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E-033 Optimization of endovascular treatment for patients with acute carotid plaque rupture and free- floating thrombus by use of two overlapping closed-cell stents with different radial force
ConclusionUse of the Carotid Wallstent as the first stent to secure the free-floating thrombus allows save delivery of the Xact stent which then adds a second closed-cell mesh layer as well as the needed radial force to expand the stent construct. This approach may decrease if not eliminate the need for post-stent angioplasty in the acute setting thus decreasing risk of thromboembolic complication.Disclosures A. Kuhn: None. J. Singh: None. S. Sarid: None. M. Garcia: None. A. Puri: 1; C; NIH, Microvention, Cerenovus, Medtronic Neurovascular and Stryker Neurovascular. 2; C; Medtronic Neurovascular, Stryker NeurovascularBalt,...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Sarid, S., Garcia, M., Puri, A. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-055 Internal carotid artery reconstruction with flow diverting stents in the treatment of acute ischemic stroke: technical considerations and medical management
ConclusionsFDS appear to be a safe and effective tool for reconstruction of a symptomatic dissection in tortuous cervical ICAs. Their flexibility allows conformation to complex anatomies and they can be traversed multiple times by aspiration catheters/stentrievers. We found excellent patency at follow up. The unique challenges posed by utilization of high-profile stents in acute stroke require appropriate technical execution and medical management.Disclosures E. Orru: None. F. Bounni: None. M. Marosfoi: None. N. Patel: None. A. Wakhloo: 1; C; Philips medical. 2; C; Stryker, Phenox. 4; C; InNeuroCo, EpiEP, Neural Analytics, ThrombX.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Orru, E., Bounni, F., Marosfoi, M., Patel, N., Wakhloo, A. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

E-157 Emergent intracranial stenting for symptomatic basilar artery and intradural vertebral artery stenosis
ConclusionEmergent intracranial stenting for symptomatic stenoses in the posterior circulation is feasible and safe when compared to the natural history of the disease.Disclosures A. Kuhn: None. J. Singh: None. F. Massari: None. A. Puri: 1; C; NIH, Microvention, Cerenovus, Medtronic Neurovascular and Stryker Neurovascular. 2; C; Medtronic Neurovascular, Stryker NeurovascularBalt, Q’Apel Medical, Cerenovus, Microvention, Imperative Care, Agile, Merit, CereVasc and Arsenal Medical. 4; C; InNeuroCo, Agile, Perfuze, Galaxy and NTI.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Kuhn, A., Singh, J., Massari, F., Puri, A. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Efficacy outcomes and safety measures of intravenous tirofiban or eptifibatide for patients with acute ischemic stroke: a systematic review and meta-analysis of prospective studies
AbstractTo review the literature for randomized control trials (RCTs) and prospective cohort studies investigating the safety and efficacy of tirofiban and eptifibatide in patients with acute ischemic stroke (AIS). PubMed, Embase, and the Cochrane library were searched for available papers published up to September 2021. The efficacy was evaluated based on the 3-month favorable outcome [modified Rankin scale (mRS)  = 0–1], functional outcome (mRS = 0–2), and the last available National Institutes of Health Stroke Scale (NIHSS) score measured in each study. Twelve studies (two RCTs and 10 prospective cohorts) an...
Source: Journal of Thrombosis and Thrombolysis - November 15, 2021 Category: Hematology Source Type: research

Safety and Efficacy of Pharmaco-invasive Approach Using Streptokinase Compared With Primary Percutaneous Coronary Angiography
Conclusion: Utilizing streptokinase in early re-perfused patients by PI approach (≤3 hrs) seems safe and efficient when PPCI delay (>120 min from symptom onset) is the other option.
Source: Critical Pathways in Cardiology - August 28, 2021 Category: Cardiology Tags: Original Study Source Type: research

Potential applications of venom peptides as anti-thrombotic agents in arterial & deep-vein thrombosis.
CONCLUSION: Ancrod isolated from Malayan pit viper venom can cause reduction in level of blood fibrinogen and has been effectively tried in various ischemic conditions, including stroke. In order to search for novel lead molecules, the emphasis should be on isolation and characterization of pharmacologically active snake venoms proteins affecting blood coagulation and platelet aggregation. In this review an attempt has been made to recapitulates and discuss venoms of different animals and arthropod having anticoagulant peptides for their potential use in therapeutics and diagnostics. PMID: 29921198 [PubMed - as supplied by publisher]
Source: Protein and Peptide Letters - June 13, 2018 Category: Biochemistry Authors: Khan S, Gul A, Noreen R, Ashraf M, Ahmad S, Awan SB Tags: Protein Pept Lett Source Type: research

