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Total 2093 results found since Jan 2013.

Evaluation of Postural Stability and Transverse Abdominal Muscle Activity in Overweight Post-Stroke Patients: A Prospective, Observational Study
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - February 19, 2020 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research

Effects and outcomes of cardiac surgery in patients with cardiometabolic syndrome
ConclusionsPatients with CMS were more likely to present with increased comorbidities. Patients with CMS undergoing CABG were at risk for worse short ‐term secondary postoperative outcomes and reduced long‐term survival. The data supports the need for further investigation for risk reduction surrounding operative revascularization.
Source: Journal of Cardiac Surgery - February 17, 2020 Category: Cardiovascular & Thoracic Surgery Authors: David Zapata, Michael Halkos, Jose Binongo, John Puskas, Robert Guyton, Omar Lattouf Tags: ORIGINAL ARTICLE Source Type: research

Young Black Adults More Prone to Stroke, but Don ' t Know It
THURSDAY, Feb. 13, 2020 -- Young black Americans face higher rates of stroke than others as a result of high blood pressure, diabetes and obesity, new research suggests. But the same study finds they typically underestimate their stroke risk. " If...
Source: Drugs.com - Daily MedNews - February 13, 2020 Category: General Medicine Source Type: news

Good oral hygiene isn’t just for the mouth: It benefits brain health too
(Natural News) Heart disease and cerebrovascular diseases (e.g., stroke) are the leading causes of death in western countries. These diseases are caused by several factors, such as hypertension, high blood cholesterol, diabetes mellitus, smoking and obesity. However, recent studies have found that there is another unexpected contributor to the development of atherosclerosis and atherothrombosis (blood clot...
Source: NaturalNews.com - February 12, 2020 Category: Consumer Health News Source Type: news

Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy
Publication date: May 2020Source: Biomedicine & Pharmacotherapy, Volume 125Author(s): Da-Hye Lee, So-Hyun Park, Yang Hoon Huh, Min Jung Kim, Hyo-Deok Seo, Tae-Youl Ha, Jiyun Ahn, Young-Jin Jang, Chang Hwa JungAbstractNonalcoholic fatty liver disease (NAFLD) is a common risk factor for metabolic syndrome that increases the risk of future cardiovascular disease, stroke, and diabetes. Recently, autophagy has been proposed as a means to prevent NAFLD. We investigated whether substances with autophagy-inducing activity alleviate NAFLD. The Valeriana fauriei (V. fauriei) was selected as a potential autophagy inducer among variou...
Source: Biomedicine and Pharmacotherapy - February 12, 2020 Category: Drugs & Pharmacology Source Type: research

Does Adherence to Mediterranean Diet Mediate the Association Between Food Environment and Obesity Among Non-Hispanic Black and White Older US Adults? A Path Analysis.
CONCLUSION: Population-tailored interventions/policies to modify food environment and promote MD consumption are needed in order to combat the obesity crisis in the United States. PMID: 32048856 [PubMed - as supplied by publisher]
Source: American Journal of Health Promotion : AJHP - February 12, 2020 Category: International Medicine & Public Health Authors: Chen M, Howard V, Harrington KF, Creger T, Judd SE, Fontaine KR Tags: Am J Health Promot Source Type: research

Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy.
Abstract Nonalcoholic fatty liver disease (NAFLD) is a common risk factor for metabolic syndrome that increases the risk of future cardiovascular disease, stroke, and diabetes. Recently, autophagy has been proposed as a means to prevent NAFLD. We investigated whether substances with autophagy-inducing activity alleviate NAFLD. The Valeriana fauriei (V. fauriei) was selected as a potential autophagy inducer among various natural materials using a Cyto-ID autophagy detection kit. V. fauriei 70 % ethanol extract (VFE) increased LC3II levels in the presence of the lysosomal inhibitor and reduced the GFP/mCherry puncta...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 10, 2020 Category: Drugs & Pharmacology Authors: Lee DH, Park SH, Huh YH, Jung Kim M, Seo HD, Ha TY, Ahn J, Jang YJ, Jung CH Tags: Biomed Pharmacother Source Type: research

