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Condition: Amyloidosis

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Total 63 results found since Jan 2013.

The ventilatory component of the muscle metaboreflex is overstimulated in transthyretin cardiac amyloidosis patients with poor aerobic capacity
Conclusion: Consistent with the “muscle hypothesis” in heart failure, it is proposed that deterioration of skeletal muscle function in hereditary CA-TTR patients may activate muscle metaboreflex, leading to an increase in ventilation and sensation of breathlessness, the perception of fatigue, and overall sympathetic activation.
Source: Frontiers in Physiology - May 15, 2023 Category: Physiology Source Type: research

Po-03-005 best anticoagulation strategy for stroke prophylaxis in atrial fibrillation patients with amyloidosis
A considerable proportion of elderly patients are known to have coexistent atrial fibrillation (AF) and amyloidosis. Both conditions increase stroke risk.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Andrea Natale, Carola Gianni, Bryan MacDonald, Angel Quintero Mayedo, Vincenzo Mirco La Fazia, Prem Geeta Torlapati, Domenico G. Della Rocca, Rami Helmy, Mohanad Elchouemi, Mohamad Bassiouny, G. Joseph Gallinghouse, John D. burkhardt, Rodney P. Horton, Lu Source Type: research

Po-05-141 association of interatrial block and the development of atrial fibrillation among patients with hypertrophic cardiomyopathy
Atrial fibrillation (AF) is the most common sustained arrhythmia among those with hypertrophic cardiomyopathy (HCM), affecting 1 in 5 patients. The combination of HCM and AF is associated with an increased risk of stroke, heart failure, and mortality. Interatrial block (IAB) is a distinct electrocardiographic (ECG) pattern describing conduction delay between the right and left atria through Bachmann ’s bundle. IAB has been identified as a predictor of AF across several disease states including congestive heart failure, valvular disease, and cardiac amyloidosis.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Abdullah Alissa, Nadia Bokhari, Munther K. Homoud, Ethan Rowin, Martin S. Maron, Christopher Madias Source Type: research

Increased risk for stroke in patients with familial Mediterranean fever: results from a large population-based study
CONCLUSION: FMF patients are at increased risk for stroke regardless of known complications.PMID:37004175 | DOI:10.1093/rheumatology/kead153
Source: Atherosclerosis - April 2, 2023 Category: Cardiology Authors: Niv Ben-Shabat Omer Gendelman Lior Fisher Uria Shani Yonatan Shneor Patt Abdulla Watad Vita Skuja Dennis McGonagle Howard Amital Source Type: research

Cerebral amyloid angiopathy-related cardiac injury: Focus on cardiac cell death
Front Cell Dev Biol. 2023 Feb 24;11:1156970. doi: 10.3389/fcell.2023.1156970. eCollection 2023.ABSTRACTCerebral amyloid angiopathy (CAA) is a kind of disease in which amyloid β (Aβ) and other amyloid protein deposits in the cerebral cortex and the small blood vessels of the brain, causing cerebrovascular and brain parenchymal damage. CAA patients are often accompanied by cardiac injury, involving Aβ, tau and transthyroxine amyloid (ATTR). Aβ is the main injury factor of CAA, which can accelerate the formation of coronary artery atherosclerosis, aortic valve osteogenesis calcification and cardiomyocytes basophilic degen...
Source: Atherosclerosis - March 13, 2023 Category: Cardiology Authors: Xiaofang Xu Huikang Xu Zhaocai Zhang Source Type: research

Effect of Patisiran on Stroke Volume in Hereditary Transthyretin ‐Mediated Amyloidosis: Insights from Pressure‐Volume Analysis of the APOLLO Study
ConclusionsPatisiran may delay progression of LV chamber dysfunction starting at 9 months of therapy. These data elucidate the mechanisms by which transthyretin reducing therapies modulate progression of cardiac disease and need to be confirmed in ongoing phase III trials.
Source: European Journal of Heart Failure - January 25, 2023 Category: Cardiology Authors: Hannah R. Rosenblum, Jan M. Griffin, Masatoshi Minamisawa, Narayana Prasad, John Vest, Matthew T. White, Scott D. Solomon, M.D. Daniel Burkhoff, Mathew S. Maurer Tags: Research Article Source Type: research

Cutis Verticis Gyrata Heralding a Diagnosis of Primary Systemic Amyloidosis in a Patient with Cardioembolic Stroke
Ayush Agarwal, Pinki Chatterpal, Surya Kant, Ajay Garg, Sudheer Arava, Achal K SrivastavaAnnals of Indian Academy of Neurology 2023 26(1):88-90
Source: Annals of Indian Academy of Neurology - January 25, 2023 Category: Neurology Authors: Ayush Agarwal Pinki Chatterpal Surya Kant Ajay Garg Sudheer Arava Achal K Srivastava Source Type: research

Neuropathology of central nervous system involvement in TTR amyloidosis
AbstractHereditary transthyretin amyloidosis (ATTRv) is a systemic disease caused by the accumulation of misfolded transthyretin (TTR). It usually presents with an adult-onset progressive axonal peripheral neuropathy and cardiomyopathy. In the central nervous system (CNS), variant TTR is produced by the choroid plexus and accumulates in the leptomeninges. CNS symptoms have been increasingly recognized in this population, including transient focal neurological episodes and stroke, particularly in patients with the V30M mutation and longstanding disease. The prevalence, pathophysiology, and progression of CNS involvement rem...
Source: Acta Neuropathologica - January 1, 2023 Category: Neurology Source Type: research

