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Will unpredictable side effects dim the promise of new Alzheimer ’s drugs?
A sea change is underway in the treatment of Alzheimer’s disease, where for the first time a drug that targets the disease’s pathology and clearly slows cognitive decline has hit the U.S. market. A related therapy will likely be approved in the coming months. As many neurologists, patients, and brain scientists celebrate, they’re also nervously eyeing complications from treatment: brain swelling and bleeding, which in clinical trials affected up to about one-third of patients and ranged from asymptomatic to fatal. The side effect—amyloid-related imaging abnormalities, or ARIA—remains mysterious. “We don’...
Source: Science of Aging Knowledge Environment - August 2, 2023 Category: Geriatrics Source Type: research

Changes of migraine aura with advancing age of patients
ConclusionThe frequency of typical characteristics of migraine aura and migraine headache including photophobia and phonophobia decreases with advancing patient age. This might have potentially difficult implications for the diagnosis of MA in the elderly.
Source: The Journal of Headache and Pain - August 1, 2023 Category: Neurology Source Type: research

A higher probability of subsequent stroke and ischemic heart disease in migraine patients: a longitudinal follow-up study in Korea
ConclusionsOur longitudinal follow-up study demonstrated a significant association between the presence of migraine and the development of stroke and ischemic heart disease in Korea, even after adjusting for cardiovascular risk factors.
Source: The Journal of Headache and Pain - July 31, 2023 Category: Neurology Source Type: research

E-110 Bilateral hypoplasia of the internal carotid artery (ICA) and intracranial vasculopathy with 'moyamoya phenomenon in association with alagille syndrome
ConclusionThe educational value of our case lies not only in the rarity of the condition but also in the uniqueness of patient presentation. It would be a helpful addition to the existing literature on rare genetic syndromes with cerebral vasculature involvement.Abstract E-110 Figure 1Disclosures H. Shakeel: None. J. Gandhi: None. R. Singh: None. A. Graziano: None. R. Cerejo: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Shakeel, H., Gandhi, J., Singh, R., Graziano, A., Cerejo, R. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-126 Multicenter flow diversion in 200 patients for treatment of intracranial aneurysms
ConclusionThis report characterizes patient demographics, aneurysm characteristics, procedure complications and long-term angiographic and clinical outcomes for a large patient population across multiple medical centers treated with flow diversion. Overall, procedures resulted in a high rate of occlusion and low rate of serious complications. Continued iterative outcomes analysis is warranted particularly as flow diversion technology evolves. Despite diverse hospital settings, differences in presentation, patient characteristics and the inclusion of off-label treatments, flow diversion procedures remained safe and effectiv...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Meister, R., Lesko, A., Marginean, H., Deshmukh, V. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-151 Efficacy of an incidental aneurysm alert system (IAAS) and the associated disparities of incidentally detected intracranial aneurysms
ConclusionsIAAS is an effective alerting system and can improve the management of incidentally discovered cerebral aneurysms. The natural history of cerebral aneurysms may differ for Hispanic andAsian Americans, suggesting a potentially higher risk at presentation. Future research is needed to better understand these disparities’ causes and reduce their risks.Disclosures K. Fukuda: None. Y. Ghochani: None. D. Enzmann: None. C. Arnold: None. X. Chen: None. J. Morales: None. D. Kimball: None. C. Beaman: None. G. Duckwiler: None. R. Jahan: None. S. Tateshima: None. V. Szeder: None. N. Kaneko: None. M. Nour: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Fukuda, K., Ghochani, Y., Enzmann, D., Arnold, C., Chen, X., Morales, J., Kimball, D., Beaman, C., Duckwiler, G., Jahan, R., Tateshima, S., Szeder, V., Kaneko, N., Nour, M. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

O-035 Endovascular treatment of cerebral venous thrombosis involving the deep venous system
ConclusionsAlthough deep venous involvement of CVT is uncommon, these patients are at risk of quickly becoming critically ill with an elevated rate of death or dependency. Although these patients may develop stroke, hemorrhage, or neurologic decline prompting consideration of endovascular therapy, the deep cerebral venous system is not easily accessible with catheters due to small lumens and risk of perforation. It has been proposed that deep cerebral veins may have a higher chance of recanalization if venous thrombus burden is reduced in other parts of the dural venous sinuses. Current literature has not fully explored th...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Morel, B., Hoffman, J., Folzenlogen, Z., Roark, C., Seinfeld, J., Case, D. Tags: SNIS 20th annual meeting oral abstracts Source Type: research

O-040 Initial clinical experience with the bendit steerable articulating tip microcatheter for intracranial access and intervention
ConclusionsInitial clinical experience with the controlled articulation that permits flexion at the tip of the microcatheter demonstrated it to be safe. Access to difficult proximal origin curves, and distal clinoidal/ophthalmic segment anatomy may be improved due to the high torque transmission, and acute angulation of this microcatheter. Further experience with the delivery of therapeutic devices will be necessary to better understand the potential role that the present catheter may play in modern neurointerventional procedures.Abstract O-040 Table 1 Patient/Indication/Comorbidities/Treatment/Bendit 21 Role 60s F Cerebr...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Qiao, Y., Zhang, Y., Tsappidi, S., Mehta, T., Hui, F. Tags: SNIS 20th annual meeting oral abstracts Source Type: research