Safety and Tolerability of Ketamine Use in Treatment-Resistant Bipolar Depression Patients with Regard to Central Nervous System Symptomatology: Literature Review and Analysis.
Abstract The current psychopharmacological treatment approaches for major depression focus on monoaminergic interventions, which are ineffective in a large proportion of patients. Globally, treatment-resistant bipolar depression (TRBD) affects up to 33% of depressive patients receiving treatment. Certain needs are still unmet and require new approaches. Many studies are in favor of treatments with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, even in single use, whose effects emerge in minutes to hours post administration. However, little data are available on ketamine performance in TRBD patients ...
Source: Medicina (Kaunas) - February 9, 2020 Category: Universities & Medical Training Authors: Włodarczyk A, Cubała WJ Tags: Medicina (Kaunas) Source Type: research

Association of increased arterial stiffness with diastolic dysfunction in ischemic stroke patients: the Norwegian Stroke in the Young Study
Background: Young and middle-aged ischemic stroke survivors have a high prevalence of hypertension, increased arterial stiffness and abnormal left ventricular (LV) geometry, which all are associated with the presence of LV diastolic dysfunction. However, the prevalence and covariates of diastolic dysfunction in these patients have not been reported. Objectives: To explore diastolic dysfunction in ischemic stroke patients aged 15–60 years included in the Norwegian Stroke in the Young Study. Methods: Data from 260 patients with acute ischemic stroke was analyzed. Diastolic dysfunction was assessed by combining tran...
Source: Journal of Hypertension - February 7, 2020 Category: Cardiology Tags: ORIGINAL PAPERS: Organ damage Source Type: research

Twitter-Characterized Sentiment Towards Racial/Ethnic Minorities and Cardiovascular Disease (CVD) Outcomes
In this study, we assessed the association between Twitter-derived sentiments towards racial/ethnic minorities at state-level and individual-level CVD-related outcomes from the 2017 Behavioral Risk Factor Surveillance System (BRFSS). Outcomes included hypertension, diabetes, obesity, stroke, myocardial infarction (MI), coronary heart disease (CHD), and any CVD from BRFSS 2017 (N = 433,434 to 433,680 across outcomes). A total of 30 million race-related tweets were collected using Twitter Streaming Application Programming Interface (API) from 2015 to 2018. Prevalence of negative and positive sentiment towards racial/ethn...
Source: Journal of Racial and Ethnic Health Disparities - February 4, 2020 Category: International Medicine & Public Health Source Type: research

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study
ConclusionsIn subjects with uncontrolled BP on existing antihypertensive therapy, switching to perindopril arginine 10  mg/indapamide 2.5 mg was associated with statistically significant decreases in BP and higher rates of target BP achievement in all BMI groups, including more than 70% of overweight and obese patients.Trial RegistrationISRCTN ID, ISRCTN14315146 (retrospectively registered 18/11/2019).
Source: Cardiology and Therapy - February 1, 2020 Category: Cardiology Source Type: research

Nicotinamide phosphoribosyltransferase contributes to cocaine addiction through sirtuin 1.
Authors: Singh S, William M, Chu XP Abstract Drug addiction is a persistent mental illness and there is no effective treatment. The precise mechanisms underlying addictive responses have not been completely understood, although ion channels, neurotransmitters as well as their receptors, and intracellular endogenous molecules in the brain have been shown to play important roles in cocaine addiction. Nicotinamide phosphoribosyltransferase (NAMPT) is an important rate-limiting enzyme found throughout the body that converts the intracellular pool of nicotinamide adenine dinucleotide (NAD) into nicotinamide mononucleoti...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 31, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Infection and atherosclerosis: TLR-dependent pathways.
This article reviews the role of TLRs in the process of atherosclerosis after C. pneumoniae and other infections and the current status of treatment, with a view to providing a new direction and potential therapeutic targets for the study of ASVD. PMID: 32002588 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Life Sciences : CMLS - January 30, 2020 Category: Cytology Authors: Li B, Xia Y, Hu B Tags: Cell Mol Life Sci Source Type: research

