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Treatments in Ischemic Stroke: Current and Future
Background and Aim: Despite progress made over the last 30 years, stroke is still a leading cause of disability and mortality; likewise, its burden is expected to increase over the next decades, due to population growth and aging. The development of drugs with better safety-efficacy profiles as well as strategies able to improve ischemic stroke management from the pre-hospital setting is needed.Summary: The pathophysiology of ischemic stroke involves multiple pathways resulting in cerebral artery obstruction and brain tissue ischemia. To date, the only approved drug for acute ischemic stroke is intravenous thrombolytic alt...
Source: European Neurology - August 2, 2022 Category: Neurology Source Type: research

PREvention of VENous Thromboembolism in Hemorrhagic Stroke Patients – PREVENTIHS Study: A Randomized Controlled Trial and a Systematic Review and Meta-Analysis
Conclusions: In patients with acute ICH, the use of anticoagulants to prevent VTE was safe but the overall level of evidence was low due to the low number of patients included in randomized clinical trials.Eur Neurol
Source: European Neurology - November 13, 2020 Category: Neurology Source Type: research

Assessment of Patients with Intracerebral Hemorrhage or Hemorrhagic Transformation in the VENOST Study
Conclusion: CVST, an important cause of stroke in the young, should be monitored closely if the patients have additional symptoms of headache, multiple sinus involvement, and CH. Older age and parenchymal lesion, either hemorrhagic infarction or intracerebral hemorrhage, imply poor outcome.Eur Neurol
Source: European Neurology - October 30, 2020 Category: Neurology Source Type: research

Cerebral Venous Thrombosis: A Comprehensive Review
Conclusion: CSVT is a potentially fatal neurological condition that is often under-diagnosed due to its nonspecific presentation. Timely diagnosis and treatment can reduce morbidity and mortality, remarkably improving the outcome in affected individuals.Eur Neurol
Source: European Neurology - September 2, 2020 Category: Neurology Source Type: research

Comparative Analysis on Low- and Standard-Dose Regimes of Alteplase Thrombolytic Therapy for Acute Ischemic Stroke: Efficacy and Safety
Conclusion: The efficacy of low-dose alteplase intravenous thrombolytic therapy for AIS was equivalent to the standard-dose regimen but with higher safety.Eur Neurol 2018;79:68 –73
Source: European Neurology - December 14, 2017 Category: Neurology Source Type: research

The Clinical Characteristics of Acute Cerebrovascular Accidents Resulting from Ovarian Hyperstimulation Syndrome
Conclusion: The MCA and ICA are easily involved in stroke resulting from OHSS. The young age may be a risk factor for developing stroke secondary to OHSS. Once thromboembolism develops, administering appropriate therapy is crucial.Eur Neurol 2017;77:221-230
Source: European Neurology - March 2, 2017 Category: Neurology Source Type: research

Susceptibility Vessel Sign in Isolated Brainstem Infarction with Large Artery Occlusion
Conclusions: SVS reflects pathology of deoxidized red cells composition in patients with isolated brainstem infarction. This finding may be useful to explore the different stroke mechanisms and therapy strategies.Eur Neurol 2016;75:251-256
Source: European Neurology - May 12, 2016 Category: Neurology Source Type: research

Is It Acute Stroke or Not - A Prospective Observational Study from a Multidisciplinary Emergency Department
Background: Acute stroke is a medical emergency with various clinical presentations. Since the introduction of systemic thrombolytic treatment, stroke diagnosis has been made quickly and with great caution, and the trend of rapid presentation at hospitals has increased. Methods: In our multidisciplinary Emergency Department, we prospectively collected and analysed data of consecutive patients presenting with suspected acute stroke (SAS) or transient ischemic attack (TIA). Results: Four hundred ten patients (200 men, mean age 68 ± 16, range 17-93 years) with SAS were admitted of which 105 were prehospitally announced as wi...
Source: European Neurology - April 1, 2016 Category: Neurology Source Type: research

Is It Acute Stroke or Not? - A Prospective Observational Study from a Multidisciplinary Emergency Department
Background: Acute stroke is a medical emergency with various clinical presentations. Since the introduction of systemic thrombolytic treatment, stroke diagnosis has been made quickly and with great caution, and the trend of rapid presentation at hospitals has increased. Methods: In our multidisciplinary Emergency Department, we prospectively collected and analysed data of consecutive patients presenting with suspected acute stroke (SAS) or transient ischemic attack (TIA). Results: Four hundred ten patients (200 men, mean age 68 ± 16, range 17-93 years) with SAS were admitted of which 105 were prehospitally announced as wi...
Source: European Neurology - March 31, 2016 Category: Neurology Source Type: research

Thalamic Lesions Caused by Deep Cerebral Venous Thrombosis: A Retrospective Study
Conclusion: Thalamic lesion can be caused by DCVT with neuropsychological and radiological features that should be considered in the differential diagnosis of intracranial artery occlusion or bleeding, especially in young patients. In this small group, most patients survived with few or mild defects.Eur Neurol 2015;74:118-126
Source: European Neurology - September 9, 2015 Category: Neurology Source Type: research

Diagnostic Yield of Venous Thrombosis and Pulmonary Embolism by Combined CT Venography and Pulmonary Angiography in Patients with Cryptogenic Stroke and Patent Foramen Ovale
Background: Paradoxical embolism via a patent foramen ovale (PFO) has been suggested as a potential stroke mechanism. Combined CT venography and pulmonary angiography (CVPA) is a simple, validated and accurate technique to diagnose deep venous thrombosis (DVT) or pulmonary embolism (PE). We sought to assess the prevalence of DVT or PE among patients with PFO and cryptogenic stroke (CS) by CVPA. Methods: Patients were identified retrospectively from a clinical registry of consecutive patients with stroke admitted to our Stroke Unit. The following criteria were required for inclusion in this study: CS, PFO identified by tran...
Source: European Neurology - July 25, 2015 Category: Neurology Source Type: research

Recanalization Rate and Clinical Outcome in Acute Carotid-T Occlusion
Background: Acute carotid-T occlusion results in both low recanalization rates and poor outcomes. We investigated clinical outcomes and recanalization in a rare case of thrombolytic therapy. Methods: A consecutive series of patients with acute carotid-T occlusion who were treated with either bridging intravenous (IV) plus intra-arterial (IA) thrombolysis or IA alone were analyzed. Complete recanalization was defined as a thrombolysis in cerebral infarction (TICI) grade of 3. A favorable outcome was defined as a modified Rankin Scale (mRS) score of ≤2. Results: Of the 40 patients, 6 (15%) had favorable outcomes, and 34 (8...
Source: European Neurology - July 4, 2015 Category: Neurology Source Type: research

Post-Thrombolysis Hemorrhage Risk of Unruptured Intracranial Aneurysms
Conclusion: Intravenous thrombolysis was safe among patients with acute ischemic stroke and incidental unruptured IAs. Future prospective studies with much larger sample sizes are required to clarify the significance of the association between pre-existing unruptured IAs and the development of post-thrombolysis ICH.Eur Neurol 2015;73:37-43
Source: European Neurology - November 7, 2014 Category: Neurology Source Type: research