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Total 617 results found since Jan 2013.

Patent Foramen Ovale Closure in hospitalized stroke patients in the United: Is there a racial disparity?
Racial disparity in stroke is well documented. Whether such disparity exists in the frequency of Patent Foramen Ovale (PFO) closure among patients with ischemic stroke (IS) is unclear.
Source: Journal of Stroke and Cerebrovascular Diseases - April 16, 2020 Category: Neurology Authors: Alain Lekoubou Tags: Poster 09 Source Type: research

Comparison of Antiplatelet Therapies for Prevention of Patent Foramen Ovale-Associated Stroke
The REDUCE study demonstrated a reduction in the risk of recurrent stroke with patent foramen ovale closure and antiplatelet therapy compared to antiplatelet therapy alone. The clinicians were allowed to choose among aspirin, clopidogrel, or aspirin/dipyridamole with the expectation that all antiplatelet therapies would have similar efficacy in this population. We tested that presumption by comparing recurrent stroke rates among antiplatelet agents within the control arm of the trial.
Source: Journal of Stroke and Cerebrovascular Diseases - February 6, 2020 Category: Neurology Authors: Scott E. Kasner, Bryan Randall, Grethe Andersen, Helle K. Iversen, Risto Roine, Christina Sjostrand, John F. Rhodes, Lars S øndergaard, The Gore REDUCE Study Investigators Source Type: research

The Fragility Index in Randomized Controlled Trials for Patent Foramen Ovale Closure in Cryptogenic Stroke
Background and Purpose: The routine use of percutaneous transcatheter patent foramen ovale closure (PPFOC) to prevent recurrent stroke in patients with cryptogenic stroke is still a matter of debate after completion major randomized controlled trials (RCTs). Methods: The fragility index of RCTs evaluating effect of PPFOC against medial therapy alone in stroke prevention was calculated to assess the robustness of statistically significant findings. Results: Literature search with PubMed identifies 6 RCTs on PPFOC.
Source: Journal of Stroke and Cerebrovascular Diseases - March 15, 2019 Category: Neurology Authors: Mehmet Akif Topcuoglu, Ethem Murat Arsava Source Type: research

Stroke in young adults: Five new things
Purpose of review The incidence of stroke in young adults is increasing, mainly driven by an increasing incidence of ischemic stroke in this population. We provide new information that has been recently presented regarding the risk factor prevalence, some specific etiologic causes, and management strategies in ischemic stroke in this population. Recent findings Recent studies indicate a rapid increase in traditional risk factors in young adults. New information regarding the management of patent foramen ovale in cryptogenic stroke and cervical artery dissection is available. Summary Stroke in young adults is a rapidly gr...
Source: Neurology Clinical Practice - December 10, 2018 Category: Neurology Authors: Bhatt, N., Malik, A. M., Chaturvedi, S. Tags: Stroke in young adults, Stroke prevention, All Cerebrovascular disease/Stroke, Carotid artery dissection Review Source Type: research

Residual Shunt after Patent Foramen Ovale Device Closure in Patients With Cryptogenic Stroke: Serial Bubble Contrast Transesophageal Echocardiography Data
Percutaneous closure of patent foramen ovale (PFO) is an alternative option to medical treatment for secondary prevention for cryptogenic stroke (CS). Despite technical success of procedure, residual shunt (RS) which is a presumable cause for recurrent stroke is observed in some patients. We evaluated the RS with serial follow-up bubble contrast transesophageal echocardiography (BCTEE) after PFO closure.
Source: Journal of Stroke and Cerebrovascular Diseases - November 3, 2018 Category: Neurology Authors: Jeonggeun Moon, Minsu Kim, Pyung Chun Oh, Dong Hoon Shin, Hyeon-MI Park, Youn Yi Jo, Ji Sung Lee, Woong Chol Kang Source Type: research