Dulaglutide: A Review in Type 2 Diabetes
AbstractSubcutaneous dulaglutide (Trulicity®) is a once-weekly glucagon-like peptide-1 receptor agonist that is approved in numerous countries as an adjunct to diet and exercise for the treatment of adults with type 2 diabetes (T2D). In the clinical trial and real-world settings, once-weekly subcutaneous dulaglutide, as monotherapy or add-on therapy to other antihyperglycaemic agents (including oral antihyperglycaemic drugs and insulin), was an effective and generally well tolerated treatment in adults with inadequately controlled T2D, including in high-risk patients [e.g. obese and elderly patients, those with stage 3 or...
Source: Drugs - January 30, 2020 Category: Drugs & Pharmacology Source Type: research

Rising rates of obesity, diabetes may reverse heart disease gains
Deaths from heart disease and stroke continue to decline nationally even as more and more people are living in poor health, a new report has found, potentially putting gains against heart disease in danger.
Source: Health News - UPI.com - January 29, 2020 Category: Consumer Health News Source Type: news

Discussion Related to “Maxillomandibular Advancement for Obstructive Sleep Apnea Is Associated with Very Long-Term Overall Sleep-Related Quality-of-Life Improvement.”
Obstructive sleep apnea (OSA) is a common chronic disease resulting from repetitive collapse of the airway during sleep, causing hypoxemia and sleep fragmentation. Untreated OSA at varying severity levels has been linked to hypertension, cardiac arrhythmias, stroke, diabetes, decreased work performance, decreased quality of life (QOL), and increased all-cause mortality. It is a costly global health concern as the increasing prevalence of OSA parallels the rising rates of obesity. OSA affects approximately 22% of men and 17% of women, while severe OSA is present in 2-4% of the adult population1.
Source: Journal of Oral and Maxillofacial Surgery - January 29, 2020 Category: ENT & OMF Authors: Jennifer M. Dolan, Ashleigh M. Weyh, Juliana Gomez, Salam O. Salman Source Type: research

Naturally prevent conditions like diabetes, heart disease and stroke with vitamin D and hormone support
(Natural News) Years of research have established a positive collaboration between estrogen and vitamin D to improve bone health. Now, recent research suggests that this dynamic duo could also play a role in staving off metabolic syndrome in postmenopausal women. Metabolic syndrome is described as a cluster of conditions – such as obesity, high blood sugar and...
Source: NaturalNews.com - January 27, 2020 Category: Consumer Health News Source Type: news

Effect of Dapagliflozin on Atrial Fibrillation in Patients with Type 2 Diabetes Mellitus: Insights from the DECLARE-TIMI 58 Trial.
Conclusions: Dapagliflozin decreased the incidence of reported episodes of AF/AFL adverse events in high-risk patients with T2DM. This effect was consistent regardless of the patients' prior history of AF, ASCVD, or HF. Clinical Trial Registration: URL: https://clinicaltrials.gov Unique Identifier: NCT01730534. PMID: 31983236 [PubMed - as supplied by publisher]
Source: Circulation - January 27, 2020 Category: Cardiology Authors: Zelniker TA, Bonaca MP, Furtado R, Mosenzon O, Kuder JF, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Budaj A, Kiss RG, Padilla F, Gause-Nilsson I, Langkilde AM, Raz I, Sabatine MS, Wiviott SD Tags: Circulation Source Type: research

