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Total 1212 results found since Jan 2013.

Association Between Early Cognitive Impairment and Midterm Functional Outcomes Among Chinese Acute Ischemic Stroke Patients: A Longitudinal Study
Conclusions: This study showed that early cognitive impairment was associated with higher risk of disability and poor activity of daily living (ADL) among Chinese AIS patients. Further studies are needed to examine the linkage between multi-domain cognitive impairment and long-term disability and ADL among stroke survivors by using neuropsychological test batteries.
Source: Frontiers in Neurology - February 26, 2020 Category: Neurology Source Type: research

A NAC nomogram to predict the probability of three-month unfavorable outcome in Chinese acute ischemic stroke patients treated with mechanical thrombectomy
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Source: International Journal of Neuroscience - February 26, 2020 Category: Neuroscience Authors: Xiang Li Yang Zou Jue Hu Xue Mei Li Chao Ping Huang Ya Jie Shan Linda Nyame Zheng Zhao Chao Sun Mako Ibrahim Xi Ding Pan Chao Liu Zhi Hong Zhao Jian Jun Zou Source Type: research

The G protein coupled receptor CCR5 in cancer.
Abstract The G coupled protein receptor CC chemokine receptor type 5 (CCR5) has the unusual characteristic in humans of being a developmentally non-essential gene that participates in several pathological processes including infection with HIV (Dean et al., 1996; Gupta et al., 2019; Samson et al., 1996), progression of stroke (Joy et al., 2019), osteoporosis (Xie et al., 2019) and the metastasis of cancer (Jiao et al., 2018; Velasco-Velazquez et al., 2012, 2014) (Reviewed in: Jiao, Nawab, et al., 2019; Jiao, Wang, & Pestell, 2019). The importance of CCR5 in HIV led to recent genetic engineering of humans to re...
Source: Advances in Cancer Research - February 25, 2020 Category: Cancer & Oncology Authors: Upadhyaya C, Jiao X, Ashton A, Patel K, Kossenkov AV, Pestell RG Tags: Adv Cancer Res Source Type: research

Treatment of basilar artery stenosis with an Apollo balloon-expandable stent: a single-centre experience with 61 consecutive cases
In this study, the Apollo BES appeared to be feasible for BA stenosis. Our experience may be valuable for reducing the number of complications. However, further study is needed.
Source: Acta Neurologica Belgica - February 25, 2020 Category: Neurology Source Type: research

Effect of the baseline pulse wave velocity on short term and long term blood pressure control in primary hypertension
Arterial stiffness may affect antihypertensive response to antihypertensive treatment. However, sufficient clinical evidence is lacking. This longitudinal study aimed to evaluate the effect of baseline arterial stiffness measured by the brachial-ankle pulse wave velocity (baPWV) on response to short-term and long-term enalapril-based treatment in 3310 hypertensive adults from the China Stroke Primary Prevention Trial (CSPPT).
Source: International Journal of Cardiology - February 24, 2020 Category: Cardiology Authors: Y. Fan, W. Gao, J. Li, F. Fan, X. Qin, L. Liu, X. Cheng, X. Xu, X. Wang, B. Wang, Y. Huo Source Type: research

Association of short-term exposure to sulfur dioxide and hospitalization for ischemic and hemorrhagic stroke in Guangzhou, China
In developing countries, ambient sulfur dioxide (SO2) is a serious air pollutant concern, but there is no enough and consistent epidemiological evidence about its health effects on stroke hospitalization.
Source: BMC Public Health - February 21, 2020 Category: Consumer Health News Authors: Shuqun Shen, Xing Li, Chao Yuan, Qin Huang, Dongyang Liu, Shuoyi Ma, Jialiang Hui, Ruiyu Liu, Tongwei Wu and Qing Chen Tags: Research article Source Type: research

Trends of antihypertensive agents in patients with hypertension and coronary artery disease in a tertiary hospital of China
Conclusion The compliance to guidelines is overall well for patients with hypertension and coronary artery disease, but improvements is needed for patients with type 2 diabetes. Multi-center studies with large-scale data are required to further assess the usage of antihypertensive agents in patients.
Source: International Journal of Clinical Pharmacy - February 20, 2020 Category: Drugs & Pharmacology Source Type: research

