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Mortality due to bleeding, myocardial infarction and stroke in dialysis patients
Journal of Thrombosis and Haemostasis,Volume 0, Issue ja, -Not available-.
Source: Journal of Thrombosis and Haemostasis - July 31, 2018 Category: Hematology Authors: Gurbey Ocak , Marlies Noordzij , Maarten B. Rookmaaker , Aleix Cases , C écile Couchoud , James G. Heaf , Faiçal Jarraya , Johan De Meester , Jaap W. Groothoff , Bård E. Waldum‐Grevbo , Runolfur Palsson , Halima Resic , Césa Source Type: research

Comparison of the Ecarin Chromogenic Assay and Diluted Thrombin Time for Quantification of Dabigatran Concentrations
ConclusionsFor detection of levels below 50 ng/mL both tests have specificities of at least 96%, suggesting that they accurately detect even low levels of drug. Therefore, regardless of whether a chromogenic or clot‐based platform is preferred, the STA‐ECA‐II and dTT are useful tests for measuring dabigatran concentrations. Unfortunately, neither test is licensed by the United States Food and Drug Administration. Although approved in other jurisdictions, the dTT and STA‐ECA‐II are not widely or rapidly available in most hospitals. Therefore, cooperation between regulators and hospitals is urgently needed to rende...
Source: Journal of Thrombosis and Haemostasis - October 4, 2017 Category: Hematology Authors: Iqbal H. Jaffer, Noel Chan, Robin Roberts, James C. Fredenburgh, John W. Eikelboom, Jeffrey I. Weitz Tags: Original Article ‐ Coagulation Source Type: research

ARHGEF10 knockout inhibits platelet aggregation and protects mice from thrombus formation
ConclusionsARHGEF10 serves as an important regulator in platelet shape change, spreading and aggregation. Moreover, ARHGEF10 also plays an important role in arterial thrombosis formation.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - August 11, 2017 Category: Hematology Authors: Dai ‐Hua Lu, Chun‐Chieh Hsu, Shiu‐Wen Huang, Huang‐Ju Tu, Tur‐Fu Huang, Houng‐Chi Liou, Hsiao‐Mei Liao, Chia‐Hsiang Chen, Wen‐Mei Fu, Susan Shur‐Fen Gau Tags: Original Article – Platelets Source Type: research

Assessment of clinically relevant bleeding as a surrogate outcome for major bleeding: validation by meta ‐analysis of randomized controlled trials
ConclusionDespite an apparent correlation between CRB and major bleeding in major orthopedic surgery, AF and for double‐blind acute VTE studies, the wide CIs suggest that CRB might not be an acceptable surrogate outcome in any of these settings.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - May 1, 2017 Category: Hematology Authors: S. Laporte, C. Chapelle, L. Bertoletti, E. Ollier, P. Zufferey, J ‐C Lega, A. Merah, H. Décousus, S. Schulman, G. Meyer, M. Cucherat, P. Mismetti Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Shear ‐sensitive nanocapsule drug release for site‐specific inhibition of occlusive thrombus formation
ConclusionsTargeted delivery of eptifibatide by shear‐sensitive nanocapsules offers site‐specific antiplatelet potential, and may form a basis for developing more potent and safer antiplatelet drugs.
Source: Journal of Thrombosis and Haemostasis - April 9, 2017 Category: Hematology Authors: C. P. Molloy, Y. Yao, H. Kammoun, T. Bonnard, T. Hoefer, K. Alt, F. Tovar ‐Lopez, G. Rosengarten, P. A. Ramsland, A. D. Meer, A. Berg, A. J. Murphy, C. E. Hagemeyer, K. Peter, E. Westein Tags: Original Article Source Type: research

A First ‐in‐human Study of DS‐1040, an Inhibitor of the Activated Form of Thrombin‐Activatable Fibrinolysis Inhibitor, in Healthy Subjects
ConclusionsThe novel fibrinolysis‐enhancing agent DS‐1040 has favorable PK/PD properties and safety profile, which warrants further clinical development.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 31, 2017 Category: Hematology Authors: Jin Zhou, Jarema Kochan, Ophelia Yin, Vance Warren, Cynthia Zamora, George Atiee, Joseph Pav, Yasushi Orihashi, Vijay Vashi, Victor Dishy Tags: Original Article ‐ Fibrinolysis Source Type: research