Closure versus Medical Therapy for Patent Foramen Ovale in Patients with Cryptogenic Stroke: An Updated Meta-Analysis of Randomized Controlled Trials
Debate continues about whether percutaneous closure of patent foramen ovale (PFO) is a better strategy for the treatment of patients with cryptogenic stroke in comparison with medical therapy alone. We performed an updated meta-analysis of 6 randomized controlled trials (RCTs) to assess the effectiveness and safety of percutaneous closure of PFO as secondary prevention for patients with previous cryptogenic stroke compared to medical therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - September 2, 2018 Category: Neurology Authors: Baoshan Qiu, Ying Cai, Dilong Wang, Jing Lin, Yuhua Fan Source Type: research

Cost-Effectiveness of Patent Foramen Ovale Closure Versus Medical Therapy for Secondary Stroke Prevention Clinical Sciences
Conclusions—PFO closure for cryptogenic strokes in the right setting is cost-effective, producing benefit in QALYs gained and potential cost savings. However, patient selection remains vitally important as marginal declines in treatment effectiveness can dramatically affect cost-effectiveness.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Michelle H. Leppert, Sharon N. Poisson, John D. Carroll, David E. Thaler, Chong H. Kim, Karen D. Orjuela, P. Michael Ho, James F. Burke, Jonathan D. Campbell Tags: Treatment, Cost-Effectiveness, Ischemic Stroke, Embolism Original Contributions Source Type: research

Patent Foramen Ovale Closure Versus Medical Therapy for Cryptogenic Ischemic Stroke Topical Review
Source: Stroke - May 25, 2018 Category: Neurology Authors: Jeffrey L. Saver, Heinrich P. Mattle, David Thaler Tags: Congenital Heart Disease, Treatment, Ischemic Stroke Topical Reviews Source Type: research

Patent Foramen Ovale Closure in the Setting of Cryptogenic Stroke: A Meta-Analysis of Five Randomized Trials
The clinical benefit of patent foramen ovale (PFO) closure after cryptogenic stroke has been a topic of debate for decades. Recently, 3 randomized controlled trials of PFO closure in patients with cryptogenic stroke demonstrated a significantly reduced risk of recurrent stroke compared with standard medical therapy alone. This meta-analysis was performed to clarify the efficacy of PFO closure for future stroke prevention in this population.
Source: Journal of Stroke and Cerebrovascular Diseases - May 24, 2018 Category: Neurology Authors: Lohit Garg, Affan Haleem, Shweta Varade, Keithan Sivakumar, Mahek Shah, Brijesh Patel, Manyoo Agarwal, Sahil Agrawal, Megan Leary, Bryan Kluck Source Type: research

Letter by Chen et al Regarding Article, “Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack: Updated Systematic Review and Meta-Analysis” Letter to the Editor
Source: Stroke - April 23, 2018 Category: Neurology Authors: Xi Chen, Shidong Chen, Qiang Dong Tags: Cerebrovascular Disease/Stroke Letters to the Editor Source Type: research

Response by Ntaios et al to Letter Regarding Article, “Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack: Updated Systematic Review and Meta-Analysis” Letter to the Editor
Source: Stroke - April 23, 2018 Category: Neurology Authors: George Ntaios, Thorsten Steiner, Patrik Michel Tags: Cerebrovascular Disease/Stroke Letters to the Editor Source Type: research

Letter by Doshi et al Regarding Article, “Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack: Updated Systematic Review and Meta-Analysis” Letter to the Editor
Source: Stroke - April 23, 2018 Category: Neurology Authors: Rajkumar Doshi, Neelesh Gupta, Vineet Meghrajani Tags: Cerebrovascular Disease/Stroke, Transient Ischemic Attack (TIA) Letters to the Editor Source Type: research

Letter by Moȷadidi et al Regarding Article, “Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack: Updated Systematic Review and Meta-Analysis” Letter to the Editor
Source: Stroke - April 23, 2018 Category: Neurology Authors: Mohammad K. Mojadidi, Muhammad O. Zaman, Nimesh K. Patel Tags: Anticoagulants, Cerebrovascular Disease/Stroke, Ischemic Stroke Letters to the Editor Source Type: research

