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Condition: Atrial Fibrillation

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Total 15704 results found since Jan 2013.

Stroke in Atrial Fibrillation and Other Atrial Dysrhythmias
AbstractPurpose of ReviewAtrial fibrillation (AF) is a major risk factor for systemic embolism and ischaemic stroke. Furthermore, AF-related strokes are associated with higher mortality, greater disability, longer hospital stays and lower rates of hospital discharge than strokes caused by other reasons. The aim of this review to summarise the existing evidence on the association of AF with ischemic stroke and provide insights on the pathophysiological mechanisms and the clinical management of patients with AF in order to reduce the burden of ischemic stroke.Recent FindingsBeyond Virchow ’s triad, several pathophysiologic...
Source: Current Cardiology Reports - March 28, 2023 Category: Cardiology Source Type: research

Stroke and Noninfective Native Valvular Disease
AbstractPurpose of ReviewEmbolic stroke of undetermined source is a challenging clinical entity. While less common than atrial fibrillation and endocarditis, many noninfective heart valve lesions have been associated with stroke and may be considered as culprits for cerebral infarcts when other more common causes are excluded. This review discusses the epidemiology, pathophysiology, and management of noninfective valvular diseases that are commonly associated with stroke.Recent FindingsCalcific debris from degenerating aortic and mitral valves may embolize to the cerebral vasculature causing small- or large-vessel ischemia...
Source: Current Cardiology Reports - March 27, 2023 Category: Cardiology Source Type: research

Family Physician Prescribing Practices and Perspectives on Shared Decision-Making Regarding the Use of Oral Anticoagulants for Stroke Prevention in Patients 75  Years or Older With Atrial Fibrillation
CONCLUSION: Family physicians strongly consider patient risks and utilize risk-assessment tools when initiating OAC in older adults with AF. Despite all physicians reporting the use of shared decision-making and that their patients were educated on the indications for OAC, confidence in initiating treatment was variable. Further exploration into factors impacting physician confidence is needed.PMID:36960556 | DOI:10.1177/21501319231164060
Source: Primary Care - March 24, 2023 Category: Primary Care Authors: Jahaan Ali Reza Abbasi-Dezfouly Sheny Khera Paul Kivi Peter George Jaminal Tian Source Type: research

Integrative identification of hub genes in development of atrial fibrillation related stroke
ConclusionsHub genesEIF4E3,ZNF595,ZNF700,MATR3,ACKR4,ANXA3,SEPSECS-AS1, andRNF166 have potential as novel biomarkers and therapeutic targets in AF-related stroke. Thehsa_circ_0018657/hsa-miR-198/EIF4E3 axis could play an important role regulating the development of AF-related stroke.
Source: PLoS One - March 23, 2023 Category: Biomedical Science Authors: Kai Huang Source Type: research

Echocardiographic correlates of MRI imaging markers of cerebral small-vessel disease in patients with atrial-fibrillation-related ischemic stroke
ConclusionIn patients with AF-related ischemic stroke, LVPW is associated with a higher risk of lacunes and CSVD burden, while RAD was associated with greater CSO-EPVS. Larger studies are required to determine these associations and to elucidate if these associations can help facilitate cognitive evaluation and brain MRI screening.
Source: Frontiers in Neurology - March 23, 2023 Category: Neurology Source Type: research

Ischemic Stroke and Systemic Embolism Among One-and-Done Direct Oral Anticoagulant Users with Non-valvular Atrial Fibrillation
CONCLUSION: A substantial proportion of patients were one-and-done DOAC users, which was associated with significantly higher risk of ischemic stroke/SE events. There is an unmet need to improve access and encourage continuous use of DOACs among patients with NVAF so that severe and fatal complications may be mitigated.PMID:36947331 | DOI:10.1007/s12325-023-02483-4
Source: Adv Data - March 22, 2023 Category: Epidemiology Authors: Mark Alberts Maryia Zhdanava Dominic Pilon Gabrielle Caron-Lapointe Patrick Lefebvre Brahim Bookhart Akshay Kharat Source Type: research

Underlying causes of cryptogenic stroke and TIA in the nordic atrial fibrillation and stroke (NOR-FIB) study - the importance of comprehensive clinical evaluation
CONCLUSION: Cryptogenic stroke often indicates the inability to identify the cause in the acute phase and should be considered as a working diagnosis until efforts of diagnostic work up succeed in identifying a specific underlying etiology. Timeframe of 6-12-month follow-up may be considered as optimal.TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT02937077, EudraCT 2018-002298-23.PMID:36944929 | DOI:10.1186/s12883-023-03155-0
Source: Atherosclerosis - March 22, 2023 Category: Cardiology Authors: B Ratajczak-Tretel A Tancin Lambert R Al-Ani K Arntzen G K Bakkejord H M O Bekkeseth V Bjerkeli G Eld øen A K Gulsvik B Halvorsen G A H øie H Ihle-Hansen S Ingebrigtsen C Kremer S B Krogseth C Kruuse M Kurz I Nakstad V Novotny H Naess R Qazi M K Rezaj D Source Type: research

