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Condition: Hemorrhagic Stroke

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Total 10535 results found since Jan 2013.

A case-based systematic review on the SARS-COVID-2-associated cerebrovascular diseases and the possible virus routes of entry
AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sparked a global pandemic that continues to affect various facets of human existence. Many sources reported virus-induced acute cerebrovascular disorders. Systematically, this paper reviews the case studies of COVID-19-related acute cerebrovascular diseases such as ischaemic stroke, intracerebral hemorrhage, and cerebral sinus thrombosis. We also spoke about how SARS-CoV-2 can infect the brain and trigger the aforementioned disorders. We stated that SARS-CoV-2 neuroinvasion and BBB dysfunction could cause the observed disorders; however, further research ...
Source: Journal of NeuroVirology - September 21, 2021 Category: Neurology Source Type: research

Endovascular Recanalization of Tandem Internal Carotid Occlusions Using the Balloon-assisted Tracking Technique.
ConclusionApplication of BAT technique in tandem occlusions appears feasible, safe, and efficient. Further evaluation of this technique is awaited.
Source: Klinische Neuroradiologie - September 21, 2021 Category: Radiology Source Type: research

Community planning for a "healthy built environment" via a human-environment nexus? A multifactorial assessment of environmental characteristics and age-specific stroke mortality in Hong Kong
In conclusion, urban plans and designs for stroke mortality prevention should implement age-specific health care to neighborhoods with particular population segments.PMID:34543905 | DOI:10.1016/j.chemosphere.2021.132043
Source: Chemosphere - September 20, 2021 Category: Chemistry Authors: Hung Chak Ho Huagui Guo Ta-Chien Chan Yuan Shi Chris Webster Kenneth N K Fong Source Type: research

Pyridoxal Isonicotinoyl Hydrazone Improves Neurological Recovery by Attenuating Ferroptosis and Inflammation in Cerebral Hemorrhagic Mice
Biomed Res Int. 2021 Sep 8;2021:9916328. doi: 10.1155/2021/9916328. eCollection 2021.ABSTRACTFerroptosis and inflammation induced by cerebral hemorrhage result in an excessive inflammatory response and irreversible neuronal injury. Alleviating ferroptosis might be an effective way to prevent neuroinflammatory injury and promote neural functional recovery. Pyridoxal isonicotinoyl hydrazine (PIH), a lipophilic iron-chelating agent, has been reported to reduce excess iron-induced cytotoxicity. However, whether PIH could ameliorate the effects of hemorrhagic stroke is not completely understood. In the present study, the preven...
Source: Biomed Res - September 20, 2021 Category: Research Authors: Hengli Zhang Min Wen Jiayu Chen Chaojie Yao Xiao Lin Zhongxiao Lin Junnan Ru Qichuan Zhuge Su Yang Source Type: research

Dual-Antiplatelet Therapy May Not Be Associated With an Increased Risk of In-hospital Bleeding in Patients With Moderate or Severe Ischemic Stroke
Conclusions: In this single center cohort, symptomatic ICH and the composite of serious systemic bleeding and symptomatic ICH was rare in patients on DAPT. Relative to single antiplatelet therapy DAPT was not associated with an increased risk of in-hospital bleeding in patients with moderate and severe ischemic stroke.
Source: Frontiers in Neurology - September 20, 2021 Category: Neurology Source Type: research

Plasma cellular prion protein concentrations correlate with severity and prognosis of aneurysmal subarachnoid hemorrhage
CONCLUSIONS: Plasma PrPc concentrations are highly associated with severity and poor outcome after hemorrhagic stroke, indicating that plasma PrPc may serve as a useful prognostic biomarker for aSAH.PMID:34537219 | DOI:10.1016/j.cca.2021.09.010
Source: International Journal of Clinical Chemistry - September 19, 2021 Category: Chemistry Authors: Hongfeng Yao Caiping Lv Fangjun Luo Chao He Source Type: research

Y-2 reduces oxidative stress and inflammation and improves neurological function of collagenase-induced intracerebral hemorrhage rats
In conclusion, Y-2 sublingual tablets might be a promising therapeutic agent for the treatment of ICH.PMID:34536364 | DOI:10.1016/j.ejphar.2021.174507
Source: European Journal of Pharmacology - September 18, 2021 Category: Drugs & Pharmacology Authors: Yao Hua Limei Zhou Weidong Yang Wenji An Xiaolin Kou Jian Ren Hailang Su Rong Chen Zhengping Zhang Jianjun Zou Zhihong Zhao Source Type: research