Response by Ntaios et al to Letter Regarding Article, “Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack: Updated Systematic Review and Meta-Analysis” Letter to the Editor
Source: Stroke - April 23, 2018 Category: Neurology Authors: George Ntaios, Thorsten Steiner, Patrik Michel Tags: Ischemic Stroke Letters to the Editor Source Type: research

Frequency of Patent Foramen Ovale and Migraine in Patients With Cryptogenic Stroke Clinical Sciences
Conclusions—In patients with cryptogenic stroke who have migraine, there is a high prevalence (79%) of PFO with right-to-left shunt. The timing of the stroke in migraineurs is usually not related to a migraine attack. These observations are consistent with the hypothesis that the mechanism of stroke in migraineurs is most likely because of a paradoxical embolus. Future cryptogenic stroke classification schemes should consider including PFO as a separate etiologic category.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Brian H. West, Nabil Noureddin, Yakov Mamzhi, Christopher G. Low, Alexandra C. Coluzzi, Evan J. Shih, Rubine Gevorgyan Fleming, Jeffrey L. Saver, David S. Liebeskind, Andrew Charles, Jonathan M. Tobis Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Embolism Original Contributions Source Type: research

The Case for Selective Patent Foramen Ovale Closure After Cryptogenic Stroke Advances in Interventional Cardiology
Controversy has persisted for over a decade whether transcatheter patent foramen ovale (PFO) closure reduces the rate of recurrent ischemic stroke for patients who have had a cryptogenic ischemic stroke and have a PFO. In September 2017, 3 positive randomized trials: RESPECT long-term (Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment trial), REDUCE (GORE® HELEX® Septal Occluder / GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke or Imaging-Confirmed TIA in Patients With Patent Foramen Ovale [PFO]), and CLOSE (Patent For...
Source: Circulation: Cardiovascular Interventions - March 16, 2018 Category: Cardiology Authors: Wiktor, D. M., Carroll, J. D. Tags: Secondary Prevention, Treatment, Ischemic Stroke Advances in Interventional Cardiology Source Type: research

Tissue Plasminogen Activator to Treat a Stroke after Foam Sclerotherapy in a Woman with a Patent Foramen Ovale
Although foam sclerotherapy to varicose veins is now a popular treatment because of its high efficacy and safety, some neurologic complications have recently been reported. Presently, the effectiveness and safety of intravenous recombinant tissue-type plasminogen activator therapy to stroke following foam sclerotherapy remain unclear. Here, we report the case of a 68-year-old woman whose ischemic symptoms following foam sclerotherapy were treated by intravenous recombinant tissue-type plasminogen activator.
Source: Journal of Stroke and Cerebrovascular Diseases - February 2, 2018 Category: Neurology Authors: Kosuke Matsuzono, Naoto Arai, Masayuki Suzuki, Younhee Kim, Tadashi Ozawa, Takafumi Mashiko, Haruo Shimazaki, Reiji Koide, Tohru Matsuura, Shigeru Fujimoto Tags: Case Studies Source Type: research

Closure of Patent Foramen Ovale Versus Medical Therapy in Patients With Cryptogenic Stroke or Transient Ischemic Attack Clinical Sciences
Conclusions—In patients with cryptogenic stroke/TIA and PFO who have their PFO closed, ischemic stroke recurrence is less frequent compared with patients receiving medical treatment. Atrial fibrillation is more frequent but mostly transient. There is no difference in TIA, all-cause mortality, or myocardial infarction.
Source: Stroke - January 22, 2018 Category: Neurology Authors: George Ntaios, Vasileios Papavasileiou, Dimitrios Sagris, Konstantinos Makaritsis, Konstantinos Vemmos, Thorsten Steiner, Patrik Michel Tags: Ischemic Stroke Original Contributions Source Type: research

New Data Support Patent Foramen Ovale Closure After Stroke Emerging Therapy Critique
Source: Stroke - December 22, 2017 Category: Neurology Authors: Christopher G. Favilla, Steven R. Messe Tags: Treatment, Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Emerging Therapy Critiques Source Type: research