Neuroprotective Effects of Qingnao Dripping Pills Against Cerebral Ischemia via Inhibiting NLRP3 Inflammasome Signaling Pathway: In Vivo and In Vitro
In conclusion, QNDP had neuroprotective effects against cerebral ischemia via inhibiting NLRP3 inflammasome signaling pathway, and was a potential candidate for the future treatment of ischemic stroke.
Source: Frontiers in Pharmacology - February 20, 2020 Category: Drugs & Pharmacology Source Type: research

Late Clinical Outcomes of LAmbre versus Amplatzer Occluders for Left Atrial Appendage Closure
ConclusionIn the presented report, in patients with nonvalvular atrial fibrillation the LAmbre offered similar long ‐term efficacy and safety in comparison to Amplatzer devices.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - February 19, 2020 Category: Cardiology Authors: Steffen Schnupp, Xiao ‐xia Liu, Eric Buffle, Steffen Gloekler, Yamen Mohrez, Mohammad Cheikh‐Ibrahim, Wasim Allakkis, Johannes Brachmann, Jai‐Wun Park, Caroline Kleinecke Tags: ORIGINAL ARTICLE Source Type: research

Design and synthesis of the ring-opened derivative of 3-n-butylphthalide-ferulic acid-glucose trihybrids as potential anti-ischemic agents
Publication date: Available online 18 February 2020Source: Chinese Chemical LettersAuthor(s): Jianbing Wu, Wei Yin, Yinqiu Zhang, Hui Ye, Yunman Li, Jide Tian, Zhangjian Huang, Yihua ZhangABSTRACTTo improve aqueous solubility and anti-ischemic activity of 3-n-butylphthalide (NBP), we designed and synthesized the ring-opened derivative of NBP-ferulic acid-glucose trihybrids (S1-S8). These hybrids inhibited adenosine diphosphate (ADP)- or arachidonic acid (AA)-induced platelet aggregation, among them, S2 was 30-fold more water-soluble, and over 10-fold more potent in inhibition of platelet aggregation, as well as reduced ROS...
Source: Chinese Chemical Letters - February 19, 2020 Category: Chemistry Source Type: research

Transcranial Doppler sonography for detecting stenosis or occlusion of intracranial arteries in people with acute ischaemic stroke.
CONCLUSIONS: This review provides evidence that TCD or TCCD, administered by professionals with adequate experience and skills, can provide useful diagnostic information for detecting stenosis or occlusion of intracranial vessels in people with acute ischaemic stroke, or guide the request for more invasive vascular neuroimaging, especially where CT or MR-based vascular imaging are not immediately available. More studies are needed to confirm or refute the results of this review in a larger sample of stroke patients, to verify the role of contrast medium and to evaluate the clinical advantage of the use of ultrasound. ...
Source: Cochrane Database of Systematic Reviews - February 19, 2020 Category: General Medicine Authors: Mattioni A, Cenciarelli S, Eusebi P, Brazzelli M, Mazzoli T, Del Sette M, Gandolfo C, Marinoni M, Finocchi C, Saia V, Ricci S Tags: Cochrane Database Syst Rev Source Type: research

Calculus bovis: A review on traditional usages, origin, chemistry, pharmacological activities and toxicology
ConclusionCBS contains analogous types and amounts of constituents and exerts approximate therapeutic effects compared to the NCB, thus the CBS might be used as the sustainable substitute of NCB. Furthermore, configuration and concentration of bile acids and bilirubin in C. bovis are responsible for the difference of pharmacological effects in four types C. bovis. The next study should focus on the structure-function relationship of bile acids and bilirubin in C. bovis by pharmacokinetics.Graphical abstract
Source: Journal of Ethnopharmacology - February 16, 2020 Category: Drugs & Pharmacology Source Type: research

Anticoagulation for atrial fibrillation patients with the CHA2DS2-VASc score =1 (beyond sex).
Authors: Xie X, Li T Abstract Objective: We investigated the risk of ischaemic stroke in patients with 1 another stroke risk factor (i.e. CHA2DS2-VASc score =1 [males] or 2 [females]) and the impact of different component risk factors.Methods: Database were collected from two hospitals in the city of Hohhot in china. Among 3148 Nonvalvular AF patients not on antiplatelet or anticoagulant therapy, we evaluated males with a CHA2DS2-VASc score of 1 and females with a CHA2DS2-VASc score of 2. The clinical endpoint was the occurrence of ischaemic stroke.Results: Among 546 AF male patients with a CHA2DS2-VASc score of ...
Source: Acta Cardiologica - February 16, 2020 Category: Cardiology Tags: Acta Cardiol Source Type: research

