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Predicting risk factors for thromboembolic complications in patients with sickle cell anaemia - lessons learned for prophylaxis
CONCLUSIONS: VTE in patients with SCA has a high impact on morbidity and mortality. PE was the leading presentation of VTE, with CVC insertion, high LDH, bilirubin, CRP and white blood cell counts along with low Hb and HbF constituting other significant risk factors.PMID:34855536 | DOI:10.1177/03000605211055385
Source: Cell Research - December 2, 2021 Category: Cytology Authors: Salam Alkindi Anwaar R Al-Ghadani Samah R Al-Zeheimi Said Y Alkindi Naglaa Fawaz Samir K Ballas Anil V Pathare Source Type: research

Thrombolysis Following Central Venous Catheter Placement
Since the importance of time in the treatment of hyperacute ischemic stroke became widely known, the frequency of thrombolysis has been gradually increasing.1,2 As thrombolytic agents are infusion formulations, securing a venous access route is mandatory.
Source: Journal of Stroke and Cerebrovascular Diseases - September 3, 2020 Category: Neurology Authors: Kenichi Sakuta, Ryoji Nakada, Shinji Miyagawa, Izumu Hasegawa, Hiroshi Yaguchi Tags: Case Report Source Type: research

Hospital-Associated Venous Thromboembolism in a Pediatric Cardiac ICU: A Multivariable Predictive Algorithm to Identify Children at High Risk
Objectives: Critically ill children with cardiac disease are at significant risk for hospital-associated venous thromboembolism, which is associated with increased morbidity, hospital length of stay, and cost. Currently, there are no widely accepted guidelines for prevention of hospital-associated venous thromboembolism in pediatrics. We aimed to develop a predictive algorithm for identifying critically ill children with cardiac disease who are at increased risk for hospital-associated venous thromboembolism as a first step to reducing hospital-associated venous thromboembolism in this population. Design: This is a pr...
Source: Pediatric Critical Care Medicine - June 1, 2020 Category: Pediatrics Tags: Online Cardiac Intensive Care Source Type: research

Paradoxical embolism through a patent foramen ovale from central venous catheter thrombosis: A potential cause of stroke
Paradoxical embolism refers to a potential condition in which an embolus arising from a venous source crosses into the systemic circulation through a right-to-left cardiac shunt causing an arterial embolism.A 39-year-old woman carrier of a central venous catheter (CVC) without evident risk factors for stroke, developed an acute right homonymous hemianopia during hemodialysis. On neuroimaging, an infarct in the territory of the left posterior cerebral artery was demonstrated. Transesophageal echocardiography revealed a patent foramen ovale (PFO) and a large fluctuating thrombus in the right atrium on the tip of the CVC, thu...
Source: Journal of the Neurological Sciences - April 3, 2020 Category: Neurology Authors: Di Stefano Vincenzo, Di Fulvio Maria, Di Liberato Lorenzo, Onofrj Marco, De Angelis Maria Vittoria Tags: Clinical Short Communication Source Type: research

Prophylaxis of Venous Thromboembolism after Hospital Discharge in Internal Medicine: Findings from the Observational FADOI-NoTEVole Study.
CONCLUSION:  In this study, one in five patients discharged from an Italian IMU received prophylaxis for VTE. The perceived thrombotic risk is significantly related to the use of prophylaxis. PMID: 31634959 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - October 20, 2019 Category: Hematology Authors: Squizzato A, Agnelli G, Campanini M, Dentali F, Agnelli F, Bonizzoni E, Franco A, Gallo A, Gussoni G, Nitti C, Triolo G, Valerio A, Ventrella F, Fontanella A, FADOI-NoTEVole Study Group Tags: Thromb Haemost Source Type: research

Predictors of venous thromboembolism recurrence and the bleeding events identified using a Japanese healthcare database.
CONCLUSIONS: These findings obtained from healthcare database suggest predictors either for recurrent VTE and bleeding that should be considered when selecting treatment to reduce the risk of recurrent VTE and mitigate bleeding. PMID: 28245956 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - February 24, 2017 Category: Cardiology Authors: Nakamura M, Yamada N, Oda E, Matsubayashi D, Ota K, Kobayashi M, Matsushita Y, Kaburagi J, Ibusuki K, Takita A, Iwashita M, Yamaguchi T Tags: J Cardiol Source Type: research

Subclavian site should be preferred for central venous access
Commentary on: Parienti JJ, Mongardon N, Mégarbane B, et al.., 3SITES Study Group. Intravascular Complications of Central Venous Catheterization by Insertion Site. N Engl J Med 2015;373:1220–9. Implications for practice and research Subclavian site should be preferred for central venous access (CVA) with a low risk of pneumothorax. Excluding patients before randomisation represents a selection bias. Post hoc sensitivity analysis may reduce the bias without fully balancing it. An adjudication committee, unaware of study-group assignments, may compensate for the absence of feasible blindness. Context Infection, ...
Source: Evidence-Based Nursing - September 21, 2016 Category: Nursing Authors: Mourvillier, B., Radjou, A., Timsit, J.-F. Tags: Health policy, Nursing issues, Drugs: infectious diseases, Drugs: cardiovascular system, Stroke, Ophthalmology, Venous thromboembolism, Health service research Source Type: research

