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Long-term effectiveness and safety of cilostazol versus clopidogrel in secondary prevention of noncardioembolic ischemic stroke
ConclusionsThis real-world study suggests that cilostazol is effective and safe for noncardioembolic ischemic stroke and may be associated with better effectiveness in hypertensive patients compared to clopidogrel.
Source: European Journal of Clinical Pharmacology - June 13, 2023 Category: Drugs & Pharmacology Source Type: research

Race and Socioeconomic Disparities in Proximal Aortic Surgery
CONCLUSIONS: Patients of Non-White race undergoing proximal aortic surgery have less insurance coverage, more urgent procedures, and a higher comorbidity burden than White patients; which translates to Non-White patients having significantly higher morbidity. A greater focus on non-fatal outcome differentials and improving access to care likely will improve aortic surgery disparities.PMID:37031768 | DOI:10.1016/j.athoracsur.2023.03.032
Source: The Annals of Thoracic Surgery - April 9, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Paige Newell Cheryl Zogg Sainath Asokan Alexander Reed Thais Faggion Vinholo Morgan Harloff Sameer Hirji Mariam Kerolos Tsuyoshi Kaneko Ashraf Sabe Source Type: research

Utilization of triple antithrombotic therapy in patients with atrial fibrillation undergoing percutaneous coronary intervention
ConclusionsThe utilization of TAT following PCI among high-stroke risk AF patients steadily increased from 2011 to 2020, reaching 65.4% by the end of the study period. However, in 2020, a significant proportion of 29.4% of patients still received DAPT, indicating that many AF patients undergoing PCI did not receive adequate antithrombotic therapy.
Source: European Journal of Clinical Pharmacology - February 24, 2023 Category: Drugs & Pharmacology Source Type: research

Long-term stroke and major bleeding risk in patients with non-valvular atrial fibrillation: A comparative analysis between non-vitamin K antagonist oral anticoagulants and warfarin using a clinical data warehouse
ConclusionsIn this CDW based study, NOACs are more effective and safer than warfarin in patients with AF even with long-term follow-up. NOACs should be used to prevent ischemic stroke in patients with AF
Source: Frontiers in Neurology - January 26, 2023 Category: Neurology Source Type: research

Vitamin-K-antagonist phenprocoumon versus direct oral anticoagulants in patients with atrial fibrillation: a real-world analysis of German claims data
Conclusions The small superiority or non-inferiority of DOACs over warfarin seen in the RCTs might not translate into relevant advantages of DOACs over phenprocoumon. To confirm the hypothesis, an RCT with phenprocoumon is needed. Next to the safety and effectiveness assessments other factors might also play a substantial role in the decision on the right OAC for stroke prevention.
Source: BMJ Open - January 2, 2023 Category: General Medicine Authors: Warkentin, L., Klohn, F., Deiters, B., Kühlein, T., Hueber, S. Tags: Open access, Pharmacology and therapeutics Source Type: research

Apixaban Versus Rivaroxaban in Patients With Atrial Fibrillation and Valvular Heart Disease : A Population-Based Study
CONCLUSION: In this study of patients with AF and VHD, patients receiving apixaban had a lower risk for ischemic stroke or systemic embolism and for bleeding when compared with those receiving rivaroxaban.PRIMARY FUNDING SOURCE: National Institutes of Health.PMID:36252244 | DOI:10.7326/M22-0318
Source: Annals of Internal Medicine - October 17, 2022 Category: Internal Medicine Authors: Ghadeer K Dawwas Adam Cuker Geoffrey D Barnes James D Lewis Sean Hennessy Source Type: research

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