The effect of intravenous ginkgolide on clinical improvement of patients with acute ischemic stroke.
Conclusion: Intravenous ginkgolide may improve the outcome of acute ischemic stroke. Differences in effect between pre-marketing and post-marketing studies may be associated with gender, time of onset to enrollment and severity of stroke. PMID: 32048567 [PubMed - as supplied by publisher]
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The Association Among Medication Beliefs, Perception of Illness and Medication Adherence in Ischemic Stroke Patients: A Cross-Sectional Study in China
Source: Patient Preference and Adherence - February 12, 2020 Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research

Establishment of a Risk Prediction Model for Mild Cognitive Impairment Among Elderly Chinese
ConclusionsThis model performs an effective prediction that may be applied to the primary prevention for patients with MCI, helping to reduce the risk of MCI.
Source: The Journal of Nutrition, Health and Aging - February 12, 2020 Category: Nutrition Source Type: research

Spirituality and resilience among family  caregivers of survivors of stroke: A scoping review.
CONCLUSIONS: Spirituality and resilience following stroke are essential factors in caregiver adjustment following stroke. Further research with a focus on causality and the link between spirituality, resilience and adjustment in this population is needed. PMID: 32039873 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - February 11, 2020 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Sanhua Decoction, a Classic Herbal Prescription, Exerts Neuroprotection Through Regulating Phosphorylated Tau Level and Promoting Adult Endogenous Neurogenesis After Cerebral Ischemia/Reperfusion Injury
Conclusions: SHD exerts neuroprotection probably by regulating p-tau level and promoting the proliferation, migration, and differentiation of endogenous neural stem cells, accompanying with neurobehavioral recovery.
Source: Frontiers in Physiology - February 11, 2020 Category: Physiology Source Type: research

Renshen Shouwu extract enhances neurogenesis and angiogenesis via inhibition of TLR4/NF-κB/NLRP3 signaling pathway following ischemic stroke in rats
ConclusionsRSSW enhances neurogenesis and angiogenesis via inhibition of TLR4/NF-κB/NLRP3 inflammatory signaling pathway following ischemic stroke in rats. Hence, RSSW may be a promising Chinese Medicine for the treatment of ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - February 10, 2020 Category: Drugs & Pharmacology Source Type: research

Low Hemoglobin Levels at Admission Are Independently Associated with Cognitive Impairment after Ischemic Stroke: a Multicenter, Population-Based Study
AbstractData on the association between hemoglobin (Hb) levels and poststroke cognitive function are limited. We investigated the relationship between Hb concentrations at admission and poststroke cognitive function using a multicenter database. In total, 1081 patients were recruited from seven Chinese medical centers within 6  months after experiencing ischemic stroke. Cognitive status was evaluated with a series of brief neuropsychological tests. A subgroup of 439 patients from a single center was followed up for 4–6 years and was eventually reassessed with a cognitive test. The association between Hb and cognitive i...
Source: Translational Stroke Research - February 10, 2020 Category: Neurology Source Type: research

Association of serum retinoic acid with depression in patients with acute ischemic stroke.
This study was aimed to evaluate the relationship between RA levels in serum and post-stroke depression (PSD). A single-center (Chengdu, China) prospective cohort study was conducted on patients with acute ischemic stroke. The RA serum level was measured at admission. The PSD was assessed in the 3-month follow-up. The RA-PSD relationship was evaluated with conditional logistic regression. In total, 239 ischemic stroke cases and 100 healthy controls were included. The median RA serum level in patients with ischemic stroke was 2.45 ng/ml (interquartile range [IQR], 0.72-4.33), lower(P<0.001) than 3.89 ng/ml of those in co...
Source: Aging - February 10, 2020 Category: Biomedical Science Authors: Yang CD, Cheng ML, Liu W, Zeng DH Tags: Aging (Albany NY) Source Type: research

