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Condition: Septic Shock

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Total 108 results found since Jan 2013.

A Simple Risk Score to Predict Clavien-Dindo Grade IV and V Complications After Non-elective Cholecystectomy
ConclusionA simple risk-score model predicts severe complications in patients undergoing unplanned cholecystectomy for common indications encountered in an acute care surgery service and identifies high-risk patients.
Source: Journal of Gastrointestinal Surgery - February 6, 2020 Category: Surgery Source Type: research

Reaction in oral mucosa due to intensive therapy polypharmacy: case report
A 51-year-old white female patient hospitalized in the intensive care unit because of acute ischemic stroke who needed tracheostomy and vasoactive drugs in high dosage evolved with aspiration pneumonia and septic shock. At 30 days of hospitalization, intraoral examination revealed multiple superficial ulcers on the lips, buccal mucosa, tongue, and mouth floor, circumscribed by erythematous halo and covered by pseudomembrane with severe pain symptomatology and evolution of 15 days. Concomitantly, the patient presented bilateral conjunctivitis with erythema in the sclera and periocular region.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: ANDRESSA COUTINHO RIBEIRO, CLAUDIA CRISTIANE BAISEREDO DE CARVALHO, ANA FL ÁVIA SCHUELER DE ASSUMPÇÃO LEITE, ADRIANA TEREZINHA NEVES NOVELLINO ALVES, SIMONE DE QUEIROZ CHAVES LOURENÇO, JOSIANE COSTA RODRIGUES DE SÁ Source Type: research

An antibody against HK blocks Alzheimer’s disease peptide {beta}-amyloid-induced bradykinin release in human plasma Immunology and Inflammation
Bradykinin is a proinflammatory factor that mediates angioedema and inflammation in many diseases. It is a key player in some types of hereditary angioedema and is involved in septic shock, traumatic injury, Alzheimer’s disease (AD), and stroke, among others. Activation of the plasma contact system leads to elevated levels of...
Source: Proceedings of the National Academy of Sciences - November 12, 2019 Category: Science Authors: Zu-Lin Chen, Pradeep Singh, Jyen Wong, Katharina Horn, Sidney Strickland, Erin H. Norris Tags: Brief Reports Biological Sciences Source Type: research

Pneumocephalus and pneumorachis after blunt chest trauma without spinal fractures: a case report
ConclusionsThis is the first case report to describe pneumorachis and pneumocephalus following blunt trauma with pneumothorax, but no spinal or skull fractures. The mechanism that is probably involved here is a migration of air with subcutaneous emphysema and a pleural hernia into the spinal canal. However, in cases of pneumorachis or pneumocephalus, skull fractures need to be investigated as these require surgery and appropriate vaccination to prevent meningitis.
Source: Journal of Medical Case Reports - October 25, 2019 Category: General Medicine Source Type: research

A Blood Filter Fights Deadly Inflammatory Response
A new blood filtration technology may prove to be life-saving for patients whose normally healthy inflammatory response to injury or illness has gone into overdrive, resulting in fatally high levels of cytokines in their blood. In an interview with MD+DI, Dr. Phillip Chan, MD, PhD, CEO of CytoSorbents Corp., explained that inflammation, and the production of substances called cytokines that drive inflammation, are the body’s natural response to heal injury or infection. But sometimes, the inflammatory response is so severe in such conditions as sepsis and infection, burn injuries, trauma, pancreatitis, li...
Source: MDDI - October 9, 2019 Category: Medical Devices Authors: Susan Shepard Tags: Cardiovascular Source Type: news

Weight! Weight! … Don’t Tell Me!
Weight-based, lifesaving medications are commonly used in hospitals and routinely used in emergency departments.1 Many weight-based medications are listed in the Institute for Safe Medication Practices (ISMP) high-alert medication list. According to ISMP, “high-alert medications are drugs that bear a heightened risk of causing significant patient harm when they are used in error.”2 These frequently used medications include anticoagulants (eg, heparin and enoxaparin), antibiotics for septic shock (eg, vancomycin and tobramycin), fibrinolytic agent s for stroke (eg, alteplase), and antiepileptic drugs (eg, phenytoin and fosphenytoin).
Source: Journal of Emergency Nursing: JEN - August 22, 2019 Category: Nursing Authors: Avani Bhalodia, Mona Hammam, Susan F. Paparella Tags: Danger Zone Source Type: research