The Progress of the Gait Impairment and Brain Activation in a Patient with Post-stroke Hemidystonia
CONCLUSION: These results suggest that there was improvement of the patient's symptoms of post-stroke hemidystonia due to changes in the brain activity during voluntary movement after BWS intervention. Body weight-supported treadmill training may thus be an effective treatment for patients with poststroke hemidystonia.PMID:34532214 | PMC:PMC8419483 | DOI:10.1298/ptr.E10032
Source: Physical Therapy - September 17, 2021 Category: Physiotherapy Authors: Satoshi Yamamoto Daisuke Ishii Kyoko Kanae Yusuke Endo Kenichi Yoshikawa Kazunori Koseki Ryo Nakazawa Hanako Takano Masahiko Monma Arito Yozu Akira Matsushita Yutaka Kohno Source Type: research

Endovascular treatment versus intravenous thrombolysis alone in isolated M2 occlusion: a meta-analysis
ConclusionsIVT alone provides similar clinical benefit compared to MT with/without IVT in cases of M2 occlusion. MT quadruplicates rates of good recanalization, but triplicates risk of sICH. Further trials are needed to define if MT confers any advantage over IVT for M2 occlusion.
Source: Neurological Sciences - September 17, 2021 Category: Neurology Source Type: research

Clinical Significance of Hyperdense Lesions on Non-enhanced Brain CT Obtained Immediately after Arterial Revascularization in Acute Ischemic Stroke Patients
CONCLUSION: Hyperdense lesions on non-enhanced brain CT obtained immediately after arterial revascularization (AR) exhibited varying features. Type I indicated a pure contrast extravasation. Type II and type III hyperdense lesions suggested higher incidence of HT, the presence of type III lesions indicated an ominous outcome.PMID:34527073 | PMC:PMC8437617 | DOI:10.1155/2021/1562502
Source: Computational and Mathematical Methods in Medicine - September 16, 2021 Category: Statistics Authors: Changbin Wang Zudong Yin Xinyi Zhang Xiumin Zhao Source Type: research

RNase A Inhibits Formation of Neutrophil Extracellular Traps in Subarachnoid Hemorrhage
Conclusion: Neutrophil extracellular trap formation following SAH originates in the ipsilateral SAS of the bleeding site and spreads gradually over time to basal, cortical, and periventricular areas in the parenchyma within 14days. Intravenous RNase application abrogates NET burden significantly in the brain parenchyma, underpinning a potential role in modulation of the innate immune activation after SAH.
Source: Frontiers in Physiology - September 16, 2021 Category: Physiology Source Type: research

Pipeline Embolization Device for the Treatment of Ruptured Intracerebral Aneurysms: A Multicenter Retrospective Study
Conclusion: The PED is a feasible and effective treatment to prevent rebleeding and achieve aneurysm occlusion, but it is associated with a substantial risk of periprocedural hemorrhage and ischemic complications in acute ruptured IAs. Therefore, the PED should be used selectively for acutely ruptured IAs. Additionally, adjunctive coiling might increase procedure-related stroke; however, it may reduce aneurysm rebleeding in acutely ruptured IAs. Patients with immediate contrast stasis in the venous phase were more likely to achieve total occlusion. A prospective study with a larger sample size should be performed to verify our results.
Source: Frontiers in Neurology - September 16, 2021 Category: Neurology Source Type: research

Atypical Posterior Reversible Encephalopathy Syndrome in a Postpartum Woman With Moyamoya Disease: A Case Report and Literature Review
Conclusions:This patient was diagnosed with reversible posterior leukoencephalopathy syndrome related to moyamoya disease. This case highlights that atypical posterior reversible encephalopathy syndrome can occur in patients with moyamoya disease, and should be considered for the differential diagnosis of cerebral infarcts and hemorrhage in a postpartum female.
Source: Frontiers in Neurology - September 16, 2021 Category: Neurology Source Type: research

Can Tirofiban Improve the Outcome of Patients With Acute Ischemic Stroke: A Propensity Score Matching Analysis
Conclusion: We demonstrated that tirofiban may be associated with improving favorable outcome for the AIS patients who underwent MT, without increasing ICH or sICH. Furthermore, our results indicated that for PCS patients tirofiban may not be associated with favorable outcome, and more comprehensive randomized controlled trials are needed to confirm this finding.
Source: Frontiers in Neurology - September 13, 2021 Category: Neurology Source Type: research

Experiences With Intravenous Thrombolysis in Acute Ischemic Stroke by Elderly Patients –A “Real World Scenario”
Conclusion: Although, the outcomes were less favorable in patients over 80 years of age, our results support the feasibility of using intravenous thrombolysis among patients over 80 years of age.
Source: Frontiers in Neurology - September 13, 2021 Category: Neurology Source Type: research