A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action for the Rougui-Fuzi Herb Pair in the Treatment of Cardiocerebral Vascular Diseases.
This study was designed to apply a system pharmacology approach to reveal the molecular mechanisms of the rougui-fuzi anti-CCVDs. The 163 candidate compounds were retrieved from Traditional Chinese Medicine System Pharmacology Database and Analysis Platform (TCMSP). And 84 potential active compounds and the corresponding 42 targets were obtained from systematic model. The underlying mechanisms of the therapeutic effect for rougui-fuzi were investigated with gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Then, component-target-disease (C-T-D) and target...
Source: Evidence-based Complementary and Alternative Medicine - February 7, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Impact of prehypertension on the risk of major adverse cardiovascular events in a Chinese rural cohort.
CONCLUSION: Prehypertensive individuals had a greater risk of incident MACE, CVD mortality and stroke, implying that improvements in BP monitoring and early intervention in individuals with prehypertension in rural China are urgently needed. PMID: 32030405 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - February 7, 2020 Category: Cardiology Authors: Duan WL, Wu JK, Liu ST, Jiao YD, Zheng LQ, Sun YX, Sun ZQ Tags: Am J Hypertens Source Type: research

Contrast-enhanced ultrasound perfusion patterns and serum lipid signatures of vulnerable carotid artery plaque in predicting stroke: A cohort study of carotid stenosis in Chinese patients.
CONCLUSION: A high level of CEUS perfusion and increased serum FFA levels are indicative of vulnerable carotid plaques, which may be useful for the prediction of stroke in patients with carotid artery disease. PMID: 32039838 [PubMed - as supplied by publisher]
Source: Clinical Hemorheology and Microcirculation - February 7, 2020 Category: Hematology Authors: Huang Y, Liu Q, Xu J, Zhu W, Jiang J, Tang L, Chen M Tags: Clin Hemorheol Microcirc Source Type: research

Predicting the Pharmacokinetic Characteristics of Edaravone Intravenous Injection and Sublingual Tablet Through Modeling and Simulation.
This study aimed to establish a pharmacokinetic (PK) model to fit the PK profile of edaravone after a single sublingual (SL) dose of a novel edaravone tablet and single IV infusion of injectable edaravone in healthy Chinese volunteers participating in a bioavailability study. The model is expected to be useful for predicting the concentration-time profiles of edaravone following different dosing regimens in a healthy Chinese population. The purposes were to identify an optimal dose and dosing regimen for the new SL formulation and to support future clinical exploration of this tablet product in its approved indications and...
Source: Clinical Therapeutics - February 6, 2020 Category: Drugs & Pharmacology Authors: Chen X, Sun Z, Wang J, Liang W, Zhao X, Wang Y, Wang Y Tags: Clin Ther Source Type: research

Effects of an integrated transitional care program for stroke survivors living in a rural community: a randomized controlled trial.
CONCLUSION: The transitional care program has been proven to be feasible and improve health-related outcomes. PMID: 32026701 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - February 6, 2020 Category: Rehabilitation Authors: Deng A, Yang S, Xiong R Tags: Clin Rehabil Source Type: research

Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization
In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject.Graphical abstract
Source: Biomedicine and Pharmacotherapy - February 4, 2020 Category: Drugs & Pharmacology Source Type: research

Cross-Cultural Adaptation and Validation of the Chinese Version of the Work-Ability Support Scale (WSS) in Young and Middle-Aged Stroke Survivors
Conclusion The WSS is a reliable and valid tool for measuring young and middle-aged Chinese stroke survivors ’ work ability and support needs during their return to work.
Source: Journal of Occupational Rehabilitation - February 4, 2020 Category: Rehabilitation Source Type: research

Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization.
In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject. PMID: 32028240 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 3, 2020 Category: Drugs & Pharmacology Authors: Wang Y, Xiao G, He S, Liu X, Zhu L, Yang X, Zhang Y, Orgah J, Feng Y, Wang X, Zhang B, Zhu Y Tags: Biomed Pharmacother Source Type: research