Echocardiographic assessment of left ventricular systolic function in neonatal calves with naturally occurring sepsis or septic shock due to diarrhea
The objectives of this study were to evaluate the clinical value of echocardiography for monitoring left ventricular (LV) systolic function in septic calves. A prospective longitudinal study was performed using a convenience sample. Twenty septic calves and 10 healthy calves were enrolled in the study. Arterial blood pressure (BP) was measured and M-mode echocardiography performed to characterize LV systolic function; the latter included measurement of ejection fraction, EF; stroke volume, SVI and cardiac output indexed to body weight, CI; E-point of septal separation, EPSS; pre-ejection period, PEP; ejection time, LVET; r...
Source: Research in Veterinary Science - August 6, 2019 Category: Veterinary Research Source Type: research

“A contemporary description of staphylococcus aureus prosthetic valve endocarditis. Differences according to the time elapsed from surgery”
Staphylococcus aureus prosthetic valve endocarditis (SAPVE) has a poor prognosis. There are no large series that accurately describe this entity. This is a retrospective observational study on a prospective cohort from 3 Spanish reference hospitals for cardiac surgery, including 78 definitive episodes of left SAPVE between 1996 and 2016. Fifty percent had a Charlson Index score>5; 53% were health care-related. Twenty percent did not present fever. Complications at diagnosis included: severe heart failure (HF, 29%), septic shock (SS, 17.9%), central nervous system abnormalities (19%), septic metastasis (4%). Hemorrhagic s...
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Prevalence, risk factors and outcomes of patients coming from the community with sepsis due to multidrug resistant bacteria
ConclusionIn light of the prevalence and impact of MDR bacteria causing sepsis in patients coming from the community, physicians should consider ESBL coverage when starting an empiric antibiotic therapy in patients with specific risk factors, especially in the presence of septic shock.
Source: Multidisciplinary Respiratory Medicine - July 5, 2019 Category: Respiratory Medicine Source Type: research

Are Patients Who Undergo THA for Infection at Higher Risk for 30-day Complications?
CONCLUSIONS: Patients undergoing revision THA for infection undergo reoperation and experience major complications more frequently in a 30-day episode of care than patients undergoing aseptic revision THA. Without risk adjustment to existing alternative payment and quality reporting models, providers may experience a disincentive to care for patients with infected THAs, who may face difficulties with access to care. LEVEL OF EVIDENCE: Level III, therapeutic study. PMID: 31268424 [PubMed - in process]
Source: Clinical Orthopaedics and Related Research - July 1, 2019 Category: Orthopaedics Authors: Boniello AJ, Lieber AM, Courtney PM Tags: Clin Orthop Relat Res Source Type: research

Beyond Triage and Resuscitation: Optimizing Care for the Critically Ill Emergency Department Patient
During my last shift in the emergency department (ED), I assumed care at sign-out of an intubated patient with an acute asthma exacerbation as well as a patient with cardiogenic pulmonary edema who was receiving noninvasive ventilation. Shortly thereafter, prehospital personnel brought us a patient with respiratory failure due to emphysema who needed to be intubated, followed by a patient having an acute stroke who would receive thrombolytics, followed by a patient with hypotension who would later require pressors for septic shock.
Source: Emergency Medicine Clinics of North America - June 29, 2019 Category: Emergency Medicine Authors: Amal Mattu Tags: Foreword Source Type: research

Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Boerhaave’s syndrome: a case report of damage control approach
ConclusionPrompt diagnosis with thoracic drainage and a damage control treatment plan might lead to good prognosis for patients with this rare and potentially fatal condition.
Source: International Journal of Surgery Case Reports - April 20, 2019 Category: Surgery Source Type: research

Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 17, 2019 Category: Allergy & Immunology Source Type: research

Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier
We examined a possible protective effect of OX-A against LPS-induced ROS formation and microglia activation. To mimic in vitro the connection between gut and brain and to study the putative effect on the cortical microglia, we used a co-culture of Caco-2 cells and primary cortical microglia with Caco-2 cells placed at the apical side of a transwell and primary cortical microglia at the basolateral side. All treatments used to study the apical vs. basal connection were applied to the apical compartment. We used DHR (10 μM, 20 min), a cell-permeable fluorogenic probe useful for the detection of ROS formation, to dete...
Source: Frontiers in Endocrinology - April 10, 2019 Category: Endocrinology Source Type: research

A Study of Convulsive Status Epilepticus Cases in Indonesia
Publication date: Available online 14 March 2019Source: Epilepsy & Behavior Case ReportsAuthor(s): Machlusil Husna, K. Shahdevi Nandar, Risma Karlina Prabawati, Siti NurlaelaAbstractStatus epilepticus (SE) is a serious health issue in developing countries, with high morbidity and mortality rates of 3%–46%. There are two types of SE, convulsive status epilepticus (CSE) and non-convulsive status epilepticus. The most common type, CSE, is easy to detect but, in several cases, the patients are diagnosed too late to be properly treated and hospitalized. The present study therefore investigated the clinical manifestations of C...
Source: Epilepsy and Behavior Case Reports - March 16, 2019 Category: Neurology Source Type: research

30-Day adverse events, length of stay and re-admissions following surgical management of pelvic/acetabular fractures
ConclusionPatients with ASA grade > II, greater co-morbidity burden and prolonged operative times were likely to experience adverse events and have a longer length of stay. Surgeons can utilize this data to risk stratify patients so that appropriate pre-operative and post-operative medical optimization can take place.
Source: Journal of Clinical Orthopaedics and Trauma - February 14, 2019 Category: Orthopaedics Source Type: research

The use of bedside echocardiography for measuring cardiac index and systemic vascular resistance in pediatric patients with septic shock
Conclusion: There was a persistently high systemic vascular resistance index in cold shock patients that influenced the stroke volume index, cardiac index, and velocity time integral. The use of echocardiograms for hemodynamic measurements is important in pediatric septic shock patients to adjust dilators, and vasopressor doses and achieve resuscitation targets in a timely manner.
Source: Revista Brasileira de Terapia Intensiva - January 17, 2019 Category: Intensive Care Source Type: research

Sepsis Update: Evidence-Based Therapy.
This article provides an overview of the current evidence of sepsis and septic shock therapy and its implementation into clinical practice. PMID: 30620955 [PubMed - in process]
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - January 1, 2019 Category: Intensive Care Authors: Martin L, Bickenbach J, Marx G Tags: Anasthesiol Intensivmed Notfallmed Schmerzther Source Type: research

Stroke volume change after digoxin loading in septic shock patients with transient left ventricular systolic dysfunction.
In conclusion, in septic shock patients with transient LV dysfunction such as TS, digoxin loading can be a feasible treatment. Further clinical study is needed. Before Digoxin LoadingAfter Digoxin LoadingpEjection Fraction (%)20.2 ± 9.422.2 ± 10.40.327Time-Velocity Integral (cm)10.8 ± 3.112.3 ± 4.60.093LVOT diameter (cm)1.82 ± 0.241.88 ± 0.260.025Stroke Volume (mL)27.6 ± 7.933.7 ± 11.90.048
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Lee, D. H., Jeong, J.-H., Kang, B. H., Um, S., Son, C. Tags: Acute Critical Care Source Type: research

Evaluation of Vasopressin for Vasoplegic Shock in Patients With Preoperative Left Ventricular Dysfunction After Cardiac Surgery: A Propensity-Score Analysis
Conclusions: Compared with norepinephrine, vasopressin could not improve the postoperative outcomes in patients with pLVD after cardiac surgery. Vasopressin should be cautious to be used as a first-line vasopressor agent in postcardiac vasoplegic shock.
Source: Shock - October 16, 2018 Category: Emergency Medicine Tags: Clinical Science Aspects Source Type: research

Risk of incident atrial fibrillation after a prior critical illness: A retrospective cohort study.
CONCLUSIONS: Our study explored incident AF among patients with critical illness in their medical history. Patients with septicemia/septic shock were at the highest risk of developing new-onset AF among these critically ill patients. PMID: 30243509 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - September 19, 2018 Category: Internal Medicine Authors: Hu WS, Lin CL Tags: Eur J Intern Med Source Type: research