Safety Outcomes After Percutaneous Transcatheter Closure of Patent Foramen Ovale Clinical Sciences
Conclusions—Approximately 1 in 14 patients who underwent percutaneous transcatheter PFO closure after ischemic stroke or TIA experienced a serious periprocedural adverse outcome or death. The risk of adverse outcomes was highest in older patients and in those with preceding ischemic stroke.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Alexander E. Merkler, Gino Gialdini, Shadi Yaghi, Peter M. Okin, Costantino Iadecola, Babak B. Navi, Hooman Kamel Tags: Cerebrovascular Disease/Stroke, Cerebrovascular Procedures Original Contributions Source Type: research

Propensity Score-Based Analysis of Percutaneous Closure Versus Medical Therapy in Patients With Cryptogenic Stroke and Patent Foramen Ovale: The IPSYS Registry (Italian Project on Stroke in Young Adults) Structural Heart Disease
Conclusions— PFO closure seems as effective as medical therapy for secondary prevention of cryptogenic ischemic stroke. Whether device treatment might be more effective in selected cases, such as in patients younger than 37 years and in those with a substantial right-to-left shunt size, deserves further investigation.
Source: Circulation: Cardiovascular Interventions - August 30, 2016 Category: Cardiology Authors: Pezzini, A., Grassi, M., Lodigiani, C., Patella, R., Gandolfo, C., Zini, A., DeLodovici, M. L., Paciaroni, M., Del Sette, M., Toriello, A., Musolino, R., Calabro, R. S., Bovi, P., Adami, A., Silvestrelli, G., Sessa, M., Cavallini, A., Marcheselli, S., Mar Tags: Risk Factors, Ischemic Stroke Structural Heart Disease Source Type: research

Practice advisory: Recurrent stroke with patent foramen ovale (update of practice parameter): Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
Conclusions: Percutaneous PFO closure with the STARFlex device possibly does not provide a benefit in preventing stroke vs medical therapy alone (risk difference [RD] 0.13%, 95% confidence interval [CI] –2.2% to 2.0%). Percutaneous PFO closure with the AMPLATZER PFO Occluder possibly decreases the risk of recurrent stroke (RD –1.68%, 95% CI –3.18% to –0.19%), possibly increases the risk of new-onset atrial fibrillation (AF) (RD 1.64%, 95% CI 0.07%–3.2%), and is highly likely to be associated with a procedural complication risk of 3.4% (95% CI 2.3%–5%). There is insufficient evidence to d...
Source: Neurology - August 21, 2016 Category: Neurology Authors: Messe, S. R., Gronseth, G., Kent, D. M., Kizer, J. R., Homma, S., Rosterman, L., Kasner, S. E. Tags: All Cerebrovascular disease/Stroke SPECIAL ARTICLE Source Type: research

Thrombolysis for Ischemic Stroke during Pregnancy: A Case Report and Review of the Literature
We report the successful use of intravenous alteplase (tissue plasminogen activator; tPA) thrombolysis in a pregnant woman with acute cardioembolic stroke presumed to be paradoxical embolism through a patent foramen ovale.
Source: Journal of Stroke and Cerebrovascular Diseases - August 10, 2016 Category: Neurology Authors: Steven Tversky, Richard B. Libman, Marina L. Reppucci, Andrea M. Tufano, Jeffrey M. Katz Tags: Case Studies Source Type: research

Recurrent Stroke due to Patent Foramen Ovale Closure Device Thrombus Eight Years after Implantation
We present a case of cardioembolic stroke secondary to a mobile thrombus on a PFO closure device 8 years after implantation.
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2016 Category: Neurology Authors: Thomas V. Kodankandath, Sanskriti Mishra, Richard B. Libman, Paul Wright Tags: Case Studies Source Type: research

Closure Versus Medical Therapy for Preventing Recurrent Stroke in Patients With Patent Foramen Ovale and a History of Cryptogenic Stroke or Transient Ischemic Attack Cochrane Corner
Source: Stroke - June 26, 2016 Category: Neurology Authors: Li, J., Liu, J., Liu, M., Zhang, S., Hao, Z., Zhang, J., Zhang, C. Tags: Secondary Prevention, Congenital Heart Disease, Ischemic Stroke Cochrane Corner Source Type: research

