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Use of antidepressants in unipolar depression in the elderly
CONCLUSIONS: Unipolar major depressive episodes in the elderly are frequent and their medicinal treatment has specific features. Knowing the specificities of antidepressant use in the elderly allows to optimize its efficiency and to limit the risk of inappropriate prescription leading to harmful adverse effects.PMID:35153054 | DOI:10.1016/j.encep.2021.11.006
Source: L Encephale - February 14, 2022 Category: Psychiatry Authors: A Pericaud C Straczek F Montastruc M Leboyer A Yrondi C Arbus Source Type: research

Warfarin and SSRIs
Depression frequently occurs in the setting of cardiovascular disease, including atrial fibrillation. Anticoagulants such as warfarin are commonly used in patients with atrial fibrillation in order to prevent the occurrence of stroke, while selective serotonin reuptake inhibitors (SSRIs), the mainstays of antidepressant pharmacology, have been associated with abnormal coagulation and have been reported to cause bleeding. This effect of the SSRIs may be secondary to their impairment of platelet aggregation and/or their inhibitory effects on cytochrome P‐450 enzymes, including those involved in the elimination of warfarin.
Source: The Brown University Psychopharmacology Update - November 19, 2017 Category: Psychiatry Authors: Y. W. Francis Lam Tags: Drug ‐Drug Interactions Source Type: research

Low medical morbidity and mortality after acute courses of electroconvulsive therapy in a population ‐based sample
ConclusionMorbidity and mortality events after ECT treatments were relatively low, supporting ECT as a low‐risk medical procedure.
Source: Acta Psychiatrica Scandinavica - September 18, 2017 Category: Psychiatry Authors: D. M. Blumberger, D. P. Seitz, N. Herrmann, J. G. Kirkham, R. Ng, C. Reimer, P. Kurdyak, A. Gruneir, M. J. Rapoport, Z. J. Daskalakis, B. H. Mulsant, S. N. Vigod Tags: Original Article Source Type: research

Platelet haemostatic function in psychiatric disorders: Effects of antidepressants and antipsychotic drugs.
Conclusions Understanding the role of platelet activation in psychiatric disorders such as schizophrenia or depression and medication may improve therapies in the future. PMID: 27112326 [PubMed - as supplied by publisher]
Source: The World Journal of Biological Psychiatry - April 25, 2016 Category: Psychiatry Authors: Dietrich-Muszalska A, Wachowicz B Tags: World J Biol Psychiatry Source Type: research

Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database
DiscussionThe results of this study will help to establish the relative safety and balance of risks for different antidepressant drugs in people aged under 65.
Source: BMC Psychiatry - Latest articles - May 10, 2013 Category: Psychiatry Authors: Carol CouplandRichard MorrissAntony ArthurMichael MooreTrevor HillJulia Hippisley-Cox Source Type: research