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The influence of blood composition and loading frequency on the behavior of embolus analogs
J Mech Behav Biomed Mater. 2023 Feb 18;140:105738. doi: 10.1016/j.jmbbm.2023.105738. Online ahead of print.ABSTRACTIn cases of acute ischemic stroke (AIS), mechanical thrombectomy (MT) can be used to directly remove lodged thromboemboli. Despite improvements in patient outcomes, one of the key factors affecting MT success is the mechanical properties of the occlusive thrombus. Therefore, the goal of this study was to investigate the viscoelastic properties of embolus analogs (EAs) and determine the influence of EA hematocrit and loading frequency. Bovine blood EAs were created over a range of physiological hematocrits (0-6...
Source: Journal of the Mechanical Behavior of Biomedical Materials - February 23, 2023 Category: Materials Science Authors: Bryan C Good Source Type: research

A low dimensional surrogate model for a fast estimation of strain in the thrombus during a thrombectomy procedure
CONCLUSIONS: The surrogate model provides nearly instantaneous estimates and constitutes a valuable tool for evaluating the risk of thrombus rupture during pre-operative planning for the treatment of acute ischemic stroke.PMID:36410165 | DOI:10.1016/j.jmbbm.2022.105577
Source: Journal of the Mechanical Behavior of Biomedical Materials - November 21, 2022 Category: Materials Science Authors: Sara Bridio Giulia Luraghi Francesco Migliavacca Sanjay Pant Alberto Garc ía-González Jose F Rodriguez Matas Source Type: research

Combined stent-retriever and aspiration intra-arterial thrombectomy performance for fragmentable blood clots: A proof-of-concept computational study
This study focuses on two aspects of the thrombectomy simulation: i) Thrombus fragmentation on the basis of a failure model calibrated with experimental tests on clot analogs; ii) the combined stent-retriever and aspiration catheter MT procedure is modeled by adding both the proximal balloon guide catheter and the distal access catheter. The adopted failure criterion is based on maximum principal stress threshold value. If elements of the thrombus exceed this criterion during the retrieval simulation, then they are deleted from the calculation. Comparison with in-vitro tests indicates that the simulation correctly reproduc...
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 18, 2022 Category: Materials Science Authors: Giulia Luraghi Sara Bridio Vittorio Lissoni Gabriele Dubini Anushree Dwivedi Ray McCarthy Behrooz Fereidoonnezhad Patrick McGarry Frank J H Gijsen Jose Felix Rodriguez Matas Francesco Migliavacca Source Type: research

Fucoidan-functionalized polysaccharide submicroparticles loaded with alteplase for efficient targeted thrombolytic therapy
Biomaterials. 2021 Aug 30;277:121102. doi: 10.1016/j.biomaterials.2021.121102. Online ahead of print.ABSTRACTIntravenous administration of fibrinolytic drugs is the standard treatment of acute thrombotic diseases. However, current fibrinolytics exhibit limited clinical efficacy because of their short plasma half-lives and might trigger hemorrhagic transformations. Therefore, it is mandatory to develop innovative nanomedicine-based solutions for more efficient and safer thrombolysis with biocompatible and biodegradable thrombus-targeted nanocarrier. Herein, fucoidan-functionalized hydrogel polysaccharide submicroparticles w...
Source: Biomaterials - September 5, 2021 Category: Materials Science Authors: Alina Zenych Charl ène Jacqmarcq Rachida Aid Louise Fournier Laura M Forero Ramirez Fr édéric Chaubet Thomas Bonnard Denis Vivien Didier Letourneur C édric Chauvierre Source Type: research

Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke
AbstractEndogenous neurogenesis in stroke is insufficient to replace the lost brain tissue, largely due to the lack of a proper biological structure to let new cells dwell in the damaged area. We hypothesized that scaffolds made of hyaluronic acid (HA) biomaterials (BM) could provide a suitable environment to home not only new neurons, but also vessels, glia and neurofilaments. Further, the addition of exogenous cells, such as adipose stem cells (ASC) could increase this effect. Athymic mice were randomly assigned to a one of four group: stroke alone, stroke and implantation of BM, stroke and implantation of BM with ASC, a...
Source: Journal of Biomedical Materials Research Part B: Applied Biomaterials - October 11, 2018 Category: Materials Science Authors: Leyre Sanchez ‐Rojas, Ulises Gómez‐Pinedo, María Soledad Benito‐Martin, Gonzalo León‐Espinosa, Fernando Rascón‐Ramirez, Cristina Lendinez, Cristina Martínez‐Ramos, Jorge Matías‐Guiu, Manuel Monleón Pradas, Juan A. Barcia Tags: Original Research Report Source Type: research

ASAP Tissue Plasminogen Activator-Porous Magnetic Microrods for Targeted Thrombolytic Therapy after Ischemic Stroke
ACS Applied Materials& InterfacesDOI: 10.1021/acsami.8b09423
Source: ACS Applied Materials and Interfaces - September 19, 2018 Category: Materials Science Authors: Jiangnan Hu, Shengwei Huang, Lu Zhu, Weijie Huang, Yiping Zhao, Kunlin Jin, Qichuan ZhuGe Source Type: research