Cardiovascular Parameters Associated With Troponin I as Indicators for 14-Day Mortality in Patients With Septic Shock.
CONCLUSIONS: Our data give an insight into interactions between cardiac and hemodynamic factors to cause cardiocyte damage and suggest that multiple factors (i.e., low CFI and high SVV) should be considered together to evaluate cardiocyte damage and mortality in sepsis. PMID: 30286819 [PubMed - in process]
Source: The American Journal of the Medical Sciences - September 1, 2018 Category: General Medicine Authors: Su WL, Shui HA, Lan CC, Yang MC, Hsieh CA, Jang SJ, Chung HW, Wu YK Tags: Am J Med Sci Source Type: research

Transporting Patients to Appropriate Receiving Destinations
Conclusion EMS is in a position to be the initiator of specialty center destination. In large cities with multiple hospitals, EMS should transport patients to the closest, most appropriate facility based on patient condition, even if this requires passing a closer facility. Where there are hospitals with multiple specialty services, EMS may be asked to activate a specific team, such as the stroke or cardiac team. In rural communities, EMS can communicate with the local hospital and by letting the hospital know of patient condition, help start the interfacility transport process from the field....
Source: JEMS Special Topics - July 19, 2018 Category: Emergency Medicine Authors: Dennis Edgerly, MEd, EMT-P Tags: Exclusive Articles Columns Operations Source Type: news

Deadly Respiratory Distress Mimic
Conclusion It’s important for prehospital providers to be able to differentiate metabolic disturbances in the setting of respiratory distress and not be fooled into thinking tachypnea always has a respiratory cause. The physical exam and adjuncts such as end-tidal capnography can assist in the prehospital diagnosis. A COPD exacerbation generally presents as diminished lung sounds, wheezing on exhalation, and a prolonged expiratory phase. Here, a patient will attempt to compensate for the inflammation and mucus accumulation associated with the destruction and narrowing of peripheral airways and a subsequent lack of availa...
Source: JEMS Special Topics - July 17, 2018 Category: Emergency Medicine Authors: Brenton Faber, PhD, NRP Tags: Airway & Respiratory Exclusive Articles Patient Care Source Type: news

Pulse-induced contour cardiac output (PiCCO) combined with passive leg raising test predicting fluid resuscitation in adult patients with septic shock
Publication date: Available online 17 July 2017Source: The Kaohsiung Journal of Medical SciencesAuthor(s): Si-Dong ZhanAbstractTo investigate the clinical value of pulse-induced contour cardiac output (PiCCO) monitoring combined with passive leg raising (PLR) test in predicting fluid responsiveness so as to guide fluid resuscitation in adult septic shock patients managed by rehydration test. One hundred and forty five adult septic shock patients, who were informed to receive PLR tests and rehydration tests. Patients were divided into two groups based on the observation of fluid responsiveness in the rehydration test. Param...
Source: The Kaohsiung Journal of Medical Sciences - July 11, 2018 Category: Universities & Medical Training Source Type: research

Heartfelt sepsis: microvascular injury due to genomic storm.
Abstract Sepsis is one of the ten leading causes of death in developed and developing countries. In the United States, sepsis mortality approaches that of acute myocardial infarction and exceeds deaths from stroke. Neonates and the elderly are the most vulnerable patients, with these groups suffering from the highest sepsis mortality. In both groups, many survivors respectively display serious developmental disabilities and cognitive decline. The National Institute of Health National Heart Lung and Blood Institute Panel redefined sepsis as a "severe endothelial dysfunction syndrome in response to intravascular and...
Source: Polish Heart Journal - July 5, 2018 Category: Cardiology Authors: Hawiger J Tags: Kardiol Pol Source Type: research

Sepsis-induced myocardial dysfunction
Purpose of review Sepsis leads to a complex intramyocardial inflammatory response that results in sepsis-induced myocardial dysfunction. Here, recent findings are reviewed in a physiologic context. Recent findings Decreased systolic contractility during sepsis limits ventricular ejection and stroke volume. Initially, this effect is compensated for by increased diastolic filling during volume resuscitation. Reduced afterload due to arterial vasodilation also compensates so that cardiac output can be maintained or increased. Recent results recognize the importance of diastolic dysfunction, reduced ventricular diastolic ...
Source: Current Opinion in Critical Care - July 2, 2018 Category: Nursing Tags: CARDIOVASCULAR SYSTEM: Edited by Stephen M. Pastores Source Type: research

