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Umbilical cord thrombosis and chorioamnionitis in neonatal arterial ischaemic stroke
A baby boy was delivered at term by emergency caesarean section because of abnormal fetal heart rate patterns during spontaneous labour. The umbilical cord arterial blood obtained at delivery had a pH of 6.97 and a lactate concentration of 12.1 mmol/L. The Apgar scores were 3 and 7, respectively, at 1 and 5 min. The proximal umbilical cord had a thrombotic aspect at delivery (figure 1). A thrombus was also identified in the ductus venosus at 1 hour of life. The boy presented left hemicorporeal seizures at 21 hours of life, which revealed a neonatal arterial ischaemic stroke (NAIS; figure 2). Placental histology revealed ac...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Dridi, M., Chabrier, S., Raia-Barjat, T., Giraud, A. Tags: Open access Images in neonatal medicine Source Type: research

Clinical Diversity of Cerebral Sinovenous Thrombosis and Arterial Ischaemic Stroke in the Neonate: A Surveillance Study
CONCLUSION: The risk for AIS is about 3 times higher than that for CSVT in neonates. A higher proportion of critically ill infants in CSVT and a later onset of symptoms may indicate that perinatal and postnatal risk factors are more important for CSVT than for AIS. The data underline the need for an increased awareness of CSVT in critically ill infants.PMID:33784682 | DOI:10.1159/000512526
Source: Neonatology - March 30, 2021 Category: Perinatology & Neonatology Authors: Anna-Lisa Sorg Mathias Klemme R üdiger von Kries Ursula Felderhoff-M üser Andreas W Flemmer Lucia Gerstl Mark Dzietko Source Type: research

Upper extremity arterial thrombus presenting at birth
We report a 36-week neonate born to a 31-year-old G2P0 woman by emergency c-section due to decreased fetal movement. The pregnancy had been uncomplicated up to that point and the mother had no significant medical history. Birth weight was 2.49 kg. Apgars were 6 and 5. Superficial skin loss and dark blue discolouration were noted along the left upper extremity and hand immediately after delivery. Fluid resuscitation and sterile saline wraps slowly improved perfusion, and the extremity pinked up over the subsequent 3 h (figure 1). She was transferred to an appropriate outside facility where Doppler ultrasound revea...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 16, 2016 Category: Perinatology & Neonatology Authors: LaBore, B. P., Bedell, T. H. Tags: Journalology, Drugs: cardiovascular system, Stroke, Pregnancy, Reproductive medicine, Radiology, Clinical diagnostic tests, Radiology (diagnostics), Competing interests (ethics), Resuscitation, Trauma Images in neonatal medicine Source Type: research

Neonatal purpura fulminans due to protein C deficiency
A 3-day-old term male neonate born of third-degree consanguineous marriage was admitted with purplish black, oval tender lesions with erythematous rim on both soles and left hip. He was normothermic, haemodynamically stable and feeding well. However, new gangrenous lesions appeared on his fingers soon after admission. C-reactive protein was negative. Complete blood count revealed a platelet count of 73 000/mm3 with normal haematocrit and leucocyte count. Prothrombin time and activated partial thromboplastin time were prolonged (PT: 26 s; INR: 2.03; aPTT>100 s). Plasma protein C activity was detected to be...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2015 Category: Perinatology & Neonatology Authors: Sharma, S., Anbazhagan, J., Plakkal, N. Tags: Journalology, Genetic screening / counselling, Immunology (including allergy), Drugs: cardiovascular system, Stroke, Pregnancy, Reproductive medicine, Competing interests (ethics) Images in neonatal medicine Source Type: research

Serial cranial ultrasonography or early MRI for detecting preterm brain injury?
Conclusions Advanced serial CUS seems highly effective in diagnosing preterm brain injury, but may miss cerebellar abnormalities. Although MRI does identify these lesions, feasibility is limited. Improved safety, better availability and tailored procedures are essential for MRI to increase its value in clinical care.
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 19, 2015 Category: Perinatology & Neonatology Authors: Plaisier, A., Raets, M. M. A., Ecury-Goossen, G. M., Govaert, P., Feijen-Roon, M., Reiss, I. K. M., Smit, L. S., Lequin, M. H., Dudink, J. Tags: Epidemiologic studies, Neurological injury, Stroke, Child health, Radiology, Clinical diagnostic tests, Radiology (diagnostics), Trauma, Guidelines, Injury Original articles Source Type: research