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Source: Platelets
Condition: Thrombosis

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Total 34 results found since Jan 2013.

Immature platelets and cardiovascular events in patients with stable coronary artery disease
Platelets. 2023 Dec;34(1):2217960. doi: 10.1080/09537104.2023.2217960.ABSTRACTMany patients with coronary artery disease (CAD) have reduced the effect of aspirin, which may partly be explained by immature platelets. We aimed to investigate whether immature platelet markers can predict cardiovascular events in a large cohort of stable CAD patients. A total of 900 stable CAD patients were included and followed for a median of 3 years. We measured markers of immature platelets (platelet count, immature platelet count, immature platelet fraction, mean platelet volume, platelet distribution width, platelet mass, and thrombopoie...
Source: Platelets - May 29, 2023 Category: Hematology Authors: Oliver Buchhave Pedersen Sanne B øjet Larsen Steen Dalby Kristensen Anne-Mette Hvas Erik Lerkevang Grove Source Type: research

Glycoprotein V : the unsolved GPV puzzle
Platelets. 2022 Jan 7:1-8. doi: 10.1080/09537104.2021.2022114. Online ahead of print.ABSTRACTGlycoprotein V (GPV) is a highly expressed 82 KDa platelet surface transmembrane protein which is loosely attached to the GPIb-IX complex. Despite remaining questions concerning its function, GPV presents several unique features which have repercussions in hematology, atherothrombosis, immunology and transfusion. GPV is specifically expressed in platelets and megakaryocytes and is an ideal marker and reporter gene for the late stages of megakaryopoiesis. The ectodomain of GPV can be released by a number of proteases, namely thrombi...
Source: Platelets - January 7, 2022 Category: Hematology Authors: Quentin Kimmerlin Sylvie Moog Catherine Ravanat Catherine Strassel Fran çois Lanza Source Type: research

The voltage-gated K < sup > + < /sup > channel Kv1.3 modulates platelet motility and α < sub > 2 < /sub > β < sub > 1 < /sub > integrin-dependent adhesion to collagen
Platelets. 2021 Aug 4:1-11. doi: 10.1080/09537104.2021.1942818. Online ahead of print.ABSTRACTKv1.3 is a voltage-gated K+-selective channel with roles in immunity, insulin-sensitivity, neuronal excitability and olfaction. Despite being one of the largest ionic conductances of the platelet surface membrane, its contribution to platelet function is poorly understood. Here we show that Kv1.3-deficient platelets display enhanced ADP-evoked platelet aggregation and secretion, and an increased surface expression of platelet integrin αIIb. In contrast, platelet adhesion and thrombus formation in vitro under arterial shear condit...
Source: Platelets - August 5, 2021 Category: Hematology Authors: Joy R Wright Sarah Jones Sasikumar Parvathy Leonard K Kaczmarek Ian Forsythe Richard W Farndale Jonathan M Gibbins Martyn P Mahaut-Smith Source Type: research

Thrombosis in Covid-19 and non-Covid-19 pneumonia: role of platelets
Platelets. 2021 Jun 7:1-9. doi: 10.1080/09537104.2021.1936478. Online ahead of print.ABSTRACTPlatelets may be a target of bacteria and viruses, which can directly or indirectly activate them so promoting thrombosis. In accordance with this, community-acquired pneumonia (CAP) is complicated by ischemia-related vascular disease (myocardial infarction and stroke) in roughly 10% of patients while the incidence of venous thrombosis is uncertain. In CAP platelet biosynthesis of TxA2 is augmented and associated with myocardial infarction; however, a cause-effect relationship is still unclear as unclear is if platelet activation p...
Source: Platelets - June 7, 2021 Category: Hematology Authors: Francesco Violi Vittoria Cammisotto Pasquale Pignatelli Source Type: research

Intravenous abciximab as a rescue therapy for immediate reocclusion after successful mechanical thrombectomy in acute ischemic stroke patients
Conclusions - Our results underscore a key role for platelet aggregation and the potential of Glycoprotein IIb/IIIa antagonists as a rescue therapy in post-MT immediate reocclusion.PMID:33840346 | DOI:10.1080/09537104.2021.1894326
Source: Platelets - April 12, 2021 Category: Hematology Authors: Fran çois Delvoye Stephane Loyau Julien Labreuche Guillaume Taylor Benjamin Maier Michel Piotin Raphael Blanc Simon Escalard Lucas Di Meglio Malek Ben Maacha Hocine Redjem Stanislas Smajda Gabriele Ciccio Sol ène Hébert Candice Sabben Martine Jandrot-P Source Type: research

Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?
Platelets. 2021 Feb 26:1-8. doi: 10.1080/09537104.2021.1887469. Online ahead of print.ABSTRACTGPVI is a critical signaling receptor responsible for collagen-induced platelet activation and a promising anti-thrombotic target in conditions such as coronary artery thrombosis, ischemic stroke, and atherothrombosis. This is due to the ability to block GPVI while having minimal effects on hemostasis, making it a more attractive target over current dual-antiplatelet therapy (DAPT) with acetyl salicylic acid and P2Y12 inhibitors where bleeding can be a problem. Our current understanding of how the structure of GPVI relates to func...
Source: Platelets - February 26, 2021 Category: Hematology Authors: Joanne C Clark Foteini-Nafsika Damaskinaki Yam Fung Hilaire Cheung Alexandre Slater Steve P Watson Source Type: research

Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases.
Authors: Harbi MH, Smith CW, Nicolson PLR, Watson SP, Thomas MR Abstract Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease. However, antiplatelet medications may cause bleeding and, furthermore, thrombotic events may still recur despite treatment. The interaction of collagen with GPVI receptors on the surface of platelets has been identified as one of the major players in the pathophysiology of arterial thrombosis that occurs following atherosclerotic plaque rupture. Promising...
Source: Platelets - December 15, 2020 Category: Hematology Tags: Platelets Source Type: research

Immunothrombosis and thromboinflammation in host defense and disease.
Authors: Martinod K, Deppermann C Abstract Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein ...
Source: Platelets - September 10, 2020 Category: Hematology Tags: Platelets Source Type: research