Maresin 1 induces a novel pro ‐resolving phenotype in human platelets
ConclusionsThese data support the concept that SPMs differentially regulate platelet function and may represent a novel class of antiplatelet agents. SPMs also may play an important role in the resolution of inflammation in cardiovascular diseases.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 11, 2017 Category: Hematology Authors: Katie L. Lannan, Sherry L. Spinelli, Neil Blumberg, Richard P. Phipps Tags: Original Article ‐ Platelets Source Type: research

Optimising stroke prevention in elderly patients with atrial fibrillation
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - August 24, 2016 Category: Hematology Authors: Gregory Y H Lip Tags: Commentary Source Type: research

The patterns of anticoagulation control and the risk of stroke, bleeding and mortality in patients with non‐valvular atrial fibrillation: comment
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - June 30, 2016 Category: Hematology Authors: Simon Mantha, Stephan Moll, Patrick Hilden, Sean Devlin, Adam Rose Tags: Letter ‐ to the Editor Source Type: research

Bleeding Risk Assessment in Atrial Fibrillation: Observations on the Use and Misuse of Bleeding Risk Scores
This article is protected by copyright. All rights reserved
Source: Journal of Thrombosis and Haemostasis - May 31, 2016 Category: Hematology Authors: Gregory Y H Lip, Deirdre A Lane Tags: Commentary Source Type: research

Impact of point‐of‐care international normalized ratio monitoring on quality of treatment with vitamin K antagonists in non‐self‐monitoring patients: a cohort study
ConclusionsAlthough associated with lower TTR, POC INR monitoring is a safe and effective alternative to laboratory INR monitoring in NSM patients on VKA.
Source: Journal of Thrombosis and Haemostasis - March 29, 2016 Category: Hematology Authors: J. S. Biedermann, N. Rein, A. M. H. P. Besselaar, P. N. Buhre, M. P. M. Maat, F. J. M. Meer, F. W. G. Leebeek, M. J. H. A. Kruip Tags: Original Article Source Type: research

Contemporary antiplatelet treatment in acute coronary syndrome patients undergoing percutaneous coronary intervention: One‐year outcomes from the GReek AntiPlatelet Registry (GRAPE)
ConclusionsIn real‐word ACS/PCI patients, prasugrel offered better antiischemic protection than clopidogrel, while use of both novel agents is accompanied by more frequent bleeding events.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - March 1, 2016 Category: Hematology Authors: D. Alexopoulos, I. Xanthopoulou, S. Deftereos, M. Hamilos, G. Sitafidis, I. Kanakakis, I. Pentara, M. Vavouranakis, P. Davlouros, G. Hahalis, J. Goudevenos Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Impact of point‐of‐care INR monitoring on quality of treatment with vitamin K antagonists in non‐self‐monitoring patients: a cohort study
ConclusionsAlthough associated with lower TTR, point‐of‐care INR monitoring is a safe and effective alternative to laboratory INR monitoring in non‐self‐monitoring patients on vitamin K antagonists.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 25, 2016 Category: Hematology Authors: Joseph S. Biedermann, Nienke Rein, Antonius M.H.P. van den Besselaar, Peter N. Buhre, Moniek P.M. de Maat, Felix J.M. van der Meer, Frank W.G. Leebeek, Marieke J.H.A. Kruip Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - December 15, 2015 Category: Hematology Authors: Jerrold H Levy, Walter Ageno, Noel C Chan, Mark Crowther, Peter Verhamme, Jeffrey I Weitz, Tags: Recommendations and Guidelines Source Type: research

Prediction models for intracranial hemorrhage or major bleeding in patients on antiplatelet therapy: a systematic review and external validation study
ConclusionA limited number of prediction models is available that predict intracranial hemorrhage or major bleeding in patients on antiplatelet therapy. Methodological quality of the models varied, but was generally low. Predictive performance in patients with cerebral ischemia was poor. In order to reliably predict the risk of bleeding in patients with cerebral ischemia, development of a prediction model according to current methodological standards is needed.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - November 12, 2015 Category: Hematology Authors: Nina A. Hilkens, Ale Algra, Jacoba P. Greving Tags: Original Article ‐ Platelets Source Type: research

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