Advancing mediation analysis in occupational health research
In recent years, mediation analysis has become a popular means to identify and quantify pathways linking an exposure to an outcome, thereby elucidating how a particular exposure contributes to the occurrence of a specific outcome. When a mediator is a modifiable risk factor, this opens up new opportunities for interventions to block (part) of the exposure`s effect on the outcome. Recent examples in Scandinavian Journal of Work Environment Health have addressed the mediating effect of wellbeing on the association between type of office and job satisfaction (1) and examined whether workplace social capital contributes to the...
Source: Scandinavian Journal of Work, Environment and Health - January 17, 2020 Category: Occupational Health Tags: Editorial Source Type: research

Physical health composite and risk of cancer mortality in the REasons for Geographic and Racial Differences in Stroke Study
We examined the association between baseline PH composite and cancer mortality adjusted for potential confounders using Cox regression. A total of 1191 cancer deaths were observed over the 10-year observation period, with the majority being lung (26.87%) and gastrointestinal (21.49%) cancers. Even after controlling for sociodemographics, health behaviors, baseline comorbidity score, and medications, participants with No PA and High RPP had 71% greater risk of cancer mortality when compared to participants with PA and Low RPP (adjusted HR: 1.71, 95% CI: 1.42–2.06). These associations persisted after examining BMI, smoking...
Source: Preventive Medicine - January 17, 2020 Category: International Medicine & Public Health Source Type: research

Naturally prevent conditions like diabetes, heart disease and stroke with vitamin D and hormone support
(Natural News) Years of research have established a positive collaboration between estrogen and vitamin D to improve bone health. Now, recent research suggests that this dynamic duo could also play a role in staving off metabolic syndrome in postmenopausal women. Metabolic syndrome is described as a cluster of conditions – such as obesity, high blood...
Source: NaturalNews.com - January 16, 2020 Category: Consumer Health News Source Type: news

Carbohydrate Quality, Glycemic Index, Glycemic Load and Cardiometabolic Risks in the US, Europe and Asia: A Dose-Response Meta-Analysis
ConclusionsOverweight/obese females can shift their carbohydrate intake for higher cereal fiber to decrease T2DM risk, but GL may cancel-out this effect.
Source: Nutrition, Metabolism and Cardiovascular Diseases - January 15, 2020 Category: Nutrition Source Type: research

The role of extracellular vesicles in skeletal muscle and systematic adaption to exercise.
This article is protected by copyright. All rights reserved. PMID: 31944292 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - January 15, 2020 Category: Physiology Authors: Vechetti IJ, Valentino T, Mobley CB, McCarthy JJ Tags: J Physiol Source Type: research

IJERPH, Vol. 17, Pages 513: Exploring the Relationship between Green Space in a Neighbourhood and Cardiovascular Health in the Winter City of China: A Study Using a Health Survey for Harbin
iuli An A severely cold climate has a significant impact on cardiovascular health, involving temperature, air environment, exercise and diet. Existing studies have revealed that green space, as an important health resource, may play a positive role in promoting cardiovascular health through the air environment and exercise. Studies focusing on the correlation between green space and cardiovascular health are rarely carried out in winter cities. The purpose of this paper is to take a winter city in China as an empirical case to explore the correlation between green space in a neighbourhood and cardiovascular health in a...
Source: International Journal of Environmental Research and Public Health - January 14, 2020 Category: Environmental Health Authors: Hong Leng Shuyuan Li Shichun Yan Xiuli An Tags: Article Source Type: research

Genes, Vol. 11, Pages 89: Pathogenesis of Ischemic Stroke: Role of Epigenetic Mechanisms
ranza Rubattu Epigenetics is the branch of molecular biology that studies modifications able to change gene expression without altering the DNA sequence. Epigenetic modulations include DNA methylation, histone modifications, and noncoding RNAs. These gene modifications are heritable and modifiable and can be triggered by lifestyle and nutritional factors. In recent years, epigenetic changes have been associated with the pathogenesis of several diseases such as diabetes, obesity, renal pathology, and different types of cancer. They have also been related with the pathogenesis of cardiovascular diseases including ischemi...
Source: Genes - January 13, 2020 Category: Genetics & Stem Cells Authors: Rosita Stanzione Maria Cotugno Franca Bianchi Simona Marchitti Maurizio Forte Massimo Volpe Speranza Rubattu Tags: Review Source Type: research

