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Score Aids Treatment Decision in Mild Large-Vessel Stroke Score Aids Treatment Decision in Mild Large-Vessel Stroke
Location and length of thrombus can identify those at highest risk for early neurologic deterioration, flagging those who may be the best candidates for thrombectomy.Medscape Medical News
Source: Medscape Cardiology Headlines - January 15, 2021 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news

Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research

Organizing stroke systems in the field for patients with suspected large vessel occlusion acute stroke.
Authors: Almekhlafi MA, Holodinsky JK, Hill MD, Kamal N, Goyal M Abstract INTRODUCTION: The dawn of endovascular stroke therapy has reshaped stroke care. Eligible patients need to be rushed to capable centers for intervention. This may entail bypassing closer hospitals that could confirm the diagnosis, administer thrombolytic therapy, then transfer patients for intervention. This has created a set of challenges: identifying endovascular candidates in the field, determining the best transport destination, and getting patients there quickly. Areas covered: This review provides a context for these emerging challenges....
Source: Expert Review of Cardiovascular Therapy - November 20, 2018 Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research

Cerebrovascular Disease and HIV in Singapore: A Single-Centre Study (P1.325)
Conclusions: Prevalence of CVS risk factors was significant in our population. Stroke in HIV patients may result from other disease mechanisms and carries significant mortality and morbidity. Fever at presentation suggests an infective etiology.Disclosure: Dr. Gan holds stock and/or stock options in a company which sponsored research in which Dr. Gan was involved as an investigator. Dr. Saini has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Ng has nothing to disclose. Dr. Tan has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Gan, E., Saini, M., Lee, C.-C., Ng, O.-T., Tan, K. Tags: HIV/AIDS Source Type: research

Identifying and Describing the Impact of Cyclone, Storm and Flood Related Disasters on Treatment Management, Care and Exacerbations of Non-communicable Diseases and the Implications for Public Health
Conclusion Cyclone, flood and storm related disasters impact on treatment management and overall care for people with NCDs. This results in an increased risk of exacerbation of illness or even death. The interruption may be caused by a range of factors, such as damaged transport routes, reduced health services, loss of power and evacuations. The health impact varies according to the NCD. For people with chronic respiratory diseases, a disaster increases the risk of acute exacerbation. Meanwhile, for people with cancer, cardiovascular diseases and diabetes there is an increased risk of their illness exacerbating, which can ...
Source: PLOS Currents Disasters - September 28, 2015 Category: Global & Universal Authors: jc164421 Source Type: research

Programmed Speed Reduction Enables Aortic Valve Opening and Increased Pulsatility in the LVAD-Assisted Heart
Aortic valve opening (AVO) during left ventricular assist device (LVAD) support aids in preventing valve fusion, incompetence, and thrombosis. The programmed low speed algorithm (PLSA) allows AVO intermittently by reducing continuous motor speed during a dwell time. AVO and hemodynamics in the LVAD-assisted heart were measured using a HeartMate II (Thoratec Corporation, Pleasanton, CA) LVAD with a PLSA controller in a mock circulatory loop. Left ventricle and aortic pressures, LVAD, and total aortic flow were measured during pre-LVAD, non-PLSA and PLSA combinations of cardiac function, and LVAD speed. The low cardiac setti...
Source: ASAIO Journal - September 1, 2015 Category: Medical Equipment Tags: Biomedical Engineering Source Type: research

Procoagulant Platelets: Not Just Full of Hot Air.
Abstract Abnormalities in coagulation are a leading cause of disease and death worldwide due to thrombotic events such as myocardial infarction, stroke, etc. It has been estimated that the cost of treatment of these disorders will rise to over 820 billion by the year 2030.(1) At the center of thrombus formation is the platelet, a cell that is seen as the cornerstone of hemostasis and thrombosis. Platelets mainly function to secure hemostasis by acting as the "band-aids of the blood". They are the first responders to sites of vascular injury, bringing with them a membrane surface that provides the "glue" for clot f...
Source: Circulation - September 1, 2015 Category: Cardiology Authors: Battinelli EM Tags: Circulation Source Type: research