Prothrombotic State in Patients With a Left Atrial Appendage Thrombus of Unknown Origin and Cerebrovascular Events Clinical Sciences
Conclusions— Prothrombotic blood alterations could be involved in the LAA thrombus formation in patients without documented atrial fibrillation and are associated with increased risk of stroke or transient ischemic attack during follow-up.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Meus, R., Son, M., Sobczyk, D., Undas, A. Tags: Ischemic Stroke Clinical Sciences Source Type: research

Prothrombotic States and Ischemic Stroke in the Young (P3.231)
Conclusions: There is no association between prothrombotic risk factors (analyzed individually or as a group) and idiopathic ischemic stroke in the young, even in those with a PFO or with migraine.Disclosure: Dr. Boudjani has nothing to disclose. Dr. Lanthier has received compensation for activities with Bristol-Myers-Squibb, Sanofi-Aventis, Boehringer-Ingelheim, and Astra-Zeneca as a speaker.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Boudjani, H., Lanthier, S. Tags: Stroke in the Young Source Type: research

An Approach to Working Up Cases of Embolic Stroke of Undetermined Source Stroke
Conclusions Our data indicate that patients with cryptogenic embolic stroke show distinct clinical and radiological features depending on the underlying causes.
Source: JAHA:Journal of the American Heart Association - March 21, 2016 Category: Cardiology Authors: Ryoo, S., Chung, J.-W., Lee, M. J., Kim, S. J., Lee, J. S., Kim, G.-M., Chung, C.-S., Lee, K. H., Hong, J. M., Bang, O. Y. Tags: Etiology, Risk Factors, Magnetic Resonance Imaging (MRI), Ischemic Stroke Source Type: research

Ischemic Stroke in Children and Young Adults With Congenital Heart Disease Congenital Heart Disease
Conclusions The risk of developing ischemic stroke was almost 11 times higher in young patients with CHD than in the general population, although absolute risk is low. Cardiovascular comorbidities were strongly associated with the development of ischemic stroke in young CHD patients.
Source: JAHA:Journal of the American Heart Association - February 23, 2016 Category: Cardiology Authors: Mandalenakis, Z., Rosengren, A., Lappas, G., Eriksson, P., Hansson, P.-O., Dellborg, M. Tags: Epidemiology, Congenital Heart Disease, Ischemic Stroke Source Type: research

Predictors for atrial fibrillation detection after cryptogenic stroke: Results from CRYSTAL AF
Conclusion: Increasing age and a prolonged PR interval at enrollment were independently associated with an increased AF incidence in CS patients. However, they offered only moderate predictive ability in determining which CS patients had AF detected by the ICM.
Source: Neurology - January 18, 2016 Category: Neurology Authors: Thijs, V. N., Brachmann, J., Morillo, C. A., Passman, R. S., Sanna, T., Bernstein, R. A., Diener, H.-C., Di Lazzaro, V., Rymer, M. M., Hogge, L., Rogers, T. B., Ziegler, P. D., Assar, M. D. Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Clinical trials Randomized controlled (CONSORT agreement), Risk factors in epidemiology ARTICLE Source Type: research

Migraine makes the stroke grow faster?
Long associated with increased incidence of stroke,1,2 migraine has been linked with mechanisms involving the vasculature (vasospasm, arterial dissection, endothelial dysfunction, venous thrombosis), heart (patent foramen ovale), and blood (hypercoagulability).3 Since cerebral ischemia can induce cortical spreading depression, the physiologic process underlying aura, migraine with aura may theoretically represent a TIA equivalent in a subset of people. In addition to the heightened occurrence of stroke in migraineurs, a growing body of evidence suggests more dire consequences when stroke occurs, with experiments in mice wi...
Source: Neurology - November 30, 2015 Category: Neurology Authors: Tietjen, G. E., Sacco, S. Tags: Migraine, All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