Novel insights into stroke risk beyond resting and maximal bicycle exercise systolic blood pressure
Conclusion: Stroke risk increased with increasing difference between resting and maximal exercise SBP, independent of BP at rest, suggesting that an exaggerated BP response to physical exercise may be an independent predictor of stroke.
Source: Journal of Hypertension - September 10, 2021 Category: Cardiology Tags: ORIGINAL PAPERS: BP and other risk factor epidemiology Source Type: research

Mechanical thrombectomy with retrievable stents and aspiration catheters for acute ischaemic stroke: a meta-analysis of randomised controlled trials
CONCLUSIONS: In patients with an acute anterior circulation stroke, modern device thrombectomy significantly reduces death and subsequent disability. The magnitude of these effects suggests that universal access to this treatment strategy should be the standard of care.PMID:34503942 | DOI:10.4244/EIJ-D-21-00343
Source: EuroIntervention - September 10, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Christopher A Rajkumar Sashiananthan Ganesananthan Yousif Ahmad Henry Seligman George D Thornton Michael Foley Alexandra N Nowbar James P Howard Darrel P Francis Thomas R Keeble Iris Q Grunwald Rasha K Al-Lamee Iqbal S Malik Matthew J Shun-Shin Source Type: research

Aspiration-Retriever Technique for Stroke with Large Bore Intermediate Catheter : A Single Center Experience
CONCLUSION: Although the clinical outcomes using the ARTS technique with a flexible large lumen distal access catheter performed as the frontline thrombectomy in patients with AIS were not significantly superior than those of other studies, this study showed a high rate of successful endovascular recanalization which was comparable to that of other studies. Therefore, ARTS using the SOFIA® catheter can be considered as the first choice of treatment for AIS due to large vessel occlusion.PMID:34503313 | DOI:10.3340/jkns.2020.0308
Source: Journal of Korean Neurosurgical Society - September 10, 2021 Category: Neurosurgery Authors: Ji Won Nam Na Young Jung Eun Suk Park Soon Chan Kwon Source Type: research

Mechanical thrombectomy with retrievable stents and aspiration catheters for acute ischaemic stroke: a meta-analysis of randomised controlled trials
CONCLUSIONS: In patients with an acute anterior circulation stroke, modern device thrombectomy significantly reduces death and subsequent disability. The magnitude of these effects suggests that universal access to this treatment strategy should be the standard of care.PMID:34503942 | DOI:10.4244/EIJ-D-21-00343
Source: EuroIntervention - September 10, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Christopher A Rajkumar Sashiananthan Ganesananthan Yousif Ahmad Henry Seligman George D Thornton Michael Foley Alexandra N Nowbar James P Howard Darrel P Francis Thomas R Keeble Iris Q Grunwald Rasha K Al-Lamee Iqbal S Malik Matthew J Shun-Shin Source Type: research

Aspiration-Retriever Technique for Stroke with Large Bore Intermediate Catheter : A Single Center Experience
CONCLUSION: Although the clinical outcomes using the ARTS technique with a flexible large lumen distal access catheter performed as the frontline thrombectomy in patients with AIS were not significantly superior than those of other studies, this study showed a high rate of successful endovascular recanalization which was comparable to that of other studies. Therefore, ARTS using the SOFIA® catheter can be considered as the first choice of treatment for AIS due to large vessel occlusion.PMID:34503313 | DOI:10.3340/jkns.2020.0308
Source: Journal of Korean Neurosurgical Society - September 10, 2021 Category: Neurosurgery Authors: Ji Won Nam Na Young Jung Eun Suk Park Soon Chan Kwon Source Type: research

Mechanical thrombectomy with retrievable stents and aspiration catheters for acute ischaemic stroke: a meta-analysis of randomised controlled trials
CONCLUSIONS: In patients with an acute anterior circulation stroke, modern device thrombectomy significantly reduces death and subsequent disability. The magnitude of these effects suggests that universal access to this treatment strategy should be the standard of care.PMID:34503942 | DOI:10.4244/EIJ-D-21-00343
Source: EuroIntervention - September 10, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Christopher A Rajkumar Sashiananthan Ganesananthan Yousif Ahmad Henry Seligman George D Thornton Michael Foley Alexandra N Nowbar James P Howard Darrel P Francis Thomas R Keeble Iris Q Grunwald Rasha K Al-Lamee Iqbal S Malik Matthew J Shun-Shin Source Type: research

