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Specialty: Orthopaedics
Condition: Thrombosis

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Total 48 results found since Jan 2013.

Why anticoagulant studies on sepsis fail frequently --- start with SCARLET
Chin J Traumatol. 2023 May 2:S1008-1275(23)00042-1. doi: 10.1016/j.cjtee.2023.04.006. Online ahead of print.ABSTRACTThe Sepsis Coagulopathy Asahi Recombinant LE Thrombomodulin (SCARLET) trial has many defects, and thus cannot be the terminator of recombinant thrombomodulin (rTM). On the contrary, it provides sufficient evidence for further research. Based on analysis focusing on the failure of SCARLET and several previous anticoagulant studies, it is most important for new studies to grasp the following two points: (1) The enrolled cases should have sufficient disease severity and a clear standard for disseminated intravas...
Source: Chinese Journal of Traumatology - June 15, 2023 Category: Orthopaedics Authors: Jian-Ying Guo Hong-Yuan Lin Source Type: research

Safety of early posterior fusion surgery without endovascular embolization for asymptomatic vertebral artery occlusion associated with cervical spine trauma
ConclusionDespite the lack of a concurrent control group with preoperative antiplatelet therapy or endovascular embolization for VAO, our results showed low symptomatic stroke rate (4.5%), high recanalization rate (40.9%), and low mortality rate (0%). Therefore, we believe that the indication for early stabilization surgery as management strategy of asymptomatic VAO might be one of the safe and effective treatment options for prevention of symptomatic cerebral infarction.
Source: European Spine Journal - July 12, 2022 Category: Orthopaedics Source Type: research

No Difference in Blood Loss and Risk of Transfusion Between Patients Treated with One or Two Doses of Intravenous Tranexamic Acid After Simultaneous Bilateral TKA
CONCLUSION: The findings of this study suggest that a single dose of intravenous TXA may be adequate to control excessive blood loss and reduce blood transfusion in simultaneous bilateral TKA. Despite its short half-life, TXA still appears to be effective in this demanding procedure without requiring prolonged plasma concentrations obtained from multiple doses. Additional high-quality studies are still needed to determine the most appropriate dosing regimen.LEVEL OF EVIDENCE: Level III, therapeutic study.PMID:35302971 | PMC:PMC8923576 | DOI:10.1097/CORR.0000000000002037
Source: Clinical Orthopaedics and Related Research - March 18, 2022 Category: Orthopaedics Authors: Jeffrey M Wilde Steven N Copp Kace A Ezzet Adam S Rosen Richard H Walker Julie C McCauley Audree S Evans William D Bugbee Source Type: research

Comparison of Extramedullary and Intramedullary Implants for Stable Intertrochanteric Fractures: Have We Swung the Pendulum Too Far the Other Way?
DISCUSSION: Our study found that extramedullary implants were associated with lower transfusions rates, lower readmissions, and better patient disposition. We recommend surgeons to consider extramedullary implants when treating stable IT fractures, especially if the patient is anemic or at high risk for hospital readmission.LEVEL OF EVIDENCE: Level III. Retrospective cohort study.PMID:35196299 | DOI:10.5435/JAAOS-D-21-00657
Source: The Journal of the American Academy of Orthopaedic Surgeons - February 23, 2022 Category: Orthopaedics Authors: Aria Darius Darbandi Ghulam H Saadat Ahmed Siddiqi Bennet A Butler Source Type: research

Postoperative Complications in Patients With Hereditary Hemochromatosis Undergoing Total Joint Arthroplasty: A Matched Cohort Analysis
This study addresses a paucity in the current literature concerning the complication profile in HH patients with destructive joint arthropathy undergoing joint arthroplasty surgery.PMID:34932508 | DOI:10.5435/JAAOS-D-21-00105
Source: The Journal of the American Academy of Orthopaedic Surgeons - December 21, 2021 Category: Orthopaedics Authors: Amil R Agarwal Kevin Y Wang Amy L Xu Matthew J Best Varun Puvanesarajah Umasuthan Srikumaran Gregory J Golladay Savya C Thakkar Source Type: research

Trends in Comorbidities and Complications Among Patients Undergoing Inpatient Spine Surgery
Study Design. Retrospective database study. Objective. We sought to identify trends in demographics, comorbidities, and postoperative complications among patients undergoing ACDF and PLF. Summary of Background Data. As demand for anterior cervical discectomy and fusion (ACDF) and posterior lumbar fusion (PLF) surgery continues to increase, it is important to understand changes in the healthcare system and patient populations undergoing these procedures. Methods. We identified 220,520 ACDF and 151,547 PLF surgeries (2006–2016; Premier Healthcare database). Annual proportions or medians were calculated for patie...
Source: Spine - August 28, 2020 Category: Orthopaedics Tags: SURGERY Source Type: research

Mortality and Morbidity of Surgical Management of Geriatric Ankle Fractures.
DISCUSSION: After controlling for comorbidities (ie, the ASA class), no increased risk is observed for the 30-day mortality or complication rate between geriatric ankle fracture in the 65 to 79 years old and the 80 to 99 years old age groups. LEVEL OF EVIDENCE: Prognostic level III, retrospective study. PMID: 32769723 [PubMed - in process]
Source: The Journal of the American Academy of Orthopaedic Surgeons - August 13, 2020 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Increased Prevalence, Complications, and Costs of Smokers Undergoing Total Knee Arthroplasty
J Knee Surg DOI: 10.1055/s-0040-1713128Given a national push toward bundled payment models, the purpose of this study was to examine the prevalence as well as the effect of smoking on early inpatient complications and cost following elective total knee arthroplasty (TKA) in the United States across multiple years. Using the nationwide inpatient sample, all primary elective TKA admissions were identified from 2012 to 2014. Patients were stratified by smoking status through a secondary diagnosis of “tobacco use disorder.” Patient characteristics as well as prevalence, costs, and incidence of complications were compared. ...
Source: Journal of Knee Surgery - June 23, 2020 Category: Orthopaedics Authors: Rajaee, Sean S. Debbi, Eytan M. Paiement, Guy D. Spitzer, Andrew I. Tags: Original Article Source Type: research