Potential new uses of non-vitamin K antagonist oral anticoagulants to treat and prevent stroke
Conclusion: There may be a role for NOACs in stroke prevention and treatment beyond atrial fibrillation. Randomized controlled trials are needed to compare NOACs to current stroke prevention and treatment strategies in certain subgroups of patients with cerebrovascular disease.
Source: Neurology - September 21, 2015 Category: Neurology Authors: Yaghi, S., Kamel, H., Elkind, M. S. V. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Infarction, Cerebral venous thrombosis VIEWS & amp;amp; REVIEWS Source Type: research

Stroke in the Young: Patent Foramen Ovale and Pregnancy Illustrative Teaching Cases
Source: Stroke - July 27, 2015 Category: Neurology Authors: Miller, B. R., Strbian, D., Sundararajan, S. Tags: Anticoagulants, Antiplatelets, Other Stroke Treatment - Surgical Illustrative Teaching Cases Source Type: research

Ischemic Stroke Patients with Active Malignancy or Extracardiac Shunts Are More Likely to Have a Right-to-Left Shunt Found by TCD Than Echocardiogram
Abstract Although the association between patent foramen ovale and ischemic stroke is controversial, the evaluation for a right-to-left shunt remains part of the standard workup for cryptogenic stroke. Transthoracic and transesophageal echocardiogram (TTE and TEE) are the screening test and gold standard to evaluate for right-to-left shunt, respectively. Studies comparing TTE or TEE to transcranial Doppler (TCD) have shown that 15–25 % of patients test positive for right-to-left shunt on TCD but are negative on TTE or TEE. We sought to further explore this phenomenon in patients with recent ischemic stroke. Bet...
Source: Translational Stroke Research - July 25, 2015 Category: Neurology Source Type: research

Ischemic stroke after pellet embolization
A 9-year-old boy was shot with a pellet shotgun and developed a visual field deficit. Head CT revealed a pellet in the left ambien cistern, in the left posterior cerebral artery on catheter angiography (figure). Chest fluoroscopy revealed multiple thoracic pellets, including a mobile cardiac pellet (video on the Neurology® Web site at Neurology.org). There was no clear cardiac injury, patent foramen ovale, or skull penetration. Arterial embolization of a pellet from the chest to the intracranial vasculature likely caused a stroke.1,2 We considered arteriotomy, endovascular retrieval, and medical therapy. The establishe...
Source: Neurology - June 8, 2015 Category: Neurology Authors: Aghaebrahim, A., Giurgiutiu, D.-V., Jankowitz, B. T., Jovin, T., Jadhav, A. P. Tags: All Cerebrovascular disease/Stroke, Embolism VIDEO NEUROIMAGES Source Type: research

Routine troponin measurements are unnecessary in acute ischemic stroke evaluations (P4.285)
CONCLUSIONS: Troponin elevation in patients with ischemic stroke is not caused by acute myocardial ischemia unless iatrogenic in the setting of vasopressor administration. Serum troponins should be measured based on clinical context rather than routinely in all acute ischemic stroke patients.Disclosure: Dr. Ali has nothing to disclose. Dr. Young has nothing to disclose. Dr. Rabinstein has received royalty payments from Elsevier and Oxford University Press. Dr. Rabinstein has received research support from DJO Global. Dr. Flemming has nothing to disclose. Dr. Fugate has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ali, F., Young, J., Rabinstein, A., Flemming, K., Fugate, J. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Ischemic Stroke Care Source Type: research

Paroxysmal Atrial Fibrillation Detection Rates In Cryptogenic Stroke Patients Selected By Stroke Specialists For Prolonged Cardiac Monitoring (P1.053)
CONCLUSION: Long term cardiac monitoring with ICM has a very high yield of detecting PAF in cryptogenic stroke patients when selected by a stroke expert.Disclosure: Dr. Salahuddin has nothing to disclose. Dr. Zaidi has nothing to disclose. Dr. Tietjen holds stock and/or stock options in Johnson & Johnson and Stryker. Dr. Cummings has nothing to disclose. Dr. Jumaa has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Salahuddin, H., Zaidi, S., Tietjen, G., Cummings, J., Jumaa, M. Tags: Cerebrovascular Disease and Interventional Neurology: Atrial Fibrillation and Cardio-embolic Stroke Source Type: research

