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Three-year changes of prothrombotic factors in a cohort of South Africans with a high clinical suspicion of obstructive sleep apnea.
Abstract A hypercoagulable state might be one important mechanism linking obstructive sleep apnea (OSA) with incident myocardial infarction and stroke. However, previous studies on prothrombotic factors in OSA are not uniform and cross-sectional. We longitudinally studied prothrombotic factors in relation to OSA risk, adjusting for baseline levels of prothrombotic factors, demographics, metabolic parameters, aspirin use, and life style factors. The Berlin Questionnaire and/or neck circumference were used to define high OSA risk in 329 South African teachers (48.0 % male, 44.6 % black) at baseline and at three-...
Source: Thrombosis and Haemostasis - September 3, 2015 Category: Hematology Authors: von Känel R, Malan NT, Hamer M, Lambert GW, Schlaich M, Reimann M, Malan L Tags: Thromb Haemost Source Type: research

D-dimer relates positively with increased blood pressure in black South Africans: The SABPA study
Conclusion: The black population had a more prothrombotic profile, with higher levels of coagulation markers and inhibited fibrinolysis, than the white study participants. The positive association between blood pressure and elevated D-dimer in the blacks may contribute to the high prevalence of hypertension and related increased cardiovascular and cerebrovascular risk in this group.
Source: Thrombosis Research - April 8, 2014 Category: Hematology Authors: Leandi Lammertyn, Aletta E. Schutte, Marlien Pieters, Rudolph Schutte Tags: Coagulation and Fibrinolysis Source Type: research