Clinical - microbiological characterization and risk factors of mortality in infective endocarditis from a tertiary care academic hospital in Southern India.
CONCLUSIONS: This study reiterates the persistent dominance of rheumatic heart disease in the population studied and α - hemolytic Streptococci as the commonest responsible microorganism. PMID: 29716704 [PubMed - in process]
Source: Indian Heart J - March 1, 2018 Category: Cardiology Authors: Subbaraju P, Rai S, Morakhia J, Midha G, Kamath A, Saravu K Tags: Indian Heart J Source Type: research

Photoluminescence intensity ratio of Eu ‐conjugated lactates—A simple optical imaging technique for biomarker analysis for critical diseases
Instant measurement of elevated biomarkers such as lactic acid offers the most promising approaches for early treatment and prevention of many critical diseases including cardiac arrest, stroke, septic shock, trauma, liver dysfunction, as well as for monitoring lactic acid level during intense exercise. In the present study, a unique dependence of visible photoluminescence of Eu3+ ions resulting from 5D0 to 7FJ(J = 0,1,2,3,4) transitions, which can be exploited for rapid detection of biomarkers, both in vitro and ex vivo, has been reported. It is observed that the integrated intensity ratio of photoluminescence signals...
Source: Journal of Biophotonics - December 18, 2017 Category: Physics Authors: Tarun Kakkar, Nikita Thomas, Eric Kumi ‐Barimah, Gin Jose, Sikha Saha Tags: FULL ARTICLE Source Type: research

Prosthetic valve endocarditis in patients on hemodialysis
We read with great interest the manuscript entitled “Prognostic factors of infective endocarditis in patients on hemodialysis: A case series from a National Multicenter Registry” by Dr. A. Ramos-Martínez and colleagues showing that hemodialysis patients with IE present a high mortality and that advanced age and complications, such as heart failu re, CNS stroke or septic shock, are associated with mortality [1].
Source: International Journal of Cardiology - December 5, 2017 Category: Cardiology Authors: Jinmiao Chen, Kui Hu, Jun Li, Tao Hong, Chunsheng Wang Tags: Correspondence Source Type: research

Combined use of high doses of vasopressin and corticosteroids in a patient with Crohn ’s disease with refractory septic shock after intestinal perforation: a case report
ConclusionsThe significant increase in her cardiac index and stroke volume index resulted in an improvement in peripheral resistance, gas exchange, and urine output and a decrease in her heart rate, interleukin-6 level, and tumor necrosis factor- α level. The administration of high doses of vasopressin and corticosteroids was demonstrated to be safe for the immune system, to reduce the systemic inflammatory response, and to have direct cardiovascular effects. Further studies are required to examine the use of vasopressin as an initial vasop ressor as well as its use in high dosages and in combination with corticosteroids.
Source: Journal of Medical Case Reports - November 13, 2017 Category: General Medicine Source Type: research

Photoluminescence intensity ratio of Eu conjugated lactates ‐ a simple optical imaging technique for biomarker analysis for critical diseases
Instant measurement of elevated biomarker such as lactic acid offers the most promising approaches for early treatment and prevention of many critical diseases including cardiac arrest, stroke, septic shock, trauma, liver dysfunction, and as well as for monitoring lactic acid level during intense exercise. In the present study a unique dependence of visible photoluminescence of Eu3+ ions resulting from 5D0 to 7FJ(J=0,1,2,3,4) transitions, which can be exploited for rapid detection of biomarkers both in vitro and ex vivo has been reported. It is observed that the integrated intensity ratio of photoluminescence signals domin...
Source: Journal of Biophotonics - October 1, 2017 Category: Physics Authors: Tarun Kakkar, Nikita Thomas, Eric Kumi Barimah, Gin Jose, Sikha Saha Tags: Full Article Source Type: research