Stroke in the Young: Etiologies and Risk Factors (P7.124)
CONCLUSIONS: Stroke in the young shares many of the same common modifiable risk factors as stroke in the elderly including hypertension, hyperlipidemia, diabetes, and tobacco abuse. Other unique disease processes also contribute to stroke in this age group, often less modifiable. Given the devastating morbidity and mortality of stroke in this age group, a larger public health effort for primary and secondary prevention of stroke in the young should be aggressively pursued.Disclosure: Dr. Govind has nothing to disclose. Dr. Ahad has nothing to disclose. Dr. Iftekhar has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Govind, P., Ahad, R., Iftekhar, A. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke in Young Source Type: research

Body Mass Index and Stroke Subtype in a Young Adult Stroke Population (P7.126)
CONCLUSIONS: In our group of young adult stroke patients, we found the highest BMI in the group with intracranial atherosclerosis. Although this group represented a small number of patients, this young adult population is at increased risk for future strokes. It is important to educate them on lifestyle modifications such as weight loss and exercise in addition to the treatment of hypertension, diabetes mellitus and hyperlipidemia.Disclosure: Dr. Youn has nothing to disclose. Dr. Aung has nothing to disclose. Dr. Afrasiabi has nothing to disclose. Dr. Clark has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Youn, J., Aung, T., Afrasiabi, M., Clark, J. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke in Young Source Type: research

Brief History of Patent Foramen Ovale and Stroke Stroke History
Source: Stroke - January 26, 2015 Category: Neurology Authors: Furlan, A. J. Tags: Embolic stroke Stroke History Source Type: research

Fibrinolytic activity and platelet function in subjects with obstructive sleep apnoea and a patent foramen ovale: is there an option for prevention of ischaemic stroke?
Authors: Reggiani M, Karttunen V, Wartiovaara-Kautto U, Riutta A, Uchiyama S, Hillbom M Abstract Obstructive sleep apnoea (OSA) carries an increased risk of ischaemic stroke, but the underlying mechanism is not clear. As right-to-left shunting can occur through a patent foramen ovale (PFO) during periods of apnoea, we investigated nocturnal changes in fibrinolytic activity and platelet function in subjects who had OSA with or without PFO and in controls. We determined plasminogen activator inhibitor 1 (PAI-1) activity and antigen and platelet activation parameters. The severity of OSA was verified by polygraphy and...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Provoked Right-to-Left Shunt in Patent Foramen Ovale Associates With Ischemic Stroke in Posterior Circulation Brief Reports
Conclusions— The predominance of posterior-circulatory infarction in provoked RLS patients suggests that the Valsalva maneuver may promote RLS and paradoxical embolization to the posterior circulation.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Kim, B. J., Kim, N.-Y., Kang, D.-W., Kim, J. S., Kwon, S. U. Tags: Doppler ultrasound, Transcranial Doppler etc. Brief Reports Source Type: research

Guidelines for the Primary Prevention of Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Guideline
The aim of this updated statement is to provide comprehensive and timely evidence-based recommendations on the prevention of stroke among individuals who have not previously experienced a stroke or transient ischemic attack. Evidence-based recommendations are included for the control of risk factors, interventional approaches to atherosclerotic disease of the cervicocephalic circulation, and antithrombotic treatments for preventing thrombotic and thromboembolic stroke. Further recommendations are provided for genetic and pharmacogenetic testing and for the prevention of stroke in a variety of other specific circumstances, ...
Source: Stroke - November 24, 2014 Category: Neurology Authors: Meschia, J. F., Bushnell, C., Boden-Albala, B., Braun, L. T., Bravata, D. M., Chaturvedi, S., Creager, M. A., Eckel, R. H., Elkind, M. S. V., Fornage, M., Goldstein, L. B., Greenberg, S. M., Horvath, S. E., Iadecola, C., Jauch, E. C., Moore, W. S., Wilson Tags: AHA Statements and Guidelines AHA/ASA Guideline Source Type: research