Porcine models for studying complications and organ crosstalk in diabetes mellitus
This article provides an overview of concepts for the development of porcine models for diabetes and obesity research, with a focus on genetically engineered models. Diabetes-associated ocular, cardiovascular and renal alterations observed in diabetic pig models are summarized and their similarities with complications in diabetic patients are discussed. Systematic multi-organ biobanking of porcine models of diabetes and obesity and molecular profiling of representative tissue samples on different levels, e.g., on the transcriptome, proteome, or metabolome level, is proposed as a strategy for discovering tissue-specific pat...
Source: Cell and Tissue Research - January 13, 2020 Category: Cytology Source Type: research

Characteristics and Outcomes of Patients Presenting With hypertensive urgency in the Office Setting: The Campania Salute Network.
CONCLUSIONS: Patients with HypUrg, have worst CV risk profile, reduced probability of BP control during FU and greater prevalence TOD, but the excess CV event risk appears to be mediated through BP control, non-blood pressure CVD risk factors, and demographic attributes. PMID: 31930302 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - January 13, 2020 Category: Cardiology Authors: Mancusi C, Losi MA, Albano G, De Stefano G, Morisco C, Barbato E, Trimarco B, De Luca N, de Simone G, Izzo R Tags: Am J Hypertens Source Type: research

Reducing Tongue Fat Could Improve Sleep Apnea, Study Says
This study shows reducing excess fat in general can reduce tongue size,” said Dr. Raj Dasgupta, a sleep specialist at Keck Medicine at the University of Southern California, who was not involved in the study. In the new paper, the researchers used MRI imaging to measure the effect on upper airways of a 10% weight loss in 67 obese patients. The images showed reducing tongue fat was the primary reason overall sleep apnea scores improved by 31%. “In fact, the more tongue fat you lost, the more your apnea improved,” said Schwab, who is the co-director of the Penn Sleep Center at Penn Medicine. Costs of sleep ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 10, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Healthwatch Syndicated CBSN Boston CNN Source Type: news

Adverse Cardiovascular Effects of Traffic Noise with a Focus on Nighttime Noise and the New WHO Noise Guidelines.
Abstract Exposure to traffic noise is associated with stress and sleep disturbances. The World Health Organization (WHO) recently concluded that road traffic noise increases the risk for ischemic heart disease and potentially other cardiometabolic diseases, including stroke, obesity, and diabetes. The WHO report focused on whole-day noise exposure, but new epidemiological and translational field noise studies indicate that nighttime noise, in particular, is an important risk factor for cardiovascular disease (CVD) through increased levels of stress hormones and vascular oxidative stress, leading to endothelial dys...
Source: Annual Review of Public Health - January 10, 2020 Category: International Medicine & Public Health Authors: Münzel T, Kroeller-Schön S, Oelze M, Gori T, Schmidt FP, Steven S, Hahad O, Röösli M, Wunderli JM, Daiber A, Sørensen M Tags: Annu Rev Public Health Source Type: research

Association Between Obesity Type and Common Vascular and Metabolic Diseases: A Cross-Sectional Study
Conclusions: Central obesity alone and compound obesity are associated with the risk of hypertension, hyperlipidemia, and diabetes mellitus. Compound obesity but not central obesity alone is associated with the risk of coronary heart disease, but further research is needed to confirm it. There are no significant relationship between stroke and central obesity alone or compound obesity.
Source: Frontiers in Endocrinology - January 9, 2020 Category: Endocrinology Source Type: research

Diagnostic strategy of pulmonary embolism in the cardiology department of Ibn Rochd University hospital, Casablanca, Morocco
ConclusionManagement of pulmonary embolism in our cardiology department is characterized by the frequent use of non-invasive techniques on the diagnostic view and appeal to heparin on the therapeutic view.
Source: Archives of Cardiovascular Diseases Supplements - January 7, 2020 Category: Cardiology Source Type: research

