neurological deficits. In total, 939 4-FA-intoxicated patients were registered. These patients used 4-FA alone (44%) or in com...
Source: Journal of Neurology - May 8, 2018 Category: Neurology Source Type: research

Endovascular Stroke Therapy: Real-World Outcomes Improving Endovascular Stroke Therapy: Real-World Outcomes Improving
Endovascular therapy for patients with acute ischemic stroke in the real world is at least as effective and safe as in randomized clinical trials, a new registry study from the Netherlands suggests.Medscape Medical News
Source: Medscape Medical News Headlines - April 12, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Increased Risk of Pregnancy Complications After Stroke Clinical Sciences
Background and Purpose—The study goal was to investigate the prevalence of pregnancy complications and pregnancy loss in women before, during, and after young ischemic stroke/transient ischemic attack.Methods—In the FUTURE study (Follow-Up of Transient Ischemic Attack and Stroke Patients and Unelucidated Risk Factor Evaluation), a prospective young stroke study, we assessed the occurrence of pregnancy, miscarriages, and pregnancy complications in 223 women aged 18 to 50 years with a first-ever ischemic stroke/transient ischemic attack. Pregnancy complications (gestational hypertension, diabetes mellitus, preeclampsia, ...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Mayte E. van Alebeek, Myrthe de Vrijer, Renate M. Arntz, Noortje A.M.M. Maaijwee, Nathalie E. Synhaeve, Hennie Schoonderwaldt, Maureen J. van der Vlugt, Ewoud J. van Dijk, Roel de Heus, Loes C.A. Rutten-Jacobs, Frank-Erik de Leeuw Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Utility-Weighted Modified Rankin Scale as Primary Outcome in Stroke Trials Clinical Sciences
Conclusions—The UW-mRS as primary outcome does not capture individual variation in utility values and may reduce the statistical power of a randomized trial.
Source: Stroke - March 26, 2018 Category: Neurology Authors: Simone A. Dijkland, Daphne C. Voormolen, Esmee Venema, Bob Roozenbeek, Suzanne Polinder, Juanita A. Haagsma, Daan Nieboer, Vicky Chalos, Albert J. Yoo, Jennifer Schreuders, Aad van der Lugt, Charles B.L.M. Majoie, Yvo B.W.E.M. Roos, Wim H. van Zwam, Rober Tags: Quality and Outcomes, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Associations Between Collateral Status and Thrombus Characteristics and Their Impact in Anterior Circulation Stroke Clinical Sciences
Conclusions—Patients with lower thrombus burden and higher thrombus perviousness scores had higher collateral score. The positive effect of thrombus perviousness on clinical outcome was only present in patients with moderate and high collateral scores.Clinical Trial Registration—URL: http://www.trialregister.nl. Unique identifier: NTR1804 and URL: http://www.controlled-trials.com Unique identifier: ISRCTN10888758.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Heitor C. Alves, Kilian M. Treurniet, Bruna G. Dutra, Ivo G. H. Jansen, Anna M.M. Boers, Emilie M.M. Santos, Olvert A. Berkhemer, Diederik W.J. Dippel, Aad van der Lugt, Wim H. van Zwam, Robert J. van Oostenbrugge, Hester F. Lingsma, Yvo B.W.E.M. Roos, Al Tags: Computerized Tomography (CT), Ischemic Stroke Original Contributions Source Type: research

Circulating Endothelial Markers in Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations Clinical Sciences
Background and Purpose—Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a monogenic small vessel disease, caused by C-terminal truncating TREX1 mutations, that can be considered a model for stroke and vascular dementia. The pathophysiology of RVCL-S is largely unknown, but systemic endothelial involvement has been suggested, leading to pathology in the brain and other highly vascularized organs. Here, we investigated circulating endothelial markers to confirm endothelial involvement and identify biomarkers for disease activity.Methods—We measured circulating levels of von W...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Nadine Pelzer, Roel Bijkerk, Marlies E.J. Reinders, Anton Jan van Zonneveld, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Jeroen Eikenboom, Gisela M. Terwindt Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Genetics, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

The Longer-term Unmet Needs after Stroke Questionnaire: Cross-Cultural Adaptation, Reliability, and Concurrent Validity in a Dutch Population
Unmet needs are common after stroke. We aimed to translate the 22-item Longer-term Unmet Needs after Stroke (LUNS) Questionnaire and validate it in a Dutch stroke population.
Source: Journal of Stroke and Cerebrovascular Diseases - September 26, 2017 Category: Neurology Authors: Iris Groeneveld, Henk Arwert, Paulien Goossens, Thea Vliet Vlieland Source Type: research