Determinants of antithrombotic choice for patent foramen ovale in cryptogenic stroke
Conclusion: Both antithrombotic regimens are widely used for secondary stroke prevention in patients with CS and PFO. Radiologic and echocardiographic features were strongly associated with treatment choice, whereas conventional vascular risk factors were not. Prior observational studies are likely to be biased by confounding by indication.
Source: Neurology - November 17, 2014 Category: Neurology Authors: Thaler, D. E., Ruthazer, R., Weimar, C., Serena, J., Mattle, H. P., Nedeltchev, K., Mono, M.-L., Di Angelantonio, E., Elkind, M. S. V., Di Tullio, M. R., Homma, S., Michel, P., Meier, B., Furlan, A. J., Lutz, J. S., Kent, D. M. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Risk factors in epidemiology ARTICLE Source Type: research

Recurrent Stroke and Patent Foramen Ovale: A Systematic Review and Meta-Analysis Clinical Sciences
Conclusions— Our findings indicate that medically treated patients with PFO do not have a higher risk for recurrent cryptogenic cerebrovascular events, compared with those without PFO. No relation between the degree of PFO and the risk of future cerebrovascular events was identified.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Katsanos, A. H., Spence, J. D., Bogiatzi, C., Parissis, J., Giannopoulos, S., Frogoudaki, A., Safouris, A., Voumvourakis, K., Tsivgoulis, G. Tags: Acute Cerebral Infarction Clinical Sciences Source Type: research

Diagnostic and Therapeutic Value of Echocardiography during the Acute Phase of Ischemic Stroke
Conclusions: Echocardiography, as currently practiced in our stroke unit, allows detection of CSE in one patient in five, and leads to change in therapy in half of these cases. Our results suggest that TTE should be used for all patients admitted for IS, and to limit the use of TEE to younger patients.
Source: Journal of Stroke and Cerebrovascular Diseases - August 8, 2014 Category: Neurology Authors: Marie Gaudron, Isabelle Bonnaud, Aaurélia Ros, Frédéric Patat, Bertrand de Toffol, Bruno Giraudeau, Séverine Debiais Tags: Original Articles Source Type: research

Diagnostic Yield of Pelvic Magnetic Resonance Venography in Patients With Cryptogenic Stroke and Patent Foramen Ovale Clinical Sciences
Conclusions— Among patients with ischemic stroke/transient ischemic attack and patent foramen ovale, the majority of detected DVTs were in LE veins rather than the pelvic veins and did not differ by stroke subtype. The routine inclusion of pelvic magnetic resonance venography in the diagnostic evaluation of CS warrants further prospective investigation.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Liberman, A. L., Daruwalla, V. J., Collins, J. D., Maas, M. B., Botelho, M. P. F., Ayache, J. B., Carr, J., Ruff, I., Bernstein, R. A., Alberts, M. J., Prabhakaran, S. Tags: Deep vein thrombosis, Other diagnostic testing, Acute Cerebral Infarction, Embolic stroke Clinical Sciences Source Type: research

Recurrent stroke predictors differ in medically treated patients with pathogenic vs other PFOs
Conclusion: Predictors of recurrence differ when PFO relatedness is classified by the RoPE score, suggesting that patients with CS and PFO form a heterogeneous group with different stroke mechanisms. Echocardiographic features were only associated with recurrence in the high RoPE score group.
Source: Neurology - July 14, 2014 Category: Neurology Authors: Thaler, D. E., Ruthazer, R., Weimar, C., Mas, J.-L., Serena, J., Di Angelantonio, E., Papetti, F., Homma, S., Mattle, H. P., Nedeltchev, K., Mono, M.-L., Jaigobin, C., Michel, P., Elkind, M. S. V., Di Tullio, M. R., Lutz, J. S., Griffith, J., Kent, D. M. Tags: Stroke prevention, All Cerebrovascular disease/Stroke, Risk factors in epidemiology ARTICLE Source Type: research