Psychosocial and behavioral characteristics of still smokers at 6 months after acute cerebro or cardiovascular events: Findings from INEV@L, a prospective pilot study
ConclusionOur pilot study in young workers highlights the low rate of smoking cessation, and generalized dual use of electronic + conventional cigarette at mid-term after acute MI or stroke. Our findings further suggest specific PSF pattern of non-quitters, associated with loss of perceived disease severity.
Source: Archives of Cardiovascular Diseases Supplements - January 7, 2020 Category: Cardiology Source Type: research

Gen X Women Get Less Sleep Than Any Other Generation. What ’s Keeping Them Up?
In the middle of the night, I wake up feeling warm. I open the window and pull my hair back into a ponytail and drink some water. Then I glance at my phone, delete a few things, and see some spam. I hit unsubscribe and go back to bed. Then I lie there thinking, What if by opening that spam email I got myself hacked? What if I just sent everyone in my contact list a Burger King ad at two in the morning? Now wide awake, I move on to other concerns: my parents’ health, my stepson’s college tuition, pending deadlines. Hours roll by. I tackle real-life math problems: how many weeks I have before getting my next free...
Source: TIME: Health - January 6, 2020 Category: Consumer Health News Authors: Ada Calhoun Tags: Uncategorized Gen X healthy sleep insomnia Source Type: news

History of Cardiovascular Disease, Intensive Lifestyle Intervention, and Cardiovascular Outcomes in the Look AHEAD Trial.
CONCLUSIONS: Intervention response heterogeneity was significant for nonfatal MI. Response heterogeneity may need consideration in a CVD-outcome trial design. PMID: 31898874 [PubMed - as supplied by publisher]
Source: Obesity - January 3, 2020 Category: Eating Disorders & Weight Management Authors: Look AHEAD Research Group, Lewis CE, Bantle JP, Bertoni AG, Blackburn G, Brancati FL, Bray GA, Cheskin LJ, Curtis JM, Egan C, Evans M, Foreyt JP, Ghazarian S, Barone Gibbs B, Glasser SP, W Gregg E, Hazuda HP, Hesson L, Hill JO, Horton ES, Hubbard VS, Jaki Tags: Obesity (Silver Spring) Source Type: research

Effects of Blood Pressure Lowering Agents on Cardiovascular Outcomes in Weight Excess Patients: A Systematic Review and Meta-analysis
ConclusionsIn hypertensive subjects with excess weight, diuretics are more effective for preventing HF and stroke than CCB and ACEI, respectively. CCB are a good first-line choice for prevention of cardiovascular disease, except HF.
Source: American Journal of Cardiovascular Drugs - January 3, 2020 Category: Cardiology Source Type: research

HFpEF Is the Substrate for Stroke in Obesity and Diabetes Independent of Atrial Fibrillation
Publication date: January 2020Source: JACC: Heart Failure, Volume 8, Issue 1Author(s): Milton PackerAbstractBoth obesity and type 2 diabetes are important risk factors for the development of heart failure with a preserved ejection fraction (HFpEF), and both disorders increase the risk of systemic thromboembolic events. Traditionally, the risk of stroke has been explained by the strong association of these disorders with atrial fibrillation (AF). However, adiposity and diabetes are risk factors for systemic thromboembolism, even in the absence of AF, because both can lead to the development of an inflammatory and fibrotic a...
Source: JACC: Heart Failure - December 31, 2019 Category: Cardiology Source Type: research

