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Effect of Standardized Perioperative Management on EEG Indexes and Nerve and Limb Functions of Patients with Acute Cerebral Infarction Undergoing Mechanical Thrombectomy
CONCLUSION: The standardized perioperative management is effective in patients with acute cerebral infarction who were treated with arteriovenous combined thrombolysis or mechanical thrombectomy, which can improve the neurological function and physical function of patients. However, the mechanical thrombectomy has a better improvement effect on the neurological function and physical function of patients, with the relatively better safety, thrombolytic effect, and long-term prognosis.PMID:36199820 | PMC:PMC9529457 | DOI:10.1155/2022/1686891
Source: Disease Markers - October 6, 2022 Category: Laboratory Medicine Authors: Yu Gong Jie Wang Source Type: research

Predictive Value of Globulin to Prealbumin Ratio for 3-Month Functional Outcomes in Acute Ischemic Stroke Patients
CONCLUSIONS: The 24 h GPR level can predict the 3-month functional outcome in AIS patients accepting recombinant tissue plasminogen activator (r-tPA) intravenous thrombosis.PMID:35340417 | PMC:PMC8947872 | DOI:10.1155/2022/1120192
Source: Disease Markers - March 28, 2022 Category: Laboratory Medicine Authors: Chunjian Li Chenguang Yang Junyan Zhu Honghao Huang Jiahui Zheng Xueting Hu Wenjing Pan Fangyue Sun Tian Zeng Haojie Qiu Zerui Jiang Yiqun Chen Yilin Chen Guangyong Chen Yiyun Weng Source Type: research

Was Antiphospholipid Syndrome a Risk Factor of Stroke? A Systemic Review and Meta-Analysis of Cohort Studies
Dis Markers. 2021 Dec 16;2021:4431907. doi: 10.1155/2021/4431907. eCollection 2021.ABSTRACTAntiphospholipid syndrome (APS) is characterized by thrombosis. This systemic review and meta-analysis was to verify the hypothesis that APS might increase the risk of stroke. Studies were identified after literature searching of PubMed, Embase, and Cochrane. Newcastle-Ottawa Quality Assessment Scale Cohort Studies (NOQAS-C) was used to assess the quality of studies. The pooled effect with 95% confidence interval (95% CI) was calculated by random-effect model. I-square (I 2) was used to test heterogeneity. Funnel plot was used to eva...
Source: Disease Markers - December 27, 2021 Category: Laboratory Medicine Authors: Kai Zhao Ping Zhou Ling Xu Ruili Li Jincai Yang Qiang Zhang Mingfei Yang Xiaoxing Wei Source Type: research

Autopsy Techniques in Patients With History of Radiofrequency Ablation for Atrial Fibrillation
CONCLUSIONS.—: To date, this is the largest collection of autopsy cases showing esophageal fistula associated with prior radiofrequency catheter ablation. The Letulle dissection method is preferable in this setting.PMID:34619753 | DOI:10.5858/arpa.2021-0161-OA
Source: Archives of Pathology and Laboratory Medicine - October 7, 2021 Category: Laboratory Medicine Authors: Bindu Challa Keluo Yao Patricia Allenby Charles L Hitchcock Youri Ivanov Sergey V Brodsky Source Type: research

Microvascular thrombosis: experimental and clinical implications.
MICROVASCULAR THROMBOSIS: EXPERIMENTAL AND CLINICAL IMPLICATIONS. Transl Res. 2020 May 23;: Authors: Bray MA, Sartain SA, Gollamudi J, Rumbaut RE Abstract A significant amount of clinical and research interest in thrombosis is focused on large vessels (e.g., stroke, myocardial infarction, deep venous thrombosis, etc.); however, thrombosis is often present in the microcirculation in a variety of significant human diseases, such as disseminated intravascular coagulation, thrombotic microangiopathy, sickle cell disease, and others. Further, microvascular thrombosis has recently been demonstrated in patie...
Source: Translational Research : the journal of laboratory and clinical medicine - May 22, 2020 Category: Laboratory Medicine Authors: Bray MA, Sartain SA, Gollamudi J, Rumbaut RE Tags: Transl Res Source Type: research

MicroRNAs in Venous Thrombo-Embolism
Publication date: Available online 1 February 2020Source: Clinica Chimica ActaAuthor(s): Anju Angelina Hembrom, Swati Srivastava, Iti Garg, Bhuvnesh KumarAbstractBackgroundVenous Thrombo-embolism (VTE) is the major preventable cause of death and disability worldwide. It has the third highest incidence rate of hospital death after coronary artery disease (CAD) and stroke. With the establishment of Virchow’s triad stating the major factors responsible for VTE including stasis, hypercoagulability and endothelial dysfunction, the last decade reported number of studies regarding its diagnosis and prophylaxis. Till date the mo...
Source: Clinica Chimica Acta - February 1, 2020 Category: Laboratory Medicine Source Type: research

Genetic Polymorphisms Associated with Thrombotic Disease Comparison of Two Territories: Myocardial Infarction and Ischemic Stroke.
Conclusions: The Thr325Ile polymorphism, but no Ala147Thr polymorphism, represents an independent risk factor for STEMI in the young Mexican population. PMID: 31781299 [PubMed - in process]
Source: Disease Markers - November 30, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

Activated protein C assays: a review
Publication date: Available online 13 November 2019Source: Clinica Chimica ActaAuthor(s): Julia Oto, Álvaro Fernández-Pardo, Manuel Miralles, Emma Plana, Francisco España, Silvia Navarro, Pilar MedinaAbstractActivated protein C (APC) acts as an “on demand” anticoagulant, reducing thrombin formation. Reduced plasma levels of APC or protein C (PC) are associated with an increased risk of venous thromboembolism. APC also displays cytoprotective functions and its therapeutic use has been evaluated in severe sepsis and is under evaluation in several diseases with an important inflammatory component. In addition, differen...
Source: Clinica Chimica Acta - November 13, 2019 Category: Laboratory Medicine Source Type: research

Myeloperoxidase – A bridge linking inflammation and oxidative stress with cardiovascular disease
Publication date: Available online 21 February 2019Source: Clinica Chimica ActaAuthor(s): Gjin NdrepepaAbstractMyeloperoxidase (MPO) is a member of the superfamily of heme peroxidases that is mainly expressed in neutrophils and monocytes. MPO-derived reactive species play a key role in neutrophil antimicrobial activity and human defense against various pathogens primarily by participating in phagocytosis. Elevated MPO levels in circulation are associated with inflammation and increased oxidative stress. Multiple lines of evidence suggest an association between MPO and cardiovascular disease (CVD) including coronary artery ...
Source: Clinica Chimica Acta - February 22, 2019 Category: Laboratory Medicine Source Type: research

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