Ischemic Stroke and Systemic Embolism Among One-and-Done Direct Oral Anticoagulant Users with Non-valvular Atrial Fibrillation
ConclusionA substantial proportion of patients were one-and-done DOAC users, which was associated with significantly higher risk of ischemic stroke/SE events. There is an unmet need to improve access and encourage continuous use of DOACs among patients with NVAF so that severe and fatal complications may be mitigated.
Source: Advances in Therapy - March 22, 2023 Category: Drugs & Pharmacology Source Type: research

Detection of Atrial Fibrillation in Patients Admitted with Ischaemic Stroke: A Non-systematic Review of the Asian Population
Central Illustration: AF Detection in Asian Patients with Ischaemic Stroke Download Search Strategy and Inclusion Criteria for the Liter...
Source: Radcliffe Cardiology - March 21, 2023 Category: Cardiology Authors: c242508f1d9059bc0f2aa9bdd5421ba2 Source Type: research

Outcomes of Early Rhythm Control Therapy in Patients With Atrial Fibrillation and a High Comorbidity Burden in Large Real-World Cohorts
CONCLUSIONS: ERC is safe and may be more favorable in a population-based sample of patients with high a comorbidity burden (CHA2DS2-VASc score ≥4).PMID:36942567 | DOI:10.1161/CIRCEP.122.011585
Source: Cancer Control - March 21, 2023 Category: Cancer & Oncology Authors: Jannis Dickow Shinwan Kany Victor Roth Cardoso Patrick T Ellinor Georgios V Gkoutos Holly K Van Houten Paulus Kirchhof Andreas Metzner Peter A Noseworthy Xiaoxi Yao Andreas Rillig Source Type: research

Underlying causes of cryptogenic stroke and TIA in the nordic atrial fibrillation and stroke (NOR-FIB) study – the importance of comprehensive clinical evaluation
Cryptogenic stroke is a heterogeneous condition, with a wide spectrum of possible underlying causes for which the optimal secondary prevention may differ substantially. Attempting a correct etiological diagnos...
Source: BMC Neurology - March 21, 2023 Category: Neurology Authors: B. Ratajczak-Tretel, A. Tancin Lambert, R. Al-Ani, K. Arntzen, G. K. Bakkejord, H. M.O. Bekkeseth, V. Bjerkeli, G. Eld øen, A. K. Gulsvik, B. Halvorsen, G. A. Høie, H. Ihle-Hansen, S. Ingebrigtsen, C. Kremer, S. B. Krogseth, C. Kruuse & hellip; Tags: Research Source Type: research

Heart failure with reduced ejection fraction and atrial fibrillation: a Sub ‐Saharan African perspective
AbstractCardiovascular diseases are a well-established cause of death in high-income countries. In the last 20  years, Sub-Saharan Africa (SSA) has seen one of the sharpest increases in cardiovascular disease-related mortality, superseding that of infectious diseases, including HIV/AIDS, in South Africa. This increase is evidenced by a growing burden of heart failure and atrial fibrillation (AF) risk factor s. AF is a common comorbidity of heart failure with reduced ejection fraction (HFrEF), which predisposes to an increased risk of stroke, rehospitalizations, and mortality compared with patients in sinus rhythm. AF had ...
Source: ESC Heart Failure - March 20, 2023 Category: Cardiology Authors: Nonkanyiso Mboweni, Muzi Maseko, Nqoba Tsabedze Tags: Review Source Type: research

Epicardial adipocytes in the pathogenesis of atrial fibrillation: An update on basic and translational studies
Epicardial adipose tissue (EAT) is an endocrine organ containing a host of cell types and undoubtedly serving a multitude of important physiologic functions. Aging and obesity cause hypertrophy of EAT. There is great interest in the possible connection between EAT and cardiovascular disease, in particular, atrial fibrillation (AF). Increased EAT is independently associated with AF and adverse events after AF ablation (e.g., recurrence of AF, and stroke). In general, the amount of EAT correlates with BMI or visceral adiposity. Yet on a molecular level, there are similarities and differences between epicardial and abdominal ...
Source: Frontiers in Endocrinology - March 20, 2023 Category: Endocrinology Source Type: research