Refining Risk-Adjustment of 90-Day Costs Following Surgical Fixation of Ankle Fractures: An Analysis of Medicare Beneficiaries
Publication date: January–February 2020Source: The Journal of Foot and Ankle Surgery, Volume 59, Issue 1Author(s): Azeem Tariq Malik, Carmen E. Quatman, Thuan V. Ly, Laura S. Phieffer, Safdar N. KhanAbstractAs the current healthcare model transitions from fee-for-service to value-based payments, identifying cost-drivers of 90-day payments following surgical procedures will be a key factor in risk-adjusting prospective bundled payments and ensuring success of these alternative payment models. The 5% Medicare Standard Analytical Files data set for 2005–2014 was used to identify patients undergoing open reduction and inte...
Source: The Journal of Foot and Ankle Surgery - December 25, 2019 Category: Orthopaedics Source Type: research

Stroke Induces Prolonged Changes in Lipid Metabolism, the Liver and Body Composition in Mice
AbstractDuring recovery, stroke patients are at risk of developing long-term complications that impact quality of life, including changes in body weight and composition, depression and anxiety, as well as an increased risk of subsequent vascular events. The aetiologies and time-course of these post-stroke complications have not been extensively studied and are poorly understood. Therefore, we assessed long-term changes in body composition, metabolic markers and behaviour after middle cerebral artery occlusion in mice. These outcomes were also studied in the context of obesity, a common stroke co-morbidity proposed to prote...
Source: Translational Stroke Research - December 21, 2019 Category: Neurology Source Type: research

Can good sleep patterns offset genetic susceptibility to heart disease and stroke?
(Tulane University) A pioneering new study led by Dr. Lu Qi, director of the Tulane University Obesity Research Center, found that even if people had a high genetic risk of heart disease or stroke, healthy sleep patterns could help offset that risk. The study is published in the European Heart Journal.
Source: EurekAlert! - Medicine and Health - December 18, 2019 Category: International Medicine & Public Health Source Type: news

Overweight and obesity among the boys of primary public schools of Baish City in Jazan Province, Saudi Arabia: A cross-sectional study
Conclusions: Overweight and obesity was substantially prevalent among primary schoolboys with a significant rural–urban difference.
Source: Indian Journal of Public Health - December 18, 2019 Category: International Medicine & Public Health Authors: Mohammed Ibrahim Fakeeh Mohd Shanawaz Fahad Khan Azeez Ibrahim Ali Arar Source Type: research

Cardiac hypertrophy with obesity is augmented after pregnancy in C57BL/6 mice
ConclusionsThese results suggest that the combined effects of pregnancy and obesity augment cardiac hypertrophy and promote remodeling. The rising prevalence of CVD in premenopausal women may be attributed to an increased prevalence of women entering pregnancy with an overweight or obese BMI.
Source: Biology of Sex Differences - December 16, 2019 Category: Biology Source Type: research

Don ’t be Caught Half-dressed When Working with Radiation
AbstractA typical 2-piece personal protective equipment apron covers only half the body. However, with radiation exposure there is evidence of the following: (1) Left-sided head exposure estimates equal to 100,000 chest X-rays over a 20-year career, (2) direct linear relationship between stroke and concentration of dose, (3) increases in ischemic heart disease and myocardial infarction, (4) accelerated aging processes, and (5) increased double-stranded DNA breaks in circulating lymphocytes when lower legs are exposed. Every exposure to ionizing radiation involves a health risk that accumulates. Interventionalists are treat...
Source: CardioVascular and Interventional Radiology - December 16, 2019 Category: Radiology Source Type: research

A nonlinear association between resting heart rate and ischemic stroke among community elderly hypertensive patients.
Conclusions: In Chinese elderly hypertensive patients, elevated resting heart rate was an independent predictor of ischemic stroke, and the optimal resting heart rate was around 70bpm. PMID: 31829063 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - December 13, 2019 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Use of Direct Oral Anticoagulants in Morbidly Obese Patients
AbstractIn 2016, the International Society on Thrombosis and Haemostasis (ISTH) published guidelines advising caution when using direct oral anticoagulants (DOACs) in patients with morbid obesity due to limited clinical efficacy and safety data supporting their use in this patient population. In this review, we analyzed published articles in the MEDLINE database (from inception through May 29, 2019), and the Cochrane Library, Google Scholar, and EMBASE databases (from inception through April 26, 2019) that evaluated morbidly obese patients with atrial fibrillation (AF) or venous thromboembolism (VTE) who received DOACs. A ...
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 13, 2019 Category: Drugs & Pharmacology Authors: Kazuhiko Kido, James C. Lee, Thaddaus Hellwig, Michael P. Gulseth Tags: REVIEW OF THERAPEUTICS Source Type: research

