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Total 54 results found since Jan 2013.

Inflammation May Be the Culprit Behind Our Deadliest Diseases
In the early days of my medical residency, I met a man whom we’ll call Jason. He arrived to our emergency room on a holiday, nonchalant yet amiable, and complained of mild chest pain. Jason was tall and trim, with a strong South Boston accent and fingertips still faintly stained from his last home-improvement project. He was only 45 years old, but he looked much younger. He didn’t smoke, barely drank alcohol, and his cholesterol levels had always been normal. No one in his family had a history of heart disease. He asked us if we could work quickly—he wanted to be home for dinner with his daughters. [time-...
Source: TIME: Health - April 11, 2023 Category: Consumer Health News Authors: Shilpa Ravella Tags: Uncategorized freelance health Source Type: news

The Impact of Longitudinal Data-Completeness of Electronic Health Record Data on the Prediction Performance of Clinical Risk Scores
Clin Pharmacol Ther. 2023 Apr 7. doi: 10.1002/cpt.2901. Online ahead of print.ABSTRACTThe impact of electronic health record (EHR) discontinuity, i.e., receiving care outside of a given EHR system, on EHR-based risk prediction is unknown. We aimed to assess the impact of EHR-continuity on performance of clinical risk scores. The study cohort consisted of patients aged ≥65 years with ≥1 EHR encounter in the two networks in Massachusetts (MA, 2007/1/1-2017/12/31, internal training and validation dataset), and one network in North Carolina (NC, 2007/1/1-2016/12/31, external validation dataset) that were linked with Medica...
Source: Clinical Pharmacology and Therapeutics - April 7, 2023 Category: Drugs & Pharmacology Authors: Yinzhu Jin Janick G Weberpals Shirley V Wang Rishi J Desai David Merola Kueiyu Joshua Lin Source Type: research

A Real-World Exploration into Clinical Outcomes of Direct Oral Anticoagulant Dosing Regimens in Morbidly Obese Patients Using Data-Driven Approaches
ConclusionData-driven approaches can identify key factors associated with clinical outcomes following the dosing of DOACs in morbidly obese patients. This will help design further studies to explore well tolerated and effective DOAC doses for morbidly obese patients.
Source: American Journal of Cardiovascular Drugs - March 6, 2023 Category: Cardiology Source Type: research

Second death linked to potential antibody treatment for Alzheimer ’s disease
A 65-year-old woman who was receiving a promising experimental treatment to slow the cognitive decline caused by her early Alzheimer’s disease recently died from a massive brain hemorrhage that some researchers link to the drug. The clinical trial death, described in an unpublished case report Science has obtained, is the second thought to be associated with the antibody called lecanemab. The newly disclosed fatality intensifies questions about its safety and how widely lecanemab should be prescribed if ultimately approved by regulators. The woman, who received infusions of the antibody as part of the trial, s...
Source: ScienceNOW - November 28, 2022 Category: Science Source Type: news

Are there differences in cardiothoracic surgery performed by trainees versus fully trained surgeons?
DiscussionTrainees can perform cardiothoracic surgery in dedicated high-volume units with outcomes comparable to those of fully trained surgeons.
Source: Journal of Cardiac Surgery - September 13, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Maria Comanici, Mohammad Yousuf Salmasi, Katharina L. Schulte, Shahzad G. Raja, Rizwan Q. Attia Tags: REVIEW Source Type: research

A Nomogram Model for Predicting Type-2 Myocardial Infarction Induced by Acute Upper Gastrointestinal Bleeding
ConclusionThe nomogram was proven to be a useful tool for the risk stratification of T2MI in AUGIB patients, and is helpful for the early identification of AUGIB patients who are prone to T2MI for early intervention, especially in emergency departments and intensive care units.
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - March 15, 2022 Category: Research Source Type: research

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Potential effects on cardiometabolic risk factors and body composition by short message service (SMS)-guided training after recent minor stroke or transient ischaemic attack: post hoc analyses of the STROKEWALK randomised controlled trial
Conclusions No clear effect of 3 months daily mobile phone delivered training instructions was detected on body composition, cardiovascular biochemical risk factors or self-perceived health. Further research is needed to evaluate secondary prevention efforts in larger populations after recent stroke. Trial registration number NCT02902367.
Source: BMJ Open - October 18, 2021 Category: General Medicine Authors: Vahlberg, B. M., Lundström, E., Eriksson, S., Holmback, U., Cederholm, T. Tags: Open access, Rehabilitation medicine Source Type: research

TAB-TICI Score: Successful Recanalization Score After Endovascular Thrombectomy in Acute Stroke
Conclusion: The TAB-TICI score is a valid and easy-to-use tool to more comprehensively define successful recanalization after endovascular thrombectomy in acute stroke patients with large vessel occlusion.
Source: Frontiers in Neurology - October 14, 2021 Category: Neurology Source Type: research

Emergency Medical Service Workers Battle a Hurricane, and COVID-19, To Bring Health Care To New Orleans
As Hurricane Ida pounded the coast of New Orleans with downpours and 150-mile-per-hour winds on the afternoon of Aug. 29, New Orleans Emergency Medical Services had to reverse course after spending 18 months running around the city at full speed battling COVID-19: staying put. For 13 hours and 41 minutes, as the storm’s worst shook their community, the workers hunkered down at their base, keeping themselves safe to be ready to protect others from whatever came next. However, the deluge of 9-1-1 calls didn’t come to a halt as EMS waited out the storm. So, after EMS workers were given the go-ahead to rush back in...
Source: TIME: Health - September 7, 2021 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized climate change COVID-19 healthscienceclimate Source Type: news

Longitudinal Gastrectomy for Nonbariatric Indications
CONCLUSION: LLG seems to be an appropriate intervention for various gastric pathologies. Training of residents and fellows in the minimally invasive surgical steps of LLG is encouraged.PMID:34035960 | PMC:PMC8124009 | DOI:10.1155/2021/9962130
Source: Minimally Invasive Surgery - May 26, 2021 Category: Surgery Authors: Oluwatobi O Onafowokan Aboubakr Khairat Mohammad Jamal Hemant Chatrath Hugo J R Bonatti Source Type: research