Risk factors of haemorrhagic transformation for acute ischaemic stroke in Chinese patients receiving intravenous thrombolysis: A meta-analysis
Conclusion: The systematic review showed that male, age, diabetes, NIHSS, OTT, atrial fibrillation, post stroke, infarct size, and ischemic signs of CT were significantly correlated with hemorrhagic transformation (HT). PROSPERO Registration number: CRD42019127499.
Source: Medicine - February 1, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Potential herb-drug interactions in community-dwelling older adults in China: the Shanghai Aging Study.
CONCLUSION: 43.3% of community-dwelling older adults who used any combination of drug-herb or herb-herb was exposed to pHDIs, and more than half of pHDIs were related to herbs with anticoagulant/antiplatelet properties. Awareness of the patterns and high-risk groups of these pHDIs may contribute to increased patient safety. PMID: 32008224 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - February 1, 2020 Category: Geriatrics Authors: Chi D, Ding D, Zhao Q, Liang X, Wu W, Luo J, Wang B Tags: Aging Clin Exp Res Source Type: research

Renshen Shouwu extract enhances neurogenesis and angiogenesis via inhibition of TLR4/NF¬κB/NLRP3 signaling pathway following ischemic stroke in rats
ConclusionsRSSW enhances neurogenesis and angiogenesis via inhibition of TLR4/NF¬κB/NLRP3 inflammatory signaling pathway following ischemic stroke in rats. Hence, RSSW may be a promising Chinese Medicine for the treatment of ischemic stroke.Graphical abstract
Source: Journal of Ethnopharmacology - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Persistence, effectiveness and safety of dabigatran in “real-world” Chinese patients with nonvalvular atrial fibrillation
In conclusion, it is of importance for Chinese clinicians to know about these information because dabigatran is a relatively new drug in China. Compared with other reported data, patients of this study have (1) lower dabigatran persistence and lower incident rates of all-cause death, systemic embolism, minor bleeding events and gastrointestinal hemorrhage and (2) higher incident rates of ischemic stroke and intracranial hemorrhage.
Source: Heart and Vessels - January 31, 2020 Category: Cardiology Source Type: research

Association Between the Polymorphism of Aldehyde Dehydrogenase 2 Gene and Cerebral Infarction in a Hakka Population in Southern China.
In conclusion, these findings support an association of ALDH2 gene polymorphisms with ischemic stroke in a Chinese Hakka population. In particular, homozygote ALDH2*2/*2 may be a risk factor for cerebral infarction in males, but contribute to reduced risk for cerebral infarction in females. PMID: 32006143 [PubMed - as supplied by publisher]
Source: Biochemical Genetics - January 31, 2020 Category: Genetics & Stem Cells Authors: Hou JY, Zhong ZX, Deng QT, Liu SD, Lin LF Tags: Biochem Genet Source Type: research

Application Values of Six Scoring Systems in the Prognosis of Stroke Patients
Conclusion: APACHE II, APACHE III, CSS, NIHSS, ADL, and GCS scores have good predictive values in the prognosis of stroke patients. APACHE II is superior among the other five scales.
Source: Frontiers in Neurology - January 30, 2020 Category: Neurology Source Type: research

Rate and Determinants of Recurrence at 1 Year and 5 Years After Stroke in a Low-Income Population in Rural China
Recurrent stroke is becoming an increasingly important public health issue owing to the increased risk of disability and death. However, population-based studies investigating the rate of recurrent stroke in China are rare. We explored the rate and determinants of recurrent stroke within 1 and 5 years after the initial stroke in a rural population in China. Data for stroke events were obtained from the Tianjin Brain Study, conducted between 1992 and 2016. The age-standardized rates of recurrent stroke within the first year and the first 5 years after the initial stroke were calculated for this period. Determinants of recur...
Source: Frontiers in Neurology - January 23, 2020 Category: Neurology Source Type: research

Two Novel SNPs in the PLCL2 Gene Associated with Large Artery Atherosclerotic Stroke Identified by Fine-Mapping
AbstractA genome-wide association study (GWAS) reported that the single nucleotide polymorphism (SNP) rs4618210 in thePLCL2 gene is related to myocardial infarction (MI) in the Japanese population, but no study has examined the correlation ofPLCL2 with ischemic stroke (IS). The present study was designed to investigate whether the genetic variation inPLCL2 is associated with large artery atherosclerotic (LAA) stroke in a Han Chinese population. Tagging SNPs (tSNPs) of thePLCL2 gene were determined by a fine-mapping strategy and were genotyped by improved multiplex ligation detection reaction (iMLDR) technology in 669 LAA s...
Source: Journal of Molecular Neuroscience - January 22, 2020 Category: Neuroscience Source Type: research