Shear ‐sensitive nanocapsule drug release for site‐specific inhibition of occlusive thrombus formation
ConclusionsTargeted delivery of eptifibatide by shear‐sensitive nanocapsules offers site‐specific antiplatelet potential, and may form a basis for developing more potent and safer antiplatelet drugs.
Source: Journal of Thrombosis and Haemostasis - April 9, 2017 Category: Hematology Authors: C. P. Molloy, Y. Yao, H. Kammoun, T. Bonnard, T. Hoefer, K. Alt, F. Tovar ‐Lopez, G. Rosengarten, P. A. Ramsland, A. D. Meer, A. Berg, A. J. Murphy, C. E. Hagemeyer, K. Peter, E. Westein Tags: Original Article Source Type: research

Ischemic Stroke After Treatment of Intraprocedural Thrombosis During Stent-Assisted Coiling and Flow Diversion Brief Report
Conclusions—Current protocols for treatment of intraprocedural thrombosis associated with placement of intra-arterial devices were effective in preventing ischemic stroke in ≈80% of cases. Current smoking was the only independent predictor of ischemic stroke.
Source: Stroke - March 27, 2017 Category: Neurology Authors: Nimer Adeeb, Christoph J. Griessenauer, Justin M. Moore, Paul M. Foreman, Hussain Shallwani, Rouzbeh Motiei-Langroudi, Raghav Gupta, Carlos E. Baccin, Abdulrahman Alturki, Mark R. Harrigan, Adnan H. Siddiqui, Elad I. Levy, Christopher S. Ogilvy, Ajith J. Tags: Cerebral Aneurysm, Ischemic Stroke Brief Reports Source Type: research

Shear sensitive nanocapsule drug release for site specific inhibition of occlusive thrombus formation.
CONCLUSIONS: Targeted delivery of eptifibatide by shear-sensitive nanocapsules offers site specific antiplatelet potential and may form a basis for developing more potent and safer antiplatelet drugs. This article is protected by copyright. All rights reserved. PMID: 28267256 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - March 6, 2017 Category: Hematology Authors: Molloy CP, Yao Y, Kammoun H, Bonnard T, Hoefer T, Alt K, Tovar-Lopez F, Rosengarten G, Ramsland PA, van der Meer AD, van den Berg A, Murphy AJ, Hagemeyer CE, Peter K, Westein E Tags: J Thromb Haemost Source Type: research

E-067 Endovascular Approach in the Repair of the Middle Cerebral Artery Aneurysm Including Those with Wide Neck and Complex in Morphology-A Case Series
ConclusionsEndovascular repair of the MCA aneurysm inclosing those with wide neck and complex are not only safe and feasible, but associated with high long-term functional outcome. Therefore, endovascular options must be offered to patients prior to surgical clipping of a MCA aneurysm. Further study may be warranted.DisclosuresY. Lodi: None. V. Reddy: None.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Lodi, Y., Reddy, V. Tags: Electronic poster abstracts Source Type: research

Comparison between the Outcomes of Intracoronary and Intravenous Administration of Eptifibatide during Primary Percutaneous Coronary Intervention in Patients with Acute ST-Elevation Myocardial Infarction.
CONCLUSIONS: IC administration of eptifibatide during PPCI in patients with STEMI in comparison with IV administration of eptifibatide is associated with significantly better coronary reperfusion and improved clinical outcomes (IRCT2012090510751N1). PMID: 26632161 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - December 5, 2015 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Abstract 245: Cost Effectiveness and Safety of Abbreviated Eptifibatide Infusion in Veterans Undergoing Percutaneous Coronary Intervention Session Title: Poster Session II
Conclusion: In this real world cohort of patients undergoing PCI, an abbreviated 2 hour eptifibatide infusion after PCI was safe and had a cost savings of greater than 50% per patient, when compared with a standard 18 hour infusion. This approach is more cost-effective and should be considered in patients undergoing PCI who are not pretreated with dual antiplatelet therapy.
Source: Circulation: Cardiovascular Quality and Outcomes - April 29, 2015 Category: Cardiology Authors: Ghadban, R., Shah, A., Ampadu, J., Linneman, T., Thomas, J.-A., Forsberg, M., Stolker, J., Klein, A. Tags: Session Title: Poster Session II Source Type: research

Rescue Treatment of Thromboembolic Complications during Endovascular Treatment of Cerebral Aneurysms: A Meta-Analysis FELLOWS' JOURNAL CLUB
CONCLUSIONS: Rescue therapy with thrombolytic agents resulted in significantly more morbidity than rescue therapy with glycoprotein IIb/IIIa inhibitors. Tirofiban/eptifibatide resulted in significantly higher recanalization rates compared with abciximab.
Source: American Journal of Neuroradiology - January 13, 2015 Category: Radiology Authors: Brinjikji, W., Morales-Valero, S. F., Murad, M. H., Cloft, H. J., Kallmes, D. F. Tags: FELLOWS ' JOURNAL CLUB Source Type: research