En mann i 40- årene med akutt innsettende talevansker og ensidig lammelse.
En mann i 40-årene med akutt innsettende talevansker og ensidig lammelse. Tidsskr Nor Laegeforen. 2019 Dec 10;139(18): Authors: Jahr SH, Myro AZ, Vegge K, Campbell P Abstract BACKGROUND: Stroke has several causes and the diagnostic investigation can be challenging. Neurosyphilis occurs when Treponema pallidum infects the central nervous system, and is a rare cause of stroke. CASE PRESENTATION: A man in in his late forties with diabetes mellitus and overweight presented with headache, speech impairment and right-sided stroke symptoms. He also had cognitive impairment and psychiatric symptoms. He ...
Source: Tidsskrift for den Norske Laegeforening - December 10, 2019 Category: General Medicine Authors: Jahr SH, Myro AZ, Vegge K, Campbell P Tags: Tidsskr Nor Laegeforen Source Type: research

Risk of postoperative pulmonary complications in adult surgical patients with metabolic syndrome: a systematic review and meta-analysis protocol
DiscussionThis review will be the first to report and summarise the risk for and incidence of PPC in adult patients with MetS undergoing surgery across a range of surgical specialities. The results have the potential to inform the development of evidenced-based interventions to improve the management of PPC in the surgical patient with MetS. Findings from this systematic review and meta-analysis will inform a subsequent Delphi study on priorities and responses to PPC in patients with MetS. We will also disseminate our results through publication in scientific peer-reviewed journals, conference presentations and promotion t...
Source: Systematic Reviews - December 6, 2019 Category: International Medicine & Public Health Source Type: research

Uric Acid Contributes to Obesity-Paradox of the Outcome of Ischemic Stroke
Conclusions: These findings suggest that low UA and low BMI have a joint effect on poor outcomes in IS patients. Across BMI categories, uric acid is differentially associated with functional outcome after stroke. This effect of low UA in the low BMI groups may be one of the mechanisms underlying the obesity-stroke paradox of the outcome in IS patients.
Source: Frontiers in Neurology - December 5, 2019 Category: Neurology Source Type: research

'Bad cholesterol' levels should be checked from age of 25 - study
Understanding risks early on could help protect from disease later in life and ‘offer chance to take statins or adjust diet’All adults as young as 25, as well as older people, need to know of their “bad cholesterol” levels so they can change their lifestyle or take drugs to protect themselves against heart attacks or strokes in later life, say scientists.A landmark study involving data from nearly 400,000 people in 19 countries has established for the first time that levels of non-HDL, or “bad cholesterol”, in the blood are closely linked to the risk of heart disease across the entire life course.Continue reading...
Source: Guardian Unlimited Science - December 4, 2019 Category: Science Authors: Sarah Boseley Health editor Tags: UK news Health Heart attack Stroke Young people Older people Nutrition Science Obesity World news Source Type: news

Fuzzy cognitive map based approach for determining the risk of ischemic stroke
In this study, the soft computing method known as fuzzy cognitive mapping was proposed for diagnosis of the risk of ischemic stroke. Non-linear Hebbian learning method was used for fuzzy cognitive maps training. In the proposed method, the risk rate for each person was determined based on the opinions of the neurologists. The accuracy of the proposed model was tested using 10-fold cross-validation, for 110 real cases, and the results were compared with those of support vector machine and K-nearest neighbours. The proposed system showed a superior performance with a total accuracy of (93.6 ± 4.5)%. The da...
Source: IET Systems Biology - November 29, 2019 Category: Biology Source Type: research