Aspiration-Retriever Technique for Stroke with Large Bore Intermediate Catheter : A Single Center Experience
CONCLUSION: Although the clinical outcomes using the ARTS technique with a flexible large lumen distal access catheter performed as the frontline thrombectomy in patients with AIS were not significantly superior than those of other studies, this study showed a high rate of successful endovascular recanalization which was comparable to that of other studies. Therefore, ARTS using the SOFIA® catheter can be considered as the first choice of treatment for AIS due to large vessel occlusion.PMID:34503313 | DOI:10.3340/jkns.2020.0308
Source: Journal of Korean Neurosurgical Society - September 10, 2021 Category: Neurosurgery Authors: Ji Won Nam Na Young Jung Eun Suk Park Soon Chan Kwon Source Type: research

Mechanical thrombectomy with retrievable stents and aspiration catheters for acute ischaemic stroke: a meta-analysis of randomised controlled trials
CONCLUSIONS: In patients with an acute anterior circulation stroke, modern device thrombectomy significantly reduces death and subsequent disability. The magnitude of these effects suggests that universal access to this treatment strategy should be the standard of care.PMID:34503942 | DOI:10.4244/EIJ-D-21-00343
Source: EuroIntervention - September 10, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Christopher A Rajkumar Sashiananthan Ganesananthan Yousif Ahmad Henry Seligman George D Thornton Michael Foley Alexandra N Nowbar James P Howard Darrel P Francis Thomas R Keeble Iris Q Grunwald Rasha K Al-Lamee Iqbal S Malik Matthew J Shun-Shin Source Type: research

Stroke in Patients with Left Ventricular Assist Devices
Background: Left ventricular assist devices (LVADs) are artificial pumps used in end-stage heart failure to support the circulatory system. These cardiac assist devices work in parallel to the heart, diverting blood from the left ventricle through an outflow graft and into the ascending aorta. LVADs have allowed patients with end-stage heart failure to live longer and with improved quality of life compared to best medical therapy alone. However, they are associated with significant risks related to both thrombosis and bleeding in this medically complex patient population. As LVADs continue to be used more widely, stroke ne...
Source: Cerebrovascular Diseases - September 10, 2021 Category: Neurology Source Type: research

Targeting focal ischemic and hemorrhagic stroke neuroprotection: current prospects for local hypothermia
AbstractTherapeutic hypothermia (TH) has applications dating back millennia. In modern history, however, TH saw its importation into medical practice where investigations have demonstrated that TH is efficacious in ischemic insults, notably cardiac arrest and hypoxic-ischemic encephalopathy. As well, studies have been undertaken to investigate whether TH can provide benefit in focal stroke (i.e., focal ischemia and intracerebral hemorrhage). However, clinical studies have encountered various challenges with induction and maintenance of post-stroke TH. Most clinical studies have attempted to use body-wide cooling protocols,...
Source: Journal of Neurochemistry - September 9, 2021 Category: Neuroscience Authors: Lane J. Liddle, Anna C.J. Kalisvaart, Ashley H. Abrahart, Mohammed Almekhlafi, Andrew Demchuk, Frederick Colbourne Tags: REVIEW Source Type: research

Early anticoagulation in atrial fibrillation-related acute ischaemic stroke: efficacy and safety profile
ConclusionsEarly anticoagulation was associated with lower ischaemic recurrence and better functional outcome at 3 months. Additional studies are needed to better clarify its haemorrhagic risk.
Source: Journal of Neurology - September 9, 2021 Category: Neurology Source Type: research

Impact of COVID-19 on Acute Stroke Presentation in a Designated COVID-19 Hospital
Conclusions: Although fewer acute stroke patients sought medical care in this designated COVID-19 hospital during the COVID-19 pandemic, this type of hospital was more efficient for timely treatment of acute stroke. Recognizing how acute strokes presented in designated COVID-19 hospitals will contribute to appropriate adjustments in strategy for dealing with acute stroke during COVID-19 and future pandemics.
Source: Frontiers in Neurology - September 8, 2021 Category: Neurology Source Type: research

CE: Acute Ischemic Stroke
This article discusses the pathophysiology underlying the various types of ischemic stroke; the risk factors for ischemic stroke; stroke presentation; and the evidence-based treatments, nursing assessments, and monitoring protocols that are critical to patient recovery.PMID:34492666 | DOI:10.1097/01.NAJ.0000790184.66496.1d
Source: The American Journal of Nursing - September 7, 2021 Category: Nursing Authors: Heather H Washington Kimberly R Glaser Nneka Lotea Ifejika Source Type: research