Association of Computed Tomography Ischemic Lesion Location With Functional Outcome in Acute Large Vessel Occlusion Ischemic Stroke Clinical Sciences
Conclusions—The association between follow-up noncontrast computed tomography ILV and outcome as assessed with mRS 3 months after stroke is strengthened by accounting for the mRS relevance of the affected brain areas. Future prediction models should account for the ILV in brain areas of high mRS relevance.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Marielle Ernst, Anna M.M. Boers, Annette Aigner, Olvert A. Berkhemer, Albert J. Yoo, Yvo B. Roos, Diederik W.J. Dippel, Aad van der Lugt, Robert J. van Oostenbrugge, Wim H. van Zwam, Jens Fiehler, Henk A. Marquering, Charles B.L.M. Majoie Tags: Ischemic Stroke Original Contributions Source Type: research

Prediction of Clinical Outcome After Acute Ischemic Stroke Brief Report
Conclusions—Follow-up imaging after 3 days improves outcome prediction compared with prediction based on baseline variables alone. CTA recanalization and CTP reperfusion do not outperform noncontrast CT at this time point.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00880113.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Jan W. Dankbaar, Alexander D. Horsch, Andor F. van den Hoven, L. Jaap Kappelle, Irene C. van der Schaaf, Tom van Seeters, Birgitta K. Velthuis Tags: Computerized Tomography (CT), Prognosis, Ischemic Stroke Brief Reports Source Type: research

Letter by Freeman Regarding Article, “Baseline Blood Pressure Effect on the Benefit and Safety of Intra-Arterial Treatment in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands)” Letter to the Editor
Source: Stroke - July 24, 2017 Category: Neurology Authors: William D. Freeman Tags: Treatment, Ischemic Stroke Letters to the Editor Source Type: research

Response by Mulder et al to Letter Regarding Article, “Baseline Blood Pressure Effect on the Benefit and Safety of Intra-Arterial Treatment in MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands)” Letter to the Editor
Source: Stroke - July 24, 2017 Category: Neurology Authors: Maxim J.H.L. Mulder, Hester F. Lingsma, Diederik W.J. Dippel Tags: High Blood Pressure, Revascularization, Cerebrovascular Disease/Stroke, Ischemic Stroke Letters to the Editor Source Type: research

Ethnic Disparities in Ischemic Stroke, Intracerebral Hemorrhage, and Subarachnoid Hemorrhage Incidence in The Netherlands Clinical Sciences
Conclusions— Our findings suggest that Surinamese have an increased risk, whereas Moroccans have a reduced risk for all the various stroke subtypes. Among other ethnic minorities, the risk seems to depend on the stroke subtype and sex. These findings underscore the need to identify the root causes of these ethnic differences to assist primary and secondary prevention efforts.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Agyemang, C., van Oeffelen, A. A. M., Norredam, M., Kappelle, L. J., Klijn, C. J. M., Bots, M. L., Stronks, K., Vaartjes, I. Tags: Cerebrovascular disease/stroke Clinical Sciences Source Type: research

The Dutch String‐of‐Pearls Stroke Study: Protocol of a large prospective multicenter genetic cohort study
BackgroundIn the last couple of years, genome‐wide association studies have largely altered the scope in genetic research in diseases in which both environmental and genetic risk factors contribute to the disease. To date, the genetic risk loci identified in stroke have lagged behind those in other complex diseases, possibly because of the heterogeneity of stroke phenotypes. Sufficiently large cohorts with well‐defined and detailed phenotyping of stroke patients are needed to identify additional genetic risk loci. DesignThe String‐of‐Pearls Institute is a unique partnership between all eight University Medical Cent...
Source: International Journal of Stroke - August 1, 2014 Category: Neurology Authors: Paul J. Nederkoorn, Ewoud J. Dijk, Peter J. Koudstaal, Gert‐Jan Luijckx, Robert J. Oostenbrugge, Marieke C. Visser, Marieke J. H. Wermer, Ynte M. Ruigrok, Ale Algra, L. Jaap Kappelle, Tags: Protocols Source Type: research