Significance of Echocardiographically Detected Central Venous Catheter Tip –Associated Thrombi
Conclusions In this sample with CVC tip–associated thrombi but without PFO or other intracardiac shunts, no embolic or other complications were detected, regardless of anticoagulation status. These data suggest a benign course for such thrombi and that anticoagulation, catheter removal, thrombectomy, and thrombolysis may be unnecessary when catheter tip–associated thrombi are incidentally detected on echocardiography.
Source: Journal of Vascular and Interventional Radiology - September 19, 2016 Category: Radiology Source Type: research

French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - May 31, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research

Inadvertent Arterial Placement of Central Venous Catheters: Diagnostic and Therapeutic Strategies
Central venous catheterization (CVC) is among the most ubiquitous medical procedures. Inadvertent arterial placement of the catheter presents a challenging dilemma to the interventionalist. Treatment options include: removal and manual compression, off-label use of percutaneous closure devices and/or stent grafts, and open surgical removal. Potential sequelae include bleeding, thrombosis, stroke, limb ischemia, neurologic deficit, and death. Our aim is to evaluate the use of open and endovascular techniques for the management of iatrogenic carotid, subclavian, and brachiocephalic arterial injuries related to inadvertent ar...
Source: Annals of Vascular Surgery - August 6, 2015 Category: Surgery Authors: Dustin Y. Yoon, Suman Annambhotla, Scott A. Resnick, Mark K. Eskandari, Heron E. Rodriguez Source Type: research

Duplex sonography for detection of deep vein thrombosis of upper extremities: a 13-year experience.
CONCLUSIONS. Upper-extremity deep vein thrombosis is uncommon among symptomatic Chinese population. The most common sign is swelling and the major risk factor for upper-extremity deep vein thrombosis identified in this study is malignancy. PMID: 25722467 [PubMed - as supplied by publisher]
Source: Hong Kong Med J - February 27, 2015 Category: Journals (General) Authors: Chung AS, Luk WH, Lo AX, Lo CF Tags: Hong Kong Med J Source Type: research

Proteomic and other mass spectrometry based “omics” biomarker discovery and validation in pediatric venous thromboembolism and arterial ischemic stroke: Current state, unmet needs, and future directions
Venous thromboembolism (VTE) and arterial ischemic stroke (AIS) are increasingly‐recognized health conditions in children, with both acute and chronic sequelae. Risk factors for, and pathogenesis of, VTE are readily related to three principal factors, consisting of venous stasis, endothelial damage, and the hypercoagulable state (i.e. thrombophilia), termed the triad of Virchow. In children, greater than 90% of VTE are provoked by an overt clinical risk factor, the most common of which is a central venous catheter. Risk factors for childhood‐onset (beyond the neonatal period) AIS include sickle cell disease, infection,...
Source: Proteomics. Clinical Applications - December 2, 2014 Category: Biochemistry Authors: Neil A. Goldenberg, Allen D. Everett, David Graham, Timothy J. Bernard, Ulrike Nowak‐Göttl Tags: Review Source Type: research

Iatrogenesis imperfecta: stroke caused by accidental carotid artery catheterization.
CONCLUSION:: Even with ultrasound-guided central venous catheterization, it is essential to remain vigilant for the early detection of vascular complications. Clinical suspicion combined with diagnostic modalities such as chest radiograph, transduction and manometry can increase the detection rates. PMID: 25041919 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - November 27, 2014 Category: Surgery Tags: J Vasc Access Source Type: research

Proteomic and other mass spectrometry‐based “Omics” biomarker discovery and validation in pediatric venous thromboembolism and arterial ischemic stroke: Current state, unmet needs, and future directions
This article is protected by copyright. All rights reserved
Source: Proteomics. Clinical Applications - October 1, 2014 Category: Biochemistry Authors: Neil A. Goldenberg, Allen D. Everett, David Graham, Timothy J. Bernard, Ulrike Nowak‐Göttl Tags: Review Source Type: research

Venous thromboembolism in children with acute lymphoblastic leukemia
Abstract Venous thromboembolism (VTE) occurs in 0.95–36 % of children with acute lymphoblastic leukemia almost exclusively during chemotherapy. It is most commonly associated with concurrent l-asparaginase and steroid therapy, central venous line use, and inherited thrombophilia. Clinical manifestations regarding the location of VTE include central nervous system thrombosis (sinus venous thrombosis, cerebral infarct/stroke), upper-/lower-limb deep venous thrombosis, pulmonary embolism, and right atrial/intracardiac and superficial venous thrombosis and can be both symptomatic and asymptomatic. The majority of ...
Source: Memo - Magazine of European Medical Oncology - September 1, 2014 Category: Cancer & Oncology Source Type: research

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