A Prospective Stroke Register in Sierra Leone: Demographics, Stroke Type, Stroke Care and Hospital Outcomes
This study reports the demographics, stroke types, stroke care and hospital outcomes for stroke in Freetown, Sierra Leone.Methods: A prospective observational register recorded all patients 18 years and over with stroke between May 2019 and April 2020. Stroke was defined according to the WHO criteria. Pearson's chi-squared test was used to examine associations between categorical variables and unpaired t-tests for continuous variables. Multivariable logistic regression, to explain in-hospital death, was reported as odds ratios (ORs) and 95% confidence intervals.Results: Three hundred eighty-five strokes were registered, an...
Source: Frontiers in Neurology - September 7, 2021 Category: Neurology Source Type: research

Intra-hematomal White Matter Tracts Act As a Scaffold for Macrophage Infiltration After Intracerebral Hemorrhage
In conclusion, white matter fibers exist within the hematoma after ICH and macrophages/microglia may use such fibers as a scaffold to infiltrate into the hematoma and aid in hematoma clearance.
Source: Translational Stroke Research - September 6, 2021 Category: Neurology Source Type: research

Increased Stroke Risk in Metabolically Abnormal Normal Weight: a 10-Year Follow-up of 102,037 Participants in China
AbstractThe purpose of this study was to investigate the risks of stroke in subjects with metabolically abnormal normal weight (MANW) in China. We recruited 102,037 participants from the Zhejiang Metabolic Syndrome Cohort and the Kailuan cohort. The mean years of follow-up were 9.9  years. General obesity was defined by body mass index (BMI) ≥ 28, overweight by BMI <  28 and ≥ 24, and normal weight by BMI <  24 and ≥ 18.5. Metabolic abnormality was defined as two or more abnormal components (elevated triglycerides, low high-density lipoprotein cholesterol, elevated systolic blood pressure or di...
Source: Translational Stroke Research - September 6, 2021 Category: Neurology Source Type: research

Characteristics of Ischemic Versus Hemorrhagic Stroke in Patients Receiving Oral Anticoagulants: Results of the PASTA Study
Conclusion The presence of CMBs, a history of stroke, natriuretic peptide and D-dimer levels, and PT-INR may be useful for risk stratification of either IS/TIA or ICH development in patients with AF receiving OACs.PMID:34483213 | DOI:10.2169/internalmedicine.8113-21
Source: Internal Medicine - September 6, 2021 Category: Internal Medicine Authors: Satoshi Suda Arata Abe Yasuyuki Iguchi Yoshiki Yagita Takao Kanzawa Seiji Okubo Nobuyuki Ohara Takayuki Mizunari Mineo Yamazaki Nobuhito Nakajima Kimito Kondo Shigeru Fujimoto Takeshi Inoue Takeshi Iwanaga Yuka Terasawa Kensaku Shibazaki Yu Kono Makoto Na Source Type: research

Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral Hemorrhage
A follow-up of the Restart or Stop Antithrombotics Randomized Trial, this study further examines the long-term effects of antiplatelet therapy after stroke caused by intracerebral hemorrhage.
Source: JAMA Neurology - September 3, 2021 Category: Neurology Source Type: research

Low vitamin D levels and the long ‐term functional outcome of stroke up to 5 years
ConclusionVitamin D level less than 38.4  nmol/L at admission is a potential risk biomarker for poor functional outcome at 5-year prognosis in AIS patients, which might provide new ideas for the prognostic assessment of stroke.
Source: Brain and Behavior - September 2, 2021 Category: Neurology Authors: Ya ‐Ying Zeng, Cheng‐Xiang Yuan, Meng‐Xuan Wu, Lin Cheng, Sheng‐Nan Zhou, Ping‐lang Hu, Kai‐Li Fan, Wen‐Jie Tang, Jin‐Cai He Tags: ORIGINAL RESEARCH Source Type: research

Development of Biomembrane-mimetic Nanoparticles for the Treatment of Ischemic Stroke
Yakugaku Zasshi. 2021;141(9):1071-1078. doi: 10.1248/yakushi.21-00114.ABSTRACTIncrease in vascular permeability of the blood-brain barrier (BBB) is a distinct pathology following ischemic stroke. In previous studies, we demonstrated that liposomal drug delivery system (DDS)-based delivery of neuroprotectants is useful for treating cerebral ischemia/reperfusion injury. Additionally, our previous studies reported that combination therapy with liposomal fasudil plus tissue plasminogen activator (t-PA), a thrombolytic agent, brings about decrease in the risk of t-PA-derived cerebral hemorrhage and prolong the therapeutic time ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 2, 2021 Category: Drugs & Pharmacology Authors: Tatsuya Fukuta Source Type: research