Should Hyperoxia Be Avoided During Sepsis? An Experimental Study in Ovine Peritonitis*
Conclusions: In this acute peritonitis model, hyperoxia induced during resuscitation provided better hemodynamics and peripheral microvascular flow and better preserved cerebral metabolism, renal function, and gas exchange. These observations are reassuring with recent concerns about excessive oxygen therapy in acute diseases.
Source: Critical Care Medicine - September 16, 2017 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Institutional care paths: Development, implementation, and evaluation.
CONCLUSION: Care paths provide a standardized approach to treatment or prevention of a disease or condition, reducing unnecessary variability and expense while promoting optimal, cost-effective patient care. PMID: 28887350 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - September 11, 2017 Category: Drugs & Pharmacology Authors: Leonard MC, Bauer SR, Ahrens C, Reddy A, Katzan I Tags: Am J Health Syst Pharm Source Type: research

Postoperative Complications Affecting Survival After Cardiac Arrest in General Surgery Patients.
CONCLUSIONS: Among general surgery patients with cardiac arrest after POD #0, complications occurring before cardiac arrest are common but are not associated with increased mortality risk. PMID: 28891912 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - September 7, 2017 Category: Anesthesiology Authors: Kim M, Li G Tags: Anesth Analg Source Type: research

Stroke volume guided resuscitation in severe sepsis and septic shock improves outcomes
This study demonstrated that SV guided fluid resuscitation in patients with severe sepsis and septic shock was associated with reduced fluid balance and improved secondary outcomes. Graphical abstract
Source: Journal of Critical Care - July 1, 2017 Category: Gastroenterology Source Type: research

Cor Triatriatum and Stroke: A Case Report and Review of Literature (P3.294)
Conclusions:This is the largest review of CTS cases with associated stroke. The review showed neuroimaging results consistent with a cardioembolic mechanism. All but two of the cases made use of anticoagulation. Three cases underwent surgery. This case has the longest follow-up and the first to demonstrate failure of anti-platelet therapy and anticoagulation. The need for further investigations regarding optimal stroke prevention in this subset of patients is emphasized.Disclosure: Dr. Diestro has nothing to disclose. Dr. Espiritu has nothing to disclose. Dr. Dorotan has nothing to disclose. Dr. Regalado has nothing to dis...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Diestro, J. D., Espiritu, A., Dorotan, M. K., Regalado, J., Pascual, J. L. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial
Publication date: March 2017 Source:The Lancet Neurology, Volume 16, Issue 3 Author(s): Jacob Elkins, Roland Veltkamp, Joan Montaner, S Claiborne Johnston, Aneesh B Singhal, Kyra Becker, Maarten G Lansberg, Weihua Tang, Ih Chang, Kumar Muralidharan, Sarah Gheuens, Lahar Mehta, Mitchell S V Elkind Background In animal models of acute ischaemic stroke, blocking of the leukocyte-endothelium adhesion by antagonism of α4 integrin reduces infarct volumes and improves outcomes. We assessed the effect of one dose of natalizumab, an antibody against the leukocyte adhesion molecule α4 integrin, in patients with acute ischaemic st...
Source: The Lancet Neurology - February 16, 2017 Category: Neurology Source Type: research

Ischemic Stroke and Septic Shock After Subacute Endocarditis Caused by Haemophilus parainfluenzae: Case Report.
Abstract Haemophilus parainfluenzae, which belongs to the HACEK (Haemophilus ssp, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae) group, is a rare cause of subacute endocarditis and may lead to ischemic stroke. A 65-year-old female patient previously diagnosed with rheumatic valve disease was submitted to surgical mitral valve repair in 1996. Physical examination did not reveal any murmurs; physical examination of the lungs and abdomen was normal. The patient was admitted to hospital with progressive dyspnea, dry cough, and fever. Transesophageal echocardiog...
Source: Clin Med Res - December 8, 2016 Category: Research Authors: Menegueti MG, Machado-Viana J, Gaspar GG, Nicolini EA, Basile-Filho A, Auxiliadora-Martins M Tags: J Clin Med Res Source Type: research

Pre-operative stroke and neurological disability do not independently affect short- and long-term mortality in infective endocarditis patients
Conclusions Pre-operative stroke and the severity of neurological disability do not independently affect short- and long-term mortality in patients with infective endocarditis. It appears that patients with pre-operative stroke present with a generally higher risk profile. This information may substantially affect decision-making.
Source: Clinical Research in Cardiology - April 27, 2016 Category: Cardiology Source Type: research