Global Public Awareness of Venous Thromboembolism.
CONCLUSIONS: On a global level, public awareness about thrombosis overall, and of VTE in particular, is low. Campaigns to increase public awareness about VTE are needed to reduce the burden from this largely preventable thrombotic disorder. This article is protected by copyright. All rights reserved. PMID: 26084415 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - June 18, 2015 Category: Hematology Authors: Wendelboe AM, McCumber M, Hylek EM, Buller H, Weitz JI, Raskob G, ISTH Steering Committee for World Thrombosis Day Tags: J Thromb Haemost Source Type: research

Global Public Awareness of Venous Thromboembolism
ConclusionsOn a global level, public awareness about thrombosis overall, and of VTE in particular, is low. Campaigns to increase public awareness about VTE are needed to reduce the burden from this largely preventable thrombotic disorder.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 1, 2015 Category: Hematology Authors: Aaron M Wendelboe, Micah McCumber, Elaine M Hylek, Harry Buller, Jeffrey I Weitz, Gary Raskob, Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

What's hot that the other lot got
Fibrinolysis for patients with intermediate-risk PE The use of fibrinolysis for normotensive patients with an intermediate risk of death after acute pulmonary embolism (PE) remains a controversial topic. The PIETHO trial (N Engl J Med 2014;370:1402–11) was a multicentre, double-blind trial, in which 1006 patients with acute PE and evidence of right ventricular dysfunction on echocardiography or CT, as well as positive cardiac troponin test, were randomly assigned to initial treatment with tenecteplase plus heparin, or placebo plus heparin. The primary outcome of death or haemodynamic compromise within 7 days of rando...
Source: Thorax - May 14, 2014 Category: Respiratory Medicine Authors: Rolin, S. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: infectious diseases, HIV/AIDS, Inflammation, Venous thromboembolism, Pulmonary embolism, Radiology (diagnostics) Chest clinic Source Type: research

Stroke in Children with Human Immunodeficiency Virus in Botswana: A Report of Six Cases (P4.303)
CONCLUSIONS: The risk of stroke appears to be increased in children with HIV, though further controlled studies are necessary to further investigate this. Etiologies for stroke in children with HIV includes HIV vasculopathy, HIV cardiomyopathy, and opportunistic infections. Evaluation should include head imaging with vascular imaging, MRI with MRA if possible, and CT. The utility of lumbar puncture and hypercoaguability workup in this population needs to be investigated further. Given the difficulties of monitoring anticoagulation in this setting, low dose aspirin is a reasonable first line treatment.Disclosure: Dr. Khuran...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Khurana, E., Bearden, D. Tags: NeuroAIDS Source Type: research

Ensuring medication adherence with direct oral anticoagulant drugs: Lessons from adherence with vitamin K antagonists (VKAs)
Abstract: Medication adherence (taking drugs properly) is uncommon among patients on warfarin. Poor adherence to warfarin leads to an increase in adverse medical events, including stroke in atrial fibrillation (AF). Factors related to patients, physicians and the health system account for poor adherence. Direct oral anticoagulants (DOACs) are easier to use than warfarin, with fewer drug and food interactions and no need for routine blood monitoring. A proper use of DOACs may reduce the risk of stroke in AF. However, in clinical settings where no laboratory monitoring is needed, a poor medication adherence is common and may...
Source: Thrombosis Research - February 12, 2014 Category: Hematology Authors: Alessandro Di Minno, Gaia Spadarella, Antonella Tufano, Domenico Prisco, Giovanni Di Minno Tags: Mini-Reviews Source Type: research

Development of smartphone application that AIDS stroke screening and identifying nearby acute stroke care hospitals.
Conclusion: This application may be useful for reducing hospital arrival times for thrombolytic candidates. PMID: 24339283 [PubMed - in process]
Source: Yonsei Medical Journal - December 19, 2013 Category: Universities & Medical Training Authors: Nam HS, Heo J, Kim J, Kim YD, Song TJ, Park E, Heo JH Tags: Yonsei Med J Source Type: research