Initial report of percutaneous left atrial appendage closure in hemodialysis patients with atrial fibrillation and high risk of bleeding in Japan
AbstractIn the countries like Japan where anticoagulation is not recommended in hemodialysis patients, the feasibility of percutaneous left atrial appendage closure (LAAC) in hemodialysis patients with non-valvular atrial fibrillation (NVAF) accompanying high risks of thromboembolic stroke and bleeding remains unknown. Peri-procedural and 45-day clinical outcomes following LAAC using WATCHMAN system, which were performed in our institute between Jun 2020 and April 2022 according to the Japanese Circulation Society guidelines, were retrospectively compared between those with and without hemodialysis. 118 patients (median 79...
Source: Cardiovascular Intervention and Therapeutics - December 23, 2022 Category: Cardiology Source Type: research

Racial Differences in Atrial Fibrillation Management Between White Patients and Black Patients in Transthyretin Cardiac Amyloid
Black patients have higher rates of stroke than White patients. Paradoxically, atrial fibrillation (AF) affects twice as many White patients compared with Black patients. Transthyretin cardiac amyloidosis (ATTR-CA) is associated with both AF and strokes. We hypothesized that although Black patients with ATTR-CA have a lower incidence of AF, when diagnosed with AF, they have increased thromboembolic events. Patients with ATTR-CA (n  = 558) at 3 international centers were retrospectively identified.
Source: The American Journal of Cardiology - December 14, 2022 Category: Cardiology Authors: Lindsey R. Mitrani, Robert A. Tumasian, Silvia Vilches, Jeffeny De Los Santos, Esther Gonzalez-Lopez, Angelo Giuseppe Caponetti, Giulia Saturi, Jesus G. Mirelis, Simone Longhi, Christian Gagliardi, Jeff Goldsmith, Claudio Rapezzi, Pablo Garc ía-Pavía, M Source Type: research

Neuropathology of central nervous system involvement in TTR amyloidosis
AbstractHereditary transthyretin amyloidosis (ATTRv) is a systemic disease caused by the accumulation of misfolded transthyretin (TTR). It usually presents with an adult-onset progressive axonal peripheral neuropathy and cardiomyopathy. In the central nervous system (CNS), variant TTR is produced by the choroid plexus and accumulates in the leptomeninges. CNS symptoms have been increasingly recognized in this population, including transient focal neurological episodes and stroke, particularly in patients with the V30M mutation and longstanding disease. The prevalence, pathophysiology, and progression of CNS involvement rem...
Source: Acta Neuropathologica - October 6, 2022 Category: Neurology Source Type: research

Atrial fibrillation, thromboembolic risk, and anticoagulation in cardiac amyloidosis: A review
Cardiac amyloidosis results from deposition of abnormal proteins in the heart called amyloid. This protein deposition leads to changes in the heart structure that ultimately predispose to rhythm disturbances, notably atrial fibrillation. The toxic effect of these proteins on the heart as well as resulting structural abnormalities often cause blood clots to form inside the heart, which can lead to stroke. Simultaneously, amyloid proteins can also increase risk of bleeding. Blood thinners are often needed in these patients to prevent stroke.
Source: Journal of Cardiac Failure - September 16, 2022 Category: Cardiology Authors: Syed Bukhari, Syed Zamrak Khan, Zubair Bashir Tags: Review Article Source Type: research

Transcatheter aortic valve replacement in aortic stenosis and cardiac amyloidosis: a systematic review and meta ‐analysis
ConclusionsTAVR is an effective and safe procedure in CA-AS patients, with a substantial survival benefit as compared with medical therapy, and a safety profile comparable with patients with AS alone except for a trend towards higher risk of permanent pacemaker implantation.
Source: ESC Heart Failure - June 30, 2022 Category: Cardiology Authors: Francesco Cannata, Mauro Chiarito, Giuseppe Pinto, Alessandro Villaschi, Jorge Sanz ‐Sánchez, Fabio Fazzari, Damiano Regazzoli, Antonio Mangieri, Renato M. Bragato, Antonio Colombo, Bernhard Reimers, Gianluigi Condorelli, Giulio G. Stefanin Tags: Original Article Source Type: research

Stroke in ATTR cardiac amyloidosis: does rhythm only matter?
Transthyretin amyloidosis (ATTR) is frequently associated with cardiac involvement in the wild type form (wtATTR) as well as in the mutated form (variant ATTR, vATTR). Although left ventricular (LV) pseudohypertrophy is currently considered a most relevant structural abnormality in cardiac amyloidosis (CA), atrial involvement due to both amyloid infiltration and secondary to LV overload and remodeling, is another key feature and a major determinant of decompensation, especially when associated with atrial arrhythmias [1].
Source: International Journal of Cardiology - June 15, 2022 Category: Cardiology Authors: Giuseppe Vergaro, Alberto Aimo, Vincenzo Castiglione, Michele Emdin Tags: Editorial Source Type: research

Stroke in ATTR cardiac amyloidosis: Does only rhythm matter?
Transthyretin amyloidosis (ATTR) is frequently associated with cardiac involvement in the wild type form (wtATTR) as well as in the mutated form (variant ATTR, vATTR). Although left ventricular (LV) pseudohypertrophy is currently considered the most relevant structural abnormality in cardiac amyloidosis (CA), atrial involvement due to both amyloid infiltration and secondary to LV overload and remodeling, is another key feature and a major determinant of decompensation, especially when associated with atrial arrhythmias [1].
Source: International Journal of Cardiology - June 15, 2022 Category: Cardiology Authors: Giuseppe Vergaro, Alberto Aimo, Vincenzo Castiglione, Michele Emdin Tags: Editorial Source Type: research