The comparison of stroke volume variation with central venous pressure in predicting fluid responsiveness in septic patients with acute circulatory failure
Conclusions: When predicting fluid responsiveness in mechanically ventilated patients in septic shock, SVV is more effective than CVP. Nevertheless, the overall correlation of baseline SVV with increases in CI remains poor. Trends in SVV, as reflected by decreases with volume replacement, seem to correlate much better with increases in CI.
Source: Indian Journal of Critical Care Medicine - July 8, 2015 Category: Intensive Care Authors: Santhalakshmi AngappanSatyen ParidaArumugam VasudevanAshok Shankar Badhe Source Type: research

Early prediction and outcome of septic encephalopathy in acute stroke patients with nosocomial coma.
CONCLUSION: High fever and severe SIRS are two early predictors of stroke patients with SE, and survival rates were worse in stroke patients with SE than those without SE. PMID: 26015818 [PubMed]
Source: Clin Med Res - May 30, 2015 Category: Research Authors: Tong DM, Zhou YT, Wang GS, Chen XD, Yang TH Tags: J Clin Med Res Source Type: research

Stroke is not a treatment dilemma for early valve surgery in active infective endocarditis.
CONCLUSION: Surgery for AIE with cerebral septic embolisms can be performed safely, with good early and mid-term follow-up results. When urgent or emergent surgery for AIE is needed, neurologic complications should not be a reason for delay. PMID: 25799711 [PubMed - in process]
Source: Journal of Heart Valve Disease - March 25, 2015 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Sepsis, septic shock, and fatal exertional heat stroke - Epstein Y, Roberts WO, Golan R, Heled Y, Sorkine P, Halpern P.
Exertional heat stroke (EHS) is a clinical syndrome of hyperthermia, encephalopathy, and multiorgan dysfunction that can be irreversible and fatal. While prompt recognition and immediate, aggressive total body cooling can prevent progression of the clinica...
Source: SafetyLit: All (Unduplicated) - January 23, 2015 Category: Global & Universal Tags: Environmental Issues, Climate, Geophysics Source Type: news

Sepsis, Septic Shock, and Fatal Exertional Heat Stroke
Exertional heat stroke (EHS) is a clinical syndrome of hyperthermia, encephalopathy, and multiorgan dysfunction that can be irreversible and fatal. While prompt recognition and immediate, aggressive total body cooling can prevent progression of the clinical syndrome, even a short delay can exacerbate the effects of hyperthermia-induced changes. EHS is linked to an inflammatory response that is akin to the systemic inflammatory response syndrome (SIRS). However because EHS is not a common problem in most hospital intensive care units and is not in the usual list of SIRS causes, it may be overlooked easily. Furthermore norma...
Source: Current Sports Medicine Reports - January 1, 2015 Category: Sports Medicine Tags: General Medical Conditions: Section Articles Source Type: research

Sepsis, septic shock, and fatal exertional heat stroke.
Abstract Exertional heat stroke (EHS) is a clinical syndrome of hyperthermia, encephalopathy, and multiorgan dysfunction that can be irreversible and fatal. While prompt recognition and immediate, aggressive total body cooling can prevent progression of the clinical syndrome, even a short delay can exacerbate the effects of hyperthermia-induced changes. EHS is linked to an inflammatory response that is akin to the systemic inflammatory response syndrome (SIRS). However because EHS is not a common problem in most hospital intensive care units and is not in the usual list of SIRS causes, it may be overlooked easily....
Source: Current Sports Medicine Reports - January 1, 2015 Category: Sports Medicine Authors: Epstein Y, Roberts WO, Golan R, Heled Y, Sorkine P, Halpern P Tags: Curr Sports Med Rep Source Type: research

Late Care in Marathon Runs Leading to Exertional Heat Stroke with Multiple Organ Failure
Conclusions: This case reminds us that, despite the advancements of knowledge in the area of EHS prevention, recognition, and treatment, knowledge has not been translated into practice.
Source: Asian Journal of Sports Medicine - December 11, 2013 Category: Sports Medicine Source Type: research