• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke
Conclusion: Direct inhibition of smooth muscle myosin by AmBleb in pre-capillary SMCs significantly contribute to the improvement of cerebral blood reperfusion and brain functions suggesting that smooth muscle myosin inhibition may have promising potential in stroke therapies as a follow-up treatment of physical or chemical removal of the occluding thrombus.
Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: M á t é P é nzes, Demeter T ú r ó s, Domokos M á th é , Kriszti á n Szigeti, Nikolett Heged ű s, Anna Á gnes Rauscher, P é ter T ó th, Ivan Ivic, Parasuraman Padmanabhan, Gabriella P á l, Á rp á d Dobolyi, M á t é Gyimesi, Andr á s M � Tags: Research Paper Source Type: research

PET Detection of Cerebral Necrosis Using an Infarct-Avid Agent 2-Deoxy-2- 18 FFluoro- d -Glucaric Acid (FGA) in a Mouse Model of the Brain Stroke
ConclusionsAccumulation of FGA correlated well with the perfusion defect and inflammatory injury. As a PET agent, FGA has potential to image infarcted core in the brain stroke injury with high sensitivity, resolution, and specificity.
Source: Molecular Imaging and Biology - June 15, 2020 Category: Molecular Biology Source Type: research

Role of Gallium-SPECT-CT in the Management of Patients with Ventricular Assist Device-Specific Percutaneous Driveline Infection
Implantable left ventricular assist device (LVAD) has dramatically improved the prognosis of patients with advanced heart failure.1 With ongoing technological innovation, patient survival and quality of life are further improving,2,3 and major complications related to LVAD such as pump thrombosis and stroke have decreased3; however, these complications have not been completely overcome. Infection remains a major complication in up to 60% of VAD patients and worsens prognosis and quality of life.
Source: Journal of Cardiac Failure - August 23, 2019 Category: Cardiology Authors: Yuki Kimura, Osamu Seguchi, Hiroki Mochizuki, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Kensuke Kuroda, Seiko Nakajima, Emi Tateishi, Takuya Watanabe, Yorihiko Matsumoto, Satsuki Fukushima, Keisuke Kiso, Masanobu Yanase, Tomoyuki Fujita, Junjiro Kobayas Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

All That Glitters Is not Gold: Peals and Pitfalls in I-131 Scans for Differentiated Thyroid Cancer
Conclusion: We review thyroid gland physiology and describe a systemic overview of potential false positive and false negative lack of uptake of radioiodine in the whole body along with illustrations and cases. By understanding the physiology and characteristics of radioiodine uptake and correlating with anatomical imaging, biochemical data, and clinical findings, physicians can be more confident in establishing proper management for patients with DTC using radioiodine whole body scans. Research Support: N/A
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Lazaga, F., Sharma, S., Sharma, P., Williams, S. Tags: Educational Exhibits Posters Source Type: research

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and the current situat...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research

Incremental Prognostic Value of Brachial-Ankle Pulse Wave Velocity to Single-Photon Emission Computed Tomography in Patients with Suspected Coronary Artery Disease.
CONCLUSIONS: baPWV has an incremental prognostic value to traditional risk factors and MPI. Therefore, baPWV can be used to identify subjects at higher risk of cardiovascular events in patients undergoing SPECT. PMID: 26235347 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - August 4, 2015 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

In Vivo Molecular Imaging of Thrombosis and Thrombolysis Using a Fibrin-Binding Positron Emission Tomographic Probe Molecular Imaging
Conclusions— We demonstrated that FBP7 is suitable for molecular imaging of thrombosis and thrombolysis in vivo and represents a promising candidate for bench-to-bedside translation.
Source: Circulation: Cardiovascular Imaging - July 15, 2014 Category: Radiology Authors: Ay, I., Blasi, F., Rietz, T. A., Rotile, N. J., Kura, S., Brownell, A. L., Day, H., Oliveira, B. L., Looby, R. J., Caravan, P. Tags: PET and SPECT Molecular Imaging Source Type: research