A comprehensive contribution of genetic variations of the insulin-like growth factor 1 signalling pathway to stroke susceptibility
The insulin-like growth factor (IGF)-1 signalling pathway has been implicated in the pathogenesis of atherosclerosis; however, the mechanism underlying its role in stroke remains unexplained. Herein, we aimed to explore the effects of genetic polymorphisms in the IGF1 pathway on stroke in the Chinese Han population.
Source: Atherosclerosis - January 18, 2020 Category: Cardiology Authors: Yingshui Yao, Hui Zhu, Lijun Zhu, Zhengmei Fang, Yao Fan, Chunlan Liu, Yuanrui Tian, Yan Chen, Wuzhuang Tang, Zhanyun Ren, Jie Li, Song Yang, Yanchun Chen, Xianghai Zhao, Chong Shen Source Type: research

Homocysteine Level Predicts Response to Dual Antiplatelet in Women With Minor Stroke or Transient Ischemic Attack: Subanalysis of the CHANCE Trial.
CONCLUSIONS: Homocysteine could be a potential biomarker to discriminate the effects of dual and single antiplatelet therapy in female patients with minor ischemic stroke or high-risk transient ischemic attack. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00979589. PMID: 31941381 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 16, 2020 Category: Cardiology Authors: Li J, Wang Y, Li H, Zuo Z, Lin J, Wang A, Zhao X, Liu L, Wang Y, CHANCE Investigators* Tags: Arterioscler Thromb Vasc Biol Source Type: research

Insulin resistance is an independent risk factor for early neurological deterioration in non-diabetic patients with acute ischemic stroke
ConclusionThis study strongly suggests that IR is probably an independent risk factor for END in non-diabetic patients with acute ischemic stroke.
Source: Neurological Sciences - January 14, 2020 Category: Neurology Source Type: research

A Comparative Study of Two Tube Feeding Methods in Patients with Dysphagia After Stroke: A Randomized Controlled Trial
Background: Dysphagia is a common symptom seen in stroke patients, it not only affects patients' nutrition supply, but also causes aspiration pneumonia. To solve the problem of nutritional support for patients with dysphagia after stroke, nasogastric tubes are routinely indwelling to provide nutrition in China. However, this feeding method sometimes causes food reflux, aspiration, pneumonia, and often affects the patients ’ comfort and self-image acceptance. Aim: The aim of this study was to determine whether a new feeding method called intermittent oroesophageal (IOE) tube feeding compared with continuous nasogastric tu...
Source: Journal of Stroke and Cerebrovascular Diseases - January 13, 2020 Category: Neurology Authors: Wei Juan, Huang Zhen, Feng Yan-Ying, Yang Hui-Xian, Zhong Tao, Guo Pei-Fen, Huo Jian-Tian Source Type: research

Human urinary kallindinogenase therapy for acute ischemic stroke according to Chinese ischemic stroke subclassification: Clinical efficacy and risk factors
ConclusionsHuman urinary kallindinogenase is an effective therapeutic approach for treatment of patients with AIS, especially in patients with LAA subtype. The absence of HUK, elevated homocysteine, and cardiogenic stroke subtype were risk factor for clinical efficacy of HUK.
Source: Brain and Behavior - January 13, 2020 Category: Neurology Authors: Si ‐Qia Chen, Dong‐Yang Mao, Dun‐Can Wei, Wen‐Zhen He Tags: ORIGINAL RESEARCH Source Type: research

Expert consensus on the diagnosis and treatment of heat stroke in China
AbstractHeat stroke (HS) is a fatal disease caused by thermal damage in the body, and it has a very high mortality rate. In 2015, the People ’s Liberation Army Professional Committee of Critical Care Medicine published the first expert consensus on HS in China,Expert consensus on standardized diagnosis and treatment for heat stroke. With an increased understanding of HS and new issues that emerged during the HS treatment in China in recent years, the 2015 consensus no longer meet the requirements for HS prevention and treatment. It is necessary to update the consensus to include the latest research evidence and establish...
Source: Military Medical Research - January 13, 2020 Category: International Medicine & Public Health Source Type: research

Characteristics of Cerebral Stroke in the Tibet Autonomous Region of China.
This article focuses on epidemiology features, risk factors, and pathogenesis of stroke in the TAR in an effort to generate a better understanding of the characteristics of stroke in this region. The special plateau-related factors such as its high elevation, limited oxygen, the high incidence of hypertension, smoking, and the unique dietary habits of the region are correlated with the high incidence of stroke. In addition to these factors, the pathogenesis of stroke in this high-altitude area is also unique. However, there is no established explanation for the unique occurrence and high incidence of stroke in the TAR. Our...
Source: Medical Science Monitor - January 11, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Cost-effectiveness of dabigatran compared with rivaroxaban for prevention of stroke and systemic embolism in patients with atrial fibrillation in China.
Abstract PURPOSE: In China, dabigatran and rivaroxaban are the only approved non-vitamin K antagonist oral anticoagulants for the treatment of atrial fibrillation (AF). The goal of this article was to assess the cost-effectiveness of dabigatran versus rivaroxaban for the prevention of stroke and systemic embolism in Chinese patients with AF from the perspective of the Chinese health care system. METHODS: A Markov model was constructed to estimate the cost-effectiveness of dabigatran versus rivaroxaban. Clinical events were modeled for a lifetime horizon, based on clinical efficacy data from indirect treatment...
Source: Clinical Therapeutics - January 10, 2020 Category: Drugs & Pharmacology Authors: Dong SJ, Wu B, Zhai SD, Zhang YJ, Chu YB, Gupta P, Li YH Tags: Clin Ther Source Type: research

Prediction of Prolonged Length of Stay for Stroke Patients on Admission for Inpatient Rehabilitation Based on the International Classification of Functioning, Disability, and Health (ICF) Generic Set: A Study from 50 Centers in China.
CONCLUSIONS The risk prediction model for prolonged LOS in stroke patients in 50 rehabilitation centers in China, based on the ICF Generic Set, showed that the scores for the type of medical insurance and the performance of daily activities (ICF, d230) on admission were independent predictors of prolonged LOS. This prediction model may allow stakeholders to estimate the risk of prolonged LOS on admission quantitatively, facilitate the financial planning, treatment regimens during hospitalization, referral after discharge, and reimbursement. PMID: 31901931 [PubMed - in process]
Source: Medical Science Monitor - January 8, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS)
Publication date: Available online 7 January 2020Source: American Heart JournalAuthor(s): Liping Huang, Maoyi Tian, Jie Yu, Qiang Li, Yishu Liu, Xuejun Yin, Jason HY Wu, Matti Marklund, Yangfeng Wu, Nicole Li, Paul Elliot, Lijing L. Yan, Darwin R. Labarthe, Zhixin Hao, Jingpu Shi, Xiangxian Feng, Jianxin Zhang, Yuhong Zhang, Ruijuan Zhang, Bo ZhouAbstractThe Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural Chin...
Source: American Heart Journal - January 7, 2020 Category: Cardiology Source Type: research

Prevalence of stroke and stroke related risk factors: a population based cross sectional survey in southwestern China
Stroke and its risk factors epidemiological survey can help identify individuals at higher risk and therefore promote stroke prevention strategies. The aim of this study was to estimate the current prevalence ...
Source: BMC Neurology - January 7, 2020 Category: Neurology Authors: Xingyang Yi, Hua Luo, Ju Zhou, Ming Yu, Xiaorong Chen, Lili Tan, Wei Wei and Jie Li Tags: Research article Source Type: research

Ischemic stroke in anti-phospholipase A2 receptor antibody-positive primary membranous nephropathy: clinical and neuroimaging characteristics.
PMID: 31929373 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - January 6, 2020 Category: General Medicine Authors: Zhang J, Shu JL, You Q, Zhang W, Huang YN Tags: Chin Med J (Engl) Source Type: research

Association between short-term exposure to air pollution and ischemic stroke onset: a time-stratified case-crossover analysis using a distributed lag nonlinear model in Shenzhen, China
Stroke, especially ischemic stroke (IS), has been a severe public health problem around the world. However, the association between air pollution and ischemic stroke remains ambiguous.
Source: Environmental Health - January 2, 2020 Category: Environmental Health Authors: Zhinghui Wang, Ji Peng, Peiyi Liu, Yanran Duan, Suli Huang, Ying Wen, Yi Liao, Hongyan Li, Siyu Yan, Jinquan Cheng and Ping Yin Tags: Research Source Type: research