E-020 Flow diversion for intracranial aneurysms: intracranial hemorrhage and thromboembolic complications in a multi-center cohort of 200 patients
ConclusionComplication rates in our study are comparable to previous reports, and our findings further support the general safety and efficacy of flow diversion. Despite a relatively large population, the low number of ICH and TE complications limit statistical significance. Further study of complications in more robust samples are needed. However, the descriptive understanding of these complications can help direction future investigations.Abstract E-020 Table 1ICH and TE Stratifications ICH Non-ICH p n=7 n=193 Hypertension 7 (100%) 97 (50.3%) 0.035 Currently Smoking 3 (42.9%) 28 (14.5%) 0.319 Mean Procedural Fluoroscopi...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Meister, R., Lesko, A., Marginean, H., Deshmukh, V. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-025 The rate and predictors of 30-day readmission in patients treated for cerebral aneurysms: a large single-center study
ConclusionIn our study, risk factors for 30-day readmission were increasing BMI, cancer, increasing aneurysm width, and anticoagulation use. Future studies should focus on aneurysm dimensions and the use of blood thinners as the literature pertaining these predictors is still scarce.Abstract E-025 Table 1 Variables N(%) 30-day Readmission 36 (6.6) Cause of Readmission: Infection Stroke Re-Rupture Wound Dehiscence Seizures CSF Leak Hydrocephalus Headache Wound Area Swelling Groin Hematoma Pseudo meningocele 9 (25)11 (30.6)1 (2.8)1 (2.8)1 (2.8)1 (2.8)1 (2.8)7 (19.4)2 (5.6)1 (2.8)1 (2.8) Causes and Rate of ReadmissionAbstrac...
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: El Naamani, K., Hunt, A., Jain, P., Lawall, C., Yudkoff, C., El Fadel, O., Ghanem, M., Momin, A., Atallah, E., Abbas, R., Zakar, R., Tjoumakaris, S., Gooch, M., Herial, N., Zarzour, H., Schmidt, R., Rosenwasser, R., Jabbour, P. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

E-049 Complications of middle meningeal artery embolization - a systematic review
ConclusionThe published literature suggests that MMA embolization is a generally well-tolerated procedure, but with a low risk of significant complications, including, but not limited to stroke, seizures, visual obscurations, and facial palsy. Further studies and sub-analyses are needed to fully characterize the incidence of such complications.Disclosures J. Gerstl: None. M. Shafi: None. S. Badikol: None. N. Nawabi: None. R. Mekary: None. M. Sukumaran: None. A. Kappel: None. A. Feroze: None. T. Smith: None. M. Aziz-Sultan: None.
Source: Journal of NeuroInterventional Surgery - July 30, 2023 Category: Neurosurgery Authors: Gerstl, J., Shafi, M., Badikol, S., Nawabi, N., Mekary, R., Sukumaran, M., Kappel, A., Feroze, A., Smith, T., Aziz-Sultan, M. Tags: SNIS 20th annual meeting electronic poster abstracts Source Type: research

I survived a stroke at 20 - here's the subtle symptom that I ignored
EXCL: Esmae Hodgetts from Chesterfield spent her New Years' Eve in hospital after collapsing at home. She felt neck and shoulder pain building up, then she was hit with a 'stabbing' headache.
Source: the Mail online | Health - July 29, 2023 Category: Consumer Health News Source Type: news

Optogenetic cortical spreading depolarization induces headache-related behaviour and neuroinflammatory responses some prolonged in familial hemiplegic migraine type 1 mice
ConclusionsCSDs, induced in a minimally invasive manner by optogenetics, investigated in freely behaving mice, cause various migraine relevant behavioural and neuroinflammatory phenotypes that are more pronounced and longer-lasting in FHM1 mutant compared to WT mice. Prevention of CSD-related neuroinflammatory changes may have therapeutic potential in the treatment of migraine.
Source: The Journal of Headache and Pain - July 26, 2023 Category: Neurology Source Type: research

Can Patent Foramen Ovales Cause Problems?
Discussion During fetal development, the heart primum and secundum septa grow and overlap leaving a small but important channel between the two atria. The foramen ovale is a flap valve moving blood from the right atrium into the left atrium directly and bypassing the high pressure pulmonary system. After birth and breathing air, the neonate’s lungs open up and the pulmonary vascular resistance decreases. The left atrium now has a relatively higher pressure than the right atria, and therefore pressure on the flap valve closes the foramen ovale. Usually within 6-12 months, the fusion of the primum and secundum of the f...
Source: PediatricEducation.org - July 24, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

How to Keep Your Home Cool in Extreme Heat
Global temperatures have reached alarmingly high levels across the U.S., Europe, and Asia as heat waves set record highs this week. Parts of European countries including most of Italy, eastern Croatia, southern Spain, southern Bosnia and Herzegovina, and Montenegro are under red alert, the European Union’s Emergency Response Coordination Centre said on Wednesday. Meanwhile, as of July 18, Phoenix had experienced 19 consecutive days of 110°F temperatures or higher. And Beijing is also experiencing a record stretch of 95°F heat. The extreme heat comes as weather phenomenon El Niño, which occurs every tw...
Source: TIME: Health - July 19, 2023 Category: Consumer Health News Authors: Solcyre Burga Tags: Uncategorized climate change